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Dietary supplement

Cissus Quadrangularis Extract Ingredients & Drug Interactions

by BulkSupplements.com

Cissus Quadrangularis Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cissus Quadrangularis Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cissus Quadrangularis Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cissus quadrangularis Aerial Parts Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cissus Quadrangularis Extract by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Cissus Quadrangularis Extract by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cissus Quadrangularis Extract by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: Cissus quadrangularis aerial parts extract. The supplement is formulated as a powder with no other inactive ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Cissus Quadrangularis's overall clinical evidence instead.

Moderate

Some clinical evidence supports Cissus Quadrangularis for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Obesity — rated "Possibly Effective" (Natural Medicines).

Cissus quadrangularis is possibly effective for obesity, according to the evidence we have on file. For other uses — including high cholesterol (hyperlipidemia), bone density, cancer, and epilepsy — the evidence isn't established or is insufficient to rate, so we can't say whether it works for those purposes based on our data.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus quadrangularis is generally well tolerated in the short term, though long-term safety hasn't been well studied. The most commonly reported side effects in trials are headache, insomnia, flatulence, diarrhea, gastritis, and dry mouth — but the rates of these effects were similar to or lower than placebo, so they're not a major concern for most people.

If you're pregnant or breastfeeding, there isn't enough safety data to know whether this supplement is appropriate, so it's best to avoid it and talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Cissus Quadrangularis Extract, double-check any antidiabetes drugs (blood sugar medications) you're taking with your doctor or pharmacist. There's a moderate risk that this supplement could increase your risk of low blood sugar when combined with these medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you're interested in support for weight management and don't take diabetes medications, this supplement has some evidence behind it and is generally well tolerated. If you do take medication to lower blood sugar, check with your own doctor or pharmacist before starting — the combination could lower your blood sugar further than intended.

For other uses, the evidence isn't strong enough yet to recommend it based on what we know.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cissus Quadrangularis Extract, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X001N1JXEP
Net contents 250 Gram(s); 8.8 Ounce(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 294464
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cissus Quadrangularis Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 mg
Maximum serving Sizes:
500 mg
Servings per container
500
UPC/BARCODE
X001N1JXEP
IngredientAmount% DV
Cissus quadrangularis Aerial Parts Extract500 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

BulkSupplements.com Clean & Pure Bulk Supplements

Formulation

Color may vary

Free of: Added Sugar, Soy, Dairy, Gluten, Additives

Precautions

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 500 mg (about 1/5 tsp) once or twice daily, or as directed by a physician.

Storage

Store in a dry, cool place

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cissus Quadrangularis Extract by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cissus Quadrangularis Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cissus Quadrangularis Extract by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 mg Dosage formPowder Servings per container500 Amounts shown are per serving.

Cissus quadrangularis Aerial Parts Extract

Interacts with
86 drugs
500 mg per serving

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus quadrangularis Aerial Parts Extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cissus Quadrangularis Extract by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Cissus Quadrangularis Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cissus quadrangularis Aerial Parts Extract 86

Individual Drug Interactions

The ingredients in Cissus Quadrangularis Extract interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cissus Quadrangularis Extract interact with drugs. Each result below shows which ingredient is responsible. Cissus quadrangularis Aerial Parts Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Cissus Quadrangularis Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cissus quadrangularis Aerial Parts Extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus quadrangularis Aerial Parts Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cissus Quadrangularis Extract, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
bulksupplements.com
Pharmacist Counseling Corner

Cissus Quadrangularis Extract by BulkSupplements.com: Common Questions

Does Cissus Quadrangularis Extract by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Cissus Quadrangularis Extract has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cissus Quadrangularis Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this supplement actually help with weight loss?
The evidence shows Cissus quadrangularis is possibly effective for obesity support — meaning small studies suggest it may help, but we'd need more research to be confident. It's not a standalone solution, but it may be worth discussing with your doctor as part of a broader weight-management plan.
What side effects should I expect?
Headache and insomnia have been reported, along with flatulence, diarrhea, gastritis, and dry mouth. The good news is that in trials, these effects happened at rates the same as or lower than placebo, so most people tolerate it well.
Is it safe to take long-term?
The short-term safety data looks fine, but long-term safety hasn't been well studied. If you're thinking of taking it regularly for months, that's a conversation to have with your doctor or pharmacist.
Can I take this while pregnant or breastfeeding?
There isn't enough safety data to know either way, so it's best to avoid it during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about what's right for your situation.
What is this extract actually made from?
It's made from the aerial parts (leaves and stems) of the Cissus quadrangularis plant, concentrated into an extract form.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cissus Quadrangularis Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cissus Quadrangularis Extract label
Go deeper

The Full Monographs Behind Cissus Quadrangularis Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Cissus Quadrangularis Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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