Interactions on record — worth a quick check against your medications. Based on 3 of 7 ingredients. Check your meds →
Dietary supplement

Creakic Hardcore Ingredients & Drug Interactions

by MuscleTech

Creakic Hardcore label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Creakic Hardcore against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Creakic Hardcore is a dietary supplement by MuscleTech with 7 active ingredients. Its ingredients are commonly taken for improving high-intensity exercise performance, building muscle strength and size, sports and athletic training.Based on those ingredients, 263 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 6-8-Thioctic Acid, L-Carnosine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Creakic Hardcore by MuscleTech

Ask about any prescription or over-the-counter medication and we check it for interactions with Creakic Hardcore by MuscleTech — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Creakic Hardcore by MuscleTech

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “CREAKIC Hardcore Proprietary Blend” is a proprietary blend — the label gives one combined amount (6,208 mg) without saying how much of each component you get.

Creakic Hardcore contains seven active ingredients. Two forms of creatine — creatine monohydrate and creatine pyruvate — are the backbone of the product, designed to support muscle strength and athletic performance.

L-carnosine is included for its potential effects on muscle and cognition. You'll also find alpha-lipoic acid (labeled here as 6-8-Thioctic Acid), which may support blood sugar control and fat metabolism.

Three other actives are in the blend — Alpha-Ketoglutarate, Ketoisocaproic Acid Calcium, and N (Omega)-Phosphocreatine — all aimed at muscle and energy support. The product also contains standard inactive ingredients like microcrystalline cellulose, povidone, and magnesium stearate as binders and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Diabetic neuropathy — rated "Possibly Effective" (Alpha-lipoic Acid) (Natural Medicines).
  • On file: Hyperlipidemia — rated "Possibly Effective" (Alpha-lipoic Acid) (Natural Medicines).
  • On file: Obesity — rated "Possibly Effective" (Alpha-lipoic Acid) (Natural Medicines).
  • On file: Athletic performance — rated "Possibly Effective" (Creatine) (Natural Medicines).
  • On file: Muscle strength — rated "Possibly Effective" (Creatine) (Natural Medicines).

The creatine in this product (both forms) is possibly effective for muscle strength, athletic performance, sarcopenia (age-related muscle loss), and cerebral creatine deficiency syndromes. Evidence doesn't support its use for Huntington disease or low bone density (osteopenia).

For L-carnosine, the evidence we hold is incomplete — we don't yet have enough reliable data on its use for athletic performance, cognitive decline, or cataracts. Alpha-lipoic acid shows possibly effective evidence for diabetic nerve pain (neuropathy), high cholesterol, and weight management.

The other three ingredients don't have effectiveness ratings on file.

The evidence, ingredient by ingredient Creatine Carnosine Alpha-lipoic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Creatine (both forms) is generally well tolerated by healthy adults, but if you have kidney problems, you'll need to be cautious. Common side effects include dehydration, diarrhea, stomach upset, muscle cramps, and water retention.

Rare but serious concerns from case reports include kidney inflammation, kidney failure, muscle breakdown (rhabdomyolysis), and blood clots. L-carnosine is generally well tolerated short-term, though long-term safety data are limited; reported side effects include decreased appetite, dry mouth, foot and joint pain, and rarely pneumonia.

Alpha-lipoic acid is generally well tolerated and commonly causes headache, heartburn, nausea, and vomiting; rare cases of a type of autoimmune low blood sugar (insulin autoimmune syndrome) have been reported. For pregnancy and breastfeeding, the safety data advises against use of creatine, L-carnosine, and alpha-lipoic acid — there isn't enough information to know either way.

Side effects, ingredient by ingredient Creatine Carnosine Alpha-lipoic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Alpha-lipoic Acid, Carnosine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications.
  • For scale: 263 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your pharmacist if you're on blood thinners or antiplatelet drugs like warfarin or aspirin (Moderate risk of increased bleeding), chemotherapy drugs (Moderate risk of reduced effectiveness), thyroid hormone replacement (Moderate risk of reduced effect), or blood sugar medications (Moderate risk of low blood sugar from L-carnosine, Minor risk from alpha-lipoic acid). We could not check interactions for Alpha-Ketoglutarate, Ketoisocaproic Acid Calcium, or N (Omega)-Phosphocreatine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Creakic Hardcore is built for athletes and people aiming to build muscle, with evidence supporting creatine's effect on strength and performance. If you have kidney disease or take blood thinners, thyroid medication, chemotherapy, or blood sugar drugs, talk with your pharmacist or doctor before you start.

Pregnant or nursing? This product isn't recommended.

Check your exact medications against the interactions on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Creakic Hardcore, straight from the product label.

Brand MuscleTech
Barcode (UPC) 631656602265
Net contents 180 Caplet(s)
Market status On market
Date entered into DSLD Mar 23, 2012
DSLD ID 6501
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Women (not pregnant or lactating), Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Creakic Hardcore by MuscleTech, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Caplet(s)
Maximum serving Sizes:
6 Caplet(s)
Servings per container
30
UPC/BARCODE
631656602265
IngredientAmount% DV
Creatine Monohydrate0 NP--
L-Carnosine0 NP--
Alpha-Ketoglutarate0 NP--
Creatine Pyruvate0 NP--
CREAKIC Hardcore Proprietary Blend6208 mg--
6-8-Thioctic Acid0 NP--
Ketoisocaproic Acid Calcium0 NP--
N (Omega)-Phosphocreatine0 NP--

Other ingredients: Microcrystalline Cellulose, Hydroxypropylcellulose, Coating, Povidone, Croscarmellose Sodium, Crospovidone, Stearic Acid, Magnesium Stearate, Silica, Natural flavor, Acesulfame-Potassium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

Discontinue use and consult a medical doctor if you experience unusual symptoms. If you experience a skin rash or any other allergic reaction, discontinue use and consult a medical doctor. Consult a medical doctor before use if you have been treated for or diagnosed with, or have a family history of, any medical condition, or if you are using any prescription or over-the-counter drug(s), including blood thinners. Consult a medical doctor before starting any diet or exercise program. Improper use of this product will not improve results and is not advised. Use only as directed.

Do not use if packaging has been tampered with.

WARNING: Not intended for use by persons under 18.

KEEP OUT OF REACH OF CHILDREN.

Do not use if pregnant or nursing.

CONTAINS SOY INGREDIENTS.

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take 1 serving (6 Caplets) of CREAKIC(R) Hardcore with a glass of water daily. On workout days, take 1 serving immediately after your workout. On non-workout days, take 1 serving in the morning upon awakening. Do not exceed 6 caplets in a 24-hour period. Consume 10 glasses of water daily to help enhance creatine absorption, to maintain an adequate state of hydration and for general good health. Read the entire label before use and follow directions.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place (60(0)F to 80(0)F).

General Statements

• Rapidly and Dramatically Builds Lean Muscle & Strength* •Delivers up to 330% More Creatine per Serving than Other Leading Creatine Pill Formulas*,‡ •Formulated with the Most Scientifically-Validated Form of Creatine in Existence

1 MONTH SUPPLY

Made in the U.S.A. from international and domestic ingredients.

NEW FORMULA

New Formula with 100% MORE Creatine

Protected by U.S. Patent #6,136,339.

Research and development

SCIENTIFICALLY DEVELOPED BASED ON RESEARCH AT: ST. FRANCIS XAVIER UNIVERSITY

TEST SUBJECTS BUILT OVER 4x MORE MUSCLE*,~

General

6385US

Brand IP Statement(s)

(C)2009

??The MuscleTech(R) brand of supplements is America's #1 selling sports supplement brand.

~In a 12-week study, test subjects taking the key ingredient in CREAKIC(R) Hardcore and following a hardcore training program increased muscle fiber protein content by 58 percent. In yet another study, test subjects consuming the key ingredient in CREAKIC Hardcore jacked up their strength capacity by 18.6 percent in just 10 days! Get CREAKIC(R) Hardcore now for real results you'll see and feel, fast!*

EXTREME MUSCLEBUILDING RESULTS MUSCLE GAINED (LBS.) 7 6 5 4 3 2 1 0 OVER 4x MORE MUSCLE KEY INGREDIENT IN CREAKIC HARDCORE PLACEBO ?In a 12-week study on 22 untrained subjects randomly assigned to one of three groups, subjects taking the key ingredient in CREAKIC(R) Hardcore built over 4 times more muscle (7.1 vs 1.3 lbs.) compared to the placebo.*

For best results, stack with LEUKIC(R) Hardcore and GAKIC(R) Hardcore.

MEGA-DOSED WITH MORE CREATINE CREATINE PER SERVING UP TO 330% MORE CREATINE CREAKIC HARDCORE OTHER CREATINE PILL ‡For rapid gains in muscle size and strength, CREAKIC(R) Hardcore is mega-dosed with up to 330 percent more creatine per serving than other leading creatine pills.*

SCIENTIFICALLY ADVANCED MUSCLEBUILDING CREATINE PILL(TM),*

The new CREAKIC(R) Hardcore formula is powered by the most scientifically validated form of creatine on the planet. New CREAKIC(R) Hardcore is also engineered with Micro-Dispersion Technology(TM) for rapid release and is loaded with 100 percent more creatine per serving than the previous formula. It's scientifically formulated to hyper-saturate your muscle cells with its advanced creatine blend, delivering rapid and dramatic gains in muscle size and strength!*

Seals/Symbols

AMERICA'S #1 SELLING SPORTS SUPPLEMENT BRAND??

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Creakic Hardcore by MuscleTech label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Creakic Hardcore label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Creakic Hardcore by MuscleTech

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

CREAKIC Hardcore Proprietary Blend

6208 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropylcellulose, Coating, Povidone, Croscarmellose Sodium, Crospovidone, Stearic Acid, Magnesium Stearate, Silica, Natural flavor, Acesulfame-Potassium. These complete the product’s ingredient list but are not active constituents.

Interaction report

Creakic Hardcore by MuscleTech Drug Interactions

Want to check YOUR meds against Creakic Hardcore?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
263Drugs
263 Moderate

Ingredients driving the most interactions

6-8-Thioctic Acid 263
L-Carnosine 86

Individual Drug Interactions

The ingredients in Creakic Hardcore interact with 263 drugs. Click any drug to see the details.

2 of the 7 ingredients in Creakic Hardcore interact with drugs. Each result below shows which ingredient is responsible. 6-8-Thioctic Acid L-Carnosine

Each ingredient & the kinds of drugs it affects

For each ingredient in Creakic Hardcore with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

6-8-Thioctic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
6-8-Thioctic Acid full monograph & interactions

L-Carnosine1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking carnosine with antidiabetes drugs might increase the risk of hypoglycemia.
Some, but not all, preliminary clinical research shows that carnosine might reduce fasting blood glucose levels.

Likelihood Possible Evidence D
L-Carnosine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Creakic Hardcore, from the product label.

MuscleTech

See all MuscleTech products
Name
Iovate Health Sciences U.S.A. Inc.
Phone Number
1-800-246-3261
Pharmacist Counseling Corner

Creakic Hardcore by MuscleTech: Common Questions

Does Creakic Hardcore by MuscleTech interact with any medications?
Yes. Based on its ingredients, Creakic Hardcore has a known interaction with 263 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Creakic Hardcore contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is creatine safe if I have kidney disease?
No, the safety data advises caution. If you have kidney problems, talk with your doctor or pharmacist before taking any creatine product — that includes both forms in this one. Creatine is generally well tolerated in healthy adults, but your kidneys are involved in processing it.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against it. There isn't enough reliable information to know if creatine, L-carnosine, or alpha-lipoic acid are safe during pregnancy or while nursing. Talk with your doctor for personalized advice.
What side effects might I experience?
Most common are dehydration, diarrhea, stomach upset, muscle cramps, and water retention from the creatine. L-carnosine may cause decreased appetite or dry mouth. Alpha-lipoic acid often causes headache, heartburn, or nausea. Serious side effects are rare but have been reported in case studies.
Does creatine actually improve muscle strength?
Yes, creatine monohydrate and creatine pyruvate are both rated possibly effective for muscle strength and athletic performance in the data we hold. Results vary by individual, and you'll want consistent training alongside supplementation.
What is alpha-lipoic acid supposed to do in this product?
Alpha-lipoic acid is possibly effective for managing blood sugar and cholesterol and supporting weight management. It's an antioxidant that may help with diabetic nerve pain. It's also one of the ingredients with documented interactions, so check your medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Creakic Hardcore is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Creakic Hardcore label
Go deeper

The Full Monographs Behind Creakic Hardcore’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Carnosine

Interacts with 86 drugs

Carnosine is a naturally occurring dipeptide (made of beta-alanine and histidine) that acts as an antioxidant and buffer in muscle and brain. It is sold as an anti-aging and performance supp...

Read the full Carnosine monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph →
Sources

Sources & How We Checked

Creakic Hardcore's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 139 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Creatine 86 references
  1. Koshy KM, Griswold E, Schneeberger EE. Interstitial nephritis in a patient taking creatine. N Engl J Med 1999;340:814-5. PubMed
  2. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  3. Greenhaff P. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;352:233-4. PubMed
  4. Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training (abstract). J Appl Physiol 1997;83:2055-63. PubMed
  5. Hultman E, Soderlund K, Timmons JA, et al. Muscle creatine loading in men. J Appl Physiol 1996;81:232-7. PubMed
  6. Pritchard NR, Kalra PA. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;351:1252-3. PubMed
  7. Poortmans JR, Auquier H, Renaut V, et al. Effect of short-term creatine supplementation on renal responses in men (abstract). Eur J Appl Physiol Occup Physiol 1997;76:566-7. PubMed
  8. Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999;31:1108-10. PubMed
  9. Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc 2000;32:291-6. PubMed
  10. Rawson ES, Wehnert ML, Clarkson PM. Effects of 30 days of creatine ingestion in older men. Eur J Appl Physiol Occup Physiol 1999;80:139-44. PubMed
  11. Earnest CP, Almada AL, Mitchell TL. High-performance capillary electrophoresis-pure creatine monohydrate reduces blood lipids in men and women. Clin Sci (Colch) 1996;91:113-8. PubMed
  12. Juhn MS. Oral creatine supplementation. Separating fact from hype. Phys Sportsmed 1999;27:47-50,53-54,56,61,89. PubMed
  13. Juhn MS, O'Kane JW, Vinci DM. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am Diet Assoc 1999;99:593-5.
  14. Green AL, Hultman E, Macdonald IA, et al. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 1996;271:E821-6. PubMed
  15. Balsom PD, Soderlund K, Sjodin B, Ekblom B. Skeletal muscle metabolism during short duration high-intensity exercise: influence of creatine supplementation. Acta Physiol Scand 1995;154:303-10. PubMed
  16. Snow RJ, McKenna MJ, Selig SE, et al. Effect of creatine supplementation on sprint exercise performance and muscle metabolism. (abstract) J Appl Physiol 1998;84:1667-73. PubMed
  17. McNaughton LR, Dalton B, Tarr J. The effects of creatine supplementation on high-intensity exercise performance in elite performers. (abstract) Eur J Appl Physiol Occup Physiol 1998;78:236-40. PubMed
  18. Groeneveld GJ, Veldink JH, van der Tweel I, et al. A randomized sequential trial of creatine in amyotrophic lateral sclerosis. Ann Neurol 2003;53:437-45. . PubMed
  19. Robinson SJ. Acute quadriceps compartment syndrome and rhabdomyolysis in a weight lifter using high-dose creatine supplementation. J Am Board Fam Pract 2000;13:134-7. PubMed
  20. Kammer RT. Lone atrial fibrillation associated with creatine monohydrate supplementation. Pharmacotherapy 2005;25:762-4. PubMed
  21. Gualano B, Ugrinowitsch C, Novaes RB, et al. Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial. Eur J Appl Physiol 2008;103:33-40. PubMed
  22. Pfeffer, G., Majamaa, K., Turnbull, D. M., Thorburn, D., and Chinnery, P. F. Treatment for mitochondrial disorders. Cochrane Database.Syst.Rev. 2012;4:CD004426. PubMed
  23. Boos, C. J., White, S. H., Bland, S. A., and McAllister, P. D. Dietary supplements and military operations: caution is advised. J R.Army Med Corps 2010;156(1):41-43. PubMed
  24. Kreider, R. B. Dietary supplements and the promotion of muscle growth with resistance exercise. Sports Med 1999;27(2):97-110. PubMed
  25. Juhn, M. S., O'Kane, J. W., and Vinci, D. M. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am.Diet.Assoc 1999;99(5):593-595.
  26. Volek, J. S., Duncan, N. D., Mazzetti, S. A., Putukian, M., Gomez, A. L., and Kraemer, W. J. No effect of heavy resistance training and creatine supplementation on blood lipids. Int J Sport Nutr.Exerc.Metab 2000;10(2):144-156. PubMed
  27. Robinson, T. M., Sewell, D. A., Casey, A., Steenge, G., and Greenhaff, P. L. Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function. Br.J Sports Med 2000;34(4):284-288. PubMed
  28. Tarnopolsky, M. A. Potential benefits of creatine monohydrate supplementation in the elderly. Curr.Opin.Clin Nutr.Metab Care 2000;3(6):497-502. PubMed
  29. Tarnopolsky, M. A. and MacLennan, D. P. Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr.Exerc.Metab 2000;10(4):452-463. PubMed
  30. Arciero, P. J., Hannibal, N. S., III, Nindl, B. C., Gentile, C. L., Hamed, J., and Vukovich, M. D. Comparison of creatine ingestion and resistance training on energy expenditure and limb blood flow. Metabolism 2001;50(12):1429-1434. PubMed
  31. Chrusch, M. J., Chilibeck, P. D., Chad, K. E., Davison, K. S., and Burke, D. G. Creatine supplementation combined with resistance training in older men. Med Sci.Sports Exerc. 2001;33(12):2111-2117. PubMed
  32. Cox, G., Mujika, I., Tumilty, D., and Burke, L. Acute creatine supplementation and performance during a field test simulating match play in elite female soccer players. Int J Sport Nutr.Exerc.Metab 2002;12(1):33-46. PubMed
  33. Kilduff, L. P., Vidakovic, P., Cooney, G., Twycross-Lewis, R., Amuna, P., Parker, M., Paul, L., and Pitsiladis, Y. P. Effects of creatine on isometric bench-press performance in resistance-trained humans. Med Sci.Sports Exerc. 2002;34(7):1176-1183. PubMed
  34. Brose, A., Parise, G., and Tarnopolsky, M. A. Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults. J Gerontol A Biol.Sci.Med Sci. 2003;58(1):11-19. PubMed
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Alpha-lipoic Acid 48 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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