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Dietary supplement

Comfrey Ingredients & Drug Interactions

by Herbal Terra

Comfrey label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Comfrey against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Comfrey is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for bruises and sprains, muscle and joint pain, minor wounds and skin irritation.Based on those ingredients, 438 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Comfrey (Symphytum uplandica) dried leaf liquid extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Comfrey by Herbal Terra

Ask about any prescription or over-the-counter medication and we check it for interactions with Comfrey by Herbal Terra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Comfrey by Herbal Terra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: certified organic Comfrey (Symphytum uplandica) dried leaf liquid extract. The extract is made using menstruum, an inactive ingredient that carries the herb's compounds into liquid form.

Comfrey has been used traditionally for various conditions, but the scientific evidence for its effectiveness remains limited or unclear.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Comfrey product and its label doesn't state a use — see Comfrey's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for comfrey isn't established in our data. The product facts show insufficient reliable evidence to rate it for bronchitis, angina, back pain, cancer, and cough.

Without reliable studies backing its use, we can't tell you whether it actually works for any of these purposes.

The evidence, ingredient by ingredient Comfrey

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Here's the critical issue: oral comfrey is unsafe. The pyrrolizidine alkaloids in comfrey can seriously damage your liver, causing cirrhosis, fibrosis, ascites (fluid buildup in the abdomen), and in severe cases, hepatic failure.

Some of these effects may appear months or even up to 2 years after you stop taking it. Comfrey can also damage your lungs and raise blood pressure in the lungs.

Topical use on unbroken skin for short periods is generally well tolerated, though mild reactions like rash, itching, or irritation can happen. Do not use this product during pregnancy or while breastfeeding.

The liver toxicity poses a risk to the baby, and harmful compounds can pass into breast milk.

Side effects, ingredient by ingredient Comfrey

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Comfrey.
  • The most serious interaction on file is rated Moderate.
  • For scale: 439 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your doctor or pharmacist if you're on any medications that are toxic to the liver or any that induce the CYP3A4 enzyme (such as phenobarbital). The Moderate severity interactions with both drug types can worsen liver damage or boost comfrey's toxicity.

The search tool on this page can help you look up your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Oral comfrey carries serious liver and lung toxicity risks that outweigh its unproven benefits. If you're considering this product, talk with your doctor or pharmacist first — especially if you take any medications that affect your liver or involve CYP3A4 enzymes.

The safety concerns here are significant enough that most people should explore safer alternatives.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Comfrey, straight from the product label.

Brand Herbal Terra
Barcode (UPC) 7429523285207
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 235312
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Comfrey by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
7429523285207
IngredientAmount% DV
certified organic Comfrey (Symphytum uplandica) dried leaf liquid extract970 mg--

Other ingredients: Menstruum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Origin of plant material: Hungary.

Manufactured in the USA in an FDA registered facility

Alcohol free

Dried herb/menstruum ratio: 1:3 Expertly extracted Laboratory tested 330 mg/1 mL Premium product Alcohol-free liquid herbal extract

Non GMO

No artificial ingredients, GMO, gluten, color additives, fillers, preservatives or binders. Natural Gluten Free

Suggested/Recommended/Usage/Directions

Direction Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz of juice or water up to 4 times a day. We recommend to seek expert medical advice before taking this or any other herbal supplements.

FDA Disclaimer Statement

Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Caution May have contraindications.

Do not use if you are allergic to any ingredients.

Consult a physician before using during pregnancy, if nursing, or if you are on any medications.

Keep out of the reach of children.

Storage

Store in a cool, dry, dark place.

Formula

Symphytum uplandica

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Made in USA Made in an FDA registered facility Natural Gluten Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Comfrey by Herbal Terra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Comfrey label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Comfrey by Herbal Terra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Certified organic Comfrey (Symphytum uplandica) dried leaf liquid extract

Interacts with
438 drugs
970 mg per serving

Comfrey is a traditional herb used mainly on the skin for bruises, sprains, and joint pain, and some topical products show modest benefit for these us...

Certified organic Comfrey (Symphytum uplandica) dried leaf liquid extract monograph & interactions

Other (inactive) ingredients: Menstruum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Comfrey by Herbal Terra Drug Interactions

Want to check YOUR meds against Comfrey?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
438Drugs
438 Moderate

Ingredients driving the most interactions

certified organic Comfrey (Symphytum uplandica) dried leaf liquid extract 438

Individual Drug Interactions

The ingredients in Comfrey interact with 438 drugs. Click any drug to see the details.

1 of the 1 ingredient in Comfrey interact with drugs. Each result below shows which ingredient is responsible. certified organic Comfrey (Symphytum uplandica) dried leaf liquid extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Comfrey with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

certified organic Comfrey (Symphytum uplandica) dried leaf liquid extract2 drug types · 438 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid constituents in comfrey.
CYP3A4 enzymes convert pyrrolizidine alkaloids, constituents of comfrey, to toxic metabolites. Some case reports show that enzyme inducers, such as phenobarbital, seem to enhance the toxicity of comfrey.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, comfrey might have additive adverse effects on the liver when used with hepatotoxic drugs.
Due to its pyrrolizidine alkaloid constituents, comfrey can cause hepatotoxic effects, including ascites, cirrhosis, hepatic fibrosis, hepatomegaly, and sinusoidal obstruction syndrome.

Likelihood Possible Evidence D
certified organic Comfrey (Symphytum uplandica) dried leaf liquid extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Comfrey, from the product label.

Herbal Terra

See all Herbal Terra products
Name
Herbal Terra
Pharmacist Counseling Corner

Comfrey by Herbal Terra: Common Questions

Does Comfrey by Herbal Terra interact with any medications?
Yes. Based on its ingredients, Comfrey has a known interaction with 438 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Comfrey contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is comfrey safe to take by mouth?
No — oral comfrey is unsafe. The compounds in it can damage your liver badly enough to cause cirrhosis, fibrosis, and in serious cases, liver failure. The risks far outweigh any unproven benefits.
Can I use comfrey while pregnant or breastfeeding?
You should avoid it. Comfrey is likely unsafe in pregnancy due to liver toxicity and potential harm to the baby, and harmful compounds can pass into breast milk. Talk with your doctor or pharmacist about safe alternatives.
What are the side effects of comfrey?
When used topically on intact skin, comfrey is generally well tolerated, though some people get rash, itching, erythema, or irritation. When taken by mouth, serious effects include liver damage (ascites, fibrosis, cirrhosis), lung damage with high blood pressure in the lungs, and in rare cases, death.
Does comfrey actually work for back pain or cough?
We don't have reliable evidence that it does. The data shows insufficient evidence to rate comfrey for back pain, cough, bronchitis, angina, or cancer, so we can't tell you whether it's effective for any of these.
Can comfrey damage my liver if I use it topically?
Topical use on unbroken skin for short periods is generally well tolerated and is not associated with the serious liver toxicity that oral use carries. However, avoid applying it to broken or damaged skin.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Comfrey label
Go deeper

The Full Monographs Behind Comfrey’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Comfrey

Interacts with 438 drugs

Comfrey is a traditional herb used mainly on the skin for bruises, sprains, and joint pain, and some topical products show modest benefit for these uses. However, comfrey contains compounds...

Read the full Comfrey monograph →
Sources

Sources & How We Checked

Comfrey's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Comfrey 13 references
  1. Stewart MJ, Steenkamp V. Pyrrolizidine poisoning: a neglected area in human toxicology. Ther Drug Monit 2001;23:698-708. PubMed
  2. Food and Drug Administration. FDA Advises Dietary Supplement Manufacturers to Remove Comfrey Products From the Market. July 6, 2001. Available at: http://www.cfsan.fda.gov/~dms/dspltr06.html.
  3. Stickel F, Seitz HK. The efficacy and safety of comfrey. Public Health Nutr 2000;3:501-8. PubMed
  4. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  5. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  6. Predel, H. G., Giannetti, B., Koll, R., Bulitta, M., and Staiger, C. Efficacy of a comfrey root extract ointment in comparison to a diclofenac gel in the treatment of ankle distortions: results of an observer-blind, randomized, multicenter study. Phytome
  7. Gyorik, S. and Stricker, H. Severe pulmonary hypertension possibly due to pyrrolizidine alkaloids in polyphytotherapy. Swiss.Med.Wkly. 4-4-2009;139(13-14):210-211.
  8. Giannetti, B. M., Staiger, C., Bulitta, M., and Predel, H. G. Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo controlled, multicentre trial. Br.J Spor PubMed
  9. Tanret, I. and Duh, D. [Pharmaceutical sheet. Symphytum officinale L., dermal use (Flexagile cream)]. J Pharm.Belg. 2012;(1):41-42.
  10. Laslett, L. L., Quinn, S. J., Darian-Smith, E., Kwok, M., Fedorova, T., Korner, H., Steels, E., March, L., and Jones, G. Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised contr
  11. Frost R, Macpherson H, O'meara S. A critical scoping review of external uses of comfrey (Symphytum spp.). Complement Ther Med. 2013;21(6):724-45. PubMed
  12. Pabst H, Schaefer A, Staiger C, Junker-samek M, Predel HG. Combination of comfrey root extract plus methyl nicotinate in patients with conditions of acute upper or low back pain: a multicentre randomised controlled trial. Phytother Res. 2013;27(6):811-7. PubMed
  13. Smith DB, Jacobson BH. Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials. J Chiropr Med. 2011;10(3) PubMed

See these in context on the Comfrey monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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