Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

DIM 200 plus CDG 100 Ingredients & Drug Interactions

by Protocol For Life Balance

DIM 200 plus CDG 100 label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DIM 200 plus CDG 100 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

DIM 200 plus CDG 100 is a dietary supplement by Protocol For Life Balance with 4 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 615 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sodium Copper Chlorophyllin, DIM, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against DIM 200 plus CDG 100 by Protocol For Life Balance

Ask about any prescription or over-the-counter medication and we check it for interactions with DIM 200 plus CDG 100 by Protocol For Life Balance — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of DIM 200 plus CDG 100 by Protocol For Life Balance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 4 active ingredients. Calcium supports bone health and is used to treat low calcium levels, heartburn, and high potassium; it's the main workhorse here.

DIM (diindolylmethane) is a compound from cruciferous vegetables like broccoli. Sodium copper chlorophyllin is a semi-synthetic form of chlorophyll, the green pigment in plants.

Calcium D-glucarate is a compound derived from calcium and glucaric acid. The capsules also contain inactive ingredients — hypromellose, microcrystalline cellulose, stearic acid, and silicon dioxide — that help hold the formula together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: healthy hormone metabolism and detoxification.
  • We looked for evidence on: Acne, Dysmenorrhea, Mastalgia, Premenstrual syndrome (PMS), Prostate cancer, Benign prostatic hyperplasia (BPH) — and 3 related terms.
  • The strongest evidence on file: Calcium is rated "Likely Effective" for Premenstrual syndrome (PMS) (Natural Medicines).
  • Also on file: Calcium D-glucarate is rated "Insufficient Reliable Evidence To Rate" for Prostate cancer.
  • Also on file: Chlorophyllin is rated "Insufficient Reliable Evidence To Rate" for Acne, Cancer.

Calcium in this product is rated Likely Effective for osteoporosis prevention and Effective for bone health, treating low calcium levels, heartburn (dyspepsia), kidney failure, and elevated potassium (hyperkalemia). The other three ingredients — DIM, sodium copper chlorophyllin, and calcium D-glucarate — all lack established evidence.

The data we hold shows insufficient reliable evidence to rate DIM for prostate health, breast concerns, colorectal or cervical health, or breast pain. Chlorophyllin is possibly ineffective for urinary odor and has insufficient evidence for acne, cancer prevention, constipation, gas, or low white blood cell counts.

Calcium D-glucarate similarly lacks established evidence for breast, prostate, or colorectal cancer. If you're taking this product mainly for one of these latter purposes, the evidence doesn't yet support that use.

The evidence, ingredient by ingredient Calcium Diindolylmethane Chlorophyllin Calcium D-glucarate

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated at recommended doses, though high amounts can cause problems. Common side effects when taken by mouth are belching, constipation, diarrhea, gas, and upset stomach.

Rare serious concerns include kidney stones and a condition called calciphylaxis. There's also some concern that very high calcium intake — over 1500 to 2000 mg daily — might increase prostate cancer risk and possibly cardiovascular risk, though research on this is mixed and debated.

DIM is generally well tolerated short-term, though long-term safety isn't firmly established. Common side effects include diarrhea, gas, headache, nausea, rash, and vomiting; a rare serious reaction (DRESS syndrome) has been reported.

One case linked DIM to stroke, but the patient had multiple risk factors, so it's unclear whether DIM was responsible. Sodium copper chlorophyllin is generally well tolerated short-term but may cause photosensitization and pseudoporphyria (a blistering condition mimicking porphyria) in rare cases.

Calcium D-glucarate appears generally tolerated in small studies, though long-term human safety data are limited. For pregnancy: calcium is considered likely safe at recommended amounts; DIM is likely safe; but sodium copper chlorophyllin and calcium D-glucarate lack enough safety information and should be avoided in pregnancy.

For breastfeeding: calcium and DIM are acceptable at recommended amounts; chlorophyllin and calcium D-glucarate should be avoided due to insufficient safety data.

Side effects, ingredient by ingredient Calcium Diindolylmethane Chlorophyllin Calcium D-glucarate

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Calcium D-glucarate, Chlorophyllin, Calcium, Diindolylmethane.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 615 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking DIM 200 plus CDG 100, double-check with your doctor or pharmacist if you take: HIV integrase inhibitors (dolutegravir, elvitegravir), ceftriaxone, thyroid medication (levothyroxine), heart rhythm drugs (sotalol, diltiazem), estrogen or hormone replacement therapy, diuretics (especially sodium-depleting ones), any drug metabolized through the liver enzyme CYP1A2, or photosensitizing medications. If you take any HIV medication, thyroid drug, or ceftriaxone, spacing and timing matter — don't start this without your prescriber's input.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product's calcium content makes it useful if you need supplemental calcium for bone health or related conditions, but it carries significant interactions — especially with HIV medications and the antibiotic ceftriaxone, and with thyroid and heart rhythm drugs. DIM, chlorophyllin, and calcium D-glucarate lack proven effectiveness for most uses they're marketed for.

Check with your doctor or pharmacist before starting, particularly if you take any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DIM 200 plus CDG 100, straight from the product label.

Brand Protocol For Life Balance
Barcode (UPC) 707359130494
Net contents 90 Veg Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2022
DSLD ID 258656
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DIM 200 plus CDG 100 by Protocol For Life Balance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
Servings per container
90
UPC/BARCODE
707359130494
IngredientAmount% DV
Calcium12 mg1%
DIM200 mg--
Sodium Copper Chlorophyllin20 mg--
Calcium D-Glucarate Tetrahydrate100 mg--

Other ingredients: Hypromellose, Microcrystalline Cellulose, Stearic Acid, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: Take 1 capsule daily with a meal, or as directed by your healthcare practitioner.

Formula

How it works: Protocol For Life Balance DIM 200 plus CDG 100 promotes healthy hormone metabolism by supporting your body's normal detoxification processes. The featured ingredient, diindolylmethane (DIM), is a phytochemical that's a metabolite of certain compounds found in cruciferous vegetables such as broccoli, Brussel sprouts, and cabbage. We've also included calcium D-glucarate (CDG) to support the glucuronidation process, an important mechanism of detoxification, aiding in the elimination of certain environmental toxins from the body.

- Diindolylmethane plus Calcium D-Glucarate

Precautions

Causes/Interactions: For adults only.

Do not take this product if you are pregnant, may become pregnant or nursing. Consult your healthcare practitioner if taking medication or have a medical condition.

Keep out of reach of children.

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Natural color variation may occur in this product.

- Promotes healthy hormone metabolism

Non-GMO

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients.

FDA Statement of Identity

A Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DIM 200 plus CDG 100 by Protocol For Life Balance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DIM 200 plus CDG 100 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DIM 200 plus CDG 100 by Protocol For Life Balance

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Calcium

Interacts with
168 drugs
12 mg per serving Form: Calcium D-Glucarate

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

DIM

Interacts with
269 drugs
200 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

DIM monograph & interactions

Sodium Copper Chlorophyllin

Interacts with
335 drugs
20 mg per serving Form: Chlorophyll

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing....

Sodium Copper Chlorophyllin monograph & interactions

Calcium D-Glucarate Tetrahydrate

Interacts with
126 drugs
100 mg per serving

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the bo...

Calcium D-Glucarate Tetrahydrate monograph & interactions

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Stearic Acid, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

DIM 200 plus CDG 100 by Protocol For Life Balance Drug Interactions

Want to check YOUR meds against DIM 200 plus CDG 100?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
615Drugs
7 Major 535 Moderate 73 Minor

Ingredients driving the most interactions

Sodium Copper Chlorophyllin 335
DIM 269
Calcium 168
Calcium D-Glucarate Tetrahydrate 126

Individual Drug Interactions

The ingredients in DIM 200 plus CDG 100 interact with 615 drugs. Click any drug to see the details.

4 of the 4 ingredients in DIM 200 plus CDG 100 interact with drugs. Each result below shows which ingredient is responsible. Sodium Copper Chlorophyllin DIM Calcium Calcium D-Glucarate Tetrahydrate

Each ingredient & the kinds of drugs it affects

For each ingredient in DIM 200 plus CDG 100 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium Copper Chlorophyllin1 drug type · 335 drugs

Photosensitizing Drugs

Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Chlorophyllin is a semi-synthetic derivative of chlorophyll. Chlorophyll has been reported to cause photosensitization. Orally, chlorophyll has also been associated with the development of pseudoporphyria in multiple case reports.

Likelihood Probable Evidence B
Sodium Copper Chlorophyllin full monograph & interactions

DIM3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
DIM full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Calcium D-Glucarate Tetrahydrate3 drug types · 126 drugs

Alcohol (Ethanol)

Theoretically, concomitant use with alcohol might decrease calcium D-glucarate activity.
There is some evidence that urinary excretion of calcium D-glucarate metabolites increases in people consuming alcohol.

Likelihood Possible Evidence B
Glucuronidated Drugs

Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.
The calcium D-glucarate metabolite, D-glucaro-1,4-lactone, inhibits the enzyme beta-glucuronidase, reducing deconjugation of glucuronides in the intestine and thereby reducing reabsorption of the drugs.

Likelihood Possible Evidence B
Kanamycin

Theoretically, calcium D-glucarate may reduce plasma levels of kanamycin.
Calcium D-glucarate may increase the rate of kanamycin elimination, which may decrease its clinical and adverse effects.

Likelihood Possible Evidence D
Calcium D-Glucarate Tetrahydrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DIM 200 plus CDG 100, from the product label.

Protocol For Life Balance

See all Protocol For Life Balance products
Name
Protocol For Life Balance
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
www.protocolforlife.com
Pharmacist Counseling Corner

DIM 200 plus CDG 100 by Protocol For Life Balance: Common Questions

Does DIM 200 plus CDG 100 by Protocol For Life Balance interact with any medications?
Yes. Based on its ingredients, DIM 200 plus CDG 100 has a known interaction with 615 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DIM 200 plus CDG 100 contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is DIM and why is it in this product?
DIM is diindolylmethane, a compound naturally found in cruciferous vegetables like broccoli and cabbage. Manufacturers include it in supplements hoping it might support hormone balance and prostate or breast health, but the evidence for these uses isn't established in our data.
Can I take this if I'm pregnant or breastfeeding?
Calcium and DIM are considered likely safe in pregnancy and breastfeeding at recommended amounts. However, the sodium copper chlorophyllin and calcium D-glucarate ingredients lack enough safety data, so they should be avoided while pregnant or nursing — talk with your doctor or pharmacist about whether this product is right for you during these times.
What are the most common side effects?
From calcium: belching, constipation, diarrhea, gas, and stomach upset. From DIM: diarrhea, gas, headache, nausea, and rash. These are usually mild, but if they're bothersome, let your doctor or pharmacist know.
Does this product actually help with cancer prevention?
Not according to the evidence we hold. DIM, chlorophyllin, and calcium D-glucarate all lack reliable evidence for cancer prevention, so it's not accurate to market this as a cancer-preventive supplement.
Why does this interact with so many medications?
The calcium in this product binds to certain drugs in your stomach and intestines, preventing your body from absorbing them fully — that's why it needs to be spaced hours away from thyroid and heart drugs. DIM changes how your liver processes some medications, and calcium D-glucarate affects how your body clears drugs through a specific liver pathway. With four ingredients, there are many opportunities for overlap with medications you might be taking.
Is it safe to take this long-term?
Calcium at recommended doses is fine long-term. However, long-term safety data for DIM, sodium copper chlorophyllin, and calcium D-glucarate are limited, so we don't have solid information on what happens if you take them for months or years. Talk with your pharmacist or doctor about how long you plan to use it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if DIM 200 plus CDG 100 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DIM 200 plus CDG 100 label
Go deeper

The Full Monographs Behind DIM 200 plus CDG 100’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph → Herb & supplement monograph

Chlorophyllin

Interacts with 335 drugs

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing. The best evidence is for its use as a d...

Read the full Chlorophyllin monograph → Herb & supplement monograph

Calcium D-glucarate

Interacts with 126 drugs

Calcium D-glucarate is a supplement form of a natural compound found in fruits and vegetables that is promoted for 'detoxification' and helping the body clear excess hormones. Human evidence...

Read the full Calcium D-glucarate monograph →
Sources

Sources & How We Checked

DIM 200 plus CDG 100's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 87 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
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Diindolylmethane 14 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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