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Dietary supplement

Cholestoril Ingredients & Drug Interactions

by Enzymatic Therapy

Cholestoril label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cholestoril against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cholestoril is a dietary supplement by Enzymatic Therapy with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, high triglycerides, heart health support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pantesin Pantethine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cholestoril by Enzymatic Therapy

Ask about any prescription or over-the-counter medication and we check it for interactions with Cholestoril by Enzymatic Therapy — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cholestoril by Enzymatic Therapy

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Cholestoril contains one active ingredient: pantethine (sold here as Pantesin Pantethine), a compound your body converts to pantothenic acid (vitamin B5). The tablet also includes several inactive ingredients — cellulose, modified cellulose, gum, stearic acid, magnesium stearate, titanium dioxide, silicon dioxide, soy lecithin, and carnauba wax — which serve as binders, fillers, and coating.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy cholesterol levels.
  • We looked for evidence on: Hyperlipidemia, Hyperlipoproteinemia.
  • The strongest evidence on file: Pantethine is rated "Possibly Effective" for Hyperlipoproteinemia (Natural Medicines).
  • Also on file: Pantethine is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia.

The evidence for pantethine is mixed. It is rated possibly effective for hyperlipoproteinemia (a disorder of blood lipid levels).

For athletic performance and other forms of high cholesterol (hyperlipidemia), the evidence is insufficient to establish whether it works. A few other uses, including pantothenate kinase-associated neurodegeneration (PKAN), lack reliable evidence as well.

The evidence, ingredient by ingredient Pantethine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pantethine is generally well tolerated in studies, though long-term safety data are limited. The most common side effects are mild gastrointestinal complaints: nausea, vomiting, diarrhea, epigastric discomfort (upper abdominal pain), bloating, and flatulence.

Mild itching has been reported rarely. The product facts note that safety during pregnancy and breastfeeding has not been well studied, so caution is advised, and there is not enough reliable safety data to recommend it unless your doctor advises otherwise.

Side effects, ingredient by ingredient Pantethine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pantethine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticoagulant or antiplatelet medications — such as warfarin, apixaban, dabigatran, heparin, aspirin, clopidogrel, or other blood thinners — check with your doctor or pharmacist before adding this product. Pantethine may theoretically increase your bleeding risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Cholestoril may be worth considering if you have hyperlipoproteinemia and your doctor agrees. If you take any blood thinners or antiplatelet drugs, confirm the combination with your doctor or pharmacist first.

Be aware that gastrointestinal side effects can occur, and long-term safety is not well established. Talk it over with your own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cholestoril, straight from the product label.

Brand Enzymatic Therapy
Barcode (UPC) 763948055043
Net contents 45 Tablet(s)
Market status On market
Date entered into DSLD Nov 24, 2015
DSLD ID 53964
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cholestoril by Enzymatic Therapy, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
763948055043
IngredientAmount% DV
Pantesin Pantethine300 mg--

Other ingredients: Cellulose, Modified Cellulose, modified Cellulose Gum, Stearic Acid, Magnesium Stearate, Titanium Dioxide color, Silicon Dioxide, Soy Lecithin, Carnauba Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Cholestoril with Pantesin

General Statements

-Helps break down fatty acids and cholesterol* -Supports healthy HDL (good cholesterol) levels already within the normal range*

Helps Maintain Healthy Cholesterol Levels* Already within the Normal Range

Heart Health*

Precautions

Keep out of reach of children.

Safety sealed with printed outer shrinkwrap and inner seal. Do not use if either is broken or missing.

If pregnant, nursing or taking any medications, consult a healthcare professional before use.

Formulation

Gluten Free. No sugar, salt, yeast, wheat, corn, dairy products, artificial flavors or preservatives.

Brand IP Statement(s)

Pantesin is a registered trademark of Daiichi Fine Chemicals, Ltd.

2015

Seals/Symbols

Vegetarian

General

LE05504. C01 BLK55OC

FDA Disclaimer Statement

* This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Take 1 tablet three times daily with meals.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cholestoril by Enzymatic Therapy label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cholestoril label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cholestoril by Enzymatic Therapy

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Pantesin Pantethine

Interacts with
122 drugs
300 mg per serving

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence i...

Pantesin Pantethine monograph & interactions

Other (inactive) ingredients: Cellulose, Modified Cellulose, Modified Cellulose Gum, Stearic Acid, Magnesium Stearate, Titanium Dioxide color, Silicon Dioxide, Soy Lecithin, Carnauba Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cholestoril by Enzymatic Therapy Drug Interactions

Want to check YOUR meds against Cholestoril?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pantesin Pantethine 122

Individual Drug Interactions

The ingredients in Cholestoril interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cholestoril interact with drugs. Each result below shows which ingredient is responsible. Pantesin Pantethine

Each ingredient & the kinds of drugs it affects

For each ingredient in Cholestoril with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pantesin Pantethine1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Some evidence suggests that pantethine reduces platelet aggregation.

Likelihood Possible Evidence B
Pantesin Pantethine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cholestoril, from the product label.

Enzymatic Therapy

Name
Enzymatic Therapy, LLC (Part of Nature’s Way Brands, LLC)
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-783-2286
Web Address
enzy.com
Pharmacist Counseling Corner

Cholestoril by Enzymatic Therapy: Common Questions

Does Cholestoril by Enzymatic Therapy interact with any medications?
Yes. Based on its ingredients, Cholestoril has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cholestoril contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pantethine, and what is it supposed to do?
Pantethine is a form of pantothenic acid (vitamin B5) that your body uses. This product is possibly effective for hyperlipoproteinemia, a lipid disorder. For other types of high cholesterol and athletic performance, the evidence isn't strong enough yet to say whether it works.
What side effects might I experience?
Pantethine is generally well tolerated, but the most common side effects are mild stomach complaints: nausea, vomiting, diarrhea, bloating, gas, and upper abdominal discomfort. Mild itching has been reported rarely.
Is pantethine safe during pregnancy or breastfeeding?
Safety during pregnancy and breastfeeding has not been well studied, so caution is advised. There isn't enough reliable data to know either way. Talk with your doctor or pharmacist for personalized advice if you're pregnant, planning to become pregnant, or breastfeeding.
Can I take this if I'm on a blood thinner like warfarin or aspirin?
Pantethine may theoretically increase bleeding risk with anticoagulants and antiplatelet drugs because it may reduce how your platelets clump. Check with your doctor or pharmacist before combining them — this isn't a yes-or-no answer, it's a conversation you need to have with your own healthcare provider.
How long should I take this before I see a difference?
The product facts don't provide information on how long pantethine takes to work. Your doctor or pharmacist can advise you on a reasonable timeline based on the condition being treated and your individual response.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cholestoril label
Go deeper

The Full Monographs Behind Cholestoril’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pantethine

Interacts with 122 drugs

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence is limited and not strong enough to repla...

Read the full Pantethine monograph →
Sources

Sources & How We Checked

Cholestoril's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pantethine 9 references
  1. Da Col PG, Cattin L, Fonda M, et al. Pantethine in the treatment of hypercholesterolemia: a randomized double-blind trial versus tiadenol. Curr Ther Res 1984;36:314-22.
  2. Rubba P, Postaiglione B, De Simone F, et al. Comparative evaluation of the lipid-lowering effects of fenofibrate and pantethine in type II hyperlipoproteinemia. Curr Ther Res 1985;38:719-27.
  3. Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.. PubMed
  4. Agrati AM, Ambrosi G, Ferraro G, Palmieri. Gemfibrozil efficacy vs pantethine in dyslipoproteinemic patients: a controlled study. Curr Ther Res 1989;45:650-63.
  5. Rumberger, J. A., Napolitano, J., Azumano, I., Kamiya, T., and Evans, M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk No
  6. Hiramatsu, K., Nozaki, H., and Arimori, S. Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia. Tokai J.Exp.Clin.Med. 1981;6(1):49-57.
  7. McRae MP. Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutrition Res 2005;25:319-333. DOI
  8. Cattin, L., Da Col, P. G., Fonda, M., Mameli, M. G., and Fergulio, G. A. Treatment of hypercholesterolemia with pantethine and fenofibrate; open randomized study on 43 subjects. Current Therapeutic Research 1985;38(Sep):386-395.
  9. Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded

See these in context on the Pantethine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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