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Dietary supplement

Choline 500 mg Ingredients & Drug Interactions

by Nested Naturals

Choline 500 mg label
See full label image
Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Choline 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Choline 500 mg is a dietary supplement by Nested Naturals with 1 active ingredient. Its ingredients are commonly taken for liver health and fatty liver, brain and memory support, prenatal nutrition and fetal development.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Choline 500 mg by Nested Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Choline 500 mg by Nested Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Choline 500 mg by Nested Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: choline, a nutrient that plays a role in brain function, cell structure, and liver health. Each capsule provides 500 mg.

The capsule itself is made from vegetable cellulose, a plant-based inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Choline's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: memory and mental clarity in healthy individuals.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Cognitive function, Dementia, Infant development, Neural tube birth defects.
  • The closest evidence on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Cognitive function, Dementia, Neural tube birth defects, and more.

The evidence we hold on choline is mixed. For athletic performance, the data suggests it's possibly ineffective.

For Alzheimer disease, age-related cognitive decline, hay fever, liver health during tube feeding (TPN-associated hepatic steatosis), and bronchitis, there isn't enough reliable evidence yet to draw a conclusion about whether it works.

The evidence, ingredient by ingredient Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Choline is generally well tolerated when you take an appropriate dose. However, high-dose supplements can cause side effects.

The daily upper limit is 3.5 grams; at doses of 9 grams or more, you may experience nausea, vomiting, diarrhea, and a fishy body odor due to how your gut breaks it down. This 500 mg dose is well below that threshold.

Choline is important during pregnancy and breastfeeding, and the safety data rates it as likely safe during both. That said, use it only at doses your doctor recommends—don't self-dose high amounts during these times.

Side effects, ingredient by ingredient Choline

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take atropine or any anticholinergic medications (Minor severity), check with your doctor or pharmacist before taking this supplement, as choline may theoretically reduce how well they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

This product is a simple, single-ingredient choline supplement that's generally well tolerated at this dose. If you take atropine or any anticholinergic medications, check your complete medication list with your doctor or pharmacist before starting.

Pregnant or breastfeeding women should confirm the dose with their healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Choline 500 mg, straight from the product label.

Brand Nested Naturals
Barcode (UPC) X000Y36ODV
Net contents 90 Vegan Capsule(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 286810
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Choline 500 mg by Nested Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegan Capsule(s)
Maximum serving Sizes:
2 Vegan Capsule(s)
Servings per container
45
UPC/BARCODE
X000Y36ODV
IngredientAmount% DV
Choline500 mg91%

Other ingredients: Vegetable Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Our mission: To better your health & wellness with clean ingredients backed by evidence-based science. Guaranteed for Life We're confident you'll love us, but if you don't... call or email us for a full refund. Radically Transparent You deserve to know everything that goes into your body, We include every single ingredient on the label.

Nested Naturals 1% for Health and Happiness Your purchase helps make the world a healthier and happier place.

Lifetime Guarantee

Get your next bottle free nestednaturals.com/free One use per customer

Made with love

Formulation

Third Party Tested Every batch is tested to ensure you get all the good stuff.

Maintains healthy memory and supports brain and liver function

Vegan

Lab Tested 3rd Party Verified for Purity & potency

Non GMO

Allergies? We have you covered. This product contains no wheat, gluten, GMO, soy, dairy, egg, corn, fish, shellfish, nuts, tree nuts, yeast, barley, or added sugar.

Gluten free

Formula

We like to think of Choline as the smarty pants nutrient. Studies suggest that choline may help to improve memory and mental clarity in healthy individuals. Maintain a healthy brain and nervous system by supporting cell metabolism. Choline, along with rest and a healthy diet, may help to support strength training and fitness goals in healthy individuals. Choline plays a supportive role in healthy cell-to-cell communication.

L + Choline Bitartrate

Suggested/Recommended/Usage/Directions

Suggested Use: Take 2 vegan capsules daily with water.

Precautions

Warning: Use only as directed.

Consult your healthcare professional if you are pregnant or nursing, have a serious medical condition, or use prescription medications.

Keep out of reach of children.

Food supplements are not a substitute for a varied diet.

Do not use if safety seal is broken.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place. Avoid excessive heat.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Choline 500 mg by Nested Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Choline 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Choline 500 mg by Nested Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Vegan Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Choline

Interacts with
16 drugs
500 mg per serving Form: L+Choline Bitartrate

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Choline 500 mg by Nested Naturals Drug Interactions

Want to check YOUR meds against Choline 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Choline 16

Individual Drug Interactions

The ingredients in Choline 500 mg interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Choline 500 mg interact with drugs. Each result below shows which ingredient is responsible. Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Choline 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Choline 500 mg, from the product label.

Nested Naturals

See all Nested Naturals products
Name
Nested Naturals Inc.
Street Address
250-997 Seymour St.
City
Vancouver
ZipCode
V6B 3M1
Phone Number
1-866-992-3677
Web Address
nestednaturals.com/free
Pharmacist Counseling Corner

Choline 500 mg by Nested Naturals: Common Questions

Does Choline 500 mg by Nested Naturals interact with any medications?
Yes. Based on its ingredients, Choline 500 mg has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Choline 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is 500 mg of choline safe to take daily?
Yes, 500 mg is well below the daily upper safe limit of 3.5 grams. At this dose, choline is generally well tolerated. Side effects like nausea, diarrhea, and fishy body odor only appear at much higher doses—9 grams daily or more.
Can I take this while pregnant or breastfeeding?
Choline is rated likely safe in pregnancy and lactation, and it's actually important during both. Use it only at the dose your doctor advises, though—don't go higher than what they recommend.
Will this improve my memory or brain function?
For Alzheimer disease and age-related cognitive decline, there isn't enough reliable evidence yet to say whether choline helps. The evidence we have doesn't support it for athletic performance either.
What's in the capsule besides choline?
The capsule itself is made from vegetable cellulose, a plant-based material. There are no other active ingredients in this product.
Can choline cause any side effects at this dose?
At 500 mg, side effects are unlikely. Problems like nausea, vomiting, diarrhea, and a fishy body odor only happen at doses of 9 grams daily or higher—much more than what you're taking.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Choline 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Choline 500 mg label
Go deeper

The Full Monographs Behind Choline 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph →
Sources

Sources & How We Checked

Choline 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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