D-Mannose Powder Ingredients & Drug Interactions
What is this page for?
First and foremost: checking D-Mannose Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose Powder is a dietary supplement by The Vitamin Shoppe with 1 active ingredient. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose Powder by The Vitamin Shoppe
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains a single active ingredient: D-mannose, a naturally occurring sugar. It's meant to support urinary tract health, though the evidence for that purpose is limited.
There are no other ingredients listed — it's just the powder itself.
Does it work?
Leans against
The evidence for D-mannose is mixed. It's considered likely effective for carbohydrate-deficient glycoprotein syndrome type 1b, a rare inherited condition.
For urinary tract infections (UTIs), the rating is possibly ineffective — meaning the evidence doesn't support its use for that common reason people buy it. If you're considering it for UTI prevention or treatment, that's worth discussing with your doctor.
How safe is it?
Well-documented data
D-mannose is generally well tolerated in the short term, but we don't have high-quality long-term safety data, so extended use without medical guidance isn't well established. The most common side effects are bloating, diarrhea, and nausea — especially at higher doses or if you take more than 200 mg per kilogram of body weight at once, which can trigger osmotic diarrhea.
Pregnancy safety data aren't reliable enough to recommend it, and breastfeeding safety hasn't been well studied, so talk with your doctor or pharmacist before using it in either situation.
Meds to double-check
No known interactions
No interactions are documented for D-mannose in our data. That said, your doctor or pharmacist can confirm there's nothing specific to your own medications or health before you start.
The bottom line
Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
D-mannose is a simple sugar with no documented medication interactions, which is reassuring if you're on prescriptions. The catch: it's possibly ineffective for the most common reason people take it — UTI prevention — and long-term safety isn't well established.
If you're pregnant, breastfeeding, or planning long-term use, check with your doctor or pharmacist first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose Powder, straight from the product label.
| Brand | The Vitamin Shoppe |
|---|---|
| Barcode (UPC) | 766536030491 |
| Net contents | 3.2 Ounce(s); 90.3 Gram(s) |
| Market status | On market |
| Date entered into DSLD | May 22, 2020 |
| DSLD ID | 221384 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose Powder by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Urinary tract health Cleanses the bladder
Gluten-free Dairy-free Soy-free Nut-free Does not contain: Gluten, sugar, salt, preservatives.
General Statements
Specialty
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
Quality Promise Tested & Trusted
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Suggested/Recommended/Usage/Directions
Directions: Take approximately 1/2 teaspoon (2.1 g) one to two times a day. Take with water or unsweetened juice.
Precautions
Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.
Keep out of reach of children.
Tamper evident Do not use if outer seal is broken or missing.
Formula
D-Mannose is a naturally occurring, simple sugar found in food. The body utilizes it to support the urinary tract and maintain a healthy bladder lining. It is metabolized in small amounts, with excess rapidly excreted in urine.
Storage
Store in cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose Powder by The Vitamin Shoppe label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose Powder by The Vitamin Shoppe
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2.1 Gram(s) Dosage formPowder Servings per container43 Amounts shown are per serving.
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
D-Mannose Powder by The Vitamin Shoppe Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose Powder. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose Powder, from the product label.
The Vitamin Shoppe
See all The Vitamin Shoppe products- Name
- The Vitamin Shoppe
- City
- Secaucus
- State
- NJ
- ZipCode
- 07094
- Phone Number
- 1-866-293-3367
- Web Address
- www.vitaminshoppe.com
D-Mannose Powder by The Vitamin Shoppe: Common Questions
Does D-Mannose Powder by The Vitamin Shoppe interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will D-mannose help prevent or treat a urinary tract infection?
What are the most common side effects?
Is it safe to take D-mannose long-term?
Can I take this while pregnant or breastfeeding?
Does this powder have any fillers or inactive ingredients?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose Powder is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose Powder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC