Cough Syrup Ingredients & Drug Interactions
by Gaia Herbs
What is this page for?
First and foremost: checking Cough Syrup against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cough Syrup is a dietary supplement by Gaia Herbs with 7 active ingredients. Its ingredients are commonly taken for cough and sore throat, wound and burn care, soothing minor skin irritation.Based on those ingredients, 1,209 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Eucalyptus Aerial Parts Essential Oil, Honey, Thyme Aerial Parts Essential Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Cough Syrup by Gaia Herbs
Ask about any prescription or over-the-counter medication and we check it for interactions with Cough Syrup by Gaia Herbs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Cough Syrup by Gaia Herbs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
This liquid cough syrup contains 7 ingredients, including honey, English Ivy Leaf Extract, Black Elderberry Fruit Extract, South African Geranium Root Extract, and essential oils from eucalyptus, Scotch pine, and thyme. Honey, a traditional throat soother, has possibly effective evidence for cough.
English Ivy Leaf Extract and the essential oils are included for respiratory support, though the evidence for their effectiveness in cough or bronchitis is not established in the data we hold. The product also contains inactive ingredients: water and lemon juice concentrate.
Does it work?
Moderate evidence
Honey in this syrup is possibly effective for cough. The other active ingredients — English Ivy Leaf Extract, Black Elderberry Fruit Extract, South African Geranium Root Extract, and the essential oils of eucalyptus, Scotch pine, and thyme — do not have established evidence for cough or respiratory conditions in the data we hold.
If you're taking this for cough relief, the evidence mainly supports the honey component.
How safe is it?
Well-documented data
Honey is generally well tolerated and considered safe as a food for adults and children over 1 year of age, though you should check with your doctor before using it medicinally. English Ivy Leaf Extract is generally well tolerated when standardized, but the raw plant is toxic.
The safety data advises against English Ivy during pregnancy and while breastfeeding. Eucalyptus oil is generally safe in small, diluted amounts for inhalation or topical use — the undiluted oil can be poisonous if swallowed.
Thyme is safe in food amounts, but concentrated essential oil should be avoided unless your doctor approves. Pregnancy and lactation safety for this syrup overall isn't established — talk with your doctor or pharmacist for personalized advice.
Meds to double-check
Moderate interaction found
Before taking this syrup, double-check your medications with the tool on this page if you're on blood thinners (anticoagulants), drugs that affect liver enzyme systems (especially CYP2C19, CYP2D6, CYP2C8, CYP1A2, or CYP3A4), blood sugar medications, amphetamines, estrogen replacement therapy, pentobarbital, or anticholinergic or cholinergic drugs. The English Ivy and essential oils in particular may raise the levels of many prescription medications.
The bottom line
Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This syrup may be worth trying if you're looking for honey-based cough support, but the other ingredients have interactions with many medications. If you take any prescription drugs — especially blood thinners, diabetes medications, antidepressants, or anything metabolized by your liver — check with your pharmacist before starting.
Also avoid if you're pregnant or breastfeeding without talking to your doctor first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cough Syrup, straight from the product label.
| Brand | Gaia Herbs |
|---|---|
| Net contents | 4 Fluid Ounce(s); 118 Milliliter(s) |
| Market status | On market |
| Date entered into DSLD | May 23, 2024 |
| DSLD ID | 309558 |
| Product type | Other Combinations |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cough Syrup by Gaia Herbs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 15 Calorie(s) | -- |
| Total Carbohydrates | 4 Gram(s) | 2% |
| Added Sugars | 4 Gram(s) | 8% |
| Total Sugars | 4 Gram(s) | -- |
| Honey | 5.2 Gram(s) | -- |
| English Ivy Leaf Extract | 22 mg | -- |
| Essential Oil Blend | 8 mg | -- |
| Black Elderberry Fruit Extract | 22 mg | -- |
| South African Geranium Root Extract | 29 mg | -- |
| Eucalyptus Aerial Parts Essential Oil | 0 NP | -- |
| Scotch Pine Needle Essential Oil | 0 NP | -- |
| Thyme Aerial Parts Essential Oil | 0 NP | -- |
Other ingredients: Water, Lemon Juice Concentrate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Connecting people, plants & planet
Discover the Gaia Difference Facebook Instagram gaiaherbs.com @gaiaherbs
New
Formulation
Purity All products are screened for pesticides, microbes & heavy metals. Potency Concentrated extracts provide a delicious & convenient way to get your daily dose of herbs. Integrity See the proof at meetyourherbs.com, the world's first traceability platform.
No artificial sweeteners No added flavors
Non GMO Project Verified nongmoproject.org
Helps soothe an occasional dry cough
Formula
Expect more from your cough syrup Our plant-powered formula contains a blend of respiratory-and immune- supporting herbs for holistic support. Featured in this formula: South African Geranium also known Pelargonium Pelargonium This traditional South African herb has been clinically studies to maintain respiratory health and support the body's natural defenses.
Cough Syrup made with Elderberry Honey Ivy leaf South African geranium
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
Non GMO Project Verified nongmoproject.org
FDA Statement of Identity
Herbal Supplement
Suggested/Recommended/Usage/Directions
Suggested use Adults take 1 teaspoon 3 times daily. Shake well before use.
Storage
Refrigerate after opening and consume within 6 months.
Precautions
Not for use during pregnancy or lactation. If you have a medical condition, or take medications, please consult with your healthcare practitioner before use.
Store away from children.
Safety-sealed at neck of bottle.
Brand IP Statement(s)
Gaia Herbs Est 1987
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cough Syrup by Gaia Herbs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cough Syrup by Gaia Herbs
These are the 7 active ingredients this product is made of. Select any to open its full monograph.
Serving size5 mL Dosage formLiquid Servings per container24 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Honey
Interacts with736 drugs
Honey is a natural food with some real, modest evidence for easing coughs and helping certain wounds, especially when special medical-grade or Manuka...
Honey monograph & interactionsEnglish Ivy Leaf Extract
Interacts with280 drugs
English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredient in many...
English Ivy Leaf Extract monograph & interactionsEssential Oil Blend
- › Eucalyptus Aerial Parts Essential Oil
- › Scotch Pine Needle Essential Oil
- › Thyme Aerial Parts Essential Oil
Black Elderberry Fruit Extract
Interacts with121 drugs
Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...
Black Elderberry Fruit Extract monograph & interactionsSouth African Geranium Root Extract
Other (inactive) ingredients: Water, Lemon Juice Concentrate. These complete the product’s ingredient list but are not active constituents.
Cough Syrup by Gaia Herbs Drug Interactions
HelloPharmacist Interaction Report
Gaia Herbs Cough Syrup contains several ingredients with documented interactions with medications.
The most serious concern is English Ivy Leaf Extract, which may increase levels of drugs metabolized by three liver enzymes (CYP2C19, CYP2D6, and CYP2C8) — all rated Moderate severity. This could affect a wide range of prescription medications, though these interactions haven't been reported in humans yet.
Read the full breakdown — every affected drug type, severity by severity
Honey in the formula has Minor interactions with blood thinners (anticoagulants) and antiplatelet drugs, and may affect how your body processes certain medications broken down by the CYP3A4 enzyme. Eucalyptus Aerial Parts Essential Oil carries Moderate interactions with four liver enzymes (CYP1A2, CYP2C19, CYP2C9, and CYP3A4), as well as with blood sugar medications, amphetamines, and pentobarbital — again, theoretical based on lab research, not confirmed in people.
Thyme Aerial Parts Essential Oil may interfere with estrogen replacement therapy, blood thinners, and medications for nerve or muscle function (anticholinergics and cholinergics), all Moderate severity.
We couldn't check Black Elderberry Fruit Extract, South African Geranium Root Extract, or Scotch Pine Needle Essential Oil because we hold no interaction data for them. Altogether, these interactions span 1,105 individual medications.
Use the medication checker on this page to search your exact prescriptions before starting this syrup.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Cough Syrup?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Cough Syrup interact with 1,209 drugs. Click any drug to see the details.
5 of the 7 ingredients in Cough Syrup interact with drugs. Each result below shows which ingredient is responsible. Eucalyptus Aerial Parts Essential Oil Honey Thyme Aerial Parts Essential Oil English Ivy Leaf Extract Black Elderberry Fruit Extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Cough Syrup — through 1 ingredient. Tap an ingredient for the detail:
Black Elderberry Fruit ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Black Elderberry Fruit Extract + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Cough Syrup — through 2 ingredients. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Ado-trastuzumab Emtansine interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Cough Syrup — through 2 ingredients. Tap an ingredient for the detail:
Thyme Aerial Parts Essential OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
Read the full Thyme Aerial Parts Essential Oil + Abciximab interactionHoneyAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Honey + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Cough Syrup — through 2 ingredients. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Abemaciclib interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Cough Syrup — through 2 ingredients. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Abiraterone interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Cough Syrup — through 2 ingredients. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Abiraterone Acetate interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Cough Syrup — through 5 ingredients. Tap an ingredient for the detail:
Thyme Aerial Parts Essential OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
Read the full Thyme Aerial Parts Essential Oil + Abrocitinib interactionBlack Elderberry Fruit ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Black Elderberry Fruit Extract + Abrocitinib interactionEnglish Ivy Leaf ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C19.
Read the full English Ivy Leaf Extract + Abrocitinib interactionEucalyptus Aerial Parts Essential OilCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP2C19 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Abrocitinib interactionHoneyAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Honey + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Cough Syrup — through 2 ingredients. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acalabrutinib interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Cough Syrup — through 1 ingredient. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, eucalyptus leaf might increase the risk of hypoglycemia.
Read the full Eucalyptus Aerial Parts Essential Oil + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Cough Syrup — through 2 ingredients. Tap an ingredient for the detail:
Thyme Aerial Parts Essential OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
Read the full Thyme Aerial Parts Essential Oil + Acenocoumarol interactionHoneyAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Honey + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Cough Syrup — through 1 ingredient. Tap an ingredient for the detail:
Thyme Aerial Parts Essential OilAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
Read the full Thyme Aerial Parts Essential Oil + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Cough Syrup — through 1 ingredient. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Cough Syrup — through 3 ingredients. Tap an ingredient for the detail:
Thyme Aerial Parts Essential OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
Read the full Thyme Aerial Parts Essential Oil + Acetaminophen, Aspirin interactionEucalyptus Aerial Parts Essential OilCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Aspirin interactionHoneyAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Honey + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Cough Syrup — through 3 ingredients. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Aspirin, Caffeine interactionThyme Aerial Parts Essential OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
Read the full Thyme Aerial Parts Essential Oil + Acetaminophen, Aspirin, Caffeine interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Cough Syrup — through 1 ingredient. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Cough Syrup — through 1 ingredient. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Cough Syrup — through 2 ingredients. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Butalbital, Caffeine interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Cough Syrup — through 3 ingredients. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Butalbital, Caffeine, Codeine interactionEnglish Ivy Leaf ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
Read the full English Ivy Leaf Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Cough Syrup — through 2 ingredients. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Butalbital, Codeine interactionEnglish Ivy Leaf ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
Read the full English Ivy Leaf Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Cough Syrup — through 2 ingredients. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Butalbital, Codeine Phosphate interactionEnglish Ivy Leaf ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
Read the full English Ivy Leaf Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Cough Syrup — through 4 ingredients. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionEnglish Ivy Leaf ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
Read the full English Ivy Leaf Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionThyme Aerial Parts Essential OilAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
Read the full Thyme Aerial Parts Essential Oil + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Cough Syrup — through 3 ingredients. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Caffeine, Codeine interactionEnglish Ivy Leaf ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
Read the full English Ivy Leaf Extract + Acetaminophen, Caffeine, Codeine interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Cough Syrup — through 3 ingredients. Tap an ingredient for the detail:
English Ivy Leaf ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
Read the full English Ivy Leaf Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionEucalyptus Aerial Parts Essential OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Caffeine, Codeine, Salicylamide interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Cough Syrup — through 3 ingredients. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Caffeine, Dihydrocodeine interactionEnglish Ivy Leaf ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
Read the full English Ivy Leaf Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Cough Syrup — through 2 ingredients. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Caffeine, Isometheptene interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Cough Syrup — through 3 ingredients. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Caffeine, Pyrilamine interactionThyme Aerial Parts Essential OilAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
Read the full Thyme Aerial Parts Essential Oil + Acetaminophen, Caffeine, Pyrilamine interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Cough Syrup — through 4 ingredients. Tap an ingredient for the detail:
Thyme Aerial Parts Essential OilAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
Read the full Thyme Aerial Parts Essential Oil + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionEucalyptus Aerial Parts Essential OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionEnglish Ivy Leaf ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
Read the full English Ivy Leaf Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Cough Syrup — through 4 ingredients. Tap an ingredient for the detail:
Eucalyptus Aerial Parts Essential OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEnglish Ivy Leaf ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
Read the full English Ivy Leaf Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionThyme Aerial Parts Essential OilAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
Read the full Thyme Aerial Parts Essential Oil + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Cough Syrup — through 4 ingredients. Tap an ingredient for the detail:
Thyme Aerial Parts Essential OilAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
Read the full Thyme Aerial Parts Essential Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionEucalyptus Aerial Parts Essential OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionEnglish Ivy Leaf ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
Read the full English Ivy Leaf Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Cough Syrup — through 4 ingredients. Tap an ingredient for the detail:
English Ivy Leaf ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
Read the full English Ivy Leaf Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionEucalyptus Aerial Parts Essential OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
Read the full Eucalyptus Aerial Parts Essential Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionThyme Aerial Parts Essential OilAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
Read the full Thyme Aerial Parts Essential Oil + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionHoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Cough Syrup with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Eucalyptus Aerial Parts Essential Oil
Amphetamines
Theoretically, inhaling eucalyptol may reduce the effectiveness of amphetamines.
Animal research suggests that inhaling eucalyptol may reduce the levels of amphetamines in the blood.
Antidiabetes Drugs
Theoretically, eucalyptus leaf might increase the risk of hypoglycemia.
Animal research suggests that eucalyptus leaf might have hypoglycemic activity, and might have additive effects when used with antidiabetes drugs.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP1A2, although this has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, eucalyptus might increase the levels of CYP2C19 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP2C19, although this has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, eucalyptus might increase the levels of CYP2C9 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP2C9, although this has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP3A4, although this has not been reported in humans.
Pentobarbital (Nembutal)
Theoretically, inhaling eucalyptol might reduce the effectiveness of pentobarbital.
Animal research suggests that inhaling eucalyptol reduces the level of pentobarbital that reaches the brain.
Honey
Phenytoin (Dilantin)
Theoretically, honey might increase levels of phenytoin.
In an animal model, the rate and extent of absorption of phenytoin was increased by honey. This effect has not been reported in humans.
Anticoagulant/Antiplatelet Drugs
Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro, honey inhibits platelet aggregation and increases the time to clotting. Furthermore, animal research suggests that feeding mice large doses of honey for 12 days increases bleeding time when compared with no intervention. However, these effects have not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Some clinical research shows that honey induces CYP3A4. However, other clinical studies found no effect on CYP3A4 activity. Different honey preparations may have different effects on CYP3A4.
Thyme Aerial Parts Essential Oil
Anticholinergic Drugs
Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.
Anticoagulant/Antiplatelet Drugs
Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that thyme leaf extract has antiplatelet effects. However, this effect has not been observed in humans.
Cholinergic Drugs
Theoretically, concurrent use of cholinergic drugs and thyme essential oil might cause additive cholinergic effects.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.
Estrogens
Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that thyme has estrogen receptor-binding activity and phytoestrogen content. However, this effect has not been observed in humans.
English Ivy Leaf Extract
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C19.
In vitro research shows that English ivy inhibits CYP2C19 enzymes. So far, this interaction has not been reported in humans.
Cytochrome P450 2C8 (Cyp2C8) Substrates
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C8.
In vitro research shows that English ivy inhibits CYP2C8 enzymes. So far, this interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
In vitro research shows that English ivy inhibits CYP2D6 enzymes. So far, this interaction has not been reported in humans.
Black Elderberry Fruit Extract
Immunosuppressants
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.
Pazopanib (Votrient)
Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
Brand information
Manufacturer and brand details for Cough Syrup, from the product label.
Gaia Herbs
See all Gaia Herbs products- Name
- Gaia Herbs Inc.
- Street Address
- 101 Gaia Herbs Drive
- City
- Brevard
- State
- NC
- ZipCode
- 28712
- Web Address
- gaiaherbs.com
Cough Syrup by Gaia Herbs: Common Questions
Does Cough Syrup by Gaia Herbs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is honey in cough syrup actually effective?
Can I give this to my young child?
What are the most common side effects I might notice?
Is it safe to use while breastfeeding?
Why do I need to check my medications with this syrup?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Cough Syrup is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cough Syrup’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Honey
Interacts with 736 drugsHoney is a natural food with some real, modest evidence for easing coughs and helping certain wounds, especially when special medical-grade or Manuka honey is used. It is generally safe for...
Read the full Honey monograph → Herb & supplement monographEnglish Ivy
Interacts with 280 drugsEnglish ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredient in many European herbal products. Some research...
Read the full English Ivy monograph → Herb & supplement monographEucalyptus
Interacts with 878 drugsEucalyptus is best known for its strong-smelling oil used in vapor rubs, inhalants, and lozenges to ease coughs and congestion. It may provide mild, short-term relief of cold symptoms, but t...
Read the full Eucalyptus monograph → Herb & supplement monographThyme
Interacts with 379 drugsThyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints. It is generally safe in the amounts found in food, and some cough products that com...
Read the full Thyme monograph → Herb & supplement monographElderberry
Interacts with 121 drugsElderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu symptoms, but the evidence is limited and n...
Read the full Elderberry monograph →Sources & How We Checked
Cough Syrup's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 100 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Honey 40 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Bose B. Honey or sugar in treatment of infected wounds? Lancet 1982;1:963. PubMed
- Ozhan H, Akdemir R, Yazici M, et al. Cardiac emergencies caused by honey ingestion: a single centre experience. Emerg Med J 2004;21:742-4. PubMed
- Centers for Disease Control. Botulism in the Unites Sates, 1899-1996. Handbook for epidemiologists, clinicians, and laboratory workers, 1998. Available online: http://www.cdc.gov/ncidod/dbmd/diseaseinfo/botulism.PDF.
- Simon A, Traynor K, Santos K, et al. Medical honey for wound care - still the 'latest resort'? Evid Based Complement Alternat Med 2009;6:165-73. PubMed
- Gethin G, Cowman S. Case series of use of Manuka honey in leg ulceration. Int Wound J 2005;2:10-15. PubMed
- Ingle R, Levin J, Polinder K. Wound healing with honey - a randomised controlled trial. S Afr Med J 2006;96:831-5.
- Johnson DW, van Eps C, Mudge DW, et al. Randomized, controlled trial of topical exit-site application of honey (Medihoney) versus mupirocin for the prevention of catheter-associated infections in hemodialysis patients. J Am Soc Nephrol 2005;16:1456-62. PubMed
- Sukriti and Garg, S. K. Influence of honey on the pharmacokinetics of phenytoin in rabbits. Ind J Pharmacol 2002;34(147).
- Jung, A. and Ottosson, J. [Infantile botulism caused by honey]. Ugeskr Laeger 2001;163(2):169.
- Gunduz, A., Turedi, S., Uzun, H., and Topbas, M. Mad honey poisoning. Am J Emerg.Med 2006;24(5):595-598.
- van der Vorst, M. M., Jamal, W., Rotimi, V. O., and Moosa, A. Infant botulism due to consumption of contaminated commercially prepared honey. First report from the Arabian Gulf States. Med Princ.Pract. 2006;15(6):456-458. PubMed
- Tushar, T., Vinod, T., Rajan, S., Shashindran, C., and Adithan, C. Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers. Basic Clin Pharmacol Toxicol 2007;100(4):269-272. PubMed
- Nilforoushzadeh, M. A., Jaffary, F., Moradi, S., Derakhshan, R., and Haftbaradaran, E. Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis. BMC Complement Altern Med 2007;7:13. PubMed
- Koca, I. and Koca, A. F. Poisoning by mad honey: a brief review. Food Chem Toxicol 2007;45(8):1315-1318. PubMed
- Akinci, S., Arslan, U., Karakurt, K., and Cengel, A. An unusual presentation of mad honey poisoning: acute myocardial infarction. Int J Cardiol 2008;129(2):e56-e58. PubMed
- Yildirim, N., Aydin, M., Cam, F., and Celik, O. Clinical presentation of non-ST-segment elevation myocardial infarction in the course of intoxication with mad honey. Am J Emerg Med 2008;26(1):108.e-2. PubMed
- Shrestha, P., Vaidya, R., and Sherpa, K. Mad honey poisoning: a rare case report of seven cases. Nepal Med Coll J 2009;11(3):212-213.
- Fetzner, L., Burhenne, J., Weiss, J., Völker, M., Unger, M., Mikus, G., and Haefeli, W. E. Daily honey consumption does not change CYP3A activity in humans. J Clin Pharmacol 2011;51(8):1223-1232. PubMed
- Thamboo, A., Thamboo, A., Philpott, C., Javer, A., and Clark, A. Single-blind study of manuka honey in allergic fungal rhinosinusitis. J Otolaryngol Head Neck Surg 2011;40(3):238-243.
- Ahmed, A., Khan, R. A., Azim, M. K., Saeed, S. A., Mesaik, M. A., Ahmed, S., and Imran, I. Effect of natural honey on human platelets and blood coagulation proteins. Pak.J Pharm Sci 2011;24(3):389-397.
- Yarlioglues, M., Akpek, M., Ardic, I., Elcik, D., Sahin, O., and Kaya, M. G. Mad-honey sexual activity and acute inferior myocardial infarctions in a married couple. Tex.Heart Inst.J 2011;38(5):577-580.
- Biberoglu, S., Biberoglu, K., and Komsuoglu, B. Mad honey. JAMA 4-1-1988;259(13):1943.
- Biberoglu, K., Biberoglu, S., and Komsuoglu, B. Transient Wolff-Parkinson-White syndrome during honey intoxication. Isr.J.Med.Sci. 1988;24(4-5):253-254.
- Gössinger, H., Hruby, K., Pohl, A., Davogg, S., Sutterlütti, G., and Mathis, G. [Poisoning with andromedotoxin-containing honey]. Dtsch Med Wochenschr 1983;108(41):1555-1558.
- Fenicia, L., Ferrini, A. M., Aureli, P., and Pocecco, M. A case of infant botulism associated with honey feeding in Italy. Eur J Epidemiol 1993;9(6):671-673. PubMed
- Sutlupinar, N., Mat, A., and Satganoglu, Y. Poisoning by toxic honey in Turkey. Arch.Toxicol. 1993;67(2):148-150. PubMed
- von Malottki, K. and Wiechmann, H. W. [Acute life-threatening bradycardia: food poisoning by Turkish wild honey]. Dtsch.Med.Wochenschr. 7-26-1996;121(30):936-938.
- Abdulla CO, Ayubi A, Zulfiquer F, Santhanam G, Ahmed MA, Deeb J. Infant botulism following honey ingestion. BMJ Case Rep. 2012 Sep 7;2012.
- Johnson DW, Badve SV, Pascoe EM, Beller E, Cass A, Clark C, de Zoysa J, Isbel NM, McTaggart S, Morrish AT, Playford EG, Scaria A, Snelling P, Vergara LA, Hawley CM; HONEYPOT Study Collaborative Group. Antibacterial honey for the prevention of peritoneal-d
- Matos D, Serrano P, Menezes Brandão F. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis. 2015 Jan;72(1):59-60. PubMed
- Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE. Honey for acute cough in children. Cochrane Database Syst Rev. 2014 Dec 23;12:CD007094. PubMed
- Vezir E, Kaya A, Toyran M, Azkur D, Dibek Misirlioglu E, Kocabas CN. Anaphylaxis/angioedema caused by honey ingestion. Allergy Asthma Proc. 2014 Jan-Feb;35(1):71-4. PubMed
- Wang YT, Qi Y, Tang FY, et al. The effect of cupping therapy for low back pain: A meta-analysis based on existing randomized controlled trials. J Back Musculoskelet Rehabil. 2017;30(6):1187-1195. PubMed
- Oduwole O, Udoh EE, Oyo-Ita A, Meremikwu MM. Honey for acute cough in children. Cochrane Database Syst Rev. 2018;4:CD007094. PubMed
- Wong D, Albietz JM, Tran H, et al. Treatment of contact lens related dry eye with antibacterial honey. Cont Lens Anterior Eye. 2017;40(6):389-393. PubMed
- Martina SJ, Ramar LAP, Silaban MRI, Luthfi M, Govindan PAP. Antiplatelet Effectivity between Aspirin with Honey on Cardiovascular Disease Based on Bleeding Time Taken on Mice. Open Access Maced J Med Sci. 2019 Oct 14;7(20):3416-3420. PubMed
- Jhawar N, Gonzalez-Estrada A. Honey-induced anaphylaxis in an adult. QJM 2022;115(5):325-326. PubMed
- Di Costanzo M, De Paulis N, Peveri S, Montagni M, Berni Canani R, Biasucci G. Anaphylaxis caused by artisanal honey in a child: a case report. J Med Case Rep 2021;15(1):235. PubMed
English Ivy 13 references
- Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
- Fazio S, Pouso J, Dolinsky D, et al. Tolerance, safety and efficacy of Hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: a prospective, open, multicentre postmarketing study in 9657 patients. Phytomedicine 2009;16 PubMed
- García M, Fernández E, Navarro JA, et al. Allergic contact dermatitis from Hedera helix L. Contact Dermatitis 1995;33(2):133-4.
- Hausen BM, Brohan J, Konig WA, et al. Allergic and irritant contact dermatitis from falcarinol and didehydrofalcarinol in common ivy (Hedera helix L.). Contact Dermatitis 1987;17(1):1-9.
- Mitchell, J. C. Allergic contact dermatitis from Hedera helix and Brassaia actinophylla (Araliaceae). Contact Dermatitis 1981;7(3):158-159.
- Boyle J, Harman RM. Contact dermatitis to Hedera helix (common ivy). Contact Dermatitis 1985;12(2):111-112. PubMed
- Yesudian PD, Franks A. Contact dermatitis from Hedera helix in a husband and wife. Contact Dermatitis 2002;46(2):125-126.
- Bregnbak D, Menné T, Johansen JD. Airborne contact dermatitis caused by common ivy (Hedera helix L. ssp. helix). Contact Dermatitis. 2015;72(4):243-4.
- Jones JM, White IR, White JM, McFadden JP. Allergic contact dermatitis to English ivy (Hedera helix)--a case series. Contact Dermatitis. 2009 Mar;60(3):179-80.
- Lurquin E, Swinnen I, Goossens A. Allergic contact dermatitis caused by Hedera helix arborescens and not by Hedera helix L. Contact Dermatitis. 2012;66(6):352-3.
- Paulsen E, Christensen LP, Andersen KE. Dermatitis from common ivy (Hedera helix L. subsp. helix) in Europe: past, present, and future. Contact Dermatitis. 2010;62(4):201-9.
- Rehman SU, Kim IS, Choi MS, Kim SH, Zhang Y, Yoo HH. Time-dependent Inhibition of CYP2C8 and CYP2C19 by Hedera helix Extracts, A Traditional Respiratory Herbal Medicine. Molecules. 2017;22(7). PubMed
- Kruttschnitt E, Wegener T, Zahner C, Henzen-Bücking S. Assessment of the Efficacy and Safety of Ivy Leaf (Hedera helix) Cough Syrup Compared with Acetylcysteine in Adults and Children with Acute Bronchitis. Evid Based Complement Alternat Med. 2020 May 4;2
Elderberry 6 references
- Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 2001;12:290-6..
- Elderberry (Sambucus species). The Poison Plant Patch, Novia Scotia Museum, 2007. Available at: http://museum.gov.ns.ca/poison/?section=species&id=117 (Accessed 16 October 2009).
- European elder. Canadian Poisonous Plants Information System. Available at: http://www.cbif.gc.ca/pls/pp/ppack.jump?p_null=all&p_psn=121&p_type=all&p_sci=comm&p_x=px (Accessed 16 October 2009).
- Raus K, Pleschka S, Klein P, Schoop R, Fisher P. Effect of an echinacea-based hot drink versus oseltamivir in Influenza treatment: a randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial. . Curr Ther Res Clin Exp. 2015;20;77:6 PubMed
- Ramachandran A, Antala D, Pudasainee P, Panginikkod S, Gupta H. A Plausible Association Between the Use of Elderberry and Autoimmune Hepatitis. Cureus 2022;14(4):e24250. PubMed
- Agarwal N, Mangla A. Elderberry interaction with pazopanib in a patient with soft-tissue sarcoma: A case report and literature review. Mol Clin Oncol 2024;20(5):36. PubMed
Eucalyptus 23 references
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
- De Vincenzi M, Silano M, De Vincenzi A, et al. Constituents of aromatic plants: eucalyptol. Fitoterapia 2002;73:269-75. PubMed
- Gray AM, Flatt PR. Antihyperglycemic actions of Eucalyptus globulus (Eucalyptus) are associated with pancreatic and extra-pancreatic effects in mice. J Nutr 1998;128:2319-23. PubMed
- Whitman BW, Ghazizadeh H. Eucalyptus oil: therapeutic and toxic aspects of pharmacology in humans and animals. J Paediatr Child Health 1994;30:190-1. PubMed
- Barker SC and Altman PM. An ex vivo, assessor blind, randomised, parallel group, comparative efficacy trial of the ovicidal activity of three pediculicides after a single application--melaleuca oil and lavender oil, eucalyptus oil and lemon tea tree oil,
- Vilaplana, J. and Romaguera, C. Allergic contact dermatitis due to eucalyptol in an anti-inflammatory cream. Contact Dermatitis 2000;43(2):118.
- Juergens, U. R. [Reducing the need for cortisone. Does eucalyptus oil work in asthma? (interview by Brigitte Moreano]. MMW.Fortschr Med 3-29-2001;143(13):14.
- Tascini, C., Ferranti, S., Gemignani, G., Messina, F., and Menichetti, F. Clinical microbiological case: fever and headache in a heavy consumer of eucalyptus extract. Clin Microbiol.Infect. 2002;8(7):437, 445-437, 446. PubMed
- Galdi, E., Perfetti, L., Calcagno, G., Marcotulli, M. C., and Moscato, G. Exacerbation of asthma related to Eucalyptus pollens and to herb infusion containing Eucalyptus. Monaldi Arch.Chest Dis. 2003;59(3):220-221.
- Spoerke, D. G., Vandenberg, S. A., Smolinske, S. C., Kulig, K., and Rumack, B. H. Eucalyptus oil: 14 cases of exposure. Vet Hum.Toxicol 1989;31(2):166-168.
- Jori, A., Bianchetti, A., Prestini, P. E., and Gerattini, S. Effect of eucalyptol (1,8-cineole) on the metabolism of other drugs in rats and in man. Eur.J Pharmacol 1970;9(3):362-366. PubMed
- Tibballs, J. Clinical effects and management of eucalyptus oil ingestion in infants and young children. Med J Aust 8-21-1995;163(4):177-180. PubMed
- Webb, N. J. and Pitt, W. R. Eucalyptus oil poisoning in childhood: 41 cases in south-east Queensland. J Paediatr.Child Health 1993;29(5):368-371. PubMed
- Gyldenløve M, Menné T, Thyssen JP. Eucalyptus contact allergy. Contact Dermatitis. 2014;71(5):303-304. PubMed
- Higgins C, Palmer A, Nixon R. Eucalyptus oil: contact allergy and safety. Contact Dermatitis. 2015;72(5):344-346. PubMed
- de Groot AC, Schmidt E. Eucalyptus oil and tea tree oil. Contact Dermatitis. 2015;73(6):381-386. PubMed
- Greive KA, Barnes TM. The efficacy of Australian essential oils for the treatment of head lice infestation in children: A randomised controlled trial. Australas J Dermatol. 2018;59(2):e99-e105. PubMed
- Paulsen E, Thormann H, Vestergaard L. Eucalyptus species as a cause of airborne allergic contact dermatitis. Contact Dermatitis. 2018;78(4):301-303.
- Mathew T, John SK, Kamath V, et al. Essential oil related seizures (EORS): A multi-center prospective study on essential oils and seizures in adults. Epilepsy Res. 2021;173:106626. PubMed
- Dudipala SC, Mandapuram P, Ch LK. Eucalyptus Oil-Induced Seizures in Children: Case Reports and Review of the Literature. J Neurosci Rural Pract 2021;12(1):112-115. PubMed
- Panda PK, Sharawat IK, Panda P, Dawman L, Kasinathan A. Clinico-laboratory characteristics and outcome of patients with eucalyptus oil-induced/provoked seizures: A case series and systematic review of the published patients. Trop Doct 2021;51(4):518-522. PubMed
- Sai Chandar D, Prashanthi M, Laxman Kumar C, Amith Kumar C. Eucalyptus Oil-Induced Seizures in Children: A Single-Center Prospective Study. Cureus 2021;13(3):e14109. PubMed
Thyme 18 references
- Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. PubMed
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Okazaki K, Kawazoe K, Takaishi Y. Human platelet aggregation inhibitors from thyme (Thymus vulgaris L.). Phytother Res 2002;16:398-9. .
- Spiewak R, Skorska C, Dutkiewicz J. Occupational airborne contact dermatitis caused by thyme dust. Contact Dermatitis 2001;44:235-9. . PubMed
- Ernst E, Marz R, Sieder C. A controlled multi-centre study of herbal versus synthetic secretolytic drugs for acute bronchitis. Phytomedicine 1997;4:287-93. PubMed
- Yamamoto J, Yamada K, Naemura A, et al. Testing various herbs for antithrombotic effect. Nutrition 2005;21(5):580-7. PubMed
- Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
- Mackiewicz, B., Skorska, C., Dutkiewicz, J., Michnar, M., Milanowski, J., Prazmo, Z., Krysinska-Traczyk, E., and Cisak, E. Allergic alveolitis due to herb dust exposure. Ann Agric Environ Med 1999;6(2):167-170.
- Martinez-Gonzalez, M. C., Goday Bujan, J. J., Martinez, Gomez W., and Fonseca, Capdevila E. Concomitant allergic contact dermatitis due to Rosmarinus officinalis (rosemary) and Thymus vulgaris (thyme). Contact Dermatitis 2007;56(1):49-50.
- Jukic, M., Politeo, O., Maksimovic, M., Milos, M., and Milos, M. In vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone. Phytother.Res 2007;21(3):259-261.
- Marzian, O. [Treatment of acute bronchitis in children and adolescents. Non-interventional postmarketing surveillance study confirms the benefit and safety of a syrup made of extracts from thyme and ivy leaves]. MMW.Fortschr.Med 6-28-2007;149(27-28 Suppl
- Cuzzolin, L. and Benoni, G. Attitudes and knowledge toward natural products safety in the pharmacy setting: an Italian study. Phytother.Res 2009;23(7):1018-1023. PubMed
- Berova, N., Stransky, L., and Krasteva, M. Studies on contact dermatitis in stomatological staff. Dermatol.Monatsschr. 1990;176(1):15-18.
- Smeenk, G., Kerckhoffs, H. P., and Schreurs, P. H. Contact allergy to a reaction product in Hirudoid cream: an example of compound allergy. Br.J Dermatol. 1987;116(2):223-231.
- Le Roy, R., Grosshans, E., and Foussereau, J. [Investigation of contact allergies in 100 cases of ulcus cruris (author's transl)]. Derm.Beruf.Umwelt. 1981;29(6):168-170.
- Lorenzi, S., Placucci, F., Vincenzi, C., Bardazzi, F., and Tosti, A. Allergic contact dermatitis due to thymol. Contact Dermatitis 1995;33(6):439-440. PubMed
- Bahadoran P, Rokni FK, Fahami F. Investigating the therapeutic effect of vaginal cream containing garlic and thyme compared to clotrimazole cream for the treatment of mycotic vaginitis. Iran J Nurs Midwifery Res 2010;15(Suppl 1):343-9.
- Erol S, Aydin B, Dilli D, Okumus N, Zenciroglu A, Gündüz M. An interesting newborn case of fructose 1-6 diphosphatase deficiency triggered after thyme juice ingestion. Clin Lab. 2014;60(1):151-3. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC