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Dietary supplement

Comfrey Leaf Mint Flavor Ingredients & Drug Interactions

by TerraVita

Comfrey Leaf Mint Flavor label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Comfrey Leaf Mint Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Comfrey Leaf Mint Flavor is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for bruises and sprains, muscle and joint pain, minor wounds and skin irritation.Based on those ingredients, 438 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Comfrey Leaf Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Comfrey Leaf Mint Flavor by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Comfrey Leaf Mint Flavor by TerraVita — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Comfrey Leaf Mint Flavor by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Comfrey Leaf Glycerite Liquid Extract. Glycerin and mint flavor are inactive ingredients that serve as the base and flavoring.

Comfrey is a plant traditionally used for various purposes, but what matters here is that it contains compounds called pyrrolizidine alkaloids, which are the source of both its effects and its safety concerns.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Comfrey's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: bruises, sprains, and muscle pain relief.
  • We looked for evidence on: Back pain, Bruises, Sprains, Osteoarthritis, joint pain, inflammation — and 1 related terms.
  • The closest evidence on file: Comfrey is rated "Insufficient Reliable Evidence To Rate" for Back pain (Natural Medicines).
  • Also on file: Comfrey is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis, Bruises, Sprains.

The evidence we hold doesn't support reliable claims that comfrey works for bronchitis, angina, back pain, cough, or cancer — the data on file rates all of these as having insufficient reliable evidence. That doesn't mean comfrey does nothing; it means the studies strong enough to say aren't in our monograph.

The evidence, ingredient by ingredient Comfrey

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Here's what you need to know: topical comfrey on unbroken skin for short periods may be acceptable, but this product is an oral liquid — and oral use is unsafe. Comfrey can cause serious liver damage, including scarring, cirrhosis, fluid buildup in the belly, and liver failure.

These effects can show up as late as two years after you start taking it. The product is also unsafe in pregnancy and while breastfeeding because the harmful alkaloids can pass to your baby.

When used by mouth, comfrey may cause sudden abdominal pain, vomiting, belly swelling, and liver enlargement. Chronic use leads to progressive weakness and fluid buildup.

Rare but serious effects include lung damage and high blood pressure in the lungs.

Side effects, ingredient by ingredient Comfrey

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Comfrey.
  • The most serious interaction on file is rated Moderate.
  • For scale: 439 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any medications that are toxic to the liver or any drugs that speed up the CYP3A4 enzyme (such as phenobarbital), you'll want to check with your doctor or pharmacist before using this product. These interactions are documented at Moderate severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Because oral comfrey carries a significant risk of liver damage on its own — and this product is designed for oral use — we'd recommend talking with your doctor or pharmacist before starting it. The interaction risks with liver-affecting and certain enzyme-inducing drugs add another layer of concern.

Your healthcare provider knows your full medical history and can help you weigh whether this is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Comfrey Leaf Mint Flavor, straight from the product label.

Brand TerraVita
Barcode (UPC) 064435223212
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 281948
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Comfrey Leaf Mint Flavor by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064435223212
IngredientAmount% DV
Comfrey Leaf Glycerite Liquid Extract0.13 mL--

Other ingredients: Glycerin, Mint Flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2018 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Mint flavored Glycerite liquid extract (1:5)

Formulation

Alcohol free

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Comfrey Leaf Mint Flavor by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Comfrey Leaf Mint Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Comfrey Leaf Mint Flavor by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Comfrey Leaf Glycerite Liquid Extract

Interacts with
438 drugs
0.13 mL per serving

Comfrey is a traditional herb used mainly on the skin for bruises, sprains, and joint pain, and some topical products show modest benefit for these us...

Comfrey Leaf Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin, Mint Flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Comfrey Leaf Mint Flavor by TerraVita Drug Interactions

Want to check YOUR meds against Comfrey Leaf Mint Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
438Drugs
438 Moderate

Ingredients driving the most interactions

Comfrey Leaf Glycerite Liquid Extract 438

Individual Drug Interactions

The ingredients in Comfrey Leaf Mint Flavor interact with 438 drugs. Click any drug to see the details.

1 of the 1 ingredient in Comfrey Leaf Mint Flavor interact with drugs. Each result below shows which ingredient is responsible. Comfrey Leaf Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Comfrey Leaf Mint Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Comfrey Leaf Glycerite Liquid Extract2 drug types · 438 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid constituents in comfrey.
CYP3A4 enzymes convert pyrrolizidine alkaloids, constituents of comfrey, to toxic metabolites. Some case reports show that enzyme inducers, such as phenobarbital, seem to enhance the toxicity of comfrey.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, comfrey might have additive adverse effects on the liver when used with hepatotoxic drugs.
Due to its pyrrolizidine alkaloid constituents, comfrey can cause hepatotoxic effects, including ascites, cirrhosis, hepatic fibrosis, hepatomegaly, and sinusoidal obstruction syndrome.

Likelihood Possible Evidence D
Comfrey Leaf Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Comfrey Leaf Mint Flavor, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Comfrey Leaf Mint Flavor by TerraVita: Common Questions

Does Comfrey Leaf Mint Flavor by TerraVita interact with any medications?
Yes. Based on its ingredients, Comfrey Leaf Mint Flavor has a known interaction with 438 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Comfrey Leaf Mint Flavor contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is comfrey safe to take by mouth?
No. Oral comfrey is unsafe because of liver toxicity — it can cause cirrhosis, scarring, and liver failure. This product is taken by mouth, so the safety data advises against it.
What are the serious side effects I should watch for?
Serious effects include sudden abdominal pain, vomiting, belly swelling, liver enlargement, and liver failure — which can develop up to two years after starting. Rare but documented effects also include lung damage and high blood pressure in the lungs. If you experience severe belly pain or vomiting, seek medical attention right away.
Can I use this product if I'm pregnant or breastfeeding?
No. The safety data rates comfrey as likely unsafe during pregnancy because of liver toxicity and possible harm to the baby, and unsafe while breastfeeding because harmful compounds pass into breast milk.
Does comfrey actually work for back pain or cough?
The evidence we have doesn't support reliable claims that it works for those — or for bronchitis, angina, or cancer. The data we hold rates the evidence as insufficient, so we can't say it's effective for these uses.
What exactly are the pyrrolizidine alkaloids I keep seeing mentioned?
They're toxic compounds naturally present in comfrey. When you take comfrey by mouth, your liver converts these alkaloids into even more toxic forms, which is why oral use is so risky — the damage can be severe and long-lasting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Comfrey Leaf Mint Flavor label
Go deeper

The Full Monographs Behind Comfrey Leaf Mint Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Comfrey

Interacts with 438 drugs

Comfrey is a traditional herb used mainly on the skin for bruises, sprains, and joint pain, and some topical products show modest benefit for these uses. However, comfrey contains compounds...

Read the full Comfrey monograph →
Sources

Sources & How We Checked

Comfrey Leaf Mint Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Comfrey 13 references
  1. Stewart MJ, Steenkamp V. Pyrrolizidine poisoning: a neglected area in human toxicology. Ther Drug Monit 2001;23:698-708. PubMed
  2. Food and Drug Administration. FDA Advises Dietary Supplement Manufacturers to Remove Comfrey Products From the Market. July 6, 2001. Available at: http://www.cfsan.fda.gov/~dms/dspltr06.html.
  3. Stickel F, Seitz HK. The efficacy and safety of comfrey. Public Health Nutr 2000;3:501-8. PubMed
  4. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  5. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  6. Predel, H. G., Giannetti, B., Koll, R., Bulitta, M., and Staiger, C. Efficacy of a comfrey root extract ointment in comparison to a diclofenac gel in the treatment of ankle distortions: results of an observer-blind, randomized, multicenter study. Phytome
  7. Gyorik, S. and Stricker, H. Severe pulmonary hypertension possibly due to pyrrolizidine alkaloids in polyphytotherapy. Swiss.Med.Wkly. 4-4-2009;139(13-14):210-211.
  8. Giannetti, B. M., Staiger, C., Bulitta, M., and Predel, H. G. Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo controlled, multicentre trial. Br.J Spor PubMed
  9. Tanret, I. and Duh, D. [Pharmaceutical sheet. Symphytum officinale L., dermal use (Flexagile cream)]. J Pharm.Belg. 2012;(1):41-42.
  10. Laslett, L. L., Quinn, S. J., Darian-Smith, E., Kwok, M., Fedorova, T., Korner, H., Steels, E., March, L., and Jones, G. Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised contr
  11. Frost R, Macpherson H, O'meara S. A critical scoping review of external uses of comfrey (Symphytum spp.). Complement Ther Med. 2013;21(6):724-45. PubMed
  12. Pabst H, Schaefer A, Staiger C, Junker-samek M, Predel HG. Combination of comfrey root extract plus methyl nicotinate in patients with conditions of acute upper or low back pain: a multicentre randomised controlled trial. Phytother Res. 2013;27(6):811-7. PubMed
  13. Smith DB, Jacobson BH. Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials. J Chiropr Med. 2011;10(3) PubMed

See these in context on the Comfrey monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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