DHEA-5 Ingredients & Drug Interactions
What is this page for?
First and foremost: checking DHEA-5 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
DHEA-5 is a dietary supplement by Integrative Therapeutics with 1 active ingredient. Its ingredients are commonly taken for anti-aging and low dhea levels, mood and depression, vaginal dryness and sexual health.Based on those ingredients, 776 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dehydroepiandrosterone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against DHEA-5 by Integrative Therapeutics
Ask about any prescription or over-the-counter medication and we check it for interactions with DHEA-5 by Integrative Therapeutics — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of DHEA-5 by Integrative Therapeutics
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
DHEA-5 contains one active ingredient per capsule: dehydroepiandrosterone (DHEA), a hormone your body naturally produces. The capsules also hold inactive ingredients — cellulose, a plant-derived capsule material, and magnesium stearate — which are fillers and binders only.
Does it work?
Strong evidence
DHEA has research backing for vaginal atrophy (drying and thinning of vaginal tissue), where it's rated likely effective. It's rated possibly effective for certain types of infertility and for aging skin.
Some evidence suggests it may help with depression, though the evidence is not conclusive. If you're considering DHEA for any other reason, the research we hold doesn't establish that benefit.
How safe is it?
Well-documented data
DHEA is generally well tolerated at typical doses over the short term, but as a hormone it carries real risks with long-term use — there's concern it may increase cancer risk with prolonged use. The most common side effects are acne (especially in women, usually mild and dose-dependent), headache, insomnia, mood changes, and nausea.
Women may experience masculinizing effects: voice deepening, irregular periods, excess hair growth, oily skin, and genital changes. Men may report aggression and breast enlargement.
DHEA can also trigger mood swings, anxiety, irritability, or mania. The safety data advises against use during pregnancy and breastfeeding — there isn't enough safety information to recommend it while nursing.
Meds to double-check
Moderate interaction found
Before you start DHEA-5, double-check these with your pharmacist: antidepressants (especially SSRIs) — risk of mood episodes; blood thinners and antiplatelet drugs like warfarin and clopidogrel — increased bleeding risk; triazolam (Halcion); cancer medications that block estrogen (aromatase inhibitors, tamoxifen, fulvestrant); and the TB vaccine. DHEA may also affect many other drugs broken down by your liver, so run your full medication list through the checker below.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
DHEA-5 may be worth considering if you're dealing with vaginal atrophy or certain infertility issues, but it's a hormone that needs medical oversight. If you take an antidepressant, blood thinner, sleep aids, cancer medications, or the TB vaccine, talk with your pharmacist or doctor before starting — the interactions are real.
Because long-term use carries unknown risks, this isn't a daily supplement to take casually.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about DHEA-5, straight from the product label.
| Brand | Integrative Therapeutics |
|---|---|
| Barcode (UPC) | 871791000681 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 23, 2021 |
| DSLD ID | 251175 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for DHEA-5 by Integrative Therapeutics, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Dehydroepiandrosterone | 5 mg | -- |
Other ingredients: Cellulose, plant-derived Capsule, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
For more information, please visit integrativepro.com.
Precautions
Keep out of reach of children.
Safety sealed with inner seal. Do not use if seal is broken or missing.
Do not exceed recommended dose. Exceeding the recommended dose may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen.
Warning: Do not use if you are pregnant, nursing, or under the age of 18. If you have a family history of prostate cancer, prostate enlargement, heart disease, low HDL cholesterol, or if you are taking prescription drugs or other dietary supplements, consult a healthcare professional before use.
Warning: Do not use if you are pregnant, nursing, or under the age of 18.
Discontinue use and call a healthcare professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.
Storage
Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.
Seals/Symbols
Quality global sourcing Bottled & tested in the USA
Formulation
Vegan
Contains no wheat, gluten, corn, soy, dairy, or artificial colors, flavors, or preservatives.
Brand IP Statement(s)
Copyright 2021 Integrative Therapeutics, LLC
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Recommendation: Adults take 1 capsule daily.
Formula
Dehydroepiandrosterone 5 mg
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
DHEA-5 by Integrative Therapeutics label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in DHEA-5 by Integrative Therapeutics
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Dehydroepiandrosterone
Interacts with776 drugs
DHEA is a natural hormone that the body makes and that declines with age, and it is sold as a supplement claiming many benefits. The evidence is mixed...
Dehydroepiandrosterone monograph & interactionsOther (inactive) ingredients: Cellulose, Plant-derived Capsule, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
DHEA-5 by Integrative Therapeutics Drug Interactions
HelloPharmacist Interaction Report
DHEA-5 by Integrative Therapeutics contains one active ingredient — dehydroepiandrosterone (DHEA) — that interacts with a significant number of medications.
The most serious documented interaction is with antidepressants (Moderate severity): in a case report, an SSRI combined with DHEA triggered a manic episode, and the risk may be higher in younger people with naturally higher DHEA levels.
Read the full breakdown — every affected drug type, severity by severity
DHEA also has Moderate interactions with blood thinners and antiplatelet drugs (warfarin, clopidogrel, aspirin, and similar agents) — it may increase bleeding risk by inhibiting platelet clumping. It can raise blood levels of triazolam (Halcion), a sleep medication, by blocking its breakdown.
Additionally, DHEA is a potent estrogen agonist and may interfere with cancer drugs that block estrogen: aromatase inhibitors (letrozole, anastrozole, exemestane), tamoxifen, and fulvestrant. It may also reduce the effectiveness of the tuberculosis vaccine.
Finally, DHEA might inhibit the liver enzyme CYP3A4, potentially raising levels of many drugs that depend on it for clearance.
Altogether, these interactions span 766 individual medications. Use the medication checker on this page to verify your exact prescriptions before starting DHEA-5.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against DHEA-5?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in DHEA-5 interact with 776 drugs. Click any drug to see the details.
1 of the 1 ingredient in DHEA-5 interact with drugs. Each result below shows which ingredient is responsible. Dehydroepiandrosterone
Aspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium OxideBufferin
How Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interactionAspirin, CarisoprodolSoma Compound
How Aspirin, Carisoprodol interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Carisoprodol interactionAspirin, Carisoprodol, Codeine PhosphateSoma Compound w/ Codeine
How Aspirin, Carisoprodol, Codeine Phosphate interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Carisoprodol, Codeine Phosphate interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, Citric Acid, Sodium BicarbonateAlka-Seltzer Pain Reliever and Antacid
How Aspirin, Citric Acid, Sodium Bicarbonate interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Citric Acid, Sodium Bicarbonate interactionAspirin, Codeine PhosphateAspirin w/ Codeine
How Aspirin, Codeine Phosphate interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Codeine Phosphate interactionAspirin, Codeine Phosphate, MethocarbamolRobaxisal C
How Aspirin, Codeine Phosphate, Methocarbamol interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Codeine Phosphate, Methocarbamol interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Codeine Phosphate, Phenobarbital interactionAspirin, Diphenhydramine, PhenylpropanolamineAlka Seltzer Plus Night Time Effervescent
How Aspirin, Diphenhydramine, Phenylpropanolamine interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Diphenhydramine, Phenylpropanolamine interactionAspirin, DipyridamoleAggrenox, Asasantin Retard
How Aspirin, Dipyridamole interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Dipyridamole interactionAspirin, Ethoheptazine, MeprobamateEquagesic
How Aspirin, Ethoheptazine, Meprobamate interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Ethoheptazine, Meprobamate interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Hydrocodone interactionAspirin, MeprobamateMicrainin
How Aspirin, Meprobamate interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Meprobamate interactionAspirin, MethocarbamolRobaxisal
How Aspirin, Methocarbamol interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Methocarbamol interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Omeprazole interactionAspirin, OxycodonePercodan
How Aspirin, Oxycodone interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Oxycodone interactionAspirin, PentazocineTalwin Compound
How Aspirin, Pentazocine interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Pentazocine interactionAtazanavirReyataz
How Atazanavir interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Atazanavir interactionAtazanavir, CobicistatEvotaz
How Atazanavir, Cobicistat interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Atazanavir, Cobicistat interactionAtogepantQulipta
How Atogepant interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Atogepant interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Atorvastatin Calcium interactionAtropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, ScopolamineAtrohist Plus, Pro Tuss, Ru-tuss, Stahist
How Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interactionAvacopanTavneos
How Avacopan interacts with DHEA-5 — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Avacopan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in DHEA-5 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Dehydroepiandrosterone
Anticoagulant/Antiplatelet Drugs
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Human and laboratory research show that DHEA and DHEA-S can inhibit platelet aggregation.
Antidepressant Drugs
Theoretically, DHEA might increase the risk of psychiatric adverse events when used with antidepressants.
In a human case report, the use of a selective serotonin reuptake inhibitor (SSRI) with DHEA caused a manic episode. Concern for this interaction may be greater in younger individuals with higher baseline DHEA levels.
Aromatase Inhibitors
Theoretically, DHEA might interfere with the clinical effects of aromatase inhibitors.
DHEA is a potent estrogen agonist, which may antagonize the anti-estrogen activity of aromatase inhibitors.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Some preliminary evidence shows that DHEA may inhibit CYP3A4; however, the clinical significance of this potential interaction is not known.
Fulvestrant (Faslodex)
Theoretically, DHEA might interfere with the anti-estrogen effects of fulvestrant.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist action of fulvestrant in estrogen-receptor positive cancer cells.
Tamoxifen (Nolvadex)
Theoretically, DHEA might interfere with the anti-estrogen effects of tamoxifen.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist activity of tamoxifen in estrogen-receptor positive cancer cells.
Triazolam (Halcion)
DHEA can increase blood levels of triazolam.
Administration of DHEA 200 mg daily for two weeks was shown to inhibit the cytochrome P450 3A4 (CYP3A4) metabolism of triazolam. This inhibition appears to be due to DHEA-S, rather than DHEA.
Tuberculosis Vaccine
DHEA might reduce the effectiveness of the tuberculosis vaccine.
Animal research shows that high doses of DHEA can reduce the efficacy of the Bacillus Calmette-Guérin (BCG) tuberculosis vaccine.
Estrogens
Theoretically, DHEA might increase the effects and adverse effects of estrogen therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. Also, in clinical research, estrogen-progestin oral contraceptives and conjugated estrogens reduce blood levels of DHEA and DHEA-S. The clinical significance of these findings is unclear.
Testosterone
Theoretically, DHEA might increase the effects and side effects of testosterone therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. The clinical significance of these findings is unclear.
Brand information
Manufacturer and brand details for DHEA-5, from the product label.
Integrative Therapeutics
See all Integrative Therapeutics products- Name
- Integrative Therapeutics, LLC
- City
- Green Bay
- State
- WI
- ZipCode
- 54311
- Phone Number
- 800.931.1709
- Web Address
- integrativepro.com
DHEA-5 by Integrative Therapeutics: Common Questions
Does DHEA-5 by Integrative Therapeutics interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take DHEA-5 if I'm pregnant or nursing?
What's the most common side effect?
Is DHEA safe to use long-term?
Does DHEA work for depression?
Can this product affect how my other medications work?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if DHEA-5 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind DHEA-5’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
DHEA-5's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 98 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Dhea 98 references
- Frye RF, Kroboth PD, Folan MM, et al. Effect of DHEA on CYP3A-mediated metabolism of triazolam. Clin Pharmacol Ther 2000;67:109 (abstract PI-82).
- Kuritzky L. DHEA: Science or wishful thinking? Hosp Pract 1998;33:85-6. PubMed
- Van Vollenhoven RF, Morabito LM, Engleman EG, et al. Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months. J Rheumatol 1998;25:285-9.
- Van Vollenhoven RF, Engleman EG, McGurie JL. Dehydroepiandrosterone in Systemic Lupus Erythematosus. Arth Rheum 1995;38:1826-31. DOI
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