Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Digestive Aid Ingredients & Drug Interactions

by Solgar

Digestive Aid label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Aid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digestive Aid is a dietary supplement by Solgar with 6 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 38 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Betaine HCl, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Digestive Aid by Solgar

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Aid by Solgar — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Digestive Aid by Solgar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Solgar's Digestive Aid contains 6 active ingredients designed to support digestion. Papain is an enzyme from papaya that breaks down protein.

Amylase and pancreatin are enzymes that help digest carbohydrates and fats. Pepsin is a protease (protein-digesting enzyme) that works in the stomach.

Betaine HCl is a form of hydrochloric acid that raises stomach acidity. Ox bile extract aids fat digestion.

The tablet also contains inactive ingredients — fillers and binders like cellulose, calcium carbonate, silica, and a touch of peppermint powder for flavor.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: digestive enzymes for nutrient breakdown and digestion.
  • We looked for evidence on: Dyspepsia, indigestion, bloating, gas.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The data we hold doesn't establish that papain works for cancer, dental cavities, radiation burns, muscle soreness, shingles, or parasite infections — the evidence is insufficient to rate it. Similarly, we have no reliable evidence that betaine HCl is effective for indigestion, low thyroid, diarrhea, rheumatoid arthritis, food allergies, or hay fever.

For pepsin and the other digestive enzymes in this product, effectiveness information isn't on file in our data. If you're considering this for a specific digestive complaint, talk with your doctor or pharmacist about whether the evidence supports it for your situation.

The evidence, ingredient by ingredient Papain Proteolytic Enzymes (proteases) Betaine Hydrochloride

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally well tolerated when used short-term and at normal doses, though some people have allergic reactions — itchy eyes, runny nose, sneezing, stomach cramps, or diarrhea. High doses may cause serious problems like esophageal perforation or severe inflammation of the stomach lining.

Pepsin and betaine HCl are generally well tolerated too, but betaine HCl can irritate the stomach and should be avoided if you have ulcers, gastritis, or reflux. During pregnancy, concentrated papain and unripe papaya products aren't recommended due to safety concerns, and there isn't enough data to know if supplemental papain is safe while breastfeeding — talk with your doctor or pharmacist before using it.

For betaine HCl, the safety data advises against it during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Papain Proteolytic Enzymes (proteases) Betaine Hydrochloride

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Papain, Betaine Hydrochloride.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 38 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or other blood thinners, talk with your pharmacist before using this product — papain may increase bleeding risk. Also double-check before starting if you take H2-blockers, antacids, or proton pump inhibitors (PPIs) for reflux or ulcers, since betaine HCl may reduce their effectiveness.

No interactions are documented for amylase, ox bile extract, or pancreatin in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with digestion if you don't have a bleeding disorder, take warfarin, or use stomach-acid-lowering medications. If you take any prescription medications — especially blood thinners or reflux drugs — check with your doctor or pharmacist before starting.

People with ulcers, gastritis, or reflux should avoid betaine HCl. Pregnant or breastfeeding women should confirm safety with their doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Aid, straight from the product label.

Brand Solgar
Barcode (UPC) 033984010017
Net contents 250 Tablet(s)
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 217649
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Aid by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
033984010017
IngredientAmount% DV
Papain32 mg--
Amylase65 mg--
Pepsin30 mg--
Betaine HCl65 mg--
Ox Bile extract130 mg--
Pancreatin130 mg--

Other ingredients: Calcium Carbonate, Microcrystalline Cellulose, Vegetable Cellulose, natural Peppermint (leaf) powder, Silica, Vegetable Magnesium Stearate, Vegetable Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Digestive enzymes break down the nutritional components of foods, making these nutrients available for the body’s energy needs, cell growth and other vital functions required for optimal health. In Solgar’s proprietary digestive aid formula, each of these digestive enzymes help to further break down the individual macronutrients, carbohydrates, fats and proteins, and assist in the assimilation of food.

Gluten & wheat free

Free of: Gluten, wheat, soy, yeast, sugar, sodium, artificial flavor, sweetener and color.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

2014 Solgar Inc.

General Statements

Solgar since 1947

FDA Statement of Identity

Dietary Supplement

Precautions

Contains milk.

If you are pregnant, nursing, taking any medications or have any medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Discontinue use and consult your healthcare practitioner if any adverse reactions occur.

Keep out of reach of children.

Do not use if outer bottle seal is missing or damaged.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement for adults, take one (1) tablet before each meal or as directed by a healthcare practitioner.

Storage

Store at room temperature.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Aid by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Aid label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Aid by Solgar

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papain

Interacts with
2 drugs
32 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Amylase

65 mg per serving Form: Aspergillus oryzae

Pepsin

No known
interactions
30 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Betaine HCl

Interacts with
36 drugs
65 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine HCl monograph & interactions

Ox Bile extract

130 mg per serving

Pancreatin

130 mg per serving

Other (inactive) ingredients: Calcium Carbonate, Microcrystalline Cellulose, Vegetable Cellulose, Natural Peppermint (leaf) powder, Silica, Vegetable Magnesium Stearate, Vegetable Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Aid by Solgar Drug Interactions

Want to check YOUR meds against Digestive Aid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
38Drugs
2 Moderate 36 Minor

Ingredients driving the most interactions

Betaine HCl 36
Papain 2

Individual Drug Interactions

The ingredients in Digestive Aid interact with 38 drugs. Click any drug to see the details.

2 of the 6 ingredients in Digestive Aid interact with drugs. Each result below shows which ingredient is responsible. Betaine HCl Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Aid with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine HCl full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Aid, from the product label.

Solgar

See all Solgar products
Name
Solgar, Inc.
Street Address
500 Willow Tree Road
City
Leonia
State
NJ
ZipCode
07605
Phone Number
1-877-765-4274
Web Address
www.solgar.com
Pharmacist Counseling Corner

Digestive Aid by Solgar: Common Questions

Does Digestive Aid by Solgar interact with any medications?
Yes. Based on its ingredients, Digestive Aid has a known interaction with 38 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Aid contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is papain safe if I'm pregnant or breastfeeding?
No — concentrated papain and unripe papaya products are not recommended in pregnancy. There isn't enough safety data to recommend supplemental papain while breastfeeding either. Talk with your doctor or pharmacist before using this product if you're pregnant or nursing.
Can I take this with my acid reflux medication?
Not safely — betaine HCl in this product increases stomach acid, which could reduce how well your H2-blocker, antacid, or PPI works. Check with your pharmacist or doctor before taking it if you use any of these medications.
What's papain, and does it really help digestion?
Papain is a protein-digesting enzyme from papaya. The data we hold doesn't establish that it's effective for any specific condition, so we can't say whether it will help your digestion. If digestion is a concern, talk with your doctor about whether this product makes sense for you.
What are the digestive enzymes in this — amylase and pancreatin?
Amylase breaks down carbohydrates, and pancreatin is a mix of enzymes from the pancreas that digest fats and proteins. We don't hold effectiveness data for them in our system, so I can't tell you how well they work in this form.
Can papain cause allergic reactions?
Yes, in people sensitive to it. Reactions can include itchy eyes, runny nose, sneezing, stomach cramps, sweating, and diarrhea. If you've had reactions to papaya or papain before, avoid this product.
Is betaine HCl safe for people with stomach ulcers?
No — betaine HCl increases stomach acid, which can irritate ulcers and slow healing. It's best avoided if you have ulcers, gastritis, or reflux.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Aid is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Aid label
Go deeper

The Full Monographs Behind Digestive Aid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph →
Sources

Sources & How We Checked

Digestive Aid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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