Culver's Root Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Culver's Root against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Culver's Root is a dietary supplement by Herbalist & Alchemist with 1 active ingredient. Its ingredients are commonly taken for constipation, liver and gallbladder complaints, digestive upset.Based on those ingredients, 78 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are dried Culver's root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Culver's Root by Herbalist & Alchemist
Ask about any prescription or over-the-counter medication and we check it for interactions with Culver's Root by Herbalist & Alchemist — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Culver's Root by Herbalist & Alchemist
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: dried Culver's root extract, which is also known as black root. It's a plant-based supplement traditionally used for its strong laxative properties.
The supplement also includes ethyl alcohol and distilled water as inactive ingredients.
Does it work?
Couldn't assess
We don't hold effectiveness ratings for Culver's Root in our data, so the evidence for what this supplement actually accomplishes isn't established here. If you're curious about what it's meant to do, your pharmacist can point you toward the research.
How safe is it?
Well-documented data
Modern safety data for Culver's Root are limited, and the fresh root can cause serious digestive trouble. The supplement may cause abdominal pain or cramps, nausea, vomiting, headache, or drowsiness.
Liver toxicity has been reported after large doses. Stay away from Culver's Root during pregnancy because of its strong laxative effect and lack of safety data — it's rated possibly unsafe.
Avoid it while breastfeeding too, since there isn't enough information to know whether it's safe for your baby.
Meds to double-check
Moderate interaction found
Before taking Culver's Root, make sure to check with us if you're on warfarin (Coumadin) or other blood thinners, diuretics (water pills), or digoxin (Lanoxin) for your heart. These are the medication types documented to interact with black root.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Culver's Root is best avoided if you take blood thinners, diuretics, or heart medications like digoxin. The limited safety data and potential for digestive upset — plus the pregnancy and breastfeeding cautions — mean it's worth a conversation with your pharmacist before you start.
If you're on any prescription medication at all, check it against your meds first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Culver's Root, straight from the product label.
| Brand | Herbalist & Alchemist |
|---|---|
| Barcode (UPC) | 667056110284 |
| Net contents | 2 fl. Oz.; 60 mL |
| Market status | On market |
| Date entered into DSLD | Mar 23, 2018 |
| DSLD ID | 173990 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Kosher |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Culver's Root by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| dried Culver's root extract | 1.5 mL | -- |
Other ingredients: Ethyl Alcohol, distilled Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Veronicastrum virginicum
OK
General Statements
Supports healthy bowel function
Botanical preparation ratio 1:4
FDA Statement of Identity
Herbal Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: 20-30 drops (1-1.5 mL) in juice or water. Take 3 times per day. Shake well before using.
Precautions
Contraindications: Do not use during pregnancy or lactation.
Do not use if you have acute gallbladder inflammation or biliary or intestinal obstruction.
Keep out of children's reach
FDA Disclaimer Statement
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
General
NO. CUV-2 1723MO
Seals/Symbols
OK
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Culver's Root by Herbalist & Alchemist label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Culver's Root by Herbalist & Alchemist
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container40 Amounts shown are per serving.
Dried Culver's root extract
Interacts with78 drugs
Black Root is a traditional North American herb that was historically used as a strong laxative and to support digestion and liver function. There is...
Dried Culver's root extract monograph & interactionsOther (inactive) ingredients: Ethyl Alcohol, Distilled Water. These complete the product’s ingredient list but are not active constituents.
Culver's Root by Herbalist & Alchemist Drug Interactions
HelloPharmacist Interaction Report
Culver's Root by Herbalist & Alchemist does interact with several medication types, and there are a few you'll want to discuss with us before starting it.
Read the full breakdown — every affected drug type, severity by severity
The most serious concern is with blood thinners like warfarin (Coumadin). This supplement has strong laxative effects, and diarrhea can actually boost how much warfarin your body absorbs, raising your bleeding risk.
If you take warfarin, you'll need to avoid excessive amounts of Culver's Root.
It also pairs poorly with diuretics (water pills). Black root can worsen the potassium loss these drugs already cause, which can be dangerous — you might need your potassium supplement adjusted.
Additionally, if you take digoxin (Lanoxin) for your heart, large amounts of Culver's Root could bind to it in your gut and make the drug less effective, though the concern is mainly with overuse. Altogether, these interactions span 78 individual medications.
Before you add this to your routine, run your exact medications through the checker below — especially if you're on a blood thinner, a diuretic, or a heart medication.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Culver's Root?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Culver's Root interact with 78 drugs. Click any drug to see the details.
1 of the 1 ingredient in Culver's Root interact with drugs. Each result below shows which ingredient is responsible. dried Culver's root extract
MethyclothiazideAquatensen, Enduron
How Methyclothiazide interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractDiuretic Drugs Moderate
Interaction Summary
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Dried Culver's Root Extract + Methyclothiazide interactionMethyclothiazide, PargylineEutron
How Methyclothiazide, Pargyline interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractDiuretic Drugs Moderate
Interaction Summary
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Dried Culver's Root Extract + Methyclothiazide, Pargyline interactionMethyclothiazide, ReserpineDiutensen-R
How Methyclothiazide, Reserpine interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractDiuretic Drugs Moderate
Interaction Summary
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Dried Culver's Root Extract + Methyclothiazide, Reserpine interactionMetolazoneDiulo, Mykrox, Zaroxolyn
How Metolazone interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractDiuretic Drugs Moderate
Interaction Summary
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Dried Culver's Root Extract + Metolazone interactionPolythiazideRenese
How Polythiazide interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractDiuretic Drugs Moderate
Interaction Summary
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Dried Culver's Root Extract + Polythiazide interactionPolythiazide, PrazosinMinizide
How Polythiazide, Prazosin interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractDiuretic Drugs Moderate
Interaction Summary
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Dried Culver's Root Extract + Polythiazide, Prazosin interactionPolythiazide, ReserpineRenese R
How Polythiazide, Reserpine interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractDiuretic Drugs Moderate
Interaction Summary
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Dried Culver's Root Extract + Polythiazide, Reserpine interactionQuinethazoneHydromox
How Quinethazone interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractDiuretic Drugs Moderate
Interaction Summary
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Dried Culver's Root Extract + Quinethazone interactionQuinethazone, ReserpineHydromox R
How Quinethazone, Reserpine interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractDiuretic Drugs Moderate
Interaction Summary
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Dried Culver's Root Extract + Quinethazone, Reserpine interactionReserpine, TrichlormethiazideMetatensin #2, Metatensin #4, Naquival
How Reserpine, Trichlormethiazide interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractDiuretic Drugs Moderate
Interaction Summary
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Dried Culver's Root Extract + Reserpine, Trichlormethiazide interactionSacubitril, ValsartanEntresto
How Sacubitril, Valsartan interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractDiuretic Drugs Moderate
Interaction Summary
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Dried Culver's Root Extract + Sacubitril, Valsartan interactionSpironolactoneAldactone, Carospir, Spiroton
How Spironolactone interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractDiuretic Drugs Moderate
Interaction Summary
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Dried Culver's Root Extract + Spironolactone interactionTheobromineTheobromine
How Theobromine interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractDiuretic Drugs Moderate
Interaction Summary
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Dried Culver's Root Extract + Theobromine interactionTorsemideDemadex, Soaanz
How Torsemide interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractDiuretic Drugs Moderate
Interaction Summary
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Dried Culver's Root Extract + Torsemide interactionTrichlormethiazideAq 4B Aquazide, Marazide II, Metahydrin, Naqua
How Trichlormethiazide interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractDiuretic Drugs Moderate
Interaction Summary
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Dried Culver's Root Extract + Trichlormethiazide interactionUreaUreaphil
How Urea interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractDiuretic Drugs Moderate
Interaction Summary
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Dried Culver's Root Extract + Urea interactionWarfarinWarfarin
How Warfarin interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractWarfarin (coumadin) Moderate
Interaction Summary
Black root has stimulant laxative effects.
Read the full Dried Culver's Root Extract + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Culver's Root — through 1 ingredient. Tap an ingredient for the detail:
Dried Culver's Root ExtractWarfarin (coumadin) Moderate
Interaction Summary
Black root has stimulant laxative effects.
Read the full Dried Culver's Root Extract + Warfarin Sodium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Culver's Root with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
dried Culver's root extract
Digoxin (Lanoxin)
Theoretically, the overuse or abuse of black root can increase the risk of adverse effects of cardiac glycoside drugs. Black root chemically binds with the glycosides while in the gastrointestinal (GI) tract, which may reduce their effectiveness if used concomitantly.
Diuretic Drugs
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia. Initiation of potassium supplementation or an increase in potassium supplement dose may be necessary for some patients. Some diuretics that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.
Warfarin (Coumadin)
Black root has stimulant laxative effects. In some people black root can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of black root.
Brand information
Manufacturer and brand details for Culver's Root, from the product label.
Herbalist & Alchemist
See all Herbalist & Alchemist products- Name
- Herbalist & Alchemist, Inc.
- City
- Washington
- State
- NJ
- ZipCode
- 07882
- Phone Number
- 800-611-8235
- Web Address
- www.herbalist-alchemist.com
Culver's Root by Herbalist & Alchemist: Common Questions
Does Culver's Root by Herbalist & Alchemist interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Culver's Root while I'm pregnant?
Is it safe to take while breastfeeding?
What side effects might I experience?
Why do I need to be careful if I take warfarin?
What's Culver's Root actually used for?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Culver's Root is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Culver's Root’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Culver's Root's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 2 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Root 2 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC