Major interaction on record — check this product against your medications before combining. Based on 7 of 12 ingredients. Check your meds →
Dietary supplement

Super Mushroom Ingredients & Drug Interactions

by Natural Factors Whole Earth & Sea

Super Mushroom label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Mushroom against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Super Mushroom is a dietary supplement by Natural Factors Whole Earth & Sea with 12 active ingredients. Its ingredients are commonly taken for high cholesterol, heart health, immune support.Based on those ingredients, 1,667 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are organic Reishi (Ganoderma lucidum) 30:1 extract, organic Chaga, organic Lion's Mane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Super Mushroom by Natural Factors Whole Earth & Sea

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Mushroom by Natural Factors Whole Earth & Sea — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Super Mushroom by Natural Factors Whole Earth & Sea

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 7 of its 56 active ingredients.
  • “Active Vegetables” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Cruciferous Vegetables” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Whole Fruit Ultra Polyphenols” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Super Mushroom contains 56 active ingredients sourced from whole-food plants and algae. The primary actives include organic acai, blueberry, kelp, artichoke, grape seed extract, chlorella, beet, spirulina, kale, strawberry, pomegranate, schisandra, cranberry, bilberry, barley grass, organic tomato, wasabi, cabbage, caper, alfalfa, and cilantro, along with several other plant and algal concentrates.

The product also contains inactive ingredients (microcrystalline cellulose, vegetarian capsule, and vegetable lubricant) that serve as fillers and capsule material.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: immune and energy support.
  • We looked for evidence on: immune function, energy levels, vitality.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for this product's overall benefit is mixed across its many ingredients. Some actives show promise: barley grass is rated Likely Effective for high cholesterol and heart disease; artichoke is rated Possibly Effective for high cholesterol and indigestion; bilberry, cranberry, and pomegranate each have Possibly Effective ratings for specific conditions; and beet is Possibly Effective for athletic performance and exercise-related muscle soreness.

However, most ingredients in this blend—including acai, blueberry, kale, spirulina, schisandra, and many others—lack sufficient evidence to rate their benefit for any condition. Because this is a multi-ingredient product without published efficacy data for the blend as a whole, we cannot say whether taking all 56 ingredients together produces any measurable health effect beyond what individual food components might offer.

The evidence, ingredient by ingredient Beta-glucans Maitake Mushroom Chaga Cordyceps Lion's Mane Mushroom Shiitake Mushroom Reishi Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 45 of the 48 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 46 of 48.
  • General safety write-ups exist for 48 of 48.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of the individual ingredients are generally well tolerated in food amounts. However, several carry important cautions.

Kelp's high iodine content poses a real risk to thyroid health, especially for people with a history of thyroid disease, and it may concentrate heavy metals—the facts advise against it in pregnancy and breastfeeding. Chlorella quality varies widely and contamination with toxins is a concern; the facts advise against it in pregnancy and breastfeeding.

Alfalfa in supplement form has estrogen-like activity and should be avoided in pregnancy; it may also trigger lupus-like syndrome with chronic use. Schisandra is rated Possibly Unsafe in pregnancy.

Blueberry, freeze-dried, caused gastrointestinal complaints in about 26% of trial participants in the first week. Spirulina may cause allergic reactions, including anaphylaxis, and barley contains gluten.

Artichoke, strawberry, and coriander can occasionally trigger allergic reactions or contact reactions in sensitive individuals. Wasabi, at the doses studied, was associated with rare kidney and liver enzyme changes in a small trial.

Side effects, ingredient by ingredient Beta-glucans Maitake Mushroom Chaga Cordyceps Lion's Mane Mushroom Shiitake Mushroom Reishi Mushroom

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 46 of the 48 matched ingredients can interact with medications — Alfalfa, Coriander, Milk Thistle, Cabbage, Bilberry, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications; lithium.
  • For scale: 1,668 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Super Mushroom, double-check with your pharmacist or doctor if you take any of the following: blood thinners like warfarin (the alfalfa interaction is Major); blood sugar medications (acai, artichoke, blueberry, spirulina, and cabbage all theoretically lower blood sugar); thyroid medications or lithium (kelp can interfere with thyroid control); blood pressure medications (artichoke, grape, cilantro, and beet may lower pressure further); statins or other cholesterol drugs (grape, beet, schisandra, and cranberry may raise drug levels); or immunosuppressants (spirulina and schisandra may interfere with them). If you take any prescription or over-the-counter medication, search it in the tool on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This 56-ingredient blend combines food plants and algae with a wide range of unproven and some proven benefits. If you take any medications—especially blood thinners, diabetes drugs, thyroid medications, statins, blood pressure pills, or immunosuppressants—you need to check this product against your specific prescriptions before taking it.

Even without medications, people sensitive to seafood (kelp), gluten (barley), or members of the cabbage family (cabbage, wasabi) should avoid it. Talk with your doctor or pharmacist about whether a multi-ingredient supplement like this makes sense for your health goals.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 51 of 56 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Mushroom, straight from the product label.

Brand Natural Factors Whole Earth & Sea
Barcode (UPC) 068958355108
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2018
DSLD ID 182958
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Mushroom by Natural Factors Whole Earth & Sea, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
068958355108
IngredientAmount% DV
organic Acai0 NP--
organic Blueberry0 NP--
Kelp0 NP--
organic Artichoke0 NP--
Grape0 NP--
organic Chlorella0 NP--
organic Beet0 NP--
organic Spirulina0 NP--
organic Kale0 NP--
Blue Green Algae0 NP--
Strawberry0 NP--
Pomegranate0 NP--
Schizandra0 NP--
organic Cranberry0 NP--
Bilberry0 NP--
Barley Grass0 NP--
Raspberry0 NP--
Dunaliella salina0 NP--
organic Tomato0 NP--
Wasabi0 NP--
organic Cabbage0 NP--
Caper0 NP--
Active Vegetables0 NP--
organic Alfalfa0 NP--
organic Cilantro0 NP--
organic Parsley0 NP--
organic Black Radish0 NP--
Cayenne Pepper0 NP--
Cruciferous Vegetables0 NP--
fresh freeze-dried sprouted Broccoli0 NP--
organic Upland Cress0 NP--
Daikon0 NP--
Red Radish0 NP--
organic Cauliflower0 NP--
organic Arugula0 NP--
organic Watercress0 NP--
sprouted Garlic0 NP--
Whole Fruit Ultra Polyphenols0 NP--
organic Indian Gooseberry0 NP--
Red Orange0 NP--
Herbals and Plants0 NP--
organic decaffeinated Green Tea0 NP--
organic Milk Thistle0 NP--
organic Echinacea0 NP--
Marigold0 NP--
organic Dandelion0 NP--
organic Oregano0 NP--
organic Peppermint0 NP--
organic Spearmint0 NP--
Whole Plant Sea Vegetables0 NP--
organic Ginger0 NP--
Red Algae0 NP--
organic Maitake50 mg--
Farm Fresh Factors200 mg--
organic Celery0 NP--
organic Chaga50 mg--
Wellmune250 mg--
Mycofusions Activated Mushroom Complex0 NP--
organic Cordyceps50 mg--
organic Lion's Mane50 mg--
organic Shiitake50 mg--
organic Reishi (Ganoderma lucidum) 30:1 extract50 mg--
Theracurmin Curcumin extract0 NP--

Other ingredients: Microcrystalline Cellulose, Vegetarian Capsule, Vegetable Lubricant

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Pure food nutrient-rich capsules 100% made, packaged, and tested in USA and Canada

We ensure the processing temperature always stays below 118(0)F. The end result is raw nutrition from whole plants, capturing all the vibrant energy and goodness of nature. Even when you grow certified organic non-GMO plants, it’s important to verify that there are no GMOs or other contaminants present. We excel at making sure that every possible test has been conducted to ensure you receive the safest, most beneficial products possible.

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Recyclable container and label.

Pure food

Feel the difference

Certified by Pacific Agricultural Certification Society. Product of Canada

Purity & potency guaranteed

At Natural Factors state of the art laboratories, we use “mass spectrometry” to test for over 400 substances. Mass spectrometry can test at the molecular – even atomic – level, detecting environmental pollutants such as pesticides, herbicides, and fungicides, as well as heavy metals and other undesirable substances.

$2 from the purchase of each bottle goes to... plant a seed & see what grows foundation www.seewhatgrows.org

Imagine getting the benefit of the whole growing season in one capsule.

R2 Made with 100% recycled material.

Formulation

The 100% organic, non-GMO nutrient-rich plants grown on Natural Factors farms are harvested at their peak and immediately raw processed at our own facilities, using our proprietary EnviroSimplex method to retain the vital bioenergetic vitamins, minerals, enzymes, phytonutrients, and antioxidants.

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs.

Suitable for vegetarians/vegans.

Non-GMO

Suitable for vegans

Suggested/Recommended/Usage/Directions

Suggested Usage: 1 capsule per day with food or as directed by a health professional.

Precautions

Cautions: As with any supplement, consult your healthcare professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Formula

Super Mushroom combines six organic mushrooms, Wellmune Beta Glucan and our nutrient-dense Farm Fresh Factors to create a vital bioenergetic immune and energy support formula.

6 mushrooms & Beta Glucan immune & energy support formula

Storage

For freshness, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Wellmune is a registered trademark of Biothera Inc. Theracurmin is a registered trademark of Theravalues Corp. MycoFusions is a registered trademark of NutraGenesis LLC and is protected under U.S. Patent 7,178,285.

Fresh, raw ingredients from our farms make this bioenergetic formula the "seed of nutrition"

FDA Statement of Identity

Dietary Supplement

General

35510U-R2

Seals/Symbols

Isura Non-GMO - Mass Spec Documentation Lab tested

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Mushroom by Natural Factors Whole Earth & Sea label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Mushroom label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Mushroom by Natural Factors Whole Earth & Sea

These are the 12 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Farm Fresh Factors

200 mg per serving
  • › Active Vegetables
  • › Cruciferous Vegetables
  • › Whole Fruit Ultra Polyphenols
  • › Herbals and Plants
  • › Whole Plant Sea Vegetables

Wellmune

Interacts with
293 drugs
250 mg per serving Form: 1,3/1,6-Glucan

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly low...

Wellmune monograph & interactions

Mycofusions Activated Mushroom Complex

0 NP per serving

Organic Reishi (Ganoderma lucidum) 30:1 extract

Interacts with
375 drugs
50 mg per serving

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Organic Reishi (Ganoderma lucidum) 30:1 extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetarian Capsule, Vegetable Lubricant. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Mushroom by Natural Factors Whole Earth & Sea Drug Interactions

Want to check YOUR meds against Super Mushroom?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,667Drugs
60 Major 1,597 Moderate 10 Minor

Ingredients driving the most interactions

organic Reishi (Ganoderma lucidum) 30:1 extract 375
organic Chaga 327
organic Lion's Mane 327
organic Shiitake 312
Wellmune 293

Individual Drug Interactions

The ingredients in Super Mushroom interact with 1,667 drugs. Click any drug to see the details.

7 of the 12 ingredients in Super Mushroom interact with drugs. Each result below shows which ingredient is responsible. organic Reishi (Ganoderma lucidum) 30:1 extract organic Chaga organic Lion's Mane organic Shiitake Wellmune organic Maitake organic Cordyceps

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Mushroom with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Reishi (Ganoderma lucidum) 30:1 extract3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
organic Reishi (Ganoderma lucidum) 30:1 extract full monograph & interactions

organic Chaga3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that chaga extract can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that chaga might decrease blood glucose levels and increase insulin levels. This has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, chaga might interfere with immunosuppressive therapy.
In vitro research suggests that certain constituents of chaga stimulate immune function. This has not been reported in humans.

Likelihood Possible Evidence D
organic Chaga full monograph & interactions

organic Lion's Mane3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
organic Lion's Mane full monograph & interactions

organic Shiitake2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
organic Shiitake full monograph & interactions

Wellmune2 drug types · 293 drugs

Antihypertensive Drugs

Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.

Likelihood Possible Evidence D
Wellmune full monograph & interactions

organic Maitake3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
organic Maitake full monograph & interactions

organic Cordyceps3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
organic Cordyceps full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Mushroom, from the product label.

Natural Factors Whole Earth & Sea

See all Natural Factors Whole Earth & Sea products
Name
Natural Factors Canada
Pharmacist Counseling Corner

Super Mushroom by Natural Factors Whole Earth & Sea: Common Questions

Does Super Mushroom by Natural Factors Whole Earth & Sea interact with any medications?
Yes. Based on its ingredients, Super Mushroom has a known interaction with 1,667 medications, including 60 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Mushroom contains 12 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Several ingredients carry cautions or are best avoided in pregnancy and breastfeeding. Kelp is rated Possibly Unsafe in pregnancy and should be avoided while breastfeeding. Alfalfa is Possibly Unsafe in pregnancy. Chlorella is not recommended in either. Other ingredients like blueberry, grape, and artichoke lack sufficient safety data in pregnancy and concentrated supplement form, so the facts advise caution. Talk to your doctor before using any supplement during pregnancy or while breastfeeding—this product is not a good choice without personalized medical advice.
Will this help me lose weight?
Several ingredients (acai, blueberry, pomegranate, and grape) are rated Possibly Ineffective for weight loss. Others lack evidence in our data. There is no established benefit of this product as a weight-loss aid.
What is kelp and why does it interact with so many drugs?
Kelp is a type of seaweed with very high iodine content. Iodine can disrupt your thyroid, interfere with thyroid medications and antithyroid drugs, and interact with lithium and amiodarone (a heart rhythm drug) because all of these work on or involve the thyroid. The data also shows kelp can affect how your liver processes some medications through enzyme inhibition.
Is this safe if I don't take any medications?
For people not on medications, the main safety concerns are: kelp's potential to disrupt the thyroid even without drugs; chlorella's variable quality and contamination risk; alfalfa's rare risk of a lupus-like syndrome with long-term use; and potential allergic reactions (especially in those with gluten sensitivity, seafood allergies, or cabbage-family sensitivities). Talk to your doctor before starting if you have thyroid disease, an allergy history, or take any supplements.
Why are there so many ingredients?
This product is formulated as a broad-spectrum 'superfood' blend intended to provide a wide range of plant nutrients and phytonutrients. However, because there is no published clinical trial of this exact combination, we cannot confirm it works better than eating individual foods or taking single-ingredient supplements.
Can I take this with my blood pressure medication?
Possibly not without monitoring. Artichoke, grape, cilantro, and beet all have the potential to lower blood pressure further, which could cause dizziness or fainting. Check with your pharmacist or doctor before combining this product with any antihypertensive drug—your dose may need adjustment.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Mushroom label
Go deeper

The Full Monographs Behind Super Mushroom’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Beta-glucans

Interacts with 293 drugs

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...

Read the full Beta-glucans monograph → Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph → Herb & supplement monograph

Chaga

Interacts with 327 drugs

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for its benefits is very limited, and it may...

Read the full Chaga monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph → Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph →
Sources

Sources & How We Checked

Super Mushroom's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1,459 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Acai 2 references
  1. Udani JK, Singh BB, Singh VJ, Barrett ML. Effects of acai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: a pilot study. Nutr J 2011;10:45.
  2. de Liz S, Cardoso AL, Copetti CLK, et al. Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study. Clin Nutr. 2020;39(12):3629-3636. PubMed

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Blueberry 7 references
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Fucus Vesiculosus 15 references
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Artichoke 16 references
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Grape 34 references
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Chlorella 13 references
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Beet 14 references
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Blue-green Algae 22 references
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Kale 2 references
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  2. Lutein and Zeaxanthin — NIH Office of Dietary Supplements Source

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Strawberry 18 references
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Pomegranate 27 references
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Schisandra 26 references
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Bilberry 14 references
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Barley 15 references
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Tomato 3 references
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Wasabi 2 references
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Cabbage 15 references
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Capers 3 references
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Alfalfa 32 references
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Coriander 12 references
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Parsley 21 references
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Radish 5 references
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Capsicum 89 references
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Cauliflower 9 references
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Spearmint 20 references
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Ginger 64 references
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Celery 48 references
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Beta-glucans 11 references
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Lion's Mane Mushroom 6 references
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See these in context on the Turmeric monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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