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Dietary supplement

Skullcap Glycerite Ingredients & Drug Interactions

by Herbalist & Alchemist

Skullcap Glycerite label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Skullcap Glycerite against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Skullcap Glycerite is a dietary supplement by Herbalist & Alchemist with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are dried Skullcap herb extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Skullcap Glycerite by Herbalist & Alchemist

Ask about any prescription or over-the-counter medication and we check it for interactions with Skullcap Glycerite by Herbalist & Alchemist — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Skullcap Glycerite by Herbalist & Alchemist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: dried skullcap herb extract. Skullcap is an herbal extract traditionally used for various conditions, though the evidence supporting many of those uses isn't well established.

The liquid is made with vegetable glycerin and distilled water as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Skullcap's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Support for stress and nervous system.
  • We looked for evidence on: Anxiety, Stress, Insomnia, Nervous tension, Relaxation, Sleep quality.
  • The closest evidence on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress.

The evidence supporting skullcap for epilepsy, stress, stroke, spasticity, contact dermatitis, and premenstrual dysphoric disorder (PMDD) is insufficient to rate. We don't hold data showing it's effective for any of these uses, so if you're considering it for a specific health concern, talk it over with your doctor or pharmacist about what the research actually supports.

The evidence, ingredient by ingredient Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Skullcap is often used short-term, but safety data is limited and product quality varies — so use it with care. The most common adverse effects reported are sedation, cognitive impairment, and digestive disturbances.

A single 100 mg dose didn't show CNS effects in research, but 200 mg or higher doses may cause sedation and cognitive impairment. About 9% of people taking 350 mg three times daily for 2 weeks experienced mild digestive upset.

Skullcap is not recommended during pregnancy or while breastfeeding because there isn't enough safety data to know either way. Talk with your doctor or pharmacist before taking it if you're pregnant, planning pregnancy, or nursing.

Side effects, ingredient by ingredient Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Skullcap.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use any CNS depressants — medications that cause drowsiness or slow your thinking, like prescription sleep aids, anti-anxiety drugs, opioids, or certain antihistamines. Skullcap may add to their effects, increasing sedation and cognitive impairment.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Skullcap Glycerite may be worth considering if you're interested in herbal support for relaxation, but be aware the evidence for specific health claims is limited and the safety data is sparse. The main concern is its additive effect with sedating medications — if you take any CNS depressants, check with your doctor or pharmacist first.

Avoid it during pregnancy and breastfeeding, and watch for sedation or digestive upset at higher doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Skullcap Glycerite, straight from the product label.

Brand Herbalist & Alchemist
Barcode (UPC) 667056125325
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD Dec 22, 2019
DSLD ID 209478
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Skullcap Glycerite by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 mL
Maximum serving Sizes:
6 mL
Servings per container
10
UPC/BARCODE
667056125325
IngredientAmount% DV
Calories20 Calorie(s)--
Total Carbohydrates5 Gram(s)2%
dried Skullcap herb extract6 mL--

Other ingredients: Vegetable Glycerin, distilled Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Scutellaria lateriflora

OK

General Statements

Support for stress and nervous system

Botanical preparation ratio 1:5

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested use: 80-120 drops (4-6 mL) in juice or water. Take 4 times per day. Shake well before using.

Precautions

Keep out of children's reach

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

OK

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Skullcap Glycerite by Herbalist & Alchemist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Skullcap Glycerite label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Skullcap Glycerite by Herbalist & Alchemist

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size4 mL Dosage formLiquid Servings per container10 Amounts shown are per serving.

Dried Skullcap herb extract

Interacts with
248 drugs
6 mL per serving

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...

Dried Skullcap herb extract monograph & interactions

Other (inactive) ingredients: Vegetable Glycerin, Distilled Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Skullcap Glycerite by Herbalist & Alchemist Drug Interactions

Want to check YOUR meds against Skullcap Glycerite?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

dried Skullcap herb extract 248

Individual Drug Interactions

The ingredients in Skullcap Glycerite interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Skullcap Glycerite interact with drugs. Each result below shows which ingredient is responsible. dried Skullcap herb extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Skullcap Glycerite with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

dried Skullcap herb extract1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
dried Skullcap herb extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Skullcap Glycerite, from the product label.

Herbalist & Alchemist

See all Herbalist & Alchemist products
Name
Herbalist & Alchemist, Inc.
City
Washington
State
NJ
ZipCode
07882
Phone Number
800-611-8235
Web Address
www.herbalist-alchemist.com
Pharmacist Counseling Corner

Skullcap Glycerite by Herbalist & Alchemist: Common Questions

Does Skullcap Glycerite by Herbalist & Alchemist interact with any medications?
Yes. Based on its ingredients, Skullcap Glycerite has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Skullcap Glycerite contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the side effects I might notice?
The most common ones are sedation, cognitive impairment, and digestive disturbances. About 9% of people taking a high dose (350 mg three times daily for 2 weeks) had mild digestive upset. A single low dose of 100 mg didn't show brain effects, but 200 mg or higher may cause drowsiness and mental fogginess.
Is it safe to take while pregnant or breastfeeding?
No — there isn't enough safety data to know either way. The safety data advises against use during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about your specific situation.
Will this help with stress?
The evidence supporting skullcap for stress relief is insufficient to rate, meaning we don't have enough reliable data to say whether it works. It's traditionally been used for that purpose, but talk with your doctor about whether it's right for you.
Does this product have fillers?
The formula contains vegetable glycerin and distilled water as inactive ingredients — these are the liquid base and carrier for the skullcap extract.
Can I take this with sleep medication?
You should check with your doctor or pharmacist first. Sleep medications are CNS depressants, and skullcap may add to their sedating effects in a way that could be unsafe — that's a Moderate concern. They need to know you're thinking of adding this.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Skullcap Glycerite is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Skullcap Glycerite label
Go deeper

The Full Monographs Behind Skullcap Glycerite’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Skullcap Glycerite's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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