CholestOff Plus 450 mg Ingredients & Drug Interactions
by Nature Made
What is this page for?
First and foremost: checking CholestOff Plus 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
CholestOff Plus 450 mg is a dietary supplement by Nature Made with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, heart health support, lowering ldl cholesterol.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of CholestOff Plus 450 mg by Nature Made
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
CholestOff Plus contains 2 active ingredients: plant sterols and plant stanols. These are naturally occurring compounds found in plants that work by blocking cholesterol absorption in your gut, which can help lower your blood cholesterol level.
The product delivers 450 mg per softgel capsule.
Does it work?
Strong evidence
Plant sterols are likely effective for lowering cholesterol (hypercholesterolemia) and for familial hypercholesterolemia, a genetic form of high cholesterol. For heart disease prevention and management, the evidence suggests they're possibly effective — meaning there's some research support, but it's not as strong.
Plant stanols are included in this product, but we don't have effectiveness information on file for them.
How safe is it?
Some data gaps
Plant sterols are generally well tolerated at the amounts typically found in foods and supplements for most adults. In rare cases, skin rashes and stomach discomfort have been reported.
Very high doses (much higher than what's in this product) have caused unusual effects in young children, but standard supplement amounts haven't shown this concern in research. If you're pregnant, the safety data on concentrated plant sterol supplements isn't well studied, so talk it over with your doctor before starting.
During breastfeeding, there's limited information available — check with your doctor or pharmacist for personalized advice.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. That said, if you take any prescription medication — especially blood thinners or cholesterol drugs — confirm with your pharmacist or doctor before you begin, since your individual health and drug list may matter.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and some safety-information gaps remain.
CholestOff Plus makes sense if you're looking to add plant sterols to your diet for cholesterol support, especially if you have high cholesterol or heart disease risk. If you take blood thinners, cholesterol drugs, or any regular prescription, check with your pharmacist or doctor before starting — even though no interactions are documented, it's smart to confirm your specific situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 24, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about CholestOff Plus 450 mg, straight from the product label.
| Brand | Nature Made |
|---|---|
| Net contents | 100 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Feb 24, 2017 |
| DSLD ID | 71081 |
| Product type | Fat/fatty Acid |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | All Other, Approved Health |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for CholestOff Plus 450 mg by Nature Made, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| Calories from Fat | 10 Calorie(s) | -- |
| Total Fat | 1 Gram(s) | 2% |
| Plant Sterols and Plant Stanols | 900 mg | -- |
| Plant Sterols | 0 NP | -- |
| Plant Stanols | 0 NP | -- |
Other ingredients: Plant Sterols, Plant Stanols, Sunflower Oil Esters, Gelatin, Glycerin, Medium Chain Triglycerides, Soy Lecithin, Water, Colors added
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Reducol is a trademark of Forbes Medi-Tech, Inc. Patent Pending
CholestOff Plus is an easy-to-swallow softgel.
CholestOff Plus softgels are made to Nature Made's guaranteed purity and potency standards.
General Statements
Daily sterol & stanol amounts Diet CholestOff Daily recommended amount Amount of phytosterols The National Institutes of Health (NIH) therapeutic lifestyle change guidelines recommendations 2000 mg Average American consumes - 200 mg CholestOff Plus provides additional: 1800 mg
Products containing at least 400 mg per serving of plant sterols and stanols, eaten twice a day with meals for a daily intake of at least 800 mg as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease. One serving of Nature Made CholestOff supplies 900 mg of plant sterols and stanols per serving for a dial intake of 1800 mg.
100% money back Results guaranteed or your money back. Visit NatureMade.com/guarantee for details
Reducol lowers cholesterol by reducing the absorption of dietary cholesterol into the bloodstream.
Before taking CholestOff Plus dietary cholesterol is absorbed into the bloodstream Intestine Bloodstream Intestine wall Cholesterol Less cholesterol absorbed in the bloodstream Plant sterols & stanols After taking CholestOff Plus less dietary cholesterol is absorbed into the bloodstream
Valid only for U.S. and Puerto Rico residents.
New softgel
Clinically proven to lower cholesterol
Colors derived from natural sources
Formula
Nature Made CholestOff Plus is made with esterified Reducol, a proprietary blend of plant-based sterols and stanols (also called phytosterols) which help lower LDL ("bad") cholesterol.
Plant sterols and stanols to support to heart health
FDA Statement of Identity
Dietary Supplement
Formulation
- No synthetic dyes No artificial flavors - No preservatives No yeast or starch - Gluten free
Suggested/Recommended/Usage/Directions
Suggested Use: Take two softgels two times daily with meals.
Precautions
Caution: Not for use by children or pregnant or lactating women. Check with your physician before using CholesOff Plus if you are currently using medication to lower your cholesterol.
Caution: Not for use by children or pregnant or lactating women.
Store in a cool, dry place out of reach of children.
Do not use if imprinted seal under cap is broken or missing.
Storage
Keep bottle tightly closed. Store in a cool, dry place out of reach of children.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
CholestOff Plus 450 mg by Nature Made label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in CholestOff Plus 450 mg by Nature Made
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container50 Amounts shown are per serving.
Plant Sterols and Plant Stanols
No knowninteractions
Plant sterols (and their close relatives, plant stanols) are natural compounds found in plants that can modestly lower LDL ('bad') cholesterol when ta...
Plant Sterols and Plant Stanols monograph & interactions- › Plant Sterols
- › Plant Stanols
Other (inactive) ingredients: Plant Sterols, Plant Stanols, Sunflower Oil Esters, Gelatin, Glycerin, Medium Chain Triglycerides, Soy Lecithin, Water, Colors added. These complete the product’s ingredient list but are not active constituents.
CholestOff Plus 450 mg by Nature Made Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in CholestOff Plus 450 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for CholestOff Plus 450 mg, from the product label.
Nature Made
See all Nature Made products- Name
- Nature Made Nutritional Products
- City
- Mission Hills
- State
- CA
- ZipCode
- 91346-9606
- Phone Number
- 1-800-276-2878
- Web Address
- www.NatureMade.com
CholestOff Plus 450 mg by Nature Made: Common Questions
Does CholestOff Plus 450 mg by Nature Made interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What are plant sterols and plant stanols?
Does this product actually lower cholesterol?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I notice?
Can I take this with my cholesterol medication or blood thinner?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if CholestOff Plus 450 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind CholestOff Plus 450 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
CholestOff Plus 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Plant Sterols 3 references
- Guardamagna, O., Abello, F., Baracco, V., Federici, G., Bertucci, P., Mozzi, A., Mannucci, L., Gnasso, A., and Cortese, C. Primary hyperlipidemias in children: effect of plant sterol supplementation on plasma lipids and markers of cholesterol synthesis a
- Haque Hussain SS, Weir J, Roberts N. Severe dermatitis secondary to plant sterol supplements. Clin Exp Dermatol. 2009 Oct;34(7):e276-7. PubMed
- Xue P, Wang Y, Chen Y, et al. A Case of Peripheral Precocious Puberty May Be Caused by a Diet Containing Phytosterols in a 20-Month-Old Boy. Horm Res Paediatr 2022;95(5):484-491. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC