Digestive Enzymes Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Digestive Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Digestive Enzymes is a dietary supplement by Dr. Drew Sinatra with 9 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 333 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Legume and Grain Digestive Enzymes, Bromelain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Digestive Enzymes by Dr. Drew Sinatra
Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Enzymes by Dr. Drew Sinatra — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Digestive Enzymes by Dr. Drew Sinatra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Dr. Drew Sinatra Digestive Enzymes contains 10 active ingredients—individual digestive enzymes and enzyme blends designed to break down different food components.
Protease breaks down protein; bromelain (from pineapple) also targets protein; lactase handles lactose; lipase breaks down fat; and amylase, cellulase, hemicellulase, xylanase, beta-glucanase, and alpha-galactosidase work on carbohydrates, fiber, and complex starches. The product also contains inactive ingredients—hydroxypropyl methylcellulose, maltodextrin, microcrystalline cellulose, and medium chain triglycerides—which are fillers and capsule materials.
Does it work?
Strong evidence
Lactase in this product is rated effective for lactose intolerance. For the other ingredients—protease, bromelain, lipase, and the carbohydrate and fiber enzymes—the evidence we hold does not establish clear effectiveness; the data shows insufficient reliable evidence to rate them for conditions like indigestion, inflammatory bowel disease, or general digestive support.
How safe is it?
Well-documented data
Protease and bromelain are generally well tolerated short-term when taken by mouth, though some people report digestive upset, diarrhea, flatulence, headache, or nausea. Rarely, either can trigger allergic reactions—including IgE-mediated responses or, if inhaled as powder, respiratory symptoms like asthma or throat itching.
Lactase is generally well tolerated; lipase also appears well tolerated in supplement form, though serious adverse effects are rare and safety data in pregnancy and breastfeeding for these enzymes is limited. Protease and bromelain are best avoided during pregnancy unless prescribed; safety data during breastfeeding is not established for either, so medical advice is needed.
Lactase is rated likely safe in pregnancy. For lipase, there is little data in pregnancy, and breastfeeding safety has not been well studied—talk with your doctor or pharmacist for personalized guidance.
Meds to double-check
Moderate interaction found
If you take blood thinners or antiplatelet drugs (such as warfarin, apixaban, aspirin, or clopidogrel), bromelain in this product may increase bleeding risk—check with your doctor or pharmacist before taking it. Tetracycline antibiotics might have higher blood levels if combined with bromelain, though human data is limited.
For all other medications, run them through the checker below.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product may help if you have lactose intolerance or want general digestive enzyme support, though evidence for the other enzymes isn't clearly established in our data. If you take blood thinners, antiplatelet drugs, or tetracycline antibiotics, check with your doctor or pharmacist before starting.
Protease and bromelain are not recommended in pregnancy unless prescribed; if you are pregnant or breastfeeding, discuss this product with your healthcare provider first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Digestive Enzymes, straight from the product label.
| Brand | Dr. Drew Sinatra |
|---|---|
| Barcode (UPC) | 678829202419 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 24, 2019 |
| DSLD ID | 201349 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Digestive Enzymes by Dr. Drew Sinatra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Protease | 0 NP | -- |
| Protein Digestive Enzymes | 0 NP | -- |
| Bromelain | 0 NP | -- |
| Carbohydrate Digestive Enzyme | 0 NP | -- |
| Fiber and Complex Carbohydrate Digestive Enzymes | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Hemicellulase | 0 NP | -- |
| Xylanase | 0 NP | -- |
| Legume and Grain Digestive Enzymes | 0 NP | -- |
| Beta-Glucanase | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Lactose Digestive Enzyme | 0 NP | -- |
| Lactase | 0 NP | -- |
| Fat Digestive Enzymes | 0 NP | -- |
| Lipase | 0 NP | -- |
| Amylase | 0 NP | -- |
Other ingredients: Hydroxypropyl Methylcellulose, Maltodextrin, Microcrystalline Cellulose, Medium Chain Triglycerides
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Unconditionally guaranteed for purity and labeled potency.
For digestive health
Storage
To preserve quality and freshness, store bottle with cap tightly closed in a cool, dry place.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Doctor’s Suggested Use: Take 1 or more capsules prior to each meal as needed.
Precautions
Note: If you are pregnant or lactating, consult a health care professional before taking this product.
Keep out of reach of children.
General
SKU: DDE 02 C11000, 2016 R-1
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Digestive Enzymes by Dr. Drew Sinatra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Digestive Enzymes by Dr. Drew Sinatra
These are the 9 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Carbohydrate Digestive Enzyme
- › Amylase
Fiber and Complex Carbohydrate Digestive Enzymes
- › Cellulase
- › Hemicellulase
- › Xylanase
Legume and Grain Digestive Enzymes
Interacts with195 drugs
Calabar bean is a highly poisonous West African seed that contains physostigmine, a powerful cholinesterase inhibitor. It is not a safe dietary supple...
Legume and Grain Digestive Enzymes monograph & interactions- › Beta-Glucanase
- › Alpha-Galactosidase
Lactose Digestive Enzyme
- › Lactase
Fat Digestive Enzymes
- › Lipase
Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Maltodextrin, Microcrystalline Cellulose, Medium Chain Triglycerides. These complete the product’s ingredient list but are not active constituents.
Digestive Enzymes by Dr. Drew Sinatra Drug Interactions
HelloPharmacist Interaction Report
Dr.
Drew Sinatra Digestive Enzymes has documented interactions through two of its active ingredients: bromelain and protease. The most serious concern is bromelain's moderate interaction with blood thinners and antiplatelet drugs (anticoagulants and antiplatelet medications), which may increase bleeding risk.
Read the full breakdown — every affected drug type, severity by severity
Bromelain also has a minor interaction with tetracycline antibiotics; lab studies suggest it might increase how your body absorbs them, though a human study found no difference in blood levels. Protease carries a rare risk of allergic reactions, particularly from airborne exposure—occupational cases have included allergic rhinitis and asthma.
Lactase and lipase, the other checked ingredients, have no interactions documented in our data. We could not check cellulase, hemicellulase, xylanase, beta-glucanase, alpha-galactosidase, or amylase—no interaction data is on file for these.
Altogether, these interactions span 141 individual medications.
Before starting this product, use the interaction checker below with your exact medications, especially if you take blood thinners, antiplatelet drugs, or tetracycline antibiotics.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Digestive Enzymes?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Digestive Enzymes interact with 333 drugs. Click any drug to see the details.
2 of the 9 ingredients in Digestive Enzymes interact with drugs. Each result below shows which ingredient is responsible. Legume and Grain Digestive Enzymes Bromelain
AcepromazineAtravet
How Acepromazine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acepromazine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, Doxylamine, PseudoephedrineEx Strength Tylenol Sinus Nighttime
How Acetaminophen, Doxylamine, Pseudoephedrine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Doxylamine, Pseudoephedrine interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Pamabrom, Pyrilamine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAclidinium BromideTudorza Pressair
How Aclidinium Bromide interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Aclidinium Bromide interactionAclidinium Bromide, Formoterol Fumarate DihydrateDuaklir Pressair
How Aclidinium Bromide, Formoterol Fumarate Dihydrate interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Aclidinium Bromide, Formoterol Fumarate Dihydrate interactionAerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
How Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interactionAmantadineGocovri, Osmolex ER, Symmetrel
How Amantadine interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Amantadine interactionAminoglutethimideCytadren
How Aminoglutethimide interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Aminoglutethimide interactionAmitriptylineElavil
How Amitriptyline interacts with Digestive Enzymes — through 1 ingredient. Tap an ingredient for the detail:
Legume And Grain Digestive EnzymesAnticholinergic Drugs Minor
Interaction Summary
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Read the full Legume And Grain Digestive Enzymes + Amitriptyline interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Digestive Enzymes with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Legume and Grain Digestive Enzymes
Anticholinergic Drugs
Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Physostigmine, a constituent of calabar bean, reverses the effects of belladonna and other drugs with anticholinergic activity.
Bromelain
Anticoagulant/Antiplatelet Drugs
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.
Tetracycline Antibiotics
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.
Brand information
Manufacturer and brand details for Digestive Enzymes, from the product label.
Dr. Drew Sinatra
See all Dr. Drew Sinatra products- Name
- Healthy Directions
- City
- Bethesda
- State
- MD
- ZipCode
- 20817
- Phone Number
- 1-866-599-9491
- Web Address
- www.healthydirections.com
Digestive Enzymes by Dr. Drew Sinatra: Common Questions
Does Digestive Enzymes by Dr. Drew Sinatra interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help with bloating and gas?
Can I take this if I'm pregnant?
Is this safe while breastfeeding?
Can this cause allergic reactions?
What are the most common side effects?
Does this actually help lactose intolerance?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Digestive Enzymes is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Digestive Enzymes’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographBromelain
Interacts with 141 drugsBromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...
Read the full Bromelain monograph → Herb & supplement monographCalabar Bean
Interacts with 195 drugsCalabar bean is a highly poisonous West African seed that contains physostigmine, a powerful cholinesterase inhibitor. It is not a safe dietary supplement, and eating the bean can cause seri...
Read the full Calabar Bean monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph →Sources & How We Checked
Digestive Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Bromelain 19 references
- Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
- Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
- Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
- Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
- Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
- Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
- Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
- Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
- Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
- Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
- Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
- Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
- Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
- Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
- Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
- Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
- Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
- Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
- Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed
Calabar Bean 2 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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