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Dietary supplement

Cubeb Ingredients & Drug Interactions

by Herbal Terra

Cubeb label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cubeb against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cubeb is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for coughs and bronchitis, indigestion and gas, urinary tract complaints.Based on those ingredients, 665 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are wildcrafted Cubeb (Piper cubeba) dried fruit liquid extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Cubeb by Herbal Terra

Ask about any prescription or over-the-counter medication and we check it for interactions with Cubeb by Herbal Terra — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Cubeb by Herbal Terra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: wildcrafted Cubeb (Piper cubeba) dried fruit as a liquid extract. Cubeb is a pepper-like spice traditionally used in herbal medicine.

The liquid extract form allows for easier dosing and absorption compared to whole dried fruit. The product also contains menstruum as an inactive ingredient — this is a liquid medium used to prepare herbal extracts, similar to how alcohol or glycerin might be used in other liquid supplements.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Cubebs product and its label doesn't state a use — see Cubebs's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't hold effectiveness ratings for Cubeb in our data, so we can't tell you what the evidence shows it works for or how strong that evidence is. If you're considering this product for a specific health goal, your doctor or pharmacist can help you weigh what's known in the medical literature.

The evidence, ingredient by ingredient Cubebs

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cubeb is likely fine in the small amounts you'd use as a spice in cooking, but safety data on medicinal doses and the essential oil is limited. The safety information we hold advises against medicinal use during pregnancy due to lack of reliable safety data.

Similarly, there isn't enough safety data to support medicinal use while breastfeeding — talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing and want to use this product. No adverse effects (side effects) are documented in our data, but that doesn't mean they don't occur — it means we don't have that information on file.

Side effects, ingredient by ingredient Cubebs

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cubebs.
  • The most serious interaction on file is rated Moderate.
  • For scale: 666 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Cubeb, check with your pharmacist or doctor if you take any CYP3A4 substrates — medications metabolized by a liver enzyme that cubeb may slow down (Moderate severity concern). Also double-check if you're on acid-reducing medications: H2-blockers, antacids, or proton pump inhibitors, since cubeb may reduce their effectiveness (Minor severity).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Cubeb is a traditional herbal extract with documented interactions mainly affecting how your liver processes certain medications and how well acid-reducing drugs work. If you take a CYP3A4 substrate (cholesterol, heart, or immunosuppressant medications) or acid-reducing medications, check your specific drugs against the list on this page before starting.

Avoid medicinal doses if you're pregnant or breastfeeding. Talk with your doctor or pharmacist about whether cubeb is right for you and your current medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cubeb, straight from the product label.

Brand Herbal Terra
Barcode (UPC) 7429523387369
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 235339
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cubeb by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
7429523387369
IngredientAmount% DV
wildcrafted Cubeb (Piper cubeba) dried fruit liquid extract970 mg--

Other ingredients: Menstruum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Origin of plant material: Indonesia.

Manufactured in the USA in an FDA registered facility

Alcohol free

Dried herb/menstruum ratio: 1:3 Expertly extracted Laboratory tested 330 mg/1 mL Premium product Alcohol-free liquid herbal extract

Non GMO

No artificial ingredients, GMO, gluten, color additives, fillers, preservatives or binders. Natural Gluten Free

Suggested/Recommended/Usage/Directions

Direction Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz of juice or water up to 4 times a day. We recommend to seek expert medical advice before taking this or any other herbal supplements.

FDA Disclaimer Statement

Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Caution May have contraindications.

Do not use if you are allergic to any ingredients.

Consult a physician before using during pregnancy, if nursing, or if you are on any medications.

Keep out of the reach of children.

Storage

Store in a cool, dry, dark place.

Formula

Piper cubeba

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Made in USA Made in an FDA registered facility Natural Gluten Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cubeb by Herbal Terra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cubeb label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cubeb by Herbal Terra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Wildcrafted Cubeb (Piper cubeba) dried fruit liquid extract

Interacts with
665 drugs
970 mg per serving

Cubebs are spicy, peppery berries from a vine in the pepper family that have long been used in traditional medicine for coughs, digestion, and urinary...

Wildcrafted Cubeb (Piper cubeba) dried fruit liquid extract monograph & interactions

Other (inactive) ingredients: Menstruum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cubeb by Herbal Terra Drug Interactions

Want to check YOUR meds against Cubeb?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
665Drugs
643 Moderate 22 Minor

Ingredients driving the most interactions

wildcrafted Cubeb (Piper cubeba) dried fruit liquid extract 665

Individual Drug Interactions

The ingredients in Cubeb interact with 665 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cubeb interact with drugs. Each result below shows which ingredient is responsible. wildcrafted Cubeb (Piper cubeba) dried fruit liquid extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Cubeb with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

wildcrafted Cubeb (Piper cubeba) dried fruit liquid extract4 drug types · 665 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro. So far, this effect has not been reported in humans. Theoretically, cubebs might increase the effects and side effects of drugs metabolized by CYP3A4. These include lovastatin (Mevacor), clarithromycin (Biaxin), cyclosporine (Neoral, Sandimmune), diltiazem (Cardizem), estrogens, indinavir (Crixivan), triazolam (Halcion), and numerous others.

Likelihood Possible Evidence D
Antacids

Theoretically, due to reports that cubebs increases stomach acid, cubebs might decrease the effectiveness of antacids.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, due to reports that cubebs increases stomach acid, cubebs might decrease the effectiveness of H2-blockers. The H2 blockers include cimetidine (Tagamet), ranitidine (Zantac), nizatidine (Axid), and famotidine (Pepcid).

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, due to reports that cubebs increases stomach acid, cubebs might decrease the effectiveness of PPIs. PPIs include omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), pantoprazole (Protonix), and esomeprazole (Nexium).

Likelihood Possible Evidence D
wildcrafted Cubeb (Piper cubeba) dried fruit liquid extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cubeb, from the product label.

Herbal Terra

See all Herbal Terra products
Name
Herbal Terra
Pharmacist Counseling Corner

Cubeb by Herbal Terra: Common Questions

Does Cubeb by Herbal Terra interact with any medications?
Yes. Based on its ingredients, Cubeb has a known interaction with 665 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cubeb contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is cubeb safe to use during pregnancy?
Safety data on medicinal doses of cubeb during pregnancy isn't reliable enough. The safety information we hold advises against medicinal use in pregnancy. Talk with your doctor or pharmacist — they can weigh your individual situation and help you decide.
Can I take cubeb while breastfeeding?
There isn't enough safety data to support medicinal use of cubeb while breastfeeding. Your doctor or pharmacist is the best person to discuss whether it's right for you and your baby.
What is cubeb used for?
We don't have effectiveness data on file for cubeb, so we can't tell you what conditions it's studied for or how well it works. A healthcare provider or herbalist familiar with traditional uses can give you more information.
Are there any side effects from cubeb?
Adverse effects aren't documented in our data, but that doesn't guarantee there aren't any — it just means we don't have that information. Culinary amounts are likely fine, but medicinal doses aren't well studied.
What's menstruum in this product?
Menstruum is the liquid medium used to make the herbal extract — it's an inactive ingredient similar to how alcohol or glycerin might be used in other liquid supplements. It helps extract and preserve the active plant compounds.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cubeb label
Go deeper

The Full Monographs Behind Cubeb’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cubebs

Interacts with 665 drugs

Cubebs are spicy, peppery berries from a vine in the pepper family that have long been used in traditional medicine for coughs, digestion, and urinary problems. Modern human studies are very...

Read the full Cubebs monograph →
Sources

Sources & How We Checked

Cubeb's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cubebs 2 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Usia T, Watabe T, Kadota S, Tezuka Y. Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod 2005;68(1):64-8.

See these in context on the Cubebs monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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