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Dietary supplement

Cissus Quadrangularis 1000 mg Ingredients & Drug Interactions

by Health Thru Nutrition

Cissus Quadrangularis 1000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cissus Quadrangularis 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cissus Quadrangularis 1000 mg is a dietary supplement by Health Thru Nutrition with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cissus quadrangularis extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cissus Quadrangularis 1000 mg by Health Thru Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Cissus Quadrangularis 1000 mg by Health Thru Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Cissus Quadrangularis 1000 mg by Health Thru Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Cissus quadrangularis extract at 1000 mg per capsule. Cissus quadrangularis is a plant used in traditional medicine, and research has looked at whether it may help with weight management and blood sugar.

The capsule itself is filled with inactive ingredients — hypromellose, maltodextrin, calcium palmitate, and silicon dioxide — which are standard binders and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Cissus Quadrangularis's overall clinical evidence instead.

Moderate

Some clinical evidence supports Cissus Quadrangularis for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Obesity — rated "Possibly Effective" (Natural Medicines).

The evidence here is mixed. For obesity, Cissus quadrangularis is rated possibly effective — meaning some small studies suggest it might help with weight management, but we'd need bigger, clearer trials to be confident.

For high cholesterol (hyperlipidemia), bone loss (osteopenia), cancer, and epilepsy, there isn't enough reliable evidence to rate whether it works. The data we have doesn't establish it as effective for those uses.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus quadrangularis is generally well tolerated in short-term use, though long-term safety hasn't been well studied — we just don't have the data yet. Headache, insomnia, flatulence, diarrhea, gastritis, and dry mouth have been reported, but the rates were about the same as or lower than placebo in trials, so they're not common concerns.

During pregnancy and breastfeeding, there isn't enough safety data, so the evidence advises against use — talk with your doctor or pharmacist before taking it if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs — medications like insulin, metformin, or other blood sugar medications — double-check with your doctor or pharmacist before starting this product. Cissus quadrangularis may lower blood sugar and increase the risk of hypoglycemia when combined with diabetes medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement might help with weight management based on small studies, but the evidence isn't definitive yet. If you take any diabetes medication, check with your doctor or pharmacist first — there's a real risk of low blood sugar if you combine them.

Long-term safety hasn't been studied, so talk it over with your healthcare provider before starting, especially if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cissus Quadrangularis 1000 mg, straight from the product label.

Brand Health Thru Nutrition
Barcode (UPC) 819193021170
Net contents 60 Vegecap(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 304831
Product type Botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cissus Quadrangularis 1000 mg by Health Thru Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegecap(s)
Maximum serving Sizes:
2 Vegecap(s)
Servings per container
30
UPC/BARCODE
819193021170
IngredientAmount% DV
Cissus quadrangularis extract1000 mg--

Other ingredients: Hypromellose, Maltodextrin, Calcium Palmitate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Free of: Milk, egg, fish, shellfish, tree nuts, wheat, peanuts and soybeans. Non-GMO, gluten free, soy free

Manufactured in a cGMP compliant U.S.A. facility.

Vegan

Precautions

Caution: Before using any dietary supplement, pregnant or lactating women should consult with a physician or health professional.

Keep out of reach of children.

Do not use if safety seal is broken or missing.

Storage

Keep bottle tightly closed. Store between 15 degrees - 30 degrees C (59 degrees - 86 degrees F).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Health Thru Nutrition is a registered trademark of EPIC.

Formula

Standardized to 2.5% phytosterols

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults: Take two (2) vegecaps daily as a dietary supplement or as recommended by your healthcare professional.

Seals/Symbols

cGMP

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cissus Quadrangularis 1000 mg by Health Thru Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cissus Quadrangularis 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cissus Quadrangularis 1000 mg by Health Thru Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Vegecap(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Cissus quadrangularis extract

Interacts with
86 drugs
1000 mg per serving Form: Phytosterols

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus quadrangularis extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Maltodextrin, Calcium Palmitate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cissus Quadrangularis 1000 mg by Health Thru Nutrition Drug Interactions

Want to check YOUR meds against Cissus Quadrangularis 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cissus quadrangularis extract 86

Individual Drug Interactions

The ingredients in Cissus Quadrangularis 1000 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cissus Quadrangularis 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Cissus quadrangularis extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Cissus Quadrangularis 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cissus quadrangularis extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus quadrangularis extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cissus Quadrangularis 1000 mg, from the product label.

Health Thru Nutrition

See all Health Thru Nutrition products
Name
Health Thru Nutrition
Street Address
30 New York Avenue
City
Westbury
State
NY
ZipCode
11590
Phone Number
1-866-319-6299
Pharmacist Counseling Corner

Cissus Quadrangularis 1000 mg by Health Thru Nutrition: Common Questions

Does Cissus Quadrangularis 1000 mg by Health Thru Nutrition interact with any medications?
Yes. Based on its ingredients, Cissus Quadrangularis 1000 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cissus Quadrangularis 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety data, so the evidence advises against it during pregnancy and breastfeeding. Talk with your doctor or pharmacist about whether this is right for you if you're in either situation.
What are the side effects?
Headache, insomnia, flatulence, diarrhea, gastritis, and dry mouth have been reported, but in trials they occurred at rates about the same as or lower than placebo — so they're not common. It's generally well tolerated in short-term use.
Does this actually work for weight loss?
It's rated possibly effective for obesity based on small clinical studies, meaning some evidence suggests it might help, but we'd need larger trials to be sure. It's not proven.
Why is there a 86 medication warning?
The ingredient interacts with 86 individual antidiabetes drugs — that's a lot of different blood sugar medications. If you take any diabetes medication, use the search tool on this page to check your exact drug before you start.
How long can I take this safely?
Short-term use is generally well tolerated, but long-term safety hasn't been well studied. Talk with your pharmacist about how long is reasonable for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cissus Quadrangularis 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cissus Quadrangularis 1000 mg label
Go deeper

The Full Monographs Behind Cissus Quadrangularis 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Cissus Quadrangularis 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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