D-Mannose Ingredients & Drug Interactions
by Hard Rhino
What is this page for?
First and foremost: checking D-Mannose against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose is a dietary supplement by Hard Rhino with 2 active ingredients. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose by Hard Rhino
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: D-mannose, a naturally occurring simple sugar. D-mannose is thought to work by being filtered into the urine, where it may help prevent certain bacteria from sticking to the urinary tract.
The product is a powder with no other inactive ingredients listed.
Does it work?
Strong evidence
The evidence here is mixed. D-mannose is rated likely effective for carbohydrate-deficient glycoprotein syndrome type 1b, a rare genetic disorder.
For urinary tract infections (UTIs), though, it's rated possibly ineffective — meaning the evidence doesn't support that it works for that use. If you're considering it for a UTI, talk with your doctor about whether it makes sense for you.
How safe is it?
Well-documented data
D-mannose is generally well tolerated in the short term, but long-term safety data are limited — that's why it's smart to discuss duration and dose with your doctor before taking it long-term. The most common side effects are bloating, diarrhea, and nausea when taken by mouth.
Doses larger than 200 mg/kg (a lot of powder at once) are more likely to cause osmotic diarrhea. Because safety data during breastfeeding aren't well studied, caution is advised if you're nursing — talk it over with your doctor or pharmacist for guidance tailored to you.
Meds to double-check
No known interactions
No interactions are documented in our data for D-mannose. That's not a guarantee none exist, so check your specific medications with the tool on this page before starting, or ask your pharmacist to review your medication list.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.
Hard Rhino D-Mannose may be worth considering if your doctor has recommended it for carbohydrate-deficient glycoprotein syndrome type 1b, though it's not supported for UTIs. Side effects like bloating and diarrhea are possible, and long-term safety data are sparse.
Chat with your own doctor or pharmacist before starting — especially if you're pregnant, breastfeeding, or planning to take it long-term.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose, straight from the product label.
| Brand | Hard Rhino |
|---|---|
| Barcode (UPC) | 818132851816 |
| Net contents | 125 Gram(s); 4.4 Oz(s) |
| Market status | On market |
| Date entered into DSLD | Mar 24, 2017 |
| DSLD ID | 72382 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose by Hard Rhino, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 8 Calorie(s) | -- |
| Total Carbohydrates | 2 Gram(s) | 1% |
| Sugar | 2 Gram(s) | -- |
| D-Mannose | 2 Gram(s) | -- |
Other ingredients: None
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
No added fillers
Allergens: This product contains no soy, dairy, dairy byproducts, eggs, shellfish, wheat, gluten, tree nuts, or sesame seeds.
This is a non-GMO ingredient.
General Statements
Only pure ingredients
Pure powder
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 2000 mg (~2/3 tsp) with 8-16 ounces of water or suitable beverage. Taken 1-3 times daily, preferably before meals on an empty stomach or as directed by your qualified health professional.
1 Carefully measure out suggested serving size using a microscale. 2 Add to preferred beverage. 3 Mix well. 4 Drink within 10-15 minutes. How to use
FDA Disclaimer Statement
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.
Precautions
Warning: Keep out of the reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).
Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).
Always consult with a qualified health physician before taking any new dietary supplement.
Do not use or consume if pressure seal is broken.
Do not use or consume if seal is broken.
Seals/Symbols
Lab tested for purity and quality
Packaged in USA
FDA Statement of Identity
Dietary Supplement
Storage
Storage: Store in a cool, dry place. Re-seal zipper immediately after use to preserve freshness.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose by Hard Rhino label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose by Hard Rhino
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Gram(s) Dosage formPowder Servings per container62 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sugar
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
D-Mannose by Hard Rhino Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose, from the product label.
Hard Rhino
See all Hard Rhino products- Name
- Guardian Wholesale
- Street Address
- 1607 West Whispering Wind Drive
- City
- Phoenix
- State
- AZ
- ZipCode
- 85085
- Phone Number
- (866) 961-8378
- Web Address
- HardRhino.com
D-Mannose by Hard Rhino: Common Questions
Does D-Mannose by Hard Rhino interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will D-mannose help my urinary tract infection?
What side effects might I notice?
Is D-mannose safe to take long-term?
Can I take D-mannose while breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC