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Dietary supplement

Choline Bitartrate 650 mg Ingredients & Drug Interactions

by NusaPure

Choline Bitartrate 650 mg label
See full label image
Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Choline Bitartrate 650 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Choline Bitartrate 650 mg is a dietary supplement by NusaPure with 1 active ingredient. Its ingredients are commonly taken for liver health and fatty liver, brain and memory support, prenatal nutrition and fetal development.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Choline Bitartrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Choline Bitartrate 650 mg by NusaPure

Ask about any prescription or over-the-counter medication and we check it for interactions with Choline Bitartrate 650 mg by NusaPure — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Choline Bitartrate 650 mg by NusaPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Choline Bitartrate” is listed as a grouped ingredient — the label gives one combined amount (650 mg) without saying how much of each component you get.

This supplement contains one active ingredient: choline bitartrate, which provides 650 mg per capsule. Choline is a nutrient your body uses to make and regulate acetylcholine, a neurotransmitter involved in nerve and muscle function, and to support cell membrane structure.

The capsule also contains inactive ingredients — cellulose, silica, magnesium stearate, and microcrystalline cellulose powder — which are fillers and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Choline product and its label doesn't state a use — see Choline's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for choline's effectiveness is limited and mixed. It's rated possibly ineffective for athletic performance.

For age-related cognitive decline, Alzheimer disease, bronchitis, hay fever, and liver fat buildup during IV nutrition support (a medical condition), we don't have enough reliable evidence yet to say whether it works. If you're considering this for a specific health goal, talk it over with your doctor or pharmacist about what the current research actually shows for your situation.

The evidence, ingredient by ingredient Choline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Choline is generally well tolerated at normal doses. The safety data advises using supplements only under professional guidance during pregnancy and breastfeeding, since your choline needs change at those times — prenatal vitamins or supplement doses should be recommended by your doctor.

At very high doses (9 grams or more daily, well above this 650 mg capsule), choline can cause fishy body odor, nausea, vomiting, diarrhea, and sweating. The upper daily limit is 3.5 grams.

Side effects, ingredient by ingredient Choline

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check whether you take atropine (Minor interaction documented). If you take any other prescription medications, use the search tool below to confirm they're safe to combine with choline.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This supplement works best for people whose doctor or pharmacist has advised them to take choline for a specific reason — it's not a proven performance or brain-health booster based on current evidence. If you take atropine or other medications, check them against the interaction tool on this page before you start.

Talk with your own doctor or pharmacist about whether choline makes sense for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Choline Bitartrate 650 mg, straight from the product label.

Brand NusaPure
Barcode (UPC) X001O6DYM1
Net contents 200 Veg Cap(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 307310
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Choline Bitartrate 650 mg by NusaPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veg Capsule(s)
Maximum serving Sizes:
2 Veg Capsule(s)
Servings per container
100
UPC/BARCODE
X001O6DYM1
IngredientAmount% DV
Choline Bitartrate650 mg48%
Choline267 mg--

Other ingredients: Cellulose, Silica, Magnesium Stearate, Microcrystalline Cellulose powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Choline Bitartrate 650mg per serving 200 Veg Caps - 267mg Elemental Choline

Choline Bitartrate 650mg per serving

General Statements

New

Suggested/Recommended/Usage/Directions

Directions: for adults, take two (2) capsules daily, preferably with a meal.

Precautions

Warning: for adults only. Keep out of reach of children.

If you are pregnant, nursing, taking any medications, or have a medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Allergen information: not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Premium Quality Assembled in USA Gluten Free FDA Registered Facility

Manufactured in a cGMP inspected facility

Formulation

GMO Free Made with non-GMO ingredients Gluten Free FDA Registered Facility

Assembled in USA Tested Supports normal nutritional supplementation Made under strict GMP guidelines Max strength

Suitable for Vegetarians/Vegans

Allergen information: not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Choline Bitartrate 650 mg by NusaPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Choline Bitartrate 650 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Choline Bitartrate 650 mg by NusaPure

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veg Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Choline Bitartrate

Interacts with
16 drugs
650 mg per serving

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline Bitartrate monograph & interactions

Other (inactive) ingredients: Cellulose, Silica, Magnesium Stearate, Microcrystalline Cellulose powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Choline Bitartrate 650 mg by NusaPure Drug Interactions

Want to check YOUR meds against Choline Bitartrate 650 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Choline Bitartrate 16

Individual Drug Interactions

The ingredients in Choline Bitartrate 650 mg interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Choline Bitartrate 650 mg interact with drugs. Each result below shows which ingredient is responsible. Choline Bitartrate

Each ingredient & the kinds of drugs it affects

For each ingredient in Choline Bitartrate 650 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Choline Bitartrate1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline Bitartrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Choline Bitartrate 650 mg, from the product label.

NusaPure

See all NusaPure products
Name
Gmax Central, LLC
Street Address
500 Westover Dr. #92909
City
Sanford
State
NC
ZipCode
27330
Pharmacist Counseling Corner

Choline Bitartrate 650 mg by NusaPure: Common Questions

Does Choline Bitartrate 650 mg by NusaPure interact with any medications?
Yes. Based on its ingredients, Choline Bitartrate 650 mg has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Choline Bitartrate 650 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant or breastfeeding?
The safety data says choline is likely safe during pregnancy and breastfeeding, but your nutrient needs are different at those times. Prenatal vitamins or supplement doses should be advised by your doctor — don't start choline supplements on your own. Talk with your doctor or pharmacist about what dose, if any, makes sense for you.
Will this help my memory or prevent Alzheimer disease?
We don't have enough reliable evidence yet to say whether choline helps with age-related memory loss or Alzheimer disease. If you're interested in choline for brain health, your doctor or pharmacist can discuss what the research currently shows and whether it's right for you.
What are the side effects?
At this dose (650 mg), choline is generally well tolerated. At very high doses — 9 grams or more daily — some people report fishy body odor, nausea, vomiting, diarrhea, and sweating. The upper daily limit is 3.5 grams.
Can I take this if I take atropine?
Choline may theoretically decrease how atropine works in the brain. If you take atropine, check with your doctor or pharmacist before starting this supplement — they can tell you if it's safe for your situation or if you need to space out your doses.
How much choline is in each capsule?
Each capsule provides 650 mg of choline bitartrate.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Choline Bitartrate 650 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Choline Bitartrate 650 mg label
Go deeper

The Full Monographs Behind Choline Bitartrate 650 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph →
Sources

Sources & How We Checked

Choline Bitartrate 650 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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