Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

David Winston's Spirolyd Support Ingredients & Drug Interactions

by Herbalist & Alchemist

David Winston's Spirolyd Support label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking David Winston's Spirolyd Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

David Winston's Spirolyd Support is a dietary supplement by Herbalist & Alchemist with 5 active ingredients. Its ingredients are commonly taken for colds and flu-like illness, sore throat, fever.Based on those ingredients, 889 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sweet Annie Herb Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against David Winston's Spirolyd Support by Herbalist & Alchemist

Ask about any prescription or over-the-counter medication and we check it for interactions with David Winston's Spirolyd Support by Herbalist & Alchemist — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of David Winston's Spirolyd Support by Herbalist & Alchemist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Blend Extract” is a proprietary blend — the label gives one combined amount (4 mL) without saying how much of each component you get.

This product contains 5 active ingredients in extract form: Isatis root, Sichuan Teasel root, Houttuynia herb, Sweet Annie herb, and Lomatium root. The proprietary blend format means the exact dose of each isn't shown on the label.

The liquid is made with water, ethyl alcohol (the solvent), and glycerin.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Lyme disease support with antibiotic supervision.
  • We looked for evidence on: Respiratory tract infections, Lyme disease, Tick-borne infections, Spirochete infections.
  • The closest evidence on file: Isatis is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections (Natural Medicines).

Isatis root is possibly effective for psoriasis, but evidence for respiratory infections, prostate cancer, ulcerative colitis, hepatitis, and aging skin is insufficient to rate. Sweet Annie is possibly effective for allergic rhinitis (hay fever), but evidence for nonalcoholic fatty liver disease, malaria, and osteoarthritis is insufficient to rate.

The effectiveness data we hold doesn't cover Sichuan Teasel, Houttuynia, or Lomatium.

The evidence, ingredient by ingredient Isatis Sweet Annie

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Isatis root has limited human safety data and is traditionally used short-term only; its safety in pregnancy and breastfeeding is not established, so the data advises against it in both. Sweet Annie is generally well-tolerated when taken by mouth, though nausea and vomiting are the most common side effects.

Rarely, it can cause liver damage—one case reported hepatitis after a 10-day course, though causation wasn't certain. The safety data advises against Sweet Annie during pregnancy and breastfeeding.

A mild allergic reaction (rash and cough) has been reported once; sublingual use in allergic individuals caused tongue numbness and throat itching.

Side effects, ingredient by ingredient Isatis Sweet Annie

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Sweet Annie.
  • The most serious interaction on file is rated Moderate.
  • For scale: 890 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any drugs that can harm the liver (Moderate risk), or any medications processed by the liver enzymes CYP3A4 or CYP2B6 (Moderate risk for both). Sweet Annie is the ingredient behind these interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with psoriasis or hay fever, though the evidence for most uses is weak or absent. The main caution is its Sweet Annie content, which can interact with many medications and potentially stress the liver.

If you take any prescription drugs—especially those metabolized by your liver or used for liver, heart, or blood sugar conditions—check them against this product with your own doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about David Winston's Spirolyd Support, straight from the product label.

Brand Herbalist & Alchemist
Barcode (UPC) 667056134044
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 297468
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for David Winston's Spirolyd Support by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
4 mL
Servings per container
15
UPC/BARCODE
667056134044
IngredientAmount% DV
Proprietary Blend Extract4 mL--
Isatis root extract0 NP--
Sichuan Teasel Root Extract0 NP--
Houttuynia Herb Extract0 NP--
Sweet Annie Herb Extract0 NP--
Lomatium root extract0 NP--

Other ingredients: Water, Distilled, Ethyl Alcohol, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Herbal Supplement

Precautions

Contraindications: Do not use during pregnancy, lactation, or as a first option in treating Lyme disease.

Contraindications: Do not use during pregnancy, lactation, or as a first option in treating Lyme disease. This formula does not replace the need for antibiotics and must be used under the supervision of a qualified expert. Discontinue use if a skin rash develops.

Keep out of children's reach

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. Take 40-80 drops (2-4 mL) in juice or water. Take 3 times per day with Spirolyd Compound for 10 days; stop both products for 7 days. Repeat treatment pattern starting with Spirolyd Compound alone and continue treatment cycles as directed by a qualified expert.

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

OK (Kosher)

Formula

OK (Kosher)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

David Winston's Spirolyd Support by Herbalist & Alchemist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

David Winston's Spirolyd Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in David Winston's Spirolyd Support by Herbalist & Alchemist

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend Extract

4 mL per serving

Other (inactive) ingredients: Water, Distilled, Ethyl Alcohol, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

David Winston's Spirolyd Support by Herbalist & Alchemist Drug Interactions

Want to check YOUR meds against David Winston's Spirolyd Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
889Drugs
889 Moderate

Ingredients driving the most interactions

Sweet Annie Herb Extract 889

Individual Drug Interactions

The ingredients in David Winston's Spirolyd Support interact with 889 drugs. Click any drug to see the details.

1 of the 5 ingredients in David Winston's Spirolyd Support interact with drugs. Each result below shows which ingredient is responsible. Sweet Annie Herb Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in David Winston's Spirolyd Support with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sweet Annie Herb Extract3 drug types · 889 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP2B6.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP2B6, possibly increasing CYP2B6 activity by 1.6-fold. However, Sweet Annie extract seems to inhibit the activity of CYP2B6 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP2B6 substrates.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP3A4, possibly increasing CYP3A4 activity by 1.9-fold. However, Sweet Annie extract seems to inhibit the activity of CYP3A4 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP3A4 substrates.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use might have additive adverse hepatotoxic effects.
There is some concern that Sweet Annie can adversely affect the liver.

Likelihood Possible Evidence D
Sweet Annie Herb Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for David Winston's Spirolyd Support, from the product label.

Herbalist & Alchemist

See all Herbalist & Alchemist products
Name
Herbalist & Alchemist, Inc.
City
Washington
State
NJ
ZipCode
07882
Phone Number
800-611-8235
Web Address
www.herbalist-alchemist.com
Pharmacist Counseling Corner

David Winston's Spirolyd Support by Herbalist & Alchemist: Common Questions

Does David Winston's Spirolyd Support by Herbalist & Alchemist interact with any medications?
Yes. Based on its ingredients, David Winston's Spirolyd Support has a known interaction with 889 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
David Winston's Spirolyd Support contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against both ingredients we checked—Isatis and Sweet Annie—during pregnancy and breastfeeding. There isn't enough information to know either way about the other three ingredients. Talk with your doctor or pharmacist about whether this product is right for you before you take it while pregnant or nursing.
What are the side effects?
Sweet Annie may cause nausea and vomiting. A mild allergic reaction with a rash and cough has been reported once. Rarely, it can cause liver damage. If you take it sublingually (under the tongue) and you're allergic to Sweet Annie, you might feel numbness or throat itching. Isatis has limited human safety data, so side effects aren't well documented.
Does this really work for what it's supposed to do?
Isatis is possibly effective for psoriasis. Sweet Annie is possibly effective for hay fever. For everything else this product claims—respiratory infections, prostate cancer, ulcerative colitis, liver disease, arthritis, and aging skin—the evidence we have is too weak to say either way.
Is this safe to use long-term?
Both Isatis and Sweet Annie are traditionally used short-term only, and the safety data don't support long-term use. Quality and dose vary widely in herbal supplements, so this shouldn't replace proven treatments. If you're considering long-term use, talk it over with your pharmacist or doctor.
What is Sweet Annie used for?
Sweet Annie extract is possibly effective for hay fever (allergic rhinitis). It's been studied for malaria, fatty liver disease, and arthritis, but the evidence isn't strong enough to confirm benefit yet.
Why do the facts say Sweet Annie both inhibits and induces my liver enzymes?
Sweet Annie is a blend of compounds. One of them, artemisinin, speeds up how your liver breaks down drugs (induction); but the extract as a whole seems to slow that process (inhibition). The net effect on your specific medications isn't clear and depends on which compounds are active in your dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if David Winston's Spirolyd Support is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

David Winston's Spirolyd Support label
Go deeper

The Full Monographs Behind David Winston's Spirolyd Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Isatis

Isatis is a plant long used in traditional Chinese medicine, mainly for sore throats, fevers, and colds. Modern evidence in people is very limited, so its benefits are not well proven. Talk...

Read the full Isatis monograph → Herb & supplement monograph

Sweet Annie

Interacts with 889 drugs

Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs. While the purified drug is well studied for malaria, the herb itself as a supp...

Read the full Sweet Annie monograph →
Sources

Sources & How We Checked

David Winston's Spirolyd Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Isatis 3 references
  1. Herbs at a Glance — NIH NCCIH Source
  2. Herbs and Supplements — MedlinePlus Source
  3. About Herbs, Botanicals & Other Products — Memorial Sloan Kettering Cancer Center Source

See these in context on the Isatis monograph →

Sweet Annie 11 references
  1. Mueller MS, Karhagomba IB, Hirt HM, Wemakor E. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol 2000;73:487-93. PubMed
  2. Rath K, Taxis K, Walz G, et al. Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood). Am J Trop Med Hyg 2004;70:128-32. DOI
  3. Centers for Disease Control and Prevention (CDC). Hepatitis temporally associated with an herbal supplement containing artemisinin-Washington, 2008. MMWR Morb Mortal Wkly Rep 2009;58:854-8.
  4. Xing J, Kirby BJ, Whittington D, et al. Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes. Drug Metabl Dispos 2012;40(9):1757-64. PubMed
  5. Savage RL, Hill GR, Barnes J, Kenyon SH, Tatley MV. Suspected hepatotoxicity with a supercritical carbon dioxide extract of Artemisia annua in grapeseed oil used in New Zealand. Front Pharmacol. 2019;10:1448. PubMed
  6. Ruperti-Repilado FJ, Haefliger S, Rehm S, et al. Danger of herbal tea: a case of acute cholestatic hepatitis due to Artemisia annua tea. Front Med (Lausanne). 2019;6:221. PubMed
  7. Yang J, Shen Z, Liu L, et al. Clinical efficacy and safety of Artesimia annua-Sublingual immunotherapy in seasonal allergic rhinitis patients based on different intervention time. Int Arch Allergy Immunol 2022;183(8):852-859.
  8. Kane NF, Kiani BH, Desrosiers MR, Towler MJ, Weathers PJ. Artemisia extracts differ from artemisinin effects on human hepatic CYP450s 2B6 and 3A4 in vitro. J Ethnopharmacol 2022. DOI
  9. Feng Y, Cao Y, Liu Y, et al. Clinical efficacy and safety of coseasonal initiation of Artemisia annua sublingual immunotherapy on patients with Artemisia-induced rhinoconjunctivitis. Am J Otolaryngol 2023;44(5):103942. PubMed
  10. Yang J, Wang W, Shen Z, et al. Efficacy and safety of Artemisia annua sublingual immunotherapy in patients with seasonal allergic rhinoconjunctivitis over two pollen seasons. Eur Arch Otorhinolaryngol. 2023;280(11):4939-4947. PubMed
  11. Shen Z, Zhang P, Kang W, et al. Clinical efficacy in one-year treatment with Artemisia annua-SLIT drops in monosensitized and polysensitized individuals. Am J Otolaryngol 2023;44(6):104002. PubMed

See these in context on the Sweet Annie monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team