Cran-Max Cranberry Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Cran-Max Cranberry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cran-Max Cranberry is a dietary supplement by Anabolic Laboratories with 1 active ingredient. Its ingredients are commonly taken for urinary tract infection prevention, bladder health, antioxidant support.Based on those ingredients, 712 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cranberry fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Cran-Max Cranberry by Anabolic Laboratories
Ask about any prescription or over-the-counter medication and we check it for interactions with Cran-Max Cranberry by Anabolic Laboratories — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Cran-Max Cranberry by Anabolic Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Cran-Max Cranberry contains one active ingredient: cranberry fruit extract, used traditionally to support urinary tract health. The capsule also holds inactive ingredients—sunflower lecithin, cranberry fiber, cranberry seed oil, and guar gum—that serve as fillers and binders.
Does it work?
Moderate evidence
The evidence supports cranberry for urinary tract infections (UTIs), where it's rated possibly effective—meaning there's reasonable support but it's not a sure thing. For other uses—age-related cognitive decline, enlarged prostate (benign prostatic hyperplasia), cancer prevention, fatty liver disease, and chronic fatigue—the evidence we have isn't enough to rate whether it works.
If you're considering cranberry for a UTI, talk it over with your doctor about whether it makes sense for you.
How safe is it?
Well-documented data
Cranberry is generally well tolerated when taken by mouth, and normal food amounts are likely fine. The most common side effects are diarrhea and stomach discomfort.
In clinical trials, some people reported nausea, vomiting, and abdominal upset, especially at higher doses or with sustained use over weeks. Very large doses—several liters of juice daily—can cause significant gastrointestinal upset, particularly in young children.
Cranberry in normal food amounts is likely safe, but concentrated supplement doses haven't been studied as thoroughly. The data on pregnancy and lactation shows cranberry is likely safe, but because concentrated supplements are less well studied than food amounts, it's worth checking with your doctor or pharmacist before taking a supplement while pregnant or breastfeeding.
Meds to double-check
Moderate interaction found
Before taking Cran-Max Cranberry, double-check with your doctor or pharmacist if you take blood thinners like warfarin (Moderately interact), cholesterol drugs like atorvastatin (Moderately interact), blood pressure medications like nifedipine (Moderately interact), or pain relievers like diclofenac (Minor interaction). These are the main medication types where interactions are documented.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Cran-Max Cranberry may help with UTI prevention, though it's not a guarantee—and it's not a substitute for medical treatment if an infection develops. The main caution is with blood thinners and certain heart and cholesterol medications, which may interact moderately with cranberry.
Most people tolerate it well, but stomach upset can happen, especially at higher doses. Check with your own doctor or pharmacist before starting, particularly if you take any prescription medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2016.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cran-Max Cranberry, straight from the product label.
| Brand | Anabolic Laboratories |
|---|---|
| Barcode (UPC) | 351953981251 |
| Net contents | 30 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 23, 2016 |
| DSLD ID | 67326 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cran-Max Cranberry by Anabolic Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Cranberry fruit extract | 500 mg | -- |
Other ingredients: Capsule, Sunflower Lecithin, Cranberry Fiber, Cranberry seed Oil, Guar Gum
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Native to North America, the cranberry has a long history of medicinal use. Recently, it has been demonstrated to promote urinary tract health and provide antioxidant support.
Through a proprietary process, the natural beneficial constituents of the whole cranberry are intensified and enhanced, making a single capsule more beneficial than 10 oz. of cranberry juice.
We guarantee our supplements for potency and purity
Professional Formula
Promotes urinary tract health
Formula
Our Cran-Max Cranberry is produced from pure cranberry fiber, infused with cranberry extract.
Brand IP Statement(s)
The Advanced Herbal Delivery System process used in manufacturing combines the marc (insoluble herb material remaining after extraction) with the extract. All beneficial components found in nature are preserved full spectrum to deliver superior bioavailability in our Cran-Max Cranberry supplement.
Advanced Herbal Delivery System
Cran-Max Cranberry Extract
CRAN-MAX and CRAN-MAX logotypes are used under license with permission of their proprietor.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Suggested/Recommended/Usage/Directions
One capsule a day
Directions: Take one capsule daily between meals.
FDA Statement of Identity
Dietary Supplement
Precautions
Keep out of reach of children.
General
981-30P 0915
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cran-Max Cranberry by Anabolic Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cran-Max Cranberry by Anabolic Laboratories
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Cranberry fruit extract
Interacts with712 drugs
Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...
Cranberry fruit extract monograph & interactionsOther (inactive) ingredients: Capsule, Sunflower Lecithin, Cranberry Fiber, Cranberry seed Oil, Guar Gum. These complete the product’s ingredient list but are not active constituents.
Cran-Max Cranberry by Anabolic Laboratories Drug Interactions
HelloPharmacist Interaction Report
Cran-Max Cranberry from Anabolic Laboratories contains a single active ingredient—cranberry fruit extract—which interacts with several medication types.
The most serious concern is with blood thinners (anticoagulants) like warfarin: cranberry may increase warfarin levels and its bleeding risk, though the evidence is mixed and case reports conflict. You'll want to check with your doctor or pharmacist before combining them.
Read the full breakdown — every affected drug type, severity by severity
Moderate interactions also affect cholesterol-lowering statins (particularly atorvastatin), blood pressure drugs like nifedipine, and a broader group of medications broken down by the liver enzyme CYP3A4. A case report describes one patient on atorvastatin who developed muscle pain, kidney damage, and liver problems after taking high-dose cranberry juice for two weeks; levels normalized once it stopped.
Animal studies suggest nifedipine levels may rise significantly with cranberry.
Minor interactions apply to pain relievers like diclofenac and medications processed by another liver enzyme, CYP2C9, though human evidence here is inconsistent. Altogether, these interactions span 713 individual medications.
If you take any prescription drugs, use the medication checker below to verify your exact medications before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Cran-Max Cranberry?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Cran-Max Cranberry interact with 712 drugs. Click any drug to see the details.
1 of the 1 ingredient in Cran-Max Cranberry interact with drugs. Each result below shows which ingredient is responsible. Cranberry fruit extract
ApremilastOtezla
How Apremilast interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Apremilast interactionAprepitantCinvanti, Emend
How Aprepitant interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Aprepitant interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Aripiprazole Lauroxil interactionArmodafinilNuvigil
How Armodafinil interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Armodafinil interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Aspirin, Hydrocodone interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Extract + Aspirin, Omeprazole interactionAtazanavirReyataz
How Atazanavir interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Atazanavir interactionAtazanavir, CobicistatEvotaz
How Atazanavir, Cobicistat interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Atazanavir, Cobicistat interactionAtogepantQulipta
How Atogepant interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Atogepant interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractAtorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
Read the full Cranberry Fruit Extract + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractAtorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
Read the full Cranberry Fruit Extract + Atorvastatin Calcium interactionAtropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, ScopolamineAtrohist Plus, Pro Tuss, Ru-tuss, Stahist
How Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interactionAvacopanTavneos
How Avacopan interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Avacopan interactionAvanafilStendra
How Avanafil interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Avanafil interactionAvapritinibAyvakit
How Avapritinib interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Avapritinib interactionAxitinibInlyta
How Axitinib interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Axitinib interactionAzelastine Hydrochloride, Fluticasone PropionateDymista
How Azelastine Hydrochloride, Fluticasone Propionate interacts with Cran-Max Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Fruit Extract + Azelastine Hydrochloride, Fluticasone Propionate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Cran-Max Cranberry with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Cranberry fruit extract
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Brand information
Manufacturer and brand details for Cran-Max Cranberry, from the product label.
Anabolic Laboratories
See all Anabolic Laboratories products- Name
- Anabolic Laboratories, LLC
- Street Address
- 1835 E Cheyenne Rd
- City
- Colorado Springs
- State
- CO
- ZipCode
- 80905
- Web Address
- www.anaboliclabs.com
Cran-Max Cranberry by Anabolic Laboratories: Common Questions
Does Cran-Max Cranberry by Anabolic Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will cranberry actually prevent UTIs?
What are the most common side effects?
Is it safe to take while pregnant?
Can I take this if I'm on a statin or blood thinner?
Does cranberry help with anything other than UTIs?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Cran-Max Cranberry is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cran-Max Cranberry’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Cran-Max Cranberry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cranberry 33 references
- Anon. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance 2003;29:8. PubMed
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
- Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.. PubMed
- Grant P. Warfarin and cranberry juice: An interaction? J Heart Valve Dis 2004;13:25-6.
- Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ 2003;327:1454. PubMed
- Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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