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Dietary supplement

Cognitive Health Support Ingredients & Drug Interactions

by GNC Preventive Nutrition

Cognitive Health Support label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cognitive Health Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cognitive Health Support is a dietary supplement by GNC Preventive Nutrition with 2 active ingredients. Its ingredients are commonly taken for liver health and fatty liver, brain and memory support, prenatal nutrition and fetal development.Based on those ingredients, 257 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zembrin Sceletium tortuosum extract, Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cognitive Health Support by GNC Preventive Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Cognitive Health Support by GNC Preventive Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cognitive Health Support by GNC Preventive Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active ingredients. Choline is a nutrient that plays a role in brain function and cell structure.

Zembrin Sceletium tortuosum extract is a plant-based ingredient derived from a succulent used traditionally in South Africa. The capsule also contains several inactive ingredients—gelatin, cellulose, stearic acid, magnesium stearate, silicon dioxide, and titanium dioxide—which serve as fillers and binders to hold the supplement together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: supports healthy brain and memory function.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Cognitive function, Dementia, mental clarity, focus — and 1 related terms.
  • The closest evidence on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Cognitive function, Dementia.

The evidence supporting either ingredient for cognitive health isn't established in the data we hold. Choline has been rated insufficient evidence for age-related cognitive decline and Alzheimer disease, and possibly ineffective for athletic performance.

Sceletium has insufficient evidence for depression, anxiety, and stress—the conditions most people might hope it would support. Neither ingredient has strong backing for the "cognitive health" claim on this product's label.

The evidence, ingredient by ingredient Choline Sceletium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Choline is generally well tolerated in typical supplement doses, though it's important to know that very high doses (above 3.5 grams daily) can cause fishy body odor, nausea, vomiting, diarrhea, and sweating. Choline is rated likely safe in pregnancy and lactation, though your doctor should guide your use.

Sceletium has less safety data. Short-term studies suggest it's generally tolerable, but long-term safety hasn't been established.

The adverse effects reported in trials include anxiety, headache, insomnia, irritability, and nausea. Sceletium is not recommended during pregnancy or while breastfeeding due to insufficient safety information.

Side effects, ingredient by ingredient Choline Sceletium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Choline, Sceletium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 257 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use CNS depressants—sedatives, sleep aids, anti-anxiety medications, or opioid pain relievers—since sceletium may add to their sedative effects (moderate interaction). Also double-check if you take atropine or medications containing it, as choline may reduce its effectiveness (minor interaction).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to someone looking for general cognitive support, but the evidence backing either ingredient is not strong. The bigger concern is the moderate interaction with CNS depressants (sleep aids, sedatives, anti-anxiety drugs) and the minor interaction with atropine.

If you take any prescription medication, especially for sleep or anxiety, talk it over with your doctor or pharmacist before starting this supplement.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cognitive Health Support, straight from the product label.

Brand GNC Preventive Nutrition
Barcode (UPC) 048107161361
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2016
DSLD ID 67164
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cognitive Health Support by GNC Preventive Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
048107161361
IngredientAmount% DV
Choline550 mg--
Zembrin Sceletium tortuosum extract25 mg--

Other ingredients: Gelatin, Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

New

Physician formulated nutrition solutions - Supports healthy brain and memory function with clinically studied ingredients

Physician endorsed

Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

This product is endorsed by the physicians on the GNC Medical Advisory Board.

Brand IP Statement(s)

Powered by Zembrin

Zembrin Zembrin is a trademark of HG&H Pharmaceuticals (Pty) Limited. U.S. Patent #6,288,104.

FDA Statement of Identity

Dietary Supplement

General

CODE 618922 GQG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take two capsules daily.

Precautions

Keep out of reach of children.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

Storage

Store in a cool, dry place.

Seals/Symbols

Gf Gluten free

Formulation

No Sugar, no Starch, no Artificial Colors, no Artificial Flavors, no Wheat, Gluten free, no Corn, no Soy, no Dairy, Yeast free.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cognitive Health Support by GNC Preventive Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cognitive Health Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cognitive Health Support by GNC Preventive Nutrition

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Choline

Interacts with
16 drugs
550 mg per serving Form: Choline Bitartrate

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Zembrin Sceletium tortuosum extract

Interacts with
248 drugs
25 mg per serving

Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood. Early human studies are small and short, s...

Zembrin Sceletium tortuosum extract monograph & interactions

Other (inactive) ingredients: Gelatin, Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cognitive Health Support by GNC Preventive Nutrition Drug Interactions

Want to check YOUR meds against Cognitive Health Support?

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257Drugs
248 Moderate 9 Minor

Ingredients driving the most interactions

Zembrin Sceletium tortuosum extract 248
Choline 16

Individual Drug Interactions

The ingredients in Cognitive Health Support interact with 257 drugs. Click any drug to see the details.

2 of the 2 ingredients in Cognitive Health Support interact with drugs. Each result below shows which ingredient is responsible. Zembrin Sceletium tortuosum extract Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in Cognitive Health Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Zembrin Sceletium tortuosum extract1 drug type · 248 drugs

Cns Depressants

Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.
Some evidence suggests that sceletium has sedative properties.

Likelihood Possible Evidence D
Zembrin Sceletium tortuosum extract full monograph & interactions

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cognitive Health Support, from the product label.

GNC Preventive Nutrition

See all GNC Preventive Nutrition products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Cognitive Health Support by GNC Preventive Nutrition: Common Questions

Does Cognitive Health Support by GNC Preventive Nutrition interact with any medications?
Yes. Based on its ingredients, Cognitive Health Support has a known interaction with 257 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cognitive Health Support contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant or breastfeeding?
Choline is rated likely safe in pregnancy and lactation, but sceletium is not—there isn't enough safety data to recommend it during either time. Talk with your doctor before taking this product if you're pregnant or nursing, since it contains both ingredients.
What does choline actually do?
Choline is a nutrient involved in brain function and how cells are built. The data we hold doesn't show strong evidence that choline supplements improve cognitive decline or Alzheimer disease, though it is important nutritionally.
What side effects might I notice?
At typical doses, choline is usually well tolerated. At very high doses (well above what's in most supplements), it can cause fishy body odor, nausea, and diarrhea. Sceletium may cause headache, insomnia, anxiety, irritability, or nausea in some people.
Can I take this with my sleep medication?
Not without checking first—sceletium may add to the sedative effects of sleep aids and other CNS depressants. Talk with your pharmacist or doctor before combining them.
Does this product actually improve memory or focus?
The evidence for either ingredient supporting cognitive health isn't established in the data we hold. Choline shows insufficient evidence for age-related cognitive decline and Alzheimer disease; sceletium shows insufficient evidence for depression, anxiety, and stress.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cognitive Health Support is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cognitive Health Support label
Go deeper

The Full Monographs Behind Cognitive Health Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph → Herb & supplement monograph

Sceletium

Interacts with 248 drugs

Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood. Early human studies are small and short, so its benefits are not well proven. Talk...

Read the full Sceletium monograph →
Sources

Sources & How We Checked

Cognitive Health Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Sceletium 3 references
  1. Smith MT, Crouch NR, Gericke N, Hirst M. Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review. J Ethnopharmacol 1996;50:119-30. PubMed
  2. Meyer GMJ, Wink CSD, Zapp J, Maurer HH. GC-MS, LC-MS(n), LC-high resolution-MS(n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum
  3. Gericke J, Lekhooa M, Steyn SF, Viljoen AM, Harvey BH. An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat. J Ethnopharmacol. 2022 Feb 10;284:114550. do PubMed

See these in context on the Sceletium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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