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Dietary supplement

Coenzymated B-1 Ingredients & Drug Interactions

by Source Naturals

Coenzymated B-1 label
See full label image
Lozenge Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Coenzymated B-1 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Coenzymated B-1 is a dietary supplement by Source Naturals with 1 active ingredient. Its ingredients are commonly taken for preventing or treating thiamine deficiency, beriberi, wernicke-korsakoff syndrome (alcohol-related).Based on those ingredients, 3 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Thiamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Coenzymated B-1 by Source Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Coenzymated B-1 by Source Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Coenzymated B-1 by Source Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Thiamine” is listed as a grouped ingredient — the label gives one combined amount (13 mg) without saying how much of each component you get.

This product contains one active ingredient: thiamine, also called vitamin B1. Thiamine is an essential B vitamin your body needs to convert food into energy and support nerve and heart function.

The form here is cocarboxylase, which is thiamine bound to a phosphate group—your body can use it the same way it uses regular thiamine.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: energy generation from carbohydrates.
  • We looked for evidence on: Thiamine deficiency, Wernicke-Korsakoff syndrome (WKS), Beriberi, Thiamine deficiency disease.
  • The strongest evidence on file: Thiamine is rated "Effective" for Thiamine deficiency (Natural Medicines).
  • Also on file: Thiamine is rated "Effective" for Wernicke-Korsakoff syndrome (WKS).

Thiamine is effective for treating thiamine deficiency and Wernicke-Korsakoff syndrome, a serious condition that can develop from severe thiamine lack. It's possibly effective for menstrual cramps (dysmenorrhea), though the evidence is less established.

For mosquito repellent and heart failure, the evidence doesn't support its use.

The evidence, ingredient by ingredient Thiamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Thiamine taken by mouth is generally very well tolerated. Rarely, it may cause a skin rash or allergic reaction.

Since thiamine is a nutrient your body needs during pregnancy and breastfeeding, this supplement is rated likely safe—but only use it at the doses your doctor or midwife recommends, not megadoses.

Side effects, ingredient by ingredient Thiamine

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Thiamine.
  • The most serious interaction on file is rated Minor.
  • For scale: 3 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Trimethoprim is the one antibiotic to flag—it may raise your thiamine blood levels slightly. If you take this antibiotic, let your doctor or pharmacist know you're considering this B-1 supplement.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This B-1 supplement works well if you have a thiamine deficiency or Wernicke-Korsakoff syndrome. Pregnant or breastfeeding folks can take it safely at recommended doses under their provider's guidance.

If you take trimethoprim (an antibiotic), mention this product to your doctor or pharmacist so they can keep an eye on your thiamine levels.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Coenzymated B-1, straight from the product label.

Brand Source Naturals
Barcode (UPC) 021078009337
Net contents 60 Lozenge(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 273030
Product type Vitamin
Supplement form Lozenge
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Coenzymated B-1 by Source Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Lozenge(s)
Maximum serving Sizes:
1 Lozenge(s)
Servings per container
60
UPC/BARCODE
021078009337
IngredientAmount% DV
Thiamine13 mg1083%
Cocarboxylase23 mg--

Other ingredients: Sorbitol, Mannitol, Sodium Citrate, natural Peppermint flavor, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formula

Cocarboxylase

In order for vitamins to be utilized by the body, they must first be converted into their active coenzyme forms. Coenzymated B1 is ready to go to work immediately. This essential nutrient plays key roles in generating energy from carbohydrates, fats, and alcohol, and in the formation of neurotransmitters in the brain. Thiamin diphosphate (TDP), also called thiamin pyrophosphate (TPP) or cocarboxylase, is the active, coenzyme form of vitamin B-1.

Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Suggested Use: 1 lozenge daily. For best results, allow to dissolve in the mouth before swallowing.

Precautions

Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Copyright SOURCE NATURALS, INC.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Coenzymated B-1 by Source Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Coenzymated B-1 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Coenzymated B-1 by Source Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Lozenge(s) Dosage formLozenge Servings per container60 Amounts shown are per serving.

Thiamine

Interacts with
3 drugs
13 mg per serving

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get eno...

Thiamine monograph & interactions

Other (inactive) ingredients: Sorbitol, Mannitol, Sodium Citrate, Natural Peppermint flavor, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Coenzymated B-1 by Source Naturals Drug Interactions

Want to check YOUR meds against Coenzymated B-1?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
3Drugs
3 Minor

Ingredients driving the most interactions

Thiamine 3

Individual Drug Interactions

The ingredients in Coenzymated B-1 interact with 3 drugs. Click any drug to see the details.

1 of the 1 ingredient in Coenzymated B-1 interact with drugs. Each result below shows which ingredient is responsible. Thiamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Coenzymated B-1 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Thiamine1 drug type · 3 drugs

Trimethoprim (Proloprim)

Trimethoprim might increase blood levels of thiamine.
In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations.

Likelihood Probable Evidence B
Thiamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Coenzymated B-1, from the product label.

Source Naturals

Name
Source Naturals, Inc.
Street Address
P. O. Box 2118
City
Santa Cruz
State
CA
ZipCode
95062
Web Address
www.sourcenaturals.com
Pharmacist Counseling Corner

Coenzymated B-1 by Source Naturals: Common Questions

Does Coenzymated B-1 by Source Naturals interact with any medications?
Yes. Based on its ingredients, Coenzymated B-1 has a known interaction with 3 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Coenzymated B-1 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant?
Thiamine is needed during pregnancy and this supplement is rated likely safe. However, use only the dose your doctor or midwife advises—don't take more than recommended without checking first.
Can I take it if I'm breastfeeding?
Yes, thiamine is needed while you breastfeed and this supplement is rated likely safe. Use it at recommended amounts under your provider's guidance.
What does cocarboxylase mean—is it different from regular B-1?
Cocarboxylase is thiamine bonded to a phosphate group. Your body uses it the same way as regular thiamine, so the difference is mainly chemical—both forms work.
Will this help with mosquitoes?
The evidence doesn't support using thiamine as a mosquito repellent, so it's not a reliable choice for that purpose.
Does this contain any allergens I should know about?
The inactive ingredients are sorbitol, mannitol, sodium citrate, peppermint flavoring, and magnesium stearate—none of which are top allergens. If you have a known allergy to peppermint or any of these, check the label or ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Coenzymated B-1 label
Go deeper

The Full Monographs Behind Coenzymated B-1’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Thiamine

Interacts with 3 drugs

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...

Read the full Thiamine monograph →
Sources

Sources & How We Checked

Coenzymated B-1's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Thiamine 7 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  4. Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann.Pharmacother. 2010;44(2):311-324. PubMed
  5. Arruti N, Bernedo N, Audicana MT, Villarreal O, Uriel O, Muñoz D. Systemic allergic dermatitis caused by thiamine after iontophoresis. Contact Dermatitis. 2013 Dec;69(6):375-6. PubMed
  6. Thiamine hydrochloride injection package insert. Lake Zurich, IL: Fresenius Kabi, LLC; September 2019.
  7. Vora B, Wen A, Yee SW, et al. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther 2023;114(2):381-392.

See these in context on the Thiamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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