Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Cogni-Fit Ingredients & Drug Interactions

by Natural Factors Whole Earth & Sea

Cogni-Fit label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cogni-Fit against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cogni-Fit is a dietary supplement by Natural Factors Whole Earth & Sea with 4 active ingredients. Its ingredients are commonly taken for liver health and fatty liver, brain and memory support, prenatal nutrition and fetal development.Based on those ingredients, 683 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cogni-Fit by Natural Factors Whole Earth & Sea

Ask about any prescription or over-the-counter medication and we check it for interactions with Cogni-Fit by Natural Factors Whole Earth & Sea — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cogni-Fit by Natural Factors Whole Earth & Sea

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (279.50 mg) without saying how much of each component you get.
  • “Romega 30” is listed as a grouped ingredient — the label gives one combined amount (650 mg) without saying how much of each component you get.
  • “Total Phospholipids” is listed as a grouped ingredient — the label gives one combined amount (195 mg) without saying how much of each component you get.

Cogni-Fit has 6 active ingredients. The main ones are omega-3 fatty acids — eicosapentaenoic acid and docosahexaenoic acid (often called EPA and DHA) — delivered partly as free fatty acids and partly bound to phospholipids, which some research suggests the body may absorb more readily.

The product also includes choline, a nutrient your cells use to make a brain chemical called acetylcholine, and astaxanthin, a carotenoid pigment from marine sources. The inactive ingredients are softgel capsule material, fish oil, mixed tocopherols (vitamin E), and rosemary leaf extract.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: brain health and cognitive performance support.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Cognitive function, Dementia, acetylcholine production, information processing.
  • The closest evidence on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Cognitive function, Dementia.
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline, Alzheimer disease, Cognitive function.

The evidence for Cogni-Fit's individual ingredients and their role in cognitive health is not well established. Choline has insufficient reliable evidence for age-related cognitive decline and Alzheimer disease, and appears possibly ineffective for athletic performance.

Astaxanthin similarly lacks reliable evidence for age-related cognitive decline, Alzheimer disease, and athletic performance. The omega-3 components (EPA and DHA) do not have effectiveness ratings on file in our data.

If you're considering this for brain health or a specific condition, talk with your doctor about what the current research actually supports.

The evidence, ingredient by ingredient Choline Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Choline is well tolerated at food amounts and rated likely safe in pregnancy and lactation — though choline is important during these times, your doctor should guide whether you need supplementation beyond diet. At high doses (over 3.5 grams daily), choline can cause fishy body odor, and even higher doses may bring nausea, vomiting, diarrhea, and sweating.

Astaxanthin appears generally well tolerated in studies, but long-term safety data are limited. The safety data advise against astaxanthin during pregnancy and breastfeeding due to insufficient information.

Side effects, ingredient by ingredient Choline Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Choline, Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • For scale: 684 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Cogni-Fit, double-check any medications metabolized by your liver's CYP3A4 or CYP2B6 enzymes (Moderate interaction with astaxanthin) — these include many statins, some blood pressure and immunosuppressant drugs, and others. Also flag if you take atropine or related anticholinergic drugs, since choline might reduce their effect (Minor interaction).

Use the medication search tool on this page to confirm your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Cogni-Fit may be worth considering if you're looking to support omega-3 and choline intake, though the evidence for cognitive benefit specifically is not clear-cut. If you take any regular medications — especially those processed by your liver — check them against this product's interaction list before starting, because astaxanthin may interfere with how your body clears certain drugs.

Pregnant or breastfeeding? Talk with your doctor or pharmacist first, since astaxanthin isn't recommended in those states.

Your own healthcare provider can help you decide if this product fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cogni-Fit, straight from the product label.

Brand Natural Factors Whole Earth & Sea
Barcode (UPC) 068958355009
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jul 24, 2015
DSLD ID 46665
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cogni-Fit by Natural Factors Whole Earth & Sea, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
068958355009
IngredientAmount% DV
Calories5 {Calories}--
Calories from Fat5 {Calories}--
Eicosapentaenoic Acid58.5 mg--
Docosahexaenoic Acid195 mg--
Cholesterol20 mg7%
Total Fat0.5 Gram(s)1%
Total Omega-3 Fatty Acids279.5 mg--
Choline27.3 mg--
Romega 30650 mg--
Total Phospholipids195 mg--
DHA Phospholipids55.25 mg--
EPA Phospholipids20.8 mg--
Astaxanthin360 mcg--

Other ingredients: Softgel, Fish Oil, Mixed Tocopherols, Rosemary leaf extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

The omega-3 fatty acids are in phospholipid form – the same form found in human cell membranes, significantly increasing their rate of absorption and therefore their ability to support the brain and overall health.

The Silver of the Seas Legend tells us that the fish of the deep chose the herring as their king, inspired perhaps by the herring's graceful swimming and its sheer beauty when massed shoals sparkle like silver through the ocean waves. The Norwegians seem to agree with the legends, giving herring such titles as "silver of the sea".

The long coastline and deep fjords of Norway are home to rich herring fishing grounds, which have long served as one of the main sources of food for the Norwegian people.

Herring oil derived from the roe of Norwegian spring-spawning herring is rich in the essential omega-3 fatty acids DHA and EPA, as well as choline and astaxanthin.

Choline is important for healthy liver function and cognitive performance, and is a precursor for the powerful brain chemical acetylcholine, which helps us process information faster and improves memory.

The oil is sourced in an environmentally friendly, sustainable manner. The Norwegian spring-spawning herring fishery has been independently certified by the Marine Stewardship Council (MSC) whose mission is to conserve the marine habitat.

PURE FOOD NUTRIENT-RICH SOFTGELS 100% MADE, PACKAGED, AND TESTED IN USA AND CANADA

NON-GMO ~ MASS SPEC Documentation Lab Tested

~ Healthy brain activity relies primarily on DHA phospholipids* ~ Enhanced absorption and bioavailability

~No fishy repeat

{chart} COMPARE AND SEE THE DIFFERENCE COGNI-FIT Krill Oil Fish Oil SMALL SOFTGEL {check} {check} OMEGA-3s {check} {check} {check} HIGHEST OMEGA-3 PHOSPHOLIPIDS {check} NATURAL CHOLINE {check} NATURAL ASTAXANTHIN {check} {check}

{Softgel} ACTUAL SIZE

PRODUCT OF SPAIN (Herring from Norway)

FREE PROTEIN BAR INSIDE $3.49 VALUE $2 from the purchase of each bottle goes to...plant a seed & see what grows FOUNDATION www.seewhatgrows.org

PURE FOOD Triple Strength DHA for Brain Power

Small ~ Easy-to-Swallow ~ No Fishy Repeat

Omega-3 fatty acids, including DHA and EPA, support cognitive health and brain function.

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Made with 100% recycled material.

Brand IP Statement(s)

isura(TM)

ROMEGA(TM) is a trademark of Arctic Nutrition AS, Orsta Norway.

Formula

A rich source of DHA and EPA in a near 3:1 ratio for optimal brain power*

~Provides more omega-3 phospholipids than krill oil ~ An ecologically friendly source of omega-3s

Fast Absorption Omega-3 Phospholipids Plus Choline & Astaxanthin

100% Sustainably Harvested Norwegian Herring Roe

Seals/Symbols

Purity & Potency Guaranteed

natural Factors(R)

Formulation

NON-GMO

NO GLUTEN ~ NO SOY ~ NO CORN

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, shellfish, salt, tree nuts, or GMOs.

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

Suggested usage: 1 softgel 1-2 times per day or as directed by a health professional.

Precautions

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Storage

For freshness, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

R0

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cogni-Fit by Natural Factors Whole Earth & Sea label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cogni-Fit label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cogni-Fit by Natural Factors Whole Earth & Sea

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Choline

Interacts with
16 drugs
27.3 mg per serving

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Romega 30

650 mg per serving
  • › Total Omega-3 Fatty Acids
  • › Total Phospholipids

Astaxanthin

Interacts with
673 drugs
360 mcg per serving Form: Haematococcus pluvialis

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

Other (inactive) ingredients: Softgel, Fish Oil, Mixed Tocopherols, Rosemary leaf extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cogni-Fit by Natural Factors Whole Earth & Sea Drug Interactions

Want to check YOUR meds against Cogni-Fit?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
683Drugs
673 Moderate 10 Minor

Ingredients driving the most interactions

Astaxanthin 673
Choline 16

Individual Drug Interactions

The ingredients in Cogni-Fit interact with 683 drugs. Click any drug to see the details.

2 of the 4 ingredients in Cogni-Fit interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Cogni-Fit with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin2 drug types · 673 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cogni-Fit, from the product label.

Natural Factors Whole Earth & Sea

See all Natural Factors Whole Earth & Sea products
Name
Natural Factors Canada
Pharmacist Counseling Corner

Cogni-Fit by Natural Factors Whole Earth & Sea: Common Questions

Does Cogni-Fit by Natural Factors Whole Earth & Sea interact with any medications?
Yes. Based on its ingredients, Cogni-Fit has a known interaction with 683 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cogni-Fit contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have omega-3s in it?
Yes. Cogni-Fit contains EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), which are omega-3 fatty acids sourced from fish oil. Some of these are bound to phospholipids, a form some research suggests may be absorbed more easily.
Is astaxanthin safe during pregnancy?
No. There isn't enough safety data on astaxanthin in pregnancy, so it's best to avoid it during that time. Talk with your doctor before taking this product if you're pregnant or planning to be.
Can I take this if I'm breastfeeding?
Choline is safe and even important while breastfeeding, but astaxanthin is not recommended due to limited safety data. Check with your doctor or pharmacist about whether this product is right for you during breastfeeding.
What does choline do?
Choline is a nutrient your cells use to make acetylcholine, a chemical messenger in your brain and nervous system. Your body can make some choline on its own, but you also get it from food and supplements.
Are there any common side effects?
At normal doses, choline is well tolerated, though a fishy body odor can occur. Astaxanthin in studies caused mild effects like slightly increased bowel movements or reddish stool color in a small number of participants.
Does this product actually help with memory or brain health?
The evidence isn't clear. Choline and astaxanthin both lack reliable evidence for Alzheimer disease and age-related cognitive decline. If brain health is your main reason, ask your doctor what the research supports for your specific situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cogni-Fit label
Go deeper

The Full Monographs Behind Cogni-Fit’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph → Herb & supplement monograph

Astaxanthin

Interacts with 673 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Cogni-Fit's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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