Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Complx5 Fruit Punch Ingredients & Drug Interactions

by Rivalus

Complx5 Fruit Punch label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Complx5 Fruit Punch against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Complx5 Fruit Punch is a dietary supplement by Rivalus with 5 active ingredients. Its ingredients are commonly taken for mental focus and alertness, coping with stress, fatigue and sleep loss.Based on those ingredients, 21 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Tyrosine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Complx5 Fruit Punch by Rivalus

Ask about any prescription or over-the-counter medication and we check it for interactions with Complx5 Fruit Punch by Rivalus — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Complx5 Fruit Punch by Rivalus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “COMPLX5 Proprietary Formula” is a proprietary blend — the label gives one combined amount (5,000 mg) without saying how much of each component you get.

Complx5 Fruit Punch has 5 active ingredients. L-Tyrosine is an amino acid that your body uses to make brain chemicals and thyroid hormones — studies suggest it may help with focus and memory.

Beta-Alanine is another amino acid that buffers lactic acid buildup in muscles during intense exercise. The product also contains Arginine (an amino acid that supports blood flow), Red Ginseng (a plant extract), and Micronized Bicarbonate (a buffering compound).

The rest of the powder is made up of inactive ingredients like maltodextrin, citric acid, and flavoring.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: pre-workout energy and athletic performance.
  • We looked for evidence on: Athletic performance, Physical performance, Fatigue, Exercise-induced muscle breakdown, Endurance, Muscle recovery — and 1 related terms.
  • The strongest evidence on file: Beta-alanine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Beta-alanine is rated "Possibly Effective" for Physical performance.
  • Also on file: Tyrosine is rated "Possibly Ineffective" for Athletic performance.

L-Tyrosine is effective for phenylketonuria (PKU), a rare metabolic disorder. It's possibly effective for sharpening focus and memory in everyday use, but the evidence isn't strong.

For athletic performance, the evidence suggests it probably doesn't help. Beta-Alanine is possibly effective for athletic performance and physical performance — the research shows a modest benefit during intense exercise.

For the other ingredients, we don't have established effectiveness ratings in our data.

The evidence, ingredient by ingredient Tyrosine Beta-alanine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Tyrosine is generally well tolerated in healthy adults, but we don't have enough long-term safety data to recommend regular use on your own — talk to your doctor first. The most common side effects are fatigue, headache, heartburn, and nausea; higher doses make these more likely.

Beta-Alanine is also generally well tolerated but commonly causes a harmless tingling sensation on your skin (usually starting on the scalp within 20 minutes) that lasts about an hour — this is dose-dependent and mild at lower amounts. Neither ingredient has enough pregnancy or breastfeeding safety data, so avoid them during pregnancy and while nursing unless your doctor says otherwise.

Side effects, ingredient by ingredient Tyrosine Beta-alanine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Tyrosine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 21 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take levodopa (Parkinson's medication) or any thyroid hormone replacements — both have Moderate interactions with L-Tyrosine in this product. We couldn't check Arginine, Red Ginseng, or Micronized Bicarbonate for interactions, so mention those names to your pharmacist too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Complx5 Fruit Punch is an athletic supplement with two amino acids that show some promise for exercise performance and focus. If you take levodopa for Parkinson's or any thyroid medication, run it through our checker first — L-Tyrosine can interfere with both.

Talk to your pharmacist before adding this to your routine, especially if you're pregnant, breastfeeding, or taking any prescription drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Complx5 Fruit Punch, straight from the product label.

Brand Rivalus
Barcode (UPC) 807156001635
Net contents 0.594 lbs; 270 Gram(s)
Market status On market
Date entered into DSLD Oct 25, 2018
DSLD ID 182063
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Complx5 Fruit Punch by Rivalus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Gram(s)
Maximum serving Sizes:
6 Gram(s)
Servings per container
45
UPC/BARCODE
807156001635
IngredientAmount% DV
L-Tyrosine0 NP--
Beta-Alanine0 NP--
Arginine0 NP--
COMPLX5 Proprietary Formula5000 mg--
Micronized Bicarbonate0 NP--
Red Ginseng0 NP--

Other ingredients: Maltodextrin, Citric Acid, Natural & Artificial flavor, Malic Acid, Sucralose, Acesulfame Potassium, Red #40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Allergen Information: Manufactured on equipment that process products containing milk, soybeans (lecithin), peanut flavor, wheat, shellfish, tree nuts, fish oil and egg.

Keep out of reach of children.

Warning: Consult a physician before using if you are unaware of your current health status, if you have a medical condition, or if you or your family has a medical history of cardiovascular disease, diabetes, psychological disorders, hormonal abnormalities, or if you are taking any prescription drug.

Do not exceed maximum daily dosage. Do not use if safety seal is broken.

Contains ingredients derived from milk.

Formulation

0 caffeine 0 banned substances

Our most powerful pre-workout formula increases muscle strength and delays fatigue with zero caffeine. Plus, zero banned substances means clean, effective energy any athlete can trust.

General Statements

5 power ingredients 45 servings per container

Natural & artificial flavor

Why Complx5? That means zero jitters or loss of motor skills during workouts.

Reduce the burn Increase endurance

Twitter@Rivalus

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Pre-workout energy enhancer

10 oz H2O + 1 Full scoop Training day: 60 min pre-workout Off day: A.M. & afternoon

Seals/Symbols

Informed-Choice.org Trusted by sport

Formula

The athlete's pre-workout energy enhancer

5 powerful pre-workout ingredients Arginine Beta Alanine Micronized Bi-Carbonate Tyrosine Natural Red Ginseng

Pro & Olympic athlete trusted worldwide 100% WADA IOC compliant

Contains ingredients derived from milk.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Complx5 Fruit Punch by Rivalus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Complx5 Fruit Punch label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Complx5 Fruit Punch by Rivalus

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Gram(s) Dosage formPowder Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

COMPLX5 Proprietary Formula

5000 mg per serving

Other (inactive) ingredients: Maltodextrin, Citric Acid, Natural & Artificial flavor, Malic Acid, Sucralose, Acesulfame Potassium, Red #40. These complete the product’s ingredient list but are not active constituents.

Interaction report

Complx5 Fruit Punch by Rivalus Drug Interactions

Want to check YOUR meds against Complx5 Fruit Punch?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
21Drugs
21 Moderate

Ingredients driving the most interactions

L-Tyrosine 21

Individual Drug Interactions

The ingredients in Complx5 Fruit Punch interact with 21 drugs. Click any drug to see the details.

1 of the 5 ingredients in Complx5 Fruit Punch interact with drugs. Each result below shows which ingredient is responsible. L-Tyrosine

Each ingredient & the kinds of drugs it affects

For each ingredient in Complx5 Fruit Punch with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Complx5 Fruit Punch, from the product label.

Rivalus

See all Rivalus products
Name
RIVALUS (A Nutrivo Company)
Street Address
1785 N. Edgelawn Dr
City
Aurora
State
IL
ZipCode
60506
Phone Number
1-800-620-4177
Web Address
RIVALUS.NET
Pharmacist Counseling Corner

Complx5 Fruit Punch by Rivalus: Common Questions

Does Complx5 Fruit Punch by Rivalus interact with any medications?
Yes. Based on its ingredients, Complx5 Fruit Punch has a known interaction with 21 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Complx5 Fruit Punch contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's the tingling I've heard about with this product?
That's Beta-Alanine — it commonly causes a pins-and-needles feeling (paresthesia) and flushing, usually starting on your scalp within 20 minutes and lasting about an hour. It's harmless and dose-dependent; lower amounts cause less tingling. At the smallest doses, only about a quarter of people notice it.
Is this safe to take while pregnant or breastfeeding?
There isn't enough safety data for the active ingredients in this product during pregnancy or breastfeeding. The safety data advises against use in both situations. Talk to your doctor or pharmacist before using it if you're pregnant, planning to be, or nursing.
Can I take this every day?
L-Tyrosine hasn't been well studied for long-term daily use, so we don't have strong safety data for that. Beta-Alanine also lacks long-term high-dose data. Talk to a healthcare provider before making this a daily habit.
Will this help me focus better?
L-Tyrosine is possibly effective for focus and memory, meaning there's some evidence but it's not strong. Results vary from person to person. For athletic performance, Beta-Alanine is possibly effective, but L-Tyrosine probably won't help much there.
What are the most common side effects?
From L-Tyrosine: fatigue, headache, heartburn, and nausea — these are more likely at higher doses. From Beta-Alanine: tingling and skin flushing, which is harmless and usually mild. Both ingredients are generally well tolerated.
Why can't you check some of the ingredients for drug interactions?
We don't hold interaction data for Arginine, Red Ginseng, or Micronized Bicarbonate in our monographs. That doesn't mean they're safe with your medications — just that we can't verify it. Mention all three to your pharmacist when you ask about this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Complx5 Fruit Punch is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Complx5 Fruit Punch label
Go deeper

The Full Monographs Behind Complx5 Fruit Punch’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph → Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph →
Sources

Sources & How We Checked

Complx5 Fruit Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

Beta-alanine 13 references
  1. Harris RC, Tallon MJ, Dunnett M, et al. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids 2006;30:279-89.
  2. Hill CA, Harris RC, Kim HJ, et al. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids 2007;32:225-33.
  3. Bellinger PM, Minahan CL. The effect of ß-alanine supplementation on cycling time trials of different length. Eur J Sport Sci 2016;16(7):829-36.
  4. Chung W, Shaw G, Anderson ME, et al. Effect of 10 week beta-alanine supplementation on competition and training performance in elite swimmers. Nutrients 2012;4(10):1441-53. PubMed
  5. Glenn JM, Gray M, Stewart R, et al. Incremental effects of 28 days of beta-alanine supplementation on high-intensity cycling performance and blood lactate in masters female cyclists. Amino Acids 2015;47(12):2593-600. PubMed
  6. Gross M, Bieri K, Hoppeler H, Norman B, Vogt M. Beta-alanine supplementation improves jumping power and affects severe-intensity performance in professional alpine skiers. Int J Sport Nutr Exerc Metab 2014;24(6):665-73. PubMed
  7. Howe ST, Bellinger PM, Driller MW, Shing CM, Fell JW. The effect of beta-alanine supplementation on isokinetic force and cycling performance in highly trained cyclists. Int J Sport Nutr Exerc Metab 2013;23(6):562-70. PubMed
  8. Sweeney KM, Wright GA, Glenn Brice A, Doberstein ST. The effect of beta-alanine supplementation on power performance during repeated sprint activity. J Strength Cond Res 2010;24(1):79-87.
  9. Décombaz J, Beaumont M, Vuichoud J, Bouisset F, Stellingwerff T. Effect of slow-release ß-alanine tablets on absorption kinetics and paresthesia. Amino Acids 2012;43(1):67-76. Erratum in: Amino Acids 2013;45(4):1015.
  10. Stellingwerff T, Anwander H, Egger A, et al. Effect of two ß-alanine dosing protocols on muscle carnosine synthesis and washout. Amino Acids 2012;42(6):2461-72. PubMed
  11. da Silva RP, de Oliveira LF, Saunders B, et al. Effects of ß-alanine and sodium bicarbonate supplementation on the estimated energy system contribution during high-intensity intermittent exercise. Amino Acids. 2019;51(1):83-96. PubMed
  12. Varanoske AN, Hoffman JR, Church DD, et al. Comparison of sustained-release and rapid-release ß-alanine formulations on changes in skeletal muscle carnosine and histidine content and isometric performance following a muscle-damaging protocol. Amino Acids. PubMed
  13. Perim P, Gobbi N, Duarte B, et al. Beta-alanine did not improve high-intensity performance throughout simulated road cycling. Eur J Sport Sci 2021. PubMed

See these in context on the Beta-alanine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team