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Dietary supplement

Pure Lion's Mane Ingredients & Drug Interactions

by Nested Naturals

Pure Lion's Mane label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure Lion's Mane against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pure Lion's Mane is a dietary supplement by Nested Naturals with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane Mushroom Fruiting Body Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pure Lion's Mane by Nested Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure Lion's Mane by Nested Naturals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pure Lion's Mane by Nested Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Pure Lion's Mane contains a single active ingredient: lion's mane mushroom fruiting body extract. There are no inactive ingredients listed for this powder, so you're getting the extract on its own.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Brain power, memory and mental focus.
  • We looked for evidence on: Memory, Cognitive function, Cognitive impairment, Dementia, Alzheimer disease, Parkinson disease — and 3 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Cognitive function, Cognitive impairment, Dementia, and more.

The evidence we hold on lion's mane for its commonly marketed uses — Alzheimer disease, anxiety, athletic performance, cancer prevention, and cognitive function — is insufficient to rate. That means the current research isn't strong enough to draw reliable conclusions about whether it works for these purposes.

If you're considering it for a specific health goal, talk it over with your doctor or pharmacist about what the research actually shows.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane is generally well tolerated when used as a food, but long-term safety in supplement form hasn't been well studied. The most common side effects reported with oral use are gastrointestinal discomfort, nausea, and skin rash — usually mild and temporary.

Pregnancy and breastfeeding: there isn't enough safety data to know whether this extract is safe during pregnancy or while breastfeeding. The data advises against use in both situations.

Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding before starting this product.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Pure Lion's Mane, double-check with your doctor or pharmacist if you're on blood thinners (anticoagulants or antiplatelets), diabetes drugs, or immunosuppressants. Lion's mane has documented moderate-severity interactions with all three categories that could affect how your medications work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane mushroom extract is generally well tolerated and may appeal to you if you're interested in cognitive or immune support, though the evidence for those uses isn't established yet. Be cautious if you take blood thinners, diabetes medications, or immunosuppressants — you'll want to check with your doctor or pharmacist first.

Avoid it if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure Lion's Mane, straight from the product label.

Brand Nested Naturals
Barcode (UPC) X003AWCD3N
Net contents 1.1 Ounce(s); 30 Gram(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 317230
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure Lion's Mane by Nested Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gram(s)
Maximum serving Sizes:
1 Gram(s)
Servings per container
30
UPC/BARCODE
X003AWCD3N
IngredientAmount% DV
Lion's Mane Mushroom Fruiting Body Extract1000 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Certified organic mushroom extract powder

Brain power Memory Mental focus

Vegan Nested Naturals Pure Lion's Mane mushroom extract powder is 100% pure, certified organic, vegan and contains no additives or fillers whatsoever.

USDA Organic Certified organic mushroom extract powder Nested Naturals Pure Lion's Mane mushroom extract powder is 100% pure, certified organic, vegan and contains no additives or fillers whatsoever.

Gluten free Non GMO

Don't let appearances fool you. These feathery mushrooms are heavyweight champs when it comes to knocking out brain fog and boosting brain power. The antioxidants in this mushroom help to support the aging process where we need it most, in our brain. Supports memory, focus, and alertness Supports a healthy nervous system Supports creativity and mood Nested Naturals Pure Lion's Mane mushroom extract powder is 100% pure, certified organic, vegan and contains no additives or fillers whatsoever.

Third party tested Every batch is tested to ensure you get all the good stuff.

Allergies? We have you covered. This product contains no gluten, GMO, soy, dairy, egg, fish, nuts, corn, yeast, shellfish or tree nuts.

This product is Certified Organic by QAI.

Made in the USA.

FDA Statement of Identity

Dietary Supplement Powder

Seals/Symbols

3rd party verified for purity & potency Lab tested USDA Organic

Formula

Just half a teaspoon of Pure Lion's Mane delivers 1,000 mg of these super mushrooms to keep you razor sharp and focused throughout the day.

General Statements

Our mission To better your health & wellness with clean ingredients backed by evidence-based science. Guaranteed for life We're confident you'll love this product, but if you don't please call or email us for a full refund. Radically transparent You deserve to know everything that goes into your body. We include every single ingredient on the label. Nested naturals 1% for health and happiness Your purchase helps make the world a healthier and happier place.

New

Suggested/Recommended/Usage/Directions

Suggested use: Add 1g (approx. 1/2 teaspoon) into your daily coffee, smoothie, water or food.

Precautions

Warning: Use only as directed.

Consult your healthcare professional before use if you are pregnant or nursing, have a serious medical condition, or use prescription medications.

For adult use only.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure Lion's Mane by Nested Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure Lion's Mane label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure Lion's Mane by Nested Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Lion's Mane Mushroom Fruiting Body Extract

Interacts with
327 drugs
1000 mg per serving

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Mushroom Fruiting Body Extract monograph & interactions
Interaction report

Pure Lion's Mane by Nested Naturals Drug Interactions

Want to check YOUR meds against Pure Lion's Mane?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane Mushroom Fruiting Body Extract 327

Individual Drug Interactions

The ingredients in Pure Lion's Mane interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pure Lion's Mane interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane Mushroom Fruiting Body Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure Lion's Mane with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane Mushroom Fruiting Body Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Mushroom Fruiting Body Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure Lion's Mane, from the product label.

Nested Naturals

See all Nested Naturals products
Name
Nested Naturals Inc.
Street Address
250-997 Seymour St.
City
Vancouver
ZipCode
V6B 3M1
Phone Number
1-866-992-3677
Web Address
nestednaturals.com
Pharmacist Counseling Corner

Pure Lion's Mane by Nested Naturals: Common Questions

Does Pure Lion's Mane by Nested Naturals interact with any medications?
Yes. Based on its ingredients, Pure Lion's Mane has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure Lion's Mane contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is lion's mane mushroom extract, and what is it supposed to do?
Lion's mane is an extract from the fruiting body of the lion's mane mushroom. It's commonly marketed for cognitive function, Alzheimer disease, anxiety, and athletic performance, but the evidence we hold on these uses is insufficient to rate reliably.
Can I take this while pregnant or breastfeeding?
No — there isn't enough safety data, so the data advises against use during pregnancy and while breastfeeding. Talk with your doctor or pharmacist if you're in either situation before taking this product.
What are the most common side effects?
Gastrointestinal discomfort, nausea, and skin rash are the most common adverse effects reported with oral lion's mane. These are usually mild and temporary.
Does this powder contain any fillers or other ingredients?
No — there are no inactive ingredients listed. You're getting the lion's mane mushroom extract on its own.
Is this safe to take long-term?
Lion's mane is generally well tolerated as a food, but long-term safety as a supplement hasn't been well studied. If you're thinking about using it regularly, check with your doctor or pharmacist.
I take a blood thinner — can I still use this?
Not without talking to your doctor first. Lion's mane may increase bleeding risk when combined with blood thinners, so you need personalized advice based on your specific medication and dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pure Lion's Mane is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure Lion's Mane label
Go deeper

The Full Monographs Behind Pure Lion's Mane’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Pure Lion's Mane's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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