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Dietary supplement

Tribulus Terrestris Extract 45% Saponins Ingredients & Drug Interactions

by Hard Rhino

Tribulus Terrestris Extract 45% Saponins label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus Terrestris Extract 45% Saponins against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus Terrestris Extract 45% Saponins is a dietary supplement by Hard Rhino with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus Terrestris. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tribulus Terrestris Extract 45% Saponins by Hard Rhino

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus Terrestris Extract 45% Saponins by Hard Rhino — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tribulus Terrestris Extract 45% Saponins by Hard Rhino

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: tribulus terrestris extract, standardized to 45% saponins. Saponins are plant compounds thought to be responsible for tribulus's effects on sexual function and athletic performance.

The powder form contains no other inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Tribulus's overall clinical evidence instead.

Moderate

Some clinical evidence supports Tribulus for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Sexual dysfunction — rated "Possibly Effective" (Natural Medicines).

The evidence for tribulus centers on sexual dysfunction, where it is rated possibly effective—meaning some clinical research supports it, but the evidence isn't yet solid. For athletic performance, the data suggests it is possibly ineffective.

For benign prostatic hyperplasia (enlarged prostate), we don't have enough reliable evidence to rate it either way. If you're considering tribulus for one of these uses, talk it over with your doctor about what the current research actually shows for your specific situation.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is generally well tolerated in the short term in healthy adults, but quality and long-term safety data are limited. Gastrointestinal side effects like stomach pain, nausea, vomiting, diarrhea, and constipation can occur, though in one study these rates were similar to placebo.

Rare serious side effects—liver and kidney injury, seizures, and chronic painful erection—have been reported, and one case of kidney failure and liver inflammation occurred in someone who drank 2 liters of tribulus water daily for just two days. Avoid tribulus during pregnancy because it may affect hormones and safety is not established.

Also avoid it while breastfeeding due to lack of reliable safety information.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood pressure medications (antihypertensive drugs), diabetes medications (antidiabetes drugs), or lithium, check with your doctor or pharmacist before using this product. All three interactions are Moderate severity and could affect how your medications work or your blood sugar and blood pressure levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus terrestris is possibly effective for sexual dysfunction, but it can interact with blood pressure, diabetes, and lithium-containing medications at a Moderate severity level. It's generally short-term tolerated but has limited long-term safety data, and it's off-limits in pregnancy and while breastfeeding.

Talk with your own doctor or pharmacist before starting it, especially if you take any of those medication types.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus Terrestris Extract 45% Saponins, straight from the product label.

Brand Hard Rhino
Barcode (UPC) 798711500390
Net contents 5 kg; 11 lbs
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 72200
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus Terrestris Extract 45% Saponins by Hard Rhino, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.75 Gram(s)
Maximum serving Sizes:
0.75 Gram(s)
Servings per container
6666
UPC/BARCODE
798711500390
IngredientAmount% DV
Tribulus Terrestris750 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

-Non-GMO -Gluten free -Allergen free

Allergens: This product contains no soy, dairy, dairy byproducts, eggs, shellfish, wheat, gluten, tree nuts, or sesame seeds.

General Statements

Bulk pail - Best value - Scoop inside - 6665 servings

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 scant scoop (~750 mg) mixed with 6-8 ounces of water or suitable beverage. Taken 1-2 times daily, preferably with meals or as directed by a qualified health professional.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.

Precautions

Warning: Keep out of the reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).

Always consult with a qualified health physician before taking any new dietary supplement.

Do not use or consume if seal is broken.

FDA Statement of Identity

Dietary Supplement

Storage

Storage: Store in a cool, dry place. Re-seal inner bag immediately after use to preserve freshness.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus Terrestris Extract 45% Saponins by Hard Rhino label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus Terrestris Extract 45% Saponins label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus Terrestris Extract 45% Saponins by Hard Rhino

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.75 Gram(s) Dosage formPowder Servings per container6666 Amounts shown are per serving.

Tribulus Terrestris

Interacts with
259 drugs
750 mg per serving Form: Saponins

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus Terrestris monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus Terrestris Extract 45% Saponins by Hard Rhino Drug Interactions

Want to check YOUR meds against Tribulus Terrestris Extract 45% Saponins?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus Terrestris 259

Individual Drug Interactions

The ingredients in Tribulus Terrestris Extract 45% Saponins interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tribulus Terrestris Extract 45% Saponins interact with drugs. Each result below shows which ingredient is responsible. Tribulus Terrestris

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus Terrestris Extract 45% Saponins with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus Terrestris3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus Terrestris full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus Terrestris Extract 45% Saponins, from the product label.

Hard Rhino

See all Hard Rhino products
Name
Guardian Wholesale
City
Phoenix
State
AZ
ZipCode
85085
Phone Number
(866)961-8378
Web Address
HardRhino.com
Pharmacist Counseling Corner

Tribulus Terrestris Extract 45% Saponins by Hard Rhino: Common Questions

Does Tribulus Terrestris Extract 45% Saponins by Hard Rhino interact with any medications?
Yes. Based on its ingredients, Tribulus Terrestris Extract 45% Saponins has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus Terrestris Extract 45% Saponins contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. Tribulus is rated possibly unsafe in pregnancy because it may affect hormones and safety hasn't been established. Avoid it while breastfeeding too, as there isn't enough reliable safety data. Talk with your doctor if you're pregnant or nursing and interested in this product.
Does tribulus actually work for sexual function?
It's rated possibly effective, which means some clinical studies support it but the evidence isn't definitive yet. Results vary person to person. If you're considering it for this reason, discuss the actual research and what to expect with your doctor.
What are the common side effects?
Tribulus can cause stomach pain, cramping, nausea, vomiting, diarrhea, and constipation. In one study, though, these gastrointestinal complaints occurred at rates similar to placebo. Serious side effects are rare but have been reported, including liver and kidney injury.
Can I use this for athletic performance?
Tribulus is rated possibly ineffective for athletic performance based on the evidence we have, so it's unlikely to help you gain strength or endurance.
How much long-term safety data exists for tribulus?
Limited. While it's generally well tolerated short-term in healthy adults, we don't have robust long-term safety information. One case report involved serious kidney and liver injury from very high intake over just two days, so quality and dose matter.
Is this product just tribulus, or does it have fillers?
This product contains only the tribulus terrestris extract standardized to 45% saponins—no other inactive ingredients listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus Terrestris Extract 45% Saponins is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus Terrestris Extract 45% Saponins label
Go deeper

The Full Monographs Behind Tribulus Terrestris Extract 45% Saponins’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus Terrestris Extract 45% Saponins's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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