Cranberry 500 mg Ingredients & Drug Interactions
by PureFormulas
What is this page for?
First and foremost: checking Cranberry 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cranberry 500 mg is a dietary supplement by PureFormulas with 1 active ingredient. Its ingredients are commonly taken for urinary tract infection prevention, bladder health, antioxidant support.Based on those ingredients, 712 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cranberry concentrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Cranberry 500 mg by PureFormulas
Ask about any prescription or over-the-counter medication and we check it for interactions with Cranberry 500 mg by PureFormulas — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Cranberry 500 mg by PureFormulas
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: cranberry concentrate at 500 mg per capsule. Cranberry is used traditionally for urinary tract health.
The capsule also contains inactive ingredients — rice flour, gelatin, and magnesium stearate — which are fillers and binders.
Does it work?
Moderate evidence
Cranberry is possibly effective for urinary tract infections (UTIs) based on the evidence we hold. For other uses listed — age-related cognitive decline, benign prostate enlargement, cancer prevention, fatty liver disease, and chronic fatigue — the evidence isn't established enough to rate it either way.
If you're taking this for UTI prevention or treatment, talk to your doctor or pharmacist about whether it fits your situation.
How safe is it?
Well-documented data
Cranberry is generally well tolerated when taken by mouth. The most common side effects are diarrhea and gastrointestinal discomfort.
In very large doses — several liters of juice daily — or even at moderate doses over weeks, some people report nausea, vomiting, abdominal upset, and diarrhea; one person developed skin redness and itching. Cranberry in normal food amounts is considered likely safe in pregnancy and lactation.
However, concentrated supplement doses have not been well studied, so check with your doctor or pharmacist before taking this product if you're pregnant, nursing, or planning to be. This product is not a substitute for medical treatment of infections.
Meds to double-check
Moderate interaction found
Before taking this product, check with your pharmacist if you take cholesterol-lowering statins (like atorvastatin), blood thinners (like warfarin), heart rhythm or blood pressure medications (like nifedipine), or nonsteroidal anti-inflammatory drugs (NSAIDs like diclofenac). Cranberry may raise levels of these drugs and increase side effects.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Cranberry 500 mg might help with urinary tract infections, though evidence is modest. The real concern is drug interactions — especially with cholesterol drugs, blood thinners, and heart medications.
If you take any prescription medication, check it against the interaction tool on this page before you start. Talk to your pharmacist if you're on a statin or warfarin.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cranberry 500 mg, straight from the product label.
| Brand | PureFormulas |
|---|---|
| Barcode (UPC) | PUF1094 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2019 |
| DSLD ID | 205532 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cranberry 500 mg by PureFormulas, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Cranberry concentrate | 500 mg | -- |
Other ingredients: Rice Flour, Gelatin, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested usage: As a dietary supplement, take 1 capsule daily, or as directed by your health care professional.
Formulation
This product contains no yeast, wheat, gluten, soy protein, corn, milk/dairy, artificial coloring, preservatives or flavoring.
Non-GMO
Precautions
This formula is produced in a facility that produces products that contain soy, dairy, peanuts, fish and crustacean shellfish.
Keep out of reach of children.
Storage
Store in a cool, dry place. Do not expose to heat, light or humidity. Close container tightly after each use.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
General Statements
Live life pure.
Supports kidney and urinary tract health
Seals/Symbols
Non-GMO
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cranberry 500 mg by PureFormulas label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cranberry 500 mg by PureFormulas
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Cranberry concentrate
Interacts with712 drugs
Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...
Cranberry concentrate monograph & interactionsOther (inactive) ingredients: Rice Flour, Gelatin, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Cranberry 500 mg by PureFormulas Drug Interactions
HelloPharmacist Interaction Report
PureFormulas Cranberry 500 mg contains cranberry concentrate, which interacts with several medication types.
The most serious concern is with cholesterol-lowering statins like atorvastatin (Lipitor) — a documented case links cranberry juice to muscle breakdown (rhabdomyolysis), back pain, and liver problems in a patient taking atorvastatin. Cranberry appears to slow how your body clears these drugs, raising their levels.
Read the full breakdown — every affected drug type, severity by severity
The product also carries Moderate interactions with blood thinners like warfarin (Coumadin) — case reports suggest cranberry may increase bleeding risk — and with calcium channel blockers like nifedipine (Procardia) for heart rhythm or blood pressure, where animal studies show cranberry can roughly double the drug's levels in your bloodstream. There is also a Moderate interaction documented specifically with atorvastatin itself.
Cranberry carries a Minor interaction with nonsteroidal anti-inflammatory drugs (NSAIDs) like diclofenac (Voltaren), though human studies suggest this effect may be weak in practice. Altogether, these interactions span 702 individual medications.
Check your exact medications with the search tool below before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Cranberry 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Cranberry 500 mg interact with 712 drugs. Click any drug to see the details.
1 of the 1 ingredient in Cranberry 500 mg interact with drugs. Each result below shows which ingredient is responsible. Cranberry concentrate
ApremilastOtezla
How Apremilast interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Apremilast interactionAprepitantCinvanti, Emend
How Aprepitant interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aprepitant interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aripiprazole Lauroxil interactionArmodafinilNuvigil
How Armodafinil interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Armodafinil interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Hydrocodone interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Concentrate + Aspirin, Omeprazole interactionAtazanavirReyataz
How Atazanavir interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Atazanavir interactionAtazanavir, CobicistatEvotaz
How Atazanavir, Cobicistat interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Atazanavir, Cobicistat interactionAtogepantQulipta
How Atogepant interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Atogepant interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateAtorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
Read the full Cranberry Concentrate + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateAtorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
Read the full Cranberry Concentrate + Atorvastatin Calcium interactionAtropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, ScopolamineAtrohist Plus, Pro Tuss, Ru-tuss, Stahist
How Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interactionAvacopanTavneos
How Avacopan interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Avacopan interactionAvanafilStendra
How Avanafil interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Avanafil interactionAvapritinibAyvakit
How Avapritinib interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Avapritinib interactionAxitinibInlyta
How Axitinib interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Axitinib interactionAzelastine Hydrochloride, Fluticasone PropionateDymista
How Azelastine Hydrochloride, Fluticasone Propionate interacts with Cranberry 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Azelastine Hydrochloride, Fluticasone Propionate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Cranberry 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Cranberry concentrate
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Brand information
Manufacturer and brand details for Cranberry 500 mg, from the product label.
PureFormulas
See all PureFormulas products- Name
- PureFormulas
- Street Address
- 11800 NW 102nd Road, Suite 2
- City
- Miami
- State
- FL
- ZipCode
- 33178
- Web Address
- www.pureformulas.com
Cranberry 500 mg by PureFormulas: Common Questions
Does Cranberry 500 mg by PureFormulas interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does cranberry actually prevent or treat urinary tract infections?
What are the side effects?
Is it safe in pregnancy or while breastfeeding?
Can I take this with my statin?
Does cranberry work for anything besides UTIs?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Cranberry 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cranberry 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Cranberry 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cranberry 33 references
- Anon. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance 2003;29:8. PubMed
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
- Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.. PubMed
- Grant P. Warfarin and cranberry juice: An interaction? J Heart Valve Dis 2004;13:25-6.
- Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ 2003;327:1454. PubMed
- Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. PubMed
- Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam - probes of CYP2C9, CYP1A2 and CYP3A4. Clin Pharmacol The 2007:81:833-9. PubMed
- Wing DA, Rumney PJ, Preslicka CW, Chung JH. Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study. J Urol 2008;180:1367-72. PubMed
- Mohammed Abdul MI, Jiang X, Williams KM, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 2008;154:1691-700. PubMed
- McMurdo MET, Argo I, Phillips G, et al. Cranberry or trimethoprim for the prevention of recurrently urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother 2009;63:389-95.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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