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Dietary supplement

Cissus Quadrangularis Ingredients & Drug Interactions

by VitaMonk

Cissus Quadrangularis label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cissus Quadrangularis against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cissus Quadrangularis is a dietary supplement by VitaMonk with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cissus quadrangularis aerial extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cissus Quadrangularis by VitaMonk

Ask about any prescription or over-the-counter medication and we check it for interactions with Cissus Quadrangularis by VitaMonk — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Cissus Quadrangularis by VitaMonk

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product is straightforward: it contains one active ingredient, Cissus quadrangularis aerial extract, which comes from the aerial (above-ground) parts of the plant. The capsule also holds two inactive ingredients — rice flour and hypromellose — that are used to make and fill the capsule itself.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Cissus Quadrangularis's overall clinical evidence instead.

Moderate

Some clinical evidence supports Cissus Quadrangularis for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Obesity — rated "Possibly Effective" (Natural Medicines).

The evidence for Cissus quadrangularis is mixed and modest. It's rated possibly effective for obesity, based on small clinical studies suggesting it may help reduce fasting blood sugar in people who are overweight or obese.

For other uses — high cholesterol (hyperlipidemia), weak bones (osteopenia), cancer, and epilepsy — the evidence we have isn't strong enough to say whether it works or doesn't.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus quadrangularis is generally well tolerated in the short term. The most common complaints in trials were headache, insomnia, flatulence, diarrhea, indigestion (gastritis), and dry mouth — but these occurred at about the same rate as placebo, meaning they're not clearly caused by the supplement itself.

The big caveat: long-term safety hasn't been well studied, so we don't know what happens if you take it for months or years. During pregnancy or breastfeeding, the safety data isn't there — there isn't enough information to know if it's safe or not.

The facts advise against it during both. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any medication that lowers blood sugar — insulin, metformin, or other antidiabetes drugs — check with your doctor or pharmacist before starting this product. It may increase your risk of low blood sugar (a Moderate-severity interaction), so your dose may need adjusting and you'll want to watch for symptoms.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product might be worth considering if you're looking for something for weight management and you don't take diabetes medication. If you do take blood-sugar-lowering drugs, check with your doctor or pharmacist first — the combination needs watching.

Avoid it during pregnancy and breastfeeding unless your healthcare provider says otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cissus Quadrangularis, straight from the product label.

Brand VitaMonk
Barcode (UPC) X0016W8WF7
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 242106
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cissus Quadrangularis by VitaMonk, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
X0016W8WF7
IngredientAmount% DV
Cissus quadrangularis aerial extract1000 mg--

Other ingredients: Rice Flour, Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions & Recommended Use: As a dietary supplement, take two capsules daily or as directed by your healthcare practitioner.

Precautions

Warning: Do not exceed recommended dose.

Pregnant or nursing mothers, children under 18 and individuals with known medical conditions should consult a physician before using this dietary supplement.

Pregnant or nursing mothers, children under 18 and individuals with known medical conditions should consult a physician before using this dietary supplement.

Discontinue use and consult your physician if any adverse reactions occur.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

GMP Good Manufacturing Practice 100% Premium Quality Satisfaction Guaranteed

Formulation

Promotes healthy joints, bones and connective tissues Promotes healthy glucose levels

FDA Statement of Identity

Dietary Supplement

General Statements

To get 15% off your next purchase, visit www.vitamonk.com/thanks

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cissus Quadrangularis by VitaMonk label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cissus Quadrangularis label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cissus Quadrangularis by VitaMonk

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Cissus quadrangularis aerial extract

Interacts with
86 drugs
1000 mg per serving Form: Total 3-Ketosterones

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus quadrangularis aerial extract monograph & interactions

Other (inactive) ingredients: Rice Flour, Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cissus Quadrangularis by VitaMonk Drug Interactions

Want to check YOUR meds against Cissus Quadrangularis?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cissus quadrangularis aerial extract 86

Individual Drug Interactions

The ingredients in Cissus Quadrangularis interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cissus Quadrangularis interact with drugs. Each result below shows which ingredient is responsible. Cissus quadrangularis aerial extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Cissus Quadrangularis with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cissus quadrangularis aerial extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus quadrangularis aerial extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cissus Quadrangularis, from the product label.

VitaMonk

See all VitaMonk products
Name
VitaMonk
Street Address
2637 E Atlantic Blvd #24351
City
Pompano Beach
State
FL
ZipCode
33062
Web Address
VitaMonk.com
Pharmacist Counseling Corner

Cissus Quadrangularis by VitaMonk: Common Questions

Does Cissus Quadrangularis by VitaMonk interact with any medications?
Yes. Based on its ingredients, Cissus Quadrangularis has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cissus Quadrangularis contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Cissus quadrangularis actually help with weight loss?
The evidence suggests it may help — it's rated possibly effective for obesity. Small clinical studies found it reduced fasting blood sugar in people who were overweight or obese, which may play a role in weight management. But the evidence isn't huge, so it's not a sure thing.
What are the side effects?
Headache, insomnia, flatulence, diarrhea, indigestion, and dry mouth have been reported, but they occurred about as often in people taking placebo as in those taking Cissus quadrangularis. The main limitation is that long-term safety hasn't been studied well, so we don't know what happens with extended use.
Is it safe to take if I'm pregnant or breastfeeding?
There isn't enough safety data, so it's best avoided during both pregnancy and breastfeeding. Talk with your doctor or pharmacist to weigh whether the benefits might outweigh the unknowns in your specific situation.
Can I take this with my diabetes medication?
Not without checking first. Cissus quadrangularis may lower blood sugar, so combining it with antidiabetes drugs could raise your risk of low blood sugar. Your doctor or pharmacist needs to know you're taking it — they may adjust your dose and monitor you more closely.
How long does it take to work?
The facts don't specify how quickly you might see results. That's a great question for your doctor or pharmacist, who can discuss timeline based on how you're using it.
Does it have any fillers or weird stuff in it?
It has two inactive ingredients: rice flour and hypromellose (a capsule binder). Those are pretty standard — no unusual additives.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cissus Quadrangularis is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cissus Quadrangularis label
Go deeper

The Full Monographs Behind Cissus Quadrangularis’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Cissus Quadrangularis's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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