Daily Probiotic 5 Billion Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Daily Probiotic 5 Billion against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Daily Probiotic 5 Billion is a dietary supplement by Spring Valley with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Probiotic Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Daily Probiotic 5 Billion by Spring Valley
Ask about any prescription or over-the-counter medication and we check it for interactions with Daily Probiotic 5 Billion by Spring Valley — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Daily Probiotic 5 Billion by Spring Valley
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 5 active probiotic ingredients: Lactobacillus acidophilus, Bifidobacterium longum, Lactobacillus plantarum, Lactobacillus rhamnosus, and Bifidobacterium animalis lactis. These are live, beneficial bacteria meant to support your gut flora.
The inactive ingredients—inulin, hypromellose, microcrystalline cellulose, rice bran extract, sunflower oil, and silica—are fillers and binders that help form and stabilize the capsule.
Does it work?
Moderate evidence
Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis; it's possibly ineffective for atopic disease (allergic conditions). Bifidobacterium longum doesn't yet have enough reliable evidence to rate it for any of the conditions tested — including antibiotic-associated diarrhea, anxiety, asthma, and allergic rhinitis.
For the other three probiotic strains in this blend, we don't hold effectiveness data.
How safe is it?
Well-documented data
Lactobacillus acidophilus is generally well tolerated in healthy adults and children, though you should check with your doctor before use. Bifidobacterium longum is also generally well tolerated in healthy people, but caution is advised if you're seriously ill or have a weakened immune system; limited safety data exist for breastfeeding, so discuss it with your doctor first.
Both ingredients can rarely cause mild digestive upset—bloating, gas, abdominal discomfort, or diarrhea—when combined with other probiotics. Very rare serious infections (bacteremia and sepsis) have been reported, mainly in critically ill or newborn patients; if you're in intensive care or have severe immune compromise, talk to your doctor before starting.
Pregnancy safety for L. acidophilus is possibly safe, and B. longum is possibly safe in both pregnancy and lactation, but limited data exist — discuss with your healthcare provider.
Meds to double-check
Moderate interaction found
Check your antibiotic medications before starting this product. Antibiotics can kill the live organisms in this probiotic, reducing how well it works.
Your doctor or pharmacist can advise you on timing — usually separating doses by a few hours helps. We have no documented interactions for the other three probiotic strains, but we couldn't fully check them either.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This probiotic makes sense if you're dealing with IBS, antibiotic-related diarrhea, or certain infections where the strains are possibly effective and your doctor agrees. The main thing to watch is spacing it away from antibiotics so the drugs don't kill the beneficial bacteria.
If you're seriously ill, immune-compromised, or pregnant, talk it over with your doctor or pharmacist first — the safety data are limited in those situations.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Daily Probiotic 5 Billion, straight from the product label.
| Brand | Spring Valley |
|---|---|
| Barcode (UPC) | 681131156943 |
| Net contents | 30 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 25, 2018 |
| DSLD ID | 178625 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Children 4 or More Years of Age, Adult (18 - 50 Years), Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Daily Probiotic 5 Billion by Spring Valley, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Lactobacillus acidophilus | 0 NP | -- |
| Bifidobacterium longum | 0 NP | -- |
| Lactobacillus plantarum | 0 NP | -- |
| Probiotic Blend | 0 NP | -- |
| Lactobacillus rhamnosus | 0 NP | -- |
| Bifidobacterium animalis lactis | 0 NP | -- |
Other ingredients: Inulin, Hypromellose, Microcrystalline Cellulose, Rice Bran extract, Sunflower Oil, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Spring Valley Daily Probiotic is the natural way to build and maintain optimal colon and digestive health.
Suggested/Recommended/Usage/Directions
Providing 5 Billion CFU of a five-strain probiotic blend, just one capsule daily helps provide digestive balance and immune health.
Suggested Use: Adults and children 6 years old and over, take 1 capsule daily with or without food.
General Statements
Individual results may vary. Promotes digestive health Supports healthy digestive tract Promotes intestinal health Helps restore digestive balance Supports immune health
What are probiotics? The human digestive system is home to trillions of bacteria that perform many helpful functions. However, the healthy balance of good bacteria can be disrupted by diet, travel or stress. Probiotics are beneficial bacteria that can help replenish and support a healthy flora balance. Probiotic strains are different types of bacteria, each of which may provide different health benefits.
Please recycle
Quality Guaranteed
Daily Probiotic 5 Billion active cultures per capsule 5 strains
Digestive health Probiotics are beneficial bacteria that support digestive and immune health. Formulated for daily use, to help promote colon, digestive and immune health
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
No artificial colors or flavors, sugar, lactose, dairy
Precautions
Keep out of reach of children.
For your protection, do not use if seal is broken.
Storage
Store at 72(0)F or cooler. Do not expose to excessive heat or moisture. No refrigeration needed.
General
GSN000000 222363
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Daily Probiotic 5 Billion by Spring Valley label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Daily Probiotic 5 Billion by Spring Valley
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Probiotic Blend
Interacts with182 drugs
Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...
Probiotic Blend monograph & interactions- › Lactobacillus acidophilus
- › Bifidobacterium longum
- › Lactobacillus plantarum
- › Lactobacillus rhamnosus
- › Bifidobacterium animalis lactis
Other (inactive) ingredients: Inulin, Hypromellose, Microcrystalline Cellulose, Rice Bran extract, Sunflower Oil, Silica. These complete the product’s ingredient list but are not active constituents.
Daily Probiotic 5 Billion by Spring Valley Drug Interactions
HelloPharmacist Interaction Report
Spring Valley's Daily Probiotic 5 Billion interacts with antibiotic drugs through its Lactobacillus acidophilus and Bifidobacterium longum content.
Both are live organisms that antibiotics can kill, which may reduce the probiotic's effectiveness — a Moderate-severity concern. The fix is straightforward: space out your antibiotic and probiotic doses.
Ask your doctor or pharmacist how many hours apart to take them; often 2 hours is suggested, but it depends on the specific antibiotic.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 182 individual medications.
We couldn't check three other ingredients in this product — Lactobacillus plantarum, Lactobacillus rhamnosus, and Bifidobacterium animalis lactis — because we hold no interaction data for them. That doesn't mean they're interaction-free; it means we simply haven't assessed them.
Use the search tool below to verify your exact medications before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Daily Probiotic 5 Billion?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Daily Probiotic 5 Billion interact with 182 drugs. Click any drug to see the details.
1 of the 1 ingredient in Daily Probiotic 5 Billion interact with drugs. Each result below shows which ingredient is responsible. Probiotic Blend
CefotetanCefotan
How Cefotetan interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Cefotetan interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cefotetan interactionCefoxitinMefoxin
How Cefoxitin interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cefoxitin interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Cefoxitin interactionCefpodoxime ProxetilVantin
How Cefpodoxime Proxetil interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Cefpodoxime Proxetil interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cefpodoxime Proxetil interactionCefprozilCefzil
How Cefprozil interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Cefprozil interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cefprozil interactionCeftazidimeCeftazidime, Ceptaz, Fortaz, Tazicef, Tazidime
How Ceftazidime interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Ceftazidime interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Ceftazidime interactionCeftibutenCedax
How Ceftibuten interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Ceftibuten interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Ceftibuten interactionCeftizoximeCefizox
How Ceftizoxime interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Ceftizoxime interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Ceftizoxime interactionCeftolozane Sulfate, Tazobactam SodiumZerbaxa
How Ceftolozane Sulfate, Tazobactam Sodium interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Ceftolozane Sulfate, Tazobactam Sodium interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Ceftolozane Sulfate, Tazobactam Sodium interactionCeftriaxoneRocephin
How Ceftriaxone interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Ceftriaxone interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Ceftriaxone interactionCefuroximeCeftin, Kefurox, Zinacef
How Cefuroxime interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Cefuroxime interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cefuroxime interactionCephalexinCephalex, Keflex, Keftab, Lexin
How Cephalexin interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Cephalexin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cephalexin interactionCephapirinCefadyl
How Cephapirin interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Cephapirin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cephapirin interactionCephradineAnspor, Velosef
How Cephradine interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Cephradine interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cephradine interactionChloramphenicolChloromycetin, Chloromycetin Injection, Chloromycetin Ophthalmic
How Chloramphenicol interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Chloramphenicol interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Chloramphenicol interactionChlortetracyclineAureomycin
How Chlortetracycline interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Chlortetracycline interactionProbiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Chlortetracycline interactionCinoxacinCinobac
How Cinoxacin interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Cinoxacin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cinoxacin interactionCiprofloxacinCiloxan, Cipro, Cipro IV, Cipro XR, Ciprobay, Otiprio
How Ciprofloxacin interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Ciprofloxacin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Ciprofloxacin interactionClarithromycinBiaxin, Biaxin XL
How Clarithromycin interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Clarithromycin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Clarithromycin interactionClinafloxacinClinafloxacin
How Clinafloxacin interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Clinafloxacin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Clinafloxacin interactionClindamycinCleocin, Cleocin T Gel, ClindaMax, Clindesse, Dalacin C
How Clindamycin interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Clindamycin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Clindamycin interactionClofazimineLamprene
How Clofazimine interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Clofazimine interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Clofazimine interactionCloxacillin SodiumCloxapen, Cloxi, Tegopen
How Cloxacillin Sodium interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Cloxacillin Sodium interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cloxacillin Sodium interactionColistimethateColy-Mycin M
How Colistimethate interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Colistimethate interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Colistimethate interactionCyclacillinCyclapen-W, Cylcapen
How Cyclacillin interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Cyclacillin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cyclacillin interactionCycloserineSeromycin
How Cycloserine interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Cycloserine interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Cycloserine interactionDalbavancin HydrochlorideDalvance
How Dalbavancin Hydrochloride interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Dalbavancin Hydrochloride interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Dalbavancin Hydrochloride interactionDapsoneAczone, Avlosulfon, Dapsone
How Dapsone interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Dapsone interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Dapsone interactionDaptomycinCubicin, Dapzura RT
How Daptomycin interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Daptomycin interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Daptomycin interactionDemeclocyclineDeclomycin
How Demeclocycline interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Demeclocycline interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Demeclocycline interactionDicloxacillin InjectionDynapen Injection
How Dicloxacillin Injection interacts with Daily Probiotic 5 Billion — through 2 ingredients. Tap an ingredient for the detail:
Probiotic BlendAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Probiotic Blend + Dicloxacillin Injection interactionBifidobacterium LongumAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum + Dicloxacillin Injection interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Daily Probiotic 5 Billion with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Probiotic Blend
Antibiotic Drugs
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.
Brand information
Manufacturer and brand details for Daily Probiotic 5 Billion, from the product label.
Spring Valley
See all Spring Valley products- Name
- Wal-Mart Stores, Inc.
- City
- Bentonville
- State
- AR
- ZipCode
- 72716
- Phone Number
- 1-866-251-1662
- Web Address
- Walmart.com/springvalley
Daily Probiotic 5 Billion by Spring Valley: Common Questions
Does Daily Probiotic 5 Billion by Spring Valley interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while I'm on antibiotics?
Is this safe if I'm pregnant?
What if I have a weak immune system?
Can this cause side effects?
How many live bacteria does each capsule have?
Does it really help with IBS?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Daily Probiotic 5 Billion is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Daily Probiotic 5 Billion’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lactobacillus Acidophilus
Interacts with 182 drugsLactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...
Read the full Lactobacillus Acidophilus monograph → Herb & supplement monographBifidobacterium Longum
Interacts with 182 drugsBifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...
Read the full Bifidobacterium Longum monograph →Sources & How We Checked
Daily Probiotic 5 Billion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 36 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lactobacillus Acidophilus 15 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
- Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
- Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
- Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
- Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
- Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
- Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
- Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
- Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
- Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
- Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
- Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
- Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
- Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.
See these in context on the Lactobacillus Acidophilus monograph →
Bifidobacterium Longum 21 references
- Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
- Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
- Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
- Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
- Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
- Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
- Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
- Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
- US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
- Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
- Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
- Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
- Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
- Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
- Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
- Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
- Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
- Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
- Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed
See these in context on the Bifidobacterium Longum monograph →
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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