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Dietary supplement

Cissus Ingredients & Drug Interactions

by PrimaForce

Cissus label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cissus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cissus is a dietary supplement by PrimaForce with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cissus quadrangularis extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cissus by PrimaForce

Ask about any prescription or over-the-counter medication and we check it for interactions with Cissus by PrimaForce — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Cissus by PrimaForce

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This powder contains one active ingredient: Cissus quadrangularis extract. It's a plant-based extract used historically and studied for support with weight management and metabolic health.

There are no inactive fillers or other ingredients in this product — you're getting the extract on its own.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Cissus Quadrangularis's overall clinical evidence instead.

Moderate

Some clinical evidence supports Cissus Quadrangularis for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Obesity — rated "Possibly Effective" (Natural Medicines).

Research on Cissus quadrangularis suggests it is possibly effective for obesity, though the evidence base is limited. For other uses — including high cholesterol (hyperlipidemia), weak bone density (osteopenia), cancer, and epilepsy — the evidence is insufficient to rate whether it works.

If weight management is your goal, a conversation with your doctor about realistic expectations is worth having.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus quadrangularis is generally well tolerated in short-term use, but how it performs over months or years isn't well studied. In trials, headache and insomnia were reported, as were flatulence, diarrhea, gastritis, and dry mouth — but these occurred at rates similar to or lower than placebo, so they're uncommon.

There isn't enough safety data to know whether it's safe in pregnancy or while breastfeeding. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs, check your specific medications with the tool below before starting Cissus. The risk is moderate, and your blood sugar may drop further than intended.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Cissus may interest you if you're exploring weight management options and want a single-ingredient supplement. If you take any diabetes medications, you'll want to check with your doctor or pharmacist first because of the moderate risk of low blood sugar.

Long-term safety isn't well established, so this is best used short-term and under professional guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cissus, straight from the product label.

Brand PrimaForce
Barcode (UPC) 811445020108
Net contents 3.5 Ounce(s); 100 Gram(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 266145
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cissus by PrimaForce, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1000 mg
Maximum serving Sizes:
1000 mg
Servings per container
100
UPC/BARCODE
811445020108
IngredientAmount% DV
Cissus quadrangularis extract1000 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: Not intended for use by persons under the age of 18.

If you are pregnant or nursing or are taking any prescription medications, consult your healthcare professional before using this or any other dietary supplement product.

Immediately discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children

To report a serious adverse event, contact: Primaforce, Inc. 1448 Industry Drive Burlington, NC 27215 www.primaforce.com

Note: This product produced in a facility that may also process ingredients containing wheat, milk, egg, soybeans, fish, shellfish, tree nuts, and peanuts.

Storage

Store in a cool, dry place and avoid excessive heat.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Standardized 40% Ketosterones/20% 3-Ketosterone

Formulation

Tested for purity and potency Helps enhance recovery Supports optimal joint health Supports healthy weight management

Product produced in a GMP certified facility.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement consume one serving (1 level scoop), twice daily, approximately 30 minutes prior to meals.

Seals/Symbols

Primaforce is a US company

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cissus by PrimaForce label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cissus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cissus by PrimaForce

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1000 mg Dosage formPowder Servings per container100 Amounts shown are per serving.

Cissus quadrangularis extract

Interacts with
86 drugs
1000 mg per serving Form: 3-Ketosterone, Total Ketosterones

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus quadrangularis extract monograph & interactions
Interaction report

Cissus by PrimaForce Drug Interactions

Want to check YOUR meds against Cissus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cissus quadrangularis extract 86

Individual Drug Interactions

The ingredients in Cissus interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cissus interact with drugs. Each result below shows which ingredient is responsible. Cissus quadrangularis extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Cissus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cissus quadrangularis extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus quadrangularis extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cissus, from the product label.

PrimaForce

See all PrimaForce products
Name
PrimeForce, Inc.
Street Address
1448 Industry Drive
City
Burlington
State
NC
ZipCode
27215
Web Address
www.primaforce.com
Pharmacist Counseling Corner

Cissus by PrimaForce: Common Questions

Does Cissus by PrimaForce interact with any medications?
Yes. Based on its ingredients, Cissus has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cissus contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Cissus actually help with weight loss?
Research suggests it's possibly effective for obesity, but the evidence is limited. It's not a proven weight-loss drug — think of it as one tool among many, and results vary from person to person.
Can I take this if I'm on diabetes medication?
Not without talking to your doctor first. Cissus may lower blood sugar on its own, so combining it with a diabetes drug raises the risk of low blood sugar (hypoglycemia). Your pharmacist or doctor can help you decide if it's safe for you.
What side effects should I watch for?
Headache, insomnia, gas, diarrhea, stomach irritation, and dry mouth have been reported, but they occurred at rates similar to or lower than placebo — so they're uncommon. Most people tolerate it well in short-term use.
Is it safe to take long-term?
Long-term safety hasn't been well studied, so we don't have solid data on what happens if you take it for months or years. Short-term use is better understood.
Can I take this while pregnant or breastfeeding?
No. There isn't enough safety data, so it's best avoided during pregnancy and while breastfeeding. Talk with your doctor if you have questions about your specific situation.
What is Cissus quadrangularis?
It's a plant extract, sometimes called veldt grape, used in traditional medicine and studied for its effects on weight and metabolic health. This product is the extract alone — no fillers added.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cissus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cissus label
Go deeper

The Full Monographs Behind Cissus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Cissus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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