CholestOff Plus Ingredients & Drug Interactions
by Nature Made
What is this page for?
First and foremost: checking CholestOff Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
CholestOff Plus is a dietary supplement by Nature Made with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, heart health support, lowering ldl cholesterol.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of CholestOff Plus by Nature Made
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
CholestOff Plus has 2 active ingredients: plant sterols and plant stanols. Both are compounds found naturally in plants that help block how much cholesterol your body absorbs from food — a simple mechanism that helps lower your cholesterol levels.
The softgel also contains several inactive ingredients (sunflower oil esters, gelatin, glycerin, and others) that help deliver and stabilize these actives.
Does it work?
Strong evidence
Plant sterols are likely effective at lowering high cholesterol (hypercholesterolemia), including the familial type, which runs in families. They're also possibly effective for reducing risk of heart disease.
The evidence for plant stanols isn't listed in our data, so we can't speak to its effectiveness here.
How safe is it?
Some data gaps
Plant sterols are generally well tolerated at the amounts found in food and typical supplements for most adults. During pregnancy, safety data on concentrated supplements is limited, so talk with your doctor before starting.
The same caution applies to breastfeeding — there isn't enough information, so check with your doctor or pharmacist for personalized guidance. Very rare side effects reported in case reports include skin rashes and abdominal discomfort.
One case of hormonal effects in a young child occurred with an unusually high dose (15 grams daily) of a chicken essence product — effects reversed when the product was stopped. These are uncommon, but if you notice rash, stomach upset, or any unusual symptoms, stop and contact your healthcare provider.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredient we could check. We do not hold interaction data for plant stanols.
Before you start, run your medications through the checker on this page or confirm with your own doctor or pharmacist — especially if you take any cholesterol-lowering drugs or blood thinners.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and some safety-information gaps remain.
CholestOff Plus is straightforward: it's for people who want to lower their cholesterol using plant compounds backed by solid evidence. If you're pregnant, breastfeeding, or take any medications, talk with your doctor or pharmacist before starting.
It's a tool that works best as part of a cholesterol-management plan that includes diet and lifestyle.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about CholestOff Plus, straight from the product label.
| Brand | Nature Made |
|---|---|
| Barcode (UPC) | 031604027896 |
| Net contents | 200 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Sep 21, 2018 |
| DSLD ID | 179818 |
| Product type | Fat/fatty Acid |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Approved Health, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for CholestOff Plus by Nature Made, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| Calories from Fat | 10 Calorie(s) | -- |
| Total Fat | 1 Gram(s) | 2% |
| Plant Sterols and Plant Stanols | 900 mg | -- |
| Plant Sterols | 0 NP | -- |
| Plant Stanols | 0 NP | -- |
Other ingredients: Plant Sterols, Plant Stanols, Sunflower Oil Esters, Gelatin, Glycerin, Medium Chain Triglycerides, Soy Lecithin, Water, Colors added
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General
List No. 2789 L201 Cat. A632 5A010 ITEM # 660923
Seals/Symbols
USP Dietary Supplement Verified
General Statements
Clinically proven to lower cholesterol
Products containing at least 400 mg per serving of plant sterols and stanols, eaten twice a day with meals for a daily intake of at least 800 mg as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease.
USP has tested and verified ingredients, potency, and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org
Formula
With 900 mg plant sterols and stanols per serving
One serving of Nature Made CholestOff Plus supplies 900 mg of plant sterols and stanols per serving for a daily intake of 1800 mg.
Contains: Soy.
FDA Statement of Identity
Dietary Supplement
Formulation
Colors derived from natural sources - No synthetic dyes No artificial flavors No preservatives No yeast or starch Gluten free
Suggested/Recommended/Usage/Directions
Suggested use: Take two softgels two times daily with your two largest meals. For easier swallowing, take with water before and during ingestion.
Precautions
Caution: Not for use by children or pregnant or lactating women.
Caution: Not for use by children or pregnant or lactating women. Check with your physician before using CholestOff Plus if you are currently using medications to lower your cholesterol.
Store in a cool, dry place, out of reach of children.
Do not use if imprinted seal under cap is broken or missing.
Contains: Soy.
Storage
Keep bottle tightly closed. Store in a cool, dry place, out of reach of children.
Brand IP Statement(s)
Reducol Reducol is a trademark of Pharmachem Laboratories Inc.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
CholestOff Plus by Nature Made label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in CholestOff Plus by Nature Made
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container100 Amounts shown are per serving.
Plant Sterols and Plant Stanols
No knowninteractions
Plant sterols (and their close relatives, plant stanols) are natural compounds found in plants that can modestly lower LDL ('bad') cholesterol when ta...
Plant Sterols and Plant Stanols monograph & interactions- › Plant Sterols
- › Plant Stanols
Other (inactive) ingredients: Plant Sterols, Plant Stanols, Sunflower Oil Esters, Gelatin, Glycerin, Medium Chain Triglycerides, Soy Lecithin, Water, Colors added. These complete the product’s ingredient list but are not active constituents.
CholestOff Plus by Nature Made Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in CholestOff Plus. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for CholestOff Plus, from the product label.
Nature Made
See all Nature Made products- Name
- Nature Made Nutritional Products
- City
- Mission Hills
- State
- CA
- ZipCode
- 91346-9606
- Phone Number
- 1-800-276-2878
- Web Address
- www.NatureMade.com
CholestOff Plus by Nature Made: Common Questions
Does CholestOff Plus by Nature Made interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will CholestOff Plus lower my cholesterol?
Can I take this while pregnant or breastfeeding?
What side effects might I notice?
What exactly are plant sterols and plant stanols?
Is this safe to use long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if CholestOff Plus is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind CholestOff Plus’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
CholestOff Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Plant Sterols 3 references
- Guardamagna, O., Abello, F., Baracco, V., Federici, G., Bertucci, P., Mozzi, A., Mannucci, L., Gnasso, A., and Cortese, C. Primary hyperlipidemias in children: effect of plant sterol supplementation on plasma lipids and markers of cholesterol synthesis a
- Haque Hussain SS, Weir J, Roberts N. Severe dermatitis secondary to plant sterol supplements. Clin Exp Dermatol. 2009 Oct;34(7):e276-7. PubMed
- Xue P, Wang Y, Chen Y, et al. A Case of Peripheral Precocious Puberty May Be Caused by a Diet Containing Phytosterols in a 20-Month-Old Boy. Horm Res Paediatr 2022;95(5):484-491. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC