Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Devil's Claw 700 mg Ingredients & Drug Interactions

by Nature's Way

Devil's Claw 700 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Devil's Claw 700 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Devil's Claw 700 mg is a dietary supplement by Nature's Way with 2 active ingredients. Its ingredients are commonly taken for osteoarthritis pain, lower back pain, joint pain and stiffness.Based on those ingredients, 804 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Devil's Claw. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Devil's Claw 700 mg by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Devil's Claw 700 mg by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Devil's Claw 700 mg by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Devil's Claw by Nature's Way contains 2 active ingredients: devil's claw (the dried root and an extract) at 700 mg per capsule. These ingredients are the same plant material in two forms—one whole and one concentrated—working together to deliver the herb's active compounds.

The capsule itself is plant-derived, and magnesium stearate is included as an inactive ingredient to help with manufacturing.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports joint health.
  • We looked for evidence on: Back pain, Osteoarthritis, Rheumatoid arthritis (RA), Tendinopathy, joint pain, joint stiffness — and 1 related terms.
  • The strongest evidence on file: Devil's Claw is rated "Possibly Effective" for Back pain (Natural Medicines).
  • Also on file: Devil's Claw is rated "Possibly Effective" for Osteoarthritis.
  • Also on file: Devil's Claw is rated "Insufficient Reliable Evidence To Rate" for Rheumatoid arthritis (RA), Tendinopathy.

Devil's claw is rated possibly effective for back pain and osteoarthritis based on the evidence we hold. For atherosclerosis, the evidence isn't strong enough to rate it one way or the other.

If you're considering this for joint or back discomfort, the data suggests it may help, but talk with your doctor about whether it fits your situation.

The evidence, ingredient by ingredient Devil's Claw

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Devil's claw is generally well tolerated for short-term use in healthy adults, but it does come with some important cautions. The most common side effects are mild: allergic skin reactions, diarrhea, and indigestion (dyspepsia).

Some people report stomach upset, appetite loss, heartburn, or taste changes—especially at higher doses. Rare but serious cases of gastrointestinal bleeding have been reported.

One trial participant had to stop after 4 days because of a throbbing headache, ringing in the ears, appetite loss, and taste changes; dizziness, drowsiness, and insomnia have also been reported rarely, though it's unclear if devil's claw caused them. Don't use this during pregnancy—the safety data advises against it because devil's claw may affect the uterus.

Avoid it while breastfeeding as well, since there isn't enough safety information. If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before taking it.

Side effects, ingredient by ingredient Devil's Claw

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Devil's Claw.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 805 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Devil's Claw by Nature's Way, double-check with your doctor or pharmacist if you take blood thinners like warfarin (Coumadin)—devil's claw may boost its blood-thinning effect. Also confirm any medications your liver breaks down (especially those processed by CYP2C19, CYP2C9, or CYP3A4 enzymes)—devil's claw may raise their levels.

If you take H2-blockers or proton pump inhibitors (PPIs) for stomach acid, let your provider know, as devil's claw might make them less effective.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Devil's Claw by Nature's Way is an option if you're looking to address back pain or osteoarthritis and want a plant-based approach—the evidence suggests it may help. However, it interacts with a significant number of medications, so if you take any prescription drugs, blood thinners, or stomach acid reducers, check with your doctor or pharmacist first.

It's not right for pregnancy or breastfeeding. Start a conversation with your healthcare provider to make sure it's safe for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Devil's Claw 700 mg, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674610008
Net contents 90 Vegan Capsule(s)
Market status On market
Date entered into DSLD Feb 26, 2020
DSLD ID 213485
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Devil's Claw 700 mg by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
033674610008
IngredientAmount% DV
Devil's Claw260 mg--
Devil's Claw root extract700 mg--

Other ingredients: plant-derived Capsule, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports joint health

Premium extract

Gluten free. No salt, yeast-derived ingredients, corn, wheat, soy, dairy products, or artificial colors, flavors, or preservatives.

Vegan

General Statements

At Nature’s Way, we believe nature knows best. That’s why our mission is to seek out the best herbs the earth has to give. We will go to any continent or country to find where herbs grow best, so we can bring you the purest botanicals possible. It’s the way we deliver uncompromising quality and the way to help you live healthier. It’s not just our way, it’s Nature's Way.

Nature’s Way Since 1969

Bottles made from 97% post-consumer recycled plastic

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Certified Authentic Tru-ID Non Gmo project verified nongmoproject.org

Quality Global Sourcing Bottled & Tested in the USA

Formula

Devil's Claw 700 mg of extract per serving

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Adults take 2 capsules twice daily, preferably with food.

Precautions

Warning: Do not use this product if you have peptic ulcer disease.

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Keep out of reach of children.

Safety sealed with printed inner seal. Do not use if seal is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Devil's Claw 700 mg by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Devil's Claw 700 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Devil's Claw 700 mg by Nature's Way

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Devil's Claw

Interacts with
804 drugs
260 mg per serving

Devil's claw is a southern African plant used mainly for arthritis and back pain, and some studies suggest it may help ease these types of discomfort....

Devil's Claw monograph & interactions

Devil's Claw root extract

Interacts with
804 drugs
700 mg per serving Form: Harpagoside

Devil's claw is a southern African plant used mainly for arthritis and back pain, and some studies suggest it may help ease these types of discomfort....

Devil's Claw root extract monograph & interactions

Other (inactive) ingredients: Plant-derived Capsule, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Devil's Claw 700 mg by Nature's Way Drug Interactions

Want to check YOUR meds against Devil's Claw 700 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
804Drugs
731 Moderate 73 Minor

Ingredients driving the most interactions

Devil's Claw 804

Individual Drug Interactions

The ingredients in Devil's Claw 700 mg interact with 804 drugs. Click any drug to see the details.

1 of the 2 ingredients in Devil's Claw 700 mg interact with drugs. Each result below shows which ingredient is responsible. Devil's Claw

Each ingredient & the kinds of drugs it affects

For each ingredient in Devil's Claw 700 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Devil's Claw7 drug types · 804 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that devil's claw might inhibit CYP2C19, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that devil's claw might inhibit CYP2C9, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that devil's claw might inhibit CYP3A4, although this has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, Devil's claw might increase the activity of warfarin.
In one case report, purpura occurred in a patient taking warfarin and devil's claw concurrently. This might indicate over-anticoagulation. It is unclear if this was due to Devil's claw or other contributing factors.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, devil's claw might decrease the effectiveness of H2-blockers.
Devil's claw has been reported to increase stomach acid, which might interfere with the effects of H2-blockers.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, devil's claw might increase levels of P-glycoprotein substrates.
In vitro research shows that devil's claw inhibits P-glycoprotein, which transports many drugs out of cells. This might increase intracellular levels of P-glycoprotein substrates, although it is unclear if this effect would be clinically important.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, devil's claw might decrease the effectiveness of PPIs.
Devil's claw has been reported to increase stomach acid, which might interfere with the effects of PPIs.

Likelihood Possible Evidence D
Devil's Claw full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Devil's Claw 700 mg, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Devil's Claw 700 mg by Nature's Way: Common Questions

Does Devil's Claw 700 mg by Nature's Way interact with any medications?
Yes. Based on its ingredients, Devil's Claw 700 mg has a known interaction with 804 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Devil's Claw 700 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Devil's Claw if I'm pregnant or breastfeeding?
No—the safety data advises against it. Devil's claw may affect the uterus and safety hasn't been established in pregnancy. There also isn't enough safety information for breastfeeding. Talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or nursing.
What are the most common side effects?
Mild digestive upset is most common: allergic skin reactions, diarrhea, and indigestion. Some people experience stomach upset, appetite loss, heartburn, or taste changes, especially at higher doses. Rare but serious gastrointestinal bleeding has been reported.
Does Devil's Claw actually work for back pain and arthritis?
The evidence suggests it's possibly effective for both back pain and osteoarthritis. That means studies show some promise, but the evidence isn't overwhelming. It may help, but results vary from person to person.
Why does this product interact with so many medications?
Devil's claw appears to affect how your liver processes certain drugs and may interfere with stomach acid medications and blood thinners. These enzyme interactions can theoretically apply to hundreds of medications that your body breaks down the same way, even though human confirmation is limited.
Is Devil's Claw safe to take long-term?
The safety data we hold covers short-term use in healthy adults. If you're thinking about taking it long-term, that's a conversation to have with your doctor or pharmacist, who can weigh the benefits and any risks for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Devil's Claw 700 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Devil's Claw 700 mg label
Go deeper

The Full Monographs Behind Devil's Claw 700 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Devil's Claw

Interacts with 804 drugs

Devil's claw is a southern African plant used mainly for arthritis and back pain, and some studies suggest it may help ease these types of discomfort. The evidence is moderate at best, and p...

Read the full Devil's Claw monograph →
Sources

Sources & How We Checked

Devil's Claw 700 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Devil's Claw 18 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Chantre P, Cappelaere A, Leblan D, et al. Efficacy and tolerance or Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 2000;7:177-83.
  4. Chrubasik S, Thanner J, Kunzel O, et al. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hip. Phytomedicine 2002;9:181-94. PubMed
  5. Circosta C, Occhiuto F, Ragusa S, et al. A drug used in traditional medicine: Harpagophytum procumbens DC. II. Cardiovascular activity. J Ethnopharmacol 1984;11:259-74. PubMed
  6. Grahame R, Robinson BV. Devils's claw (Harpagophytum procumbens): pharmacological and clinical studies. Ann Rheum Dis 1981;40:632. PubMed
  7. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  8. Wegener T, Lupke NP. Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil's claw (Harpagophytum procumbens DC). Phytother Res 2003;17:1165-72.
  9. Chrubasik S, Kunzel O, Thanner J, et al. A 1-year follow-up after a pilot study with Doloteffin for low back pain. Phytomedicine 2005;12:1-9. PubMed
  10. Romiti N, Tramonti G, Corti A, Chieli E. Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein. Phytomedicine 2009;16:1095-100. PubMed
  11. Chrubasik, S., Junck, H., Breitschwerdt, H., Conradt, C., and Zappe, H. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double- blind study. Eur.J Anaesthesiol. 1999;16(2 DOI
  12. Laudahn, D. and Walper, A. Efficacy and tolerance of Harpagophytum extract LI 174 in patients with chronic non-radicular back pain. Phytother.Res. 2001;15(7):621-624.
  13. Belaiche P. Etude clinique de 630 cas d'artrose traites par le nebulisat aqueux d'Harpagophytum procumbens (Radix). Phytotherapy 1982;1:22-28.
  14. Chrubasik S, Model A, Black A, and et al. A randomized double-blind pilot study comparing Doloteffin® and Vioxx® in the treatment of low back pain. Rheumatology 2003;42:141-148.
  15. Cuspidi C, Sala C, Tadic M, et al. Systemic hypertension induced by Harpagophytum procumbens (devil's claw): a case report. J Clin Hypertens (Greenwich) 2015;17(11):908-10.
  16. Mahomed IM, Ojewole JAO. Oxytocin-like effect of Harpagophytum procumbens [Pedaliacae] secondary root aqueous extract on rat isolated uterus. Afr J Trad CAM 2006;3(1):82-89.
  17. Carvalho RR, Donadel CD, Cortez AF, Valviesse VR, Vianna PF, Correa BB. J Bras Nefrol. 2017 Mar;39(1):79-81.
  18. Anon. Devil's claw root: ulcers and gastrointestinal bleeding. Prescrire Int 2013;22(144):296.

See these in context on the Devil's Claw monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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