Cranberry NS Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Cranberry NS against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cranberry NS is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for urinary tract infection prevention, bladder health, antioxidant support.Based on those ingredients, 712 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cranberry (Vaccinium macrocarpon) concentrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Cranberry NS by Pure Encapsulations
Ask about any prescription or over-the-counter medication and we check it for interactions with Cranberry NS by Pure Encapsulations — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Cranberry NS by Pure Encapsulations
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Cranberry NS contains one active ingredient: cranberry (Vaccinium macrocarpon) concentrate. This is a concentrated extract of the fruit, designed to deliver cranberry's active compounds — particularly proanthocyanidins and other polyphenols — in capsule form.
The inactive ingredients are cranberry fiber, cranberry seed oil, guar gum, sunflower lecithin, and a vegetarian capsule.
Does it work?
Moderate evidence
Cranberry concentrate is possibly effective for urinary tract infections (UTIs) — that's the best-supported use we have. For other conditions listed here — age-related cognitive decline, benign prostatic hyperplasia (enlarged prostate), cancer, nonalcoholic fatty liver disease, and chronic fatigue syndrome — the evidence isn't established in our data, so we can't say whether it works.
How safe is it?
Well-documented data
Pregnancy and lactation: Cranberry in food amounts is likely safe during pregnancy and breastfeeding. However, concentrated supplement doses have not been well studied at these times, so talk with your provider first.
Like all high-dose supplements, it's wise to check before taking it while pregnant or nursing.
Meds to double-check
Moderate interaction found
Before taking this product, check with your pharmacist if you take warfarin or other blood thinners (Moderate risk of increased bleeding), cholesterol-lowering statins like atorvastatin (Moderate risk of higher statin levels and muscle breakdown), blood pressure medications like nifedipine (Moderate risk of lower blood pressure), or other drugs metabolized through the liver's CYP3A4 pathway. Also mention pain relievers and other CYP2C9 substrates, though the evidence there is weaker.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Cranberry NS is most useful if you're dealing with recurrent UTIs. If you take warfarin, a statin, a blood pressure medication, or other prescriptions that affect how your liver works, you'll want to double-check this product with your pharmacist before starting.
It's generally tolerable, but concentrated doses are less well studied than the food form, so a quick conversation with your doctor or pharmacist is smart.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cranberry NS, straight from the product label.
| Brand | Pure Encapsulations |
|---|---|
| Barcode (UPC) | 766298000862 |
| Net contents | 180 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2021 |
| DSLD ID | 246023 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cranberry NS by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Cranberry (Vaccinium macrocarpon) concentrate | 500 mg | -- |
Other ingredients: Cranberry Fiber, Vegetarian Capsule, Cranberry seed Oil, Guar Gum, Sunflower Lecithin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage
Store in a cool, dry place.
Suggested/Recommended/Usage/Directions
Recommendations: As a dietary supplement, take 1 capsule, 1-3 times daily, between meals.
Precautions
Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.
Keep out of the reach of children.
Use only if safety seal is intact.
General Statements
Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.
Scan to learn about our hypoallergenic supplements
Formulation
Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org
Gluten-free, Non-GMO & Hypoallergenic
Gluten-free, Non-GMO & Hypoallergenic
This unique cranberry product provides the benefits of cranberry juice cocktail without any sugars.
Formula
From whole cranberry fruit; supports urinary tract health
This unique cranberry product provides the benefits of cranberry juice cocktail without any sugars. Each capsule contains approximately 3 calories.
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
GF (Gluten Free)
Brand IP Statement(s)
Cran-Max Cranberry Concentrate The cranberry concentrate in Cranberry NS is Cran-Max. CranMax is a registered trademark of Pharmachem Laboratories, LLC.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cranberry NS by Pure Encapsulations label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cranberry NS by Pure Encapsulations
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.
Cranberry (Vaccinium macrocarpon) concentrate
Interacts with712 drugs
Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...
Cranberry (Vaccinium macrocarpon) concentrate monograph & interactionsOther (inactive) ingredients: Cranberry Fiber, Vegetarian Capsule, Cranberry seed Oil, Guar Gum, Sunflower Lecithin. These complete the product’s ingredient list but are not active constituents.
Cranberry NS by Pure Encapsulations Drug Interactions
HelloPharmacist Interaction Report
Cranberry NS by Pure Encapsulations contains one active ingredient — cranberry concentrate — which does interact with several medications.
The most serious concern is with blood thinners like warfarin (Coumadin); cranberry may increase warfarin levels and blood-thinning effects, though the evidence is mixed. Case reports have linked cranberry juice to higher INR (a measure of blood thinning) in patients on warfarin, but some studies show conflicting results.
Read the full breakdown — every affected drug type, severity by severity
Cranberry also interacts moderately with cholesterol-lowering statins like atorvastatin (Lipitor) and calcium channel blockers like nifedipine (Procardia), both used for heart disease and high blood pressure. The mechanism is the same: cranberry may slow how your liver breaks down these drugs, raising their levels in your blood.
One case report documented muscle breakdown and liver problems in a patient taking atorvastatin with high-dose cranberry juice. Theoretically, cranberry affects other drugs metabolized by the same liver pathway (CYP3A4 substrates).
Cranberry may also modestly affect certain pain relievers and other drugs processed through a different liver pathway (CYP2C9 substrates), though human evidence is limited. Altogether, these interactions span 702 individual medications.
If you take any blood thinner, statin, blood pressure medication, or other prescription drugs, check them against the tool on this page before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Cranberry NS?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Cranberry NS interact with 712 drugs. Click any drug to see the details.
1 of the 1 ingredient in Cranberry NS interact with drugs. Each result below shows which ingredient is responsible. Cranberry (Vaccinium macrocarpon) concentrate
Buproprion, DextromethorphanAuvelity
How Buproprion, Dextromethorphan interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Buproprion, Dextromethorphan interactionBuspironeBuSpar
How Buspirone interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Buspirone interactionBusulfanBusulfex, Myleran
How Busulfan interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Busulfan interactionCabazitaxelCabazitaxel, Jetvana
How Cabazitaxel interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Cabazitaxel interactionCabotegravir, RilpivirineCabenuva
How Cabotegravir, Rilpivirine interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Cabotegravir, Rilpivirine interactionCabozantinibCometriq
How Cabozantinib interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Cabozantinib interactionCabozantinib S-malateCabometyx
How Cabozantinib S-malate interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Cabozantinib S-malate interactionCaffeine (otc Drug)Molie, Overtime, Vivarin
How Caffeine (otc Drug) interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Caffeine (otc Drug) interactionCaffeine (prescription Drug)Caffeine, Dextrophin
How Caffeine (prescription Drug) interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Caffeine (prescription Drug) interactionCaffeine , Sodium BenzoateCaffeine and Sodium Benzoate
How Caffeine , Sodium Benzoate interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Caffeine , Sodium Benzoate interactionCaffeine, Diphenhydramine, Ergotamine (prescription Drug)Ergodryl
How Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interactionCaffeine, Ergotamine (prescription Drug)Migergot
How Caffeine, Ergotamine (prescription Drug) interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Caffeine, Ergotamine (prescription Drug) interactionCaffeine, Ergotamine Tartrate (prescription Drug)Cafergot, Wigraine
How Caffeine, Ergotamine Tartrate (prescription Drug) interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Caffeine, Ergotamine Tartrate (prescription Drug) interactionCaffeine, Potassium Salicylate, SalicylamideTrim-Elim
How Caffeine, Potassium Salicylate, Salicylamide interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Caffeine, Potassium Salicylate, Salicylamide interactionCalcifediolRayaldee
How Calcifediol interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Calcifediol interactionCannabidiol (prescription Drug)Epidiolex
How Cannabidiol (prescription Drug) interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Cannabidiol (prescription Drug) interactionCapivasertibTruqap
How Capivasertib interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Capivasertib interactionCapmatinib HydrochlorideTabrecta
How Capmatinib Hydrochloride interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Capmatinib Hydrochloride interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Carbamazepine interactionCarbetapentane Tannate, Chlorpheniramine TannateTussi-12
How Carbetapentane Tannate, Chlorpheniramine Tannate interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Carbetapentane Tannate, Chlorpheniramine Tannate interactionCarbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine TannateQuadratuss, Ry Tuss, Rynatuss, Tri Tannate Plus
How Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interactionCarbetapentane, Chlorpheniramine, PhenylephrineRicotuss
How Carbetapentane, Chlorpheniramine, Phenylephrine interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Carbetapentane, Chlorpheniramine, Phenylephrine interactionCarbetapentane, Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Potassium GuaiacolsulfonateCophene-X
How Carbetapentane, Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Potassium Guaiacolsulfonate interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Carbetapentane, Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Potassium Guaiacolsulfonate interactionCariprazine HydrochlorideVraylar
How Cariprazine Hydrochloride interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Cariprazine Hydrochloride interactionCelecoxib, TramadolSeglentis
How Celecoxib, Tramadol interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Celecoxib, Tramadol interactionCevimelineEvoxac
How Cevimeline interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Cevimeline interactionChlorpheniramineChlor-Trimeton, Teldrin
How Chlorpheniramine interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Chlorpheniramine interactionChlorpheniramine Maleate, Dextromethorphan HydrobromideCoricidin HBP Cough & Cold, Coricidin II Cough & Cold, Pediatric Vicks Formula 44m Cough & Cold Relief
How Chlorpheniramine Maleate, Dextromethorphan Hydrobromide interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide interactionChlorpheniramine Maleate, Hydrocodone BitartrateVituz
How Chlorpheniramine Maleate, Hydrocodone Bitartrate interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Chlorpheniramine Maleate, Hydrocodone Bitartrate interactionChlorpheniramine Polistirex, Codeine PolistirexTuzistra XR
How Chlorpheniramine Polistirex, Codeine Polistirex interacts with Cranberry NS — through 1 ingredient. Tap an ingredient for the detail:
Cranberry (vaccinium Macrocarpon) ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry (vaccinium Macrocarpon) Concentrate + Chlorpheniramine Polistirex, Codeine Polistirex interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Cranberry NS with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Cranberry (Vaccinium macrocarpon) concentrate
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Brand information
Manufacturer and brand details for Cranberry NS, from the product label.
Pure Encapsulations
See all Pure Encapsulations products- Name
- Pure Encapsulations
- Street Address
- 490 Boston Post Road
- City
- Sudbury
- State
- MA
- Phone Number
- 1-800-753-2277
- Web Address
- www.PureEncapsulations.com
Cranberry NS by Pure Encapsulations: Common Questions
Does Cranberry NS by Pure Encapsulations interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does cranberry actually prevent or treat UTIs?
What's the difference between cranberry juice and this concentrate?
Can I take this if I'm on warfarin?
What are the side effects?
Is it safe to take while pregnant or breastfeeding?
Does this contain any fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cranberry NS’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Cranberry NS's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cranberry 33 references
- Anon. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance 2003;29:8. PubMed
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
- Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.. PubMed
- Grant P. Warfarin and cranberry juice: An interaction? J Heart Valve Dis 2004;13:25-6.
- Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ 2003;327:1454. PubMed
- Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. PubMed
- Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam - probes of CYP2C9, CYP1A2 and CYP3A4. Clin Pharmacol The 2007:81:833-9. PubMed
- Wing DA, Rumney PJ, Preslicka CW, Chung JH. Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study. J Urol 2008;180:1367-72. PubMed
- Mohammed Abdul MI, Jiang X, Williams KM, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 2008;154:1691-700. PubMed
- McMurdo MET, Argo I, Phillips G, et al. Cranberry or trimethoprim for the prevention of recurrently urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother 2009;63:389-95.
- Mergenhagen KA, Sherman O. Elevated International Normalized Ratio after concurrent ingestion of cranberry sauce and warfarin. Am J Health-Syst Pharm 2008;65:2113-6. PubMed
- Ansell J, McDonough M, Zhao Y, et al. The absence of an interaction between warfarin and cranberry juice: a randomized, double-blind trial. J Clin Pharmacol 2009;49:824-30. PubMed
- Haber SL, Cauthon KA, Raney EC. Cranberry and warfarin interaction: a case report and review of the literature. Consult Pharm 2012;27:58-65. PubMed
- Hamann GL, Campbell JD, George CM. Warfarin-cranberry juice interaction. Ann Pharmacother 2011;45:e17. PubMed
- Roberts D, Flanagan P. Case report: Cranberry juice and warfarin. Home Healthc Nurse 2011;29:92-7.
- Garcia-Calatayud, S., Larreina Cordoba, J. J., and Lozano De La Torre MJ. [Severe cranberry juice poisoning]. An.Esp.Pediatr. 2002;56(1):72-73.
- Patel, D. A., Gillespie, B., Sobel, J. D., Leaman, D., Nyirjesy, P., Weitz, M. V., and Foxman, B. Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study. Am J Obstet.Gy PubMed
- Isele, H. [Fatal bleeding under warfarin plus cranberry juice. Is it due to salicylic acid?]. MMW.Fortschr.Med 3-11-2004;146(11):13.
- Linsenmeyer, T. A., Harrison, B., Oakley, A., Kirshblum, S., Stock, J. A., and Millis, S. R. Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury. A prospecti
- McMurdo, M. E., Bissett, L. Y., Price, R. J., Phillips, G., and Crombie, I. K. Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial. Age Ageing 2005;34(3):256- PubMed
- Sylvan, L. and Justice, N. P. Possible interaction between warfarin and cranberry juice. Am Fam.Physician 9-15-2005;72(6):1000.
- Niklasson, A. and Andren, L. [Interaction between Waran and cranberry juice]. Lakartidningen 3-15-2006;103(11):853-854.
- Rindone, J. P. and Murphy, T. W. Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding. Am J Ther 2006;13(3):283-284. PubMed
- Uesawa, Y. and Mohri, K. Effects of cranberry juice on nifedipine pharmacokinetics in rats. J Pharm Pharmacol 2006;58(8):1067-1072. PubMed
- Valentova, K., Stejskal, D., Bednar, P., Vostalova, J., Cihalik, C., Vecerova, R., Koukalova, D., Kolar, M., Reichenbach, R., Sknouril, L., Ulrichova, J., and Simanek, V. Biosafety, antioxidant status, and metabolites in urine after consumption of dried
- Royer, D. J., George, J. N., and Terrell, D. R. Thrombocytopenia as an adverse effect of complementary and alternative medicines, herbal remedies, nutritional supplements, foods, and beverages. Eur J Haematol 2010;84(5):421-429. PubMed
- Stapleton, A. E., Dziura, J., Hooton, T. M., Cox, M. E., Yarova-Yarovaya, Y., Chen, S., and Gupta, K. Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial. Mayo.Clin.Proc. PubMed
- Doad GJ, Kabange W. Cranberry juice, atorvastatin and back pain. J Med Assoc Ga 2014;103(1):14.
- Griffiths AP, Beddall A, Pegler S. Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin. J R Soc Promot Health 2008;128(6):324-6. PubMed
- Mellen CK, Ford M, Rindone JP. Effect of high-dose cranberry juice on the pharmacodynamics of warfarin in patients. Br J Clin Pharmacol 2010;70(1):139-42. PubMed
- Ushijima K, Tsuruoka S, Tsuda H, Hasegawa G, Obi Y, Kaneda T, Takahashi M, Maekawa T, Sasaki T, Koshimizu TA, Fujimura A. Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects. Br J Clin Pharmaco PubMed
- Ngo N, Brantley SJ, Carrizosa DR, et al. The warfarin-cranberry juice interaction revisited: A systematic in vitro-in vivo evaluation. J Exp Pharmacol. 2010;2010(2):83-91.
- Williams G, Stothart CI, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 2023;11(11):CD001321. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC