Interactions on record — worth a quick check against your medications. Based on 10 of 18 ingredients. Check your meds →
Dietary supplement

Colon Cleanse Max Probiotic Fiber Ingredients & Drug Interactions

by Health Plus

Colon Cleanse Max Probiotic Fiber label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Colon Cleanse Max Probiotic Fiber against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Colon Cleanse Max Probiotic Fiber is a dietary supplement by Health Plus with 18 active ingredients. Its ingredients are commonly taken for constipation and regularity, prebiotic gut health, blood sugar support.Based on those ingredients, 2,247 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Slippery Elm, Fennel, L. acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Colon Cleanse Max Probiotic Fiber by Health Plus

Ask about any prescription or over-the-counter medication and we check it for interactions with Colon Cleanse Max Probiotic Fiber by Health Plus — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Colon Cleanse Max Probiotic Fiber by Health Plus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 5 of its 18 active ingredients.
  • “Proprietary Digestive Enzymes” is a proprietary blend — the label gives one combined amount (50 mg) without saying how much of each component you get.
  • “Proprietary Prebiotic Blend” is a proprietary blend — the label gives one combined amount (175 mg) without saying how much of each component you get.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (105 mg) without saying how much of each component you get.

Colon Cleanse Max Probiotic Fiber contains 18 ingredients, including several active components. The two live probiotics—L. acidophilus and B. longum—are meant to support gut health by colonizing your intestines with beneficial bacteria.

You'll also find three soluble and insoluble fibers: inulin, psyllium, and apple pectin, which add bulk and may help with regularity. Fennel, burdock, and slippery elm are traditional digestive herbs included for their mucilage and traditional colon-support roles.

The product also includes rice bran, oat bran, and larch arabinogalactan as prebiotic and fiber sources, plus digestive enzymes (xylanase, pectinase, hemicellulases, beta-glucanase, and phytase) to help break down food. Cardamom seed extract rounds out the herbal support.

The inactive ingredient is gelatin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy colon and immune system.
  • We looked for evidence on: Abdominal pain, Antibiotic-associated diarrhea, Clostridioides difficile infection, Colic, Colorectal cancer, Constipation — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Inulin is rated "Possibly Effective" for Constipation.
  • Also on file: Rice Bran is rated "Possibly Ineffective" for Colorectal cancer.

Evidence for this product's ingredients is mixed and mostly limited. Inulin, apple pectin, and L. acidophilus are all rated possibly effective for constipation or related digestive issues—constipation and possible weight support are the main wellness claims.

Inulin is also possibly effective for diabetes control, and pectin for cholesterol. L. acidophilus has solid evidence for irritable bowel syndrome, antibiotic-associated diarrhea, and bacterial vaginosis.

B. longum, however, has no strong evidence for any condition we hold data on. Most other ingredients—burdock, slippery elm, fennel, rice bran, cardamom, and larch arabinogalactan—lack reliable evidence for the conditions tested.

Rice bran is possibly effective for cholesterol; cardamom, fennel, and the others show insufficient evidence or poor results in the studies we have.

The evidence, ingredient by ingredient Inulin Burdock Larch Arabinogalactan Lactobacillus Acidophilus Bifidobacterium Longum Slippery Elm Fennel Cardamom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 10 of the 10 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 10 of 10.
  • General safety write-ups exist for 10 of 10.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients in this product are generally well tolerated, but several carry important cautions. Inulin and pectin commonly cause bloating, gas, flatulence, and cramping, especially at higher doses—these are mild but frequent.

Burdock is likely safe as food or short-term use but has limited human safety data; rare cases of liver inflammation have been reported, though causation wasn't clear. Slippery elm is generally well tolerated but lacks high-quality safety data.

Both L. acidophilus and B. longum are considered generally well tolerated in healthy adults, but there are rare reports of serious infection (bacteremia, sepsis) in critically ill or immune-compromised patients; use caution if you're seriously ill. Fennel may cause gastrointestinal upset, photosensitivity, and rarely seizures; it also has hormone-like effects.

Rice bran can trigger allergic reactions, including rare anaphylaxis. Larch arabinogalactan is generally well tolerated but may cause bloating or gas.

Side effects, ingredient by ingredient Inulin Burdock Larch Arabinogalactan Lactobacillus Acidophilus Bifidobacterium Longum Slippery Elm Fennel Cardamom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 8 of the 10 matched ingredients can interact with medications — Burdock, Fennel, Pectin, Lactobacillus Acidophilus, Larch Arabinogalactan, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications.
  • For scale: 2,248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take blood thinners (anticoagulants or antiplatelet drugs like warfarin or clopidogrel)—Moderate risk of increased bleeding from burdock and fennel. Also watch for interactions with oral antibiotics (both probiotics may be killed by antibiotics—Moderate), oral contraceptives and estrogen replacement therapy (fennel—Moderate), digoxin, lovastatin, and tetracycline antibiotics (apple pectin—Moderate), ciprofloxacin (fennel—Moderate), and immunosuppressants like tacrolimus or cyclosporine (fennel and larch arabinogalactan—Moderate).

Diabetes drugs carry Minor risk from inulin. We could not check oat bran, xylanase, pectinase, L. plantarum, psyllium, hemicellulases, or phytase for interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a multi-ingredient fiber and probiotic blend best suited for people seeking digestive support and regularity without serious medical conditions or a complex medication regimen. If you take blood thinners, oral antibiotics, oral contraceptives, digoxin, lovastatin, tetracyclines, diabetes drugs, or immunosuppressants, you'll need to check your specific medications before starting.

Talk to your pharmacist or doctor first—this product has multiple interactions that could reduce your medication's effectiveness or increase bleeding risk.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 10 of 18 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Colon Cleanse Max Probiotic Fiber, straight from the product label.

Brand Health Plus
Barcode (UPC) 083502103479
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2015
DSLD ID 47100
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Colon Cleanse Max Probiotic Fiber by Health Plus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
083502103479
IngredientAmount% DV
Oat Bran0 NP--
Inulin0 NP--
Burdock0 NP--
Slippery Elm0 NP--
Xylanase1000 XU--
Pectinase50 PGU--
L. acidophilus0 NP--
Beta-Glucanase50 BGU--
B. longum0 NP--
L. plantarum0 NP--
Rice Bran0 NP--
Apple Pectin0 NP--
Fennel0 NP--
Psyllium0 NP--
Proprietary Digestive Enzymes50 mg--
Hemicellulases1000 HCU--
4-Phytase1 PU--
Proprietary Prebiotic Blend175 mg--
Arabinogalactin0 NP--
Proprietary Probiotic Blend105 mg--
Proprietary Digestive Herbal Support100 mg--
Cardamom seed extract 4:10 NP--
Proprietary Soluble Fiber Blend70 mg--

Other ingredients: Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

TAMPER EVIDENT SEAL UNDER CAP. DO NOT USE IF BROKEN.

Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication or have a medical condition before using this product.

Keep this product out of reach of children.

For California Residents Only. Warning: This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.

Brand IP Statement(s)

Colon Cleanse(R) MAX PROBIOTIC FIBER(TM)

For better results, include COLON CLEANS MAX: SUPER FIBER BLEND(R) and DIGESTI CLEANSE(R) in your cleansing regimen.

Suggested/Recommended/Usage/Directions

SUGGESTED USE: Adults, 1 capsule twice daily. Probiotic Fiber may be taken continually to support overall health.

Storage

Store below 72(0)F (22(0)C).

General Statements

SUPPORTS A HEALTHY COLON ~ SUPPORTS THE IMMUNE SYSTEM ~ FORMULATED WITH PROBIOTICS & PREBIOTICS

1 billion colony forming units at time of manufacture.

HEALTHY LIVING...NATURALLY

Probiotic Fiber helps nourish your colon with what it craves to stay healthy: prebiotics, probiotics, digestive herbs, soluble fiber, and digestive enzymes. With 1 billion colony forming units per capsule, our proprietary formulation helps promote good digestion. Your colon is an important part of your immune system, which is why we have added the ultimate support for your digestive system with prebiotics and probiotics. Probiotics are good bacteria that help support your immune system and prebiotics are considered food for the probiotics to assist with good bacteria growth. This process is known as the symbiotic effect, where probiotics and prebiotics work together for better immune support and a happy digestive system.

FDA Statement of Identity

Probiotic Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

1 0000026/09/5

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Colon Cleanse Max Probiotic Fiber by Health Plus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Colon Cleanse Max Probiotic Fiber label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Colon Cleanse Max Probiotic Fiber by Health Plus

These are the 18 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Digestive Enzymes

50 mg per serving
  • › Xylanase
  • › Pectinase
  • › Beta-Glucanase
  • › Hemicellulases
  • › 4-Phytase

Proprietary Prebiotic Blend

175 mg per serving

Proprietary Probiotic Blend

105 mg per serving

Proprietary Digestive Herbal Support

100 mg per serving

Proprietary Soluble Fiber Blend

70 mg per serving

Other (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Colon Cleanse Max Probiotic Fiber by Health Plus Drug Interactions

Want to check YOUR meds against Colon Cleanse Max Probiotic Fiber?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,247Drugs
2,219 Moderate 28 Minor

Ingredients driving the most interactions

Slippery Elm 2,022
Fennel 740
L. acidophilus 182
B. longum 182
Burdock 122

Individual Drug Interactions

The ingredients in Colon Cleanse Max Probiotic Fiber interact with 2,247 drugs. Click any drug to see the details.

8 of the 18 ingredients in Colon Cleanse Max Probiotic Fiber interact with drugs. Each result below shows which ingredient is responsible. Slippery Elm Fennel L. acidophilus B. longum Burdock Arabinogalactin Inulin Apple Pectin

Each ingredient & the kinds of drugs it affects

For each ingredient in Colon Cleanse Max Probiotic Fiber with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Slippery Elm1 drug type · 2,022 drugs

Oral Drugs

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.

Likelihood Possible Evidence D
Slippery Elm full monograph & interactions

Fennel6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
Fennel full monograph & interactions

L. acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
L. acidophilus full monograph & interactions

B. longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
B. longum full monograph & interactions

Burdock1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

In vitro research shows that lignans from burdock reduce rabbit platelet aggregation by inhibiting platelet activating factor. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Burdock full monograph & interactions

Arabinogalactin1 drug type · 121 drugs

Immunosuppressants

Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and other drugs.

Likelihood Possible Evidence D
Arabinogalactin full monograph & interactions

Inulin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.
Some clinical research shows that inulin improves glycemic control in patients with diabetes; however, it is unclear if it has hypoglycemic effects.

Likelihood Unlikely Evidence D
Inulin full monograph & interactions

Apple Pectin3 drug types · 23 drugs

Digoxin (Lanoxin)

Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.

Likelihood Possible Evidence B
Lovastatin (Mevacor)

Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.

Likelihood Possible Evidence B
Apple Pectin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Colon Cleanse Max Probiotic Fiber, from the product label.

Health Plus

See all Health Plus products
Name
health Plus Inc
City
CHINO
State
CA
ZipCode
91710
Phone Number
(800) 822-6225
Web Address
www.healthplusinc.com
Pharmacist Counseling Corner

Colon Cleanse Max Probiotic Fiber by Health Plus: Common Questions

Does Colon Cleanse Max Probiotic Fiber by Health Plus interact with any medications?
Yes. Based on its ingredients, Colon Cleanse Max Probiotic Fiber has a known interaction with 2,247 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Colon Cleanse Max Probiotic Fiber contains 18 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
Data vary by ingredient. Inulin and rice bran are likely safe in pregnancy; L. acidophilus and B. longum are possibly safe. However, burdock should be avoided in medicinal amounts during pregnancy, and fennel is possibly unsafe—its hormone-like effects raise concern. Slippery elm and pectin have insufficient data. Talk with your doctor or pharmacist before use during pregnancy for personalized guidance.
Can I take this while breastfeeding?
Inulin, L. acidophilus, B. longum, rice bran, and cardamom are all likely or possibly safe while breastfeeding. Burdock and fennel should be avoided in medicinal amounts due to lack of safety data. Slippery elm and pectin have too little information to be sure. Check with your doctor or pharmacist before starting.
Will this help my constipation?
Inulin and apple pectin are both rated possibly effective for constipation. L. acidophilus is possibly effective for irritable bowel syndrome and antibiotic-associated diarrhea. However, slippery elm and most other ingredients lack reliable evidence for constipation. Results depend on which active ingredient does the work for you—fiber helps many people, but the response varies.
What causes the gas and bloating I might feel?
Inulin, apple pectin, rice bran, and larch arabinogalactan are all fibers that commonly cause bloating, gas, and flatulence, especially when you first start them or at higher doses. The probiotics L. acidophilus and B. longum may also cause these effects. These side effects usually subside as your gut adjusts, but starting with a lower dose can help.
Is this safe if I'm on antibiotics?
No—or more precisely, timing matters. Both L. acidophilus and B. longum are live organisms that antibiotics will kill. To get any benefit from the probiotics, separate their dose from your antibiotic by at least 2–3 hours. Ask your pharmacist for specific timing guidance based on your antibiotic.
Will this interact with my blood thinner?
Possibly, yes. Both burdock and fennel in this product may increase bleeding risk if you're on a blood thinner like warfarin or clopidogrel. Check your exact medication through the interaction tool on this page, and talk to your pharmacist or doctor before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Colon Cleanse Max Probiotic Fiber is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Colon Cleanse Max Probiotic Fiber label
Go deeper

The Full Monographs Behind Colon Cleanse Max Probiotic Fiber’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Inulin

Interacts with 86 drugs

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements and processed foods. It may help with regu...

Read the full Inulin monograph → Herb & supplement monograph

Burdock

Interacts with 122 drugs

Burdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and most claims are not well proven. It is wid...

Read the full Burdock monograph → Herb & supplement monograph

Larch Arabinogalactan

Interacts with 121 drugs

Larch arabinogalactan is a soluble fiber from larch trees that is mainly used as a prebiotic and for immune support. Early research is interesting but limited, and most claims are not yet fi...

Read the full Larch Arabinogalactan monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Slippery Elm

Interacts with 2,022 drugs

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...

Read the full Slippery Elm monograph → Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Cardamom

Cardamom is a popular cooking spice that has long been used in traditional medicine for digestion and fresh breath. As a food, it is generally safe for most people, but high-dose supplements...

Read the full Cardamom monograph → Herb & supplement monograph

Rice Bran

Rice bran is the nutrient-rich outer layer of the rice grain and is a good source of fiber, healthy fats, and plant compounds. It is most studied for helping lower cholesterol, but for most...

Read the full Rice Bran monograph → Herb & supplement monograph

Pectin

Interacts with 23 drugs

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly help with cholesterol, blood sugar, and di...

Read the full Pectin monograph →
Sources

Sources & How We Checked

Colon Cleanse Max Probiotic Fiber's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 112 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Inulin 17 references
  1. Williams CM. Effects of inulin on lipid parameters in humans. J Nutr 1999 Jul;129(7 Suppl):1471S-3S. PubMed
  2. Pedersen A, Sandstrom B, Van Amelsvoort JM. The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females. Br J Nutr 1997;78:215-22. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Bonnema AL, Kolberg LW, Thomas W, Slavin JL. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc 2010;110(6):865-8. PubMed
  5. Dehghan P, Gargari BP, Jafar-Abadi MA, Aliasgharzadeh A. Inulin controls inflammation and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized-controlled clinical trial. Int J Food Sci Nutr 2014;65(1):117-23. PubMed
  6. Guess ND, Dornhorst A, Oliver N, Frost GS. A randomised crossover trial: the effect of inulin on glucose homeostasis in subtypes of prediabetes. Ann Nutr Metab 2016;68(1):26-34. PubMed
  7. Marteau P, Jacobs H, Cazaubiel M, Signoret C, Prevel JM, Housez B. Effects of chicory inulin in constipated elderly people: a double-blind controlled trial. Int J Food Sci Nutr 2011;62(2):164-70. PubMed
  8. Mensink MA, Frijlink HW, van der Voort Maarschalk K, Hinrichs WL. Inulin, a flexible oligosaccharide I: review of its physicochemical characteristics. Carbohydr Polym 2015;130:405-19. PubMed
  9. Slavin J, Feirtag J. Chicory inulin does not increase stool weight or speed up intestinal transit time in healthy male subjects. Food Funct. 2011;2(1):72-7. PubMed
  10. Micka A, Siepelmeyer A, Holz A, Theis S, Schön C. Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial. Int J Food Sci Nutr. 2017;68(1):82-89. PubMed
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  12. Cai X, Yu H, Liu L, et al. Milk powder co-supplemented with inulin and resistant dextrin improves glycemic control and insulin resistance in elderly type 2 diabetes mellitus: a 12-week randomized, double-blind, placebo-controlled trial. Mol Nutr Food Res PubMed
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See these in context on the Inulin monograph →

Burdock 11 references
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See these in context on the Burdock monograph →

Slippery Elm 3 references
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  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Czarnecki D, Nixon R, Bekhor P, and et al. Delayed prolonged contact urticaria from the elm tree. Contact Dermatitis 1993;28:196-197. PubMed

See these in context on the Slippery Elm monograph →

Lactobacillus Acidophilus 15 references
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  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
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  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
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  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
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  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Longum 21 references
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  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
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  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
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See these in context on the Bifidobacterium Longum monograph →

Rice Bran 7 references
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  3. Uenotsuchi T, Satoh E, Kiryu H, Yano Y. Pyemotes dermatitis caused by indirect contact with husk rice. Br J Dermatol 2000;143:680-2. DOI
  4. Satoh R, Tsuge I, Tokuda R, Teshima R. Analysis of the distribution of rice allergens in brown rice grains and of the allergenicity of products containing rice bran. Food Chem. 2019;276:761-767. PubMed
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  6. So WKW, Chan JYW, Law BMH, et al. Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial. Nutrients 2021;13(2):526. PubMed
  7. Haneda Y, Kadowaki S, Furui M, Taketani T. A pediatric case of food-dependent exercise-induced anaphylaxis due to rice bran. Asia Pac Allergy 2021;11(1):e4. PubMed

See these in context on the Rice Bran monograph →

Pectin 11 references
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  2. Westphal W, et al. [Exogenous allergic asthma following pectin exposure-a new occupational allergen]. Pneumologie 1990;44(Suppl 1):337-8.
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  4. Cohen AJ, Forse MS, Tarlo SM. Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 1993;103:309-11.
  5. Kraut A, et al. Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 1992;102:1605-7. PubMed
  6. Richter WO, Jacob BG, Schwandt P. Interaction between fibre and lovastatin. Lancet 1991;338:706.
  7. Albert KS, Ayres JW, DiSanto AR, et al. Influence of kaolin-pectin suspension on digoxin bioavailability. J Pharm Sci 1978;67:1582-6. PubMed
  8. Albert KS, Welch RD, DeSante KA, et al. Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture. J Pharm Sci 1979;68:586-8. PubMed
  9. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  10. Federal Register April 17,2003. Anti-Diarrheal Products for over-the-counter human use; final monograph. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/03-9380.pdf (Accessed 27 December 2004).
  11. Washio K, Nakamura M, Sato N, et al. Anaphylaxis in a pectin- and cashew nut-allergic child caused by a citrus bath. Allergol Int 2022;71(1):155-157. PubMed

See these in context on the Pectin monograph →

Fennel 17 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Zhu M, Wong PY, Li RC. Effect of oral administration of fennel (Foeniculum vulgare) on ciprofloxacin absorption and disposition in the rat. J Pharm Pharmacol 1999;51:1391-6.
  4. Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603.
  5. Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
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  7. Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eur.J Clin Pharmacol. 2006;62:37-42. PubMed
  8. Tognolini, M., Ballabeni, V., Bertoni, S., Bruni, R., Impicciatore, M., and Barocelli, E. Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. Pharmacol.Res 2007;56(3):254-260. PubMed
  9. Subehan, Usia, T., Iwata, H., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol. 5-24-2006;105(3):449-455. PubMed
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  11. Subehan, Zaidi, S. F., Kadota, S., and Tezuka, Y. Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator. J Agric.Food Chem. 12-12-2007;55(25):101 PubMed
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  13. Ottolenghi, A., De Chiara, A., Arrigoni, S., Terracciano, L., and De Amici, M. [Diagnosis of food allergy caused by fruit and vegetables in children with atopic dermatitis]. Pediatr Med Chir 1995;17(6):525-530.
  14. Trabace L, Tucci P, Ciuffreda L, et al. "Natural" relief of pregnancy-related symptoms and neonatal outcomes: above all do no harm. J Ethnopharmacol. 2015;174:396-402. PubMed
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  16. Lee HW, Ang L, Lee MS, Alimoradi Z, Kim E. Fennel for reducing pain in primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials. Nutrients 2020;12(11):3438. PubMed
  17. Mathew T, John SK, Javali M, Vasireddy M, Nadig R, Sarma GRK. Substance use related cluster headache: A case series. Headache 2022;62(7):908-910. PubMed

See these in context on the Fennel monograph →

Larch Arabinogalactan 8 references
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  2. Kelly GS. Larch arabinogalactan: Clinical relevance of a novel immune-enhancing polysaccharide. Alt Med Rev 1999;4:96-103.
  3. Marett R, Slavin JL. No long-term benefits of supplementation with arabinogalactan on serum lipids and glucose. J Am Diet Assoc 2004;104:636-9.
  4. Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr 2001;20:279-85. PubMed
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  6. Grube B, Stier H, Riede L, Gruenwald J. Tolerability of a proprietary larch arabinogalactan extract: a randomized, double-blind, placebo-controlled clinical trial in healthy subjects. Food Nutr Sci 2012;3:1533-8. DOI
  7. Dion C, Chappuis E, Ripoll C. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Nutr Metab (Lond) 2016;13:28. PubMed
  8. Riede L, Grube B, Gruenwald J. Larch arabinogalactan effects on reducing incidence of upper respiratory tract infections. Curr Med Res Opin 2013;29(3):251-8.

See these in context on the Larch Arabinogalactan monograph →

Cardamom 2 references
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  2. Aghasi M, Koohdani F, Qorbani M, et al. Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial. J Sci Food Agri PubMed

See these in context on the Cardamom monograph →

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