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Dietary supplement

Cubeb Ingredients & Drug Interactions

by Hawaii Pharm

Cubeb label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cubeb against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cubeb is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for coughs and bronchitis, indigestion and gas, urinary tract complaints.Based on those ingredients, 665 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cubeb Fruit Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cubeb by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Cubeb by Hawaii Pharm — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Cubeb by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: cubeb fruit extract (in dry form). Cubebs are the dried berries of a pepper plant, traditionally used in cooking and herbal practice.

The liquid also includes alcohol, water, and glycerin as inactive ingredients to deliver the extract.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Cubebs product and its label doesn't state a use — see Cubebs's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't hold effectiveness ratings for cubeb in our data, so the evidence for what it may do isn't established in our monograph.

The evidence, ingredient by ingredient Cubebs

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cubeb is likely fine in small culinary amounts, but safety at medicinal doses — and especially the essential oil — isn't well studied. The safety data advises against taking medicinal amounts during pregnancy and while breastfeeding, since there isn't enough reliable information to know it's safe in those situations.

If you're pregnant or nursing and thinking about using this product, talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Cubebs

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cubebs.
  • The most serious interaction on file is rated Moderate.
  • For scale: 666 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking cubeb, check with your doctor or pharmacist if you take any drugs broken down by the liver enzyme CYP3A4 (such as lovastatin, clarithromycin, cyclosporine, or diltiazem). Also double-check if you use H2-blockers (cimetidine, ranitidine, nizatidine, famotidine), proton pump inhibitors like omeprazole or esomeprazole, or antacids.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Cubeb is a traditional culinary ingredient, but as a medicinal supplement, its safety and effectiveness aren't well established. If you take medications metabolized by your liver, or medications to control stomach acid, you'll want to check with your doctor or pharmacist before adding this — and definitely skip it if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cubeb, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 840253616876
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 301503
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cubeb by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
840253616876
IngredientAmount% DV
Cubeb Fruit Extract, Dry983 mg--

Other ingredients: Alcohol, Water, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Hawaii Pharm Herbal Extract Highest quality since 2008

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.

Precautions

Warning: We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.

Keep out of the reach of children!

Storage

Store in a cool dry place.

Seals/Symbols

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Organic Alcohol Based USA Made in United States of America

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Scan this QR-code to get 15% discount on your next purchase. Limited time deal.

Formula

Piper cubeba

Organic Alcohol Based

Formulation

Only natural ingredients Purity is laboratory tested and verified

All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives

Not tested on animals

Organic Alcohol Based

Made in USA, Hawaii

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cubeb by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cubeb label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cubeb by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Cubeb Fruit Extract, Dry

Interacts with
665 drugs
983 mg per serving

Cubebs are spicy, peppery berries from a vine in the pepper family that have long been used in traditional medicine for coughs, digestion, and urinary...

Cubeb Fruit Extract, Dry monograph & interactions

Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cubeb by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Cubeb?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
665Drugs
643 Moderate 22 Minor

Ingredients driving the most interactions

Cubeb Fruit Extract, Dry 665

Individual Drug Interactions

The ingredients in Cubeb interact with 665 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cubeb interact with drugs. Each result below shows which ingredient is responsible. Cubeb Fruit Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Cubeb with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cubeb Fruit Extract, Dry4 drug types · 665 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro. So far, this effect has not been reported in humans. Theoretically, cubebs might increase the effects and side effects of drugs metabolized by CYP3A4. These include lovastatin (Mevacor), clarithromycin (Biaxin), cyclosporine (Neoral, Sandimmune), diltiazem (Cardizem), estrogens, indinavir (Crixivan), triazolam (Halcion), and numerous others.

Likelihood Possible Evidence D
Antacids

Theoretically, due to reports that cubebs increases stomach acid, cubebs might decrease the effectiveness of antacids.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, due to reports that cubebs increases stomach acid, cubebs might decrease the effectiveness of H2-blockers. The H2 blockers include cimetidine (Tagamet), ranitidine (Zantac), nizatidine (Axid), and famotidine (Pepcid).

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, due to reports that cubebs increases stomach acid, cubebs might decrease the effectiveness of PPIs. PPIs include omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), pantoprazole (Protonix), and esomeprazole (Nexium).

Likelihood Possible Evidence D
Cubeb Fruit Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cubeb, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
Street Address
510 Sumner St. Ste. 613
City
Honolulu
State
HI
ZipCode
96817
Phone Number
888-854-2924
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Cubeb by Hawaii Pharm: Common Questions

Does Cubeb by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Cubeb has a known interaction with 665 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cubeb contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is cubeb safe to take while I'm pregnant?
The safety data advises against taking medicinal amounts of cubeb during pregnancy because there isn't enough information to know it's safe. Talk with your doctor or pharmacist before taking it if you're pregnant or planning to become pregnant.
Can I use cubeb while breastfeeding?
No reliable safety data exists for medicinal use during breastfeeding, so it's best avoided while nursing. If you're breastfeeding and want to try cubeb, discuss it with your doctor or pharmacist first.
What is cubeb, and what is it used for?
Cubeb is the dried berry of a pepper plant, traditionally used in small amounts as a culinary spice. We don't have established effectiveness ratings for it in our data, so what it's meant to do medicinally isn't confirmed in the evidence we hold.
Does this product contain fillers or other inactive ingredients?
Yes, the liquid includes alcohol, water, and glycerin to carry the cubeb extract — these are the inactive ingredients.
Why might cubeb interact with stomach acid medications?
Cubeb is thought to increase stomach acid, which could make acid-reducing medications like H2-blockers and proton pump inhibitors work less well. That's why you should mention it to your doctor or pharmacist if you take any of those drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cubeb is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cubeb label
Go deeper

The Full Monographs Behind Cubeb’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cubebs

Interacts with 665 drugs

Cubebs are spicy, peppery berries from a vine in the pepper family that have long been used in traditional medicine for coughs, digestion, and urinary problems. Modern human studies are very...

Read the full Cubebs monograph →
Sources

Sources & How We Checked

Cubeb's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cubebs 2 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Usia T, Watabe T, Kadota S, Tezuka Y. Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod 2005;68(1):64-8.

See these in context on the Cubebs monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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