Interaction check not available yet — this product's ingredients haven't been matched to our database.
Dietary supplement

Digest Smart Chewable Enzyme Mixed Berry Flavor Ingredients & Drug Interactions

by Renew Life

Digest Smart Chewable Enzyme Mixed Berry Flavor label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digest Smart Chewable Enzyme Mixed Berry Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digest Smart Chewable Enzyme Mixed Berry Flavor is a dietary supplement by Renew Life with 4 active ingredients.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digest Smart Chewable Enzyme Mixed Berry Flavor by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Digest Smart Chewable Enzyme Mixed Berry Flavor by Renew Life — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Digest Smart Chewable Enzyme Mixed Berry Flavor by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 11 active ingredients.
  • “Plant Enzyme Blend:” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Protein Enzyme Activity Values” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Fat Enzyme Activity Value” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Digest Smart contains 11 active ingredients, all digestive enzymes designed to break down different parts of your food. Bromelain comes from pineapple and helps digest protein.

Protease and acid protease also break down proteins. Lipase handles fats.

Lactase breaks down milk sugar (lactose). Cellulase, hemicellulase, and phytase break down plant fiber and carbohydrates.

Glucoamylase and alpha-galactosidase round out the carb digestion. The product also lists inactive ingredients—fillers and binders like xylitol, cellulose, and silica—to hold the tablet together and provide the mixed berry flavor.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support digestive health and nutrient absorption.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, Inflammatory bowel disease (IBD), Celiac disease, Bloating and gas, Indigestion — and 1 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Inflammatory bowel disease (IBD), Dyspepsia, Celiac disease.

The evidence on these enzymes is mixed and often limited. Lactase is effective for lactose intolerance—that's well established.

For the other enzymes in this blend—bromelain, protease, lipase, phytase—the evidence isn't strong enough to rate how well they work. We hold insufficient reliable evidence for claims about hay fever, burns, cancer support, or various digestive conditions.

If you're taking this to help with digestion in general, the data we have doesn't prove it works for that purpose.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these enzymes are generally well tolerated in the short term. The main concerns are rare allergic reactions—some people may react to bromelain, protease, or phytase if they're sensitized to them, especially through inhalation in occupational settings.

Bromelain has caused side effects like diarrhea, flatulence, gastric upset, and headache in some people. Protease may also cause digestive upset.

Lactase is well tolerated when used as directed. If you have a serious digestive condition, talk to your doctor before starting any enzyme supplement.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 5 matched ingredients can interact with medications — Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take blood thinners or antiplatelet drugs—bromelain in this product may increase bleeding risk (moderate severity). Also check if you take tetracycline antibiotics, as bromelain may theoretically raise their levels, though this is minor and hasn't been proven in people.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking for digestive enzyme support and don't take blood thinners or tetracycline antibiotics, this product is generally well tolerated. If you do take either of those drug types, check your exact medications with the tool on this page before you start.

Anyone with a serious digestive condition or a known allergy to pineapple or enzyme supplements should talk to their pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digest Smart Chewable Enzyme Mixed Berry Flavor, straight from the product label.

Brand Renew Life
Barcode (UPC) 631257159762
Net contents 90 Chewable Tablet(s)
Market status On market
Date entered into DSLD Jun 25, 2018
DSLD ID 178231
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digest Smart Chewable Enzyme Mixed Berry Flavor by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
90
UPC/BARCODE
631257159762
IngredientAmount% DV
Calories3 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Amylase0 NP--
Bromelain0 NP--
Protease0 NP--
Lipase0 NP--
Lactase0 NP--
Sugar Alcohol1 Gram(s)--
Cellulase0 NP--
Alpha-Galactosidase0 NP--
Acid Protease0 NP--
Phytase0 NP--
Hemicellulase0 NP--
Plant Enzyme Blend:0 NP--
Protein Enzyme Activity Values0 NP--
Fat Enzyme Activity Value0 NP--
Fiber Enzyme Activity Value0 NP--
Carbohydrate Enzyme Activity Values:0 NP--
Glucoamylase, Powder0 NP--

Other ingredients: Xylitol, Stearic Acid, Cellulose, Raspberry, Malic Acid, Rice Dextrin, Silica, Monk Fruit, Magnesium Stearate, natural Berry flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

65558A

Digestive wellness, naturally At Renew Life, we believe a healthy gut is a happy gut. For nearly two decades, we have pioneered superior-quality digestive care supplements to help people achieve optimal health from the inside out.

Good for your gut! Your gut is your engine, your digestive core. Keep it running smoothly at every meal with Renew Life digestive enzymes.

Our multi-functional, plant-based blends promote optimal digestion and nutrient availability so you feel better, lighter, and more energized.

Benefits you can feel Today's highly processed and cooked foods often lacks digestive enzymes, so your body may have to work harder to break down and absorb nutrients. Our potent enzyme formulas work hard to support digestion and unlock the nutrient goodness found in your food. Multi-enzyme formula Good digestive balance is key to your well-being.

Live digestively.

New!

Formula

Chewable digestive enzyme

Digest Smart Chewable Enzyme is formulated with 12 plant-based enzymes to help your body's natural processes break down proteins, carbohydrates, fats, and fiber so you can comfortably enjoy more of your favorite foods.

Each delicious tablet is bursting with natural mixed berry flavor, and contains no artificial ingredients.

Digest Smart is made with multiple enzymes to support the breakdown of proteins, carbohydrates, and fats for digestive balance and harmony.

Suggested/Recommended/Usage/Directions

Just one Digest Smart Chewable Enzyme before each meal helps promote optimal digestion and nutrient available to support your digestive health.

Directions: Chew one (1) tablet before each meal.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Tamper Evident: Do not use if safety seal on bottle is broken or missing.

May contain traces of soy, milk and wheat from ingredients used in the fermentation process to make enzymes.

Keep out of reach of children.

Consult your healthcare professional before using this or any product if you are pregnant, nursing, or under medical supervision.

Formulation

Plant-based formula

Helps digest all types of food Promotes optimal digestion Great tasting chewable tablet

No artificial ingredients

Quality, purity, and potency guaranteed through expiration.

Manufactured in USA in a GMP facility.

FDA Statement of Identity

Enzyme Supplement

Storage

Store at 77 degrees F (25 degrees C) or below.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digest Smart Chewable Enzyme Mixed Berry Flavor by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digest Smart Chewable Enzyme Mixed Berry Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digest Smart Chewable Enzyme Mixed Berry Flavor by Renew Life

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Plant Enzyme Blend:

0 NP per serving
  • › Protein Enzyme Activity Values
  • › Fat Enzyme Activity Value
  • › Fiber Enzyme Activity Value
  • › Carbohydrate Enzyme Activity Values:

Other (inactive) ingredients: Xylitol, Stearic Acid, Cellulose, Raspberry, Malic Acid, Rice Dextrin, Silica, Monk Fruit, Magnesium Stearate, Natural Berry flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digest Smart Chewable Enzyme Mixed Berry Flavor by Renew Life Drug Interactions

Want to check YOUR meds against Digest Smart Chewable Enzyme Mixed Berry Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Digest Smart Chewable Enzyme Mixed Berry Flavor interact with 141 drugs. Click any drug to see the details.

0 of the 4 ingredients in Digest Smart Chewable Enzyme Mixed Berry Flavor interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Digest Smart Chewable Enzyme Mixed Berry Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Digest Smart Chewable Enzyme Mixed Berry Flavor, from the product label.

Renew Life

Name
Renew Life Formulas
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
1-800-830-1800
Pharmacist Counseling Corner

Digest Smart Chewable Enzyme Mixed Berry Flavor by Renew Life: Common Questions

Does Digest Smart Chewable Enzyme Mixed Berry Flavor by Renew Life interact with any medications?
Yes. Based on its ingredients, Digest Smart Chewable Enzyme Mixed Berry Flavor has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digest Smart Chewable Enzyme Mixed Berry Flavor contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant?
Bromelain safety data advises against use in pregnancy. For the other enzymes—protease, acid protease, lipase, phytase—there isn't enough data to know either way. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy.
What about breastfeeding?
Safety while breastfeeding hasn't been well studied for most of the enzymes here. Bromelain should be avoided. Check with your doctor or pharmacist before using this product if you're nursing.
Will this help me digest food better?
The evidence isn't strong enough to say these enzymes improve digestion in general. Lactase, one of the ingredients, does work for breaking down milk sugar if you have lactose intolerance. For the others, we don't have reliable proof they help with digestion.
Can I take this if I have a sensitive stomach?
Bromelain and protease may cause diarrhea, flatulence, gastric upset, or nausea in some people. If you have a serious digestive condition, check with your doctor before starting—these enzymes might not be right for you without medical guidance.
Could I be allergic to this?
Yes. Rare allergic reactions have been reported with bromelain, protease, and phytase. If you have a known allergy to pineapple, enzyme supplements, or any of these ingredients, avoid this product and talk to your pharmacist.
Does this product have a lot of fillers?
It contains several inactive ingredients—xylitol, cellulose, silica, stearic acid, and magnesium stearate—which are standard binders and flow agents. If you prefer minimal additives, this may not be the best fit for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digest Smart Chewable Enzyme Mixed Berry Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digest Smart Chewable Enzyme Mixed Berry Flavor label
Sources

Sources & How We Checked

Digest Smart Chewable Enzyme Mixed Berry Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Phytase 7 references
  1. Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
  2. Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
  3. van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
  4. Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
  5. Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
  6. Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
  7. Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.

See these in context on the Phytase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team