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Dietary supplement

DIM - Avail Ingredients & Drug Interactions

by Designs for Health

DIM - Avail label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DIM - Avail against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

DIM - Avail is a dietary supplement by Designs for Health with 1 active ingredient. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 269 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Diindolymethane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DIM - Avail by Designs for Health

Ask about any prescription or over-the-counter medication and we check it for interactions with DIM - Avail by Designs for Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DIM - Avail by Designs for Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains one active ingredient: diindolylmethane (DIM), a compound found naturally in cruciferous vegetables like broccoli and cabbage. It's included in a softgel capsule along with medium chain triglycerides, mixed tocopherols, beeswax, lecithin, gelatin, glycerine, water, and annatto for color.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Diindolylmethane product and its label doesn't state a use — see Diindolylmethane's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that diindolylmethane works for benign prostatic hyperplasia, breast cancer, colorectal cancer, cervical dysplasia, or breast pain (mastalgia). Each of these conditions is rated as having insufficient reliable evidence to rate, which means the research so far hasn't been strong enough to draw firm conclusions.

The evidence, ingredient by ingredient Diindolylmethane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Diindolylmethane is generally well tolerated in short-term studies, but long-term safety isn't well established. The most common side effects are diarrhea, gas, headache, nausea, rash, and vomiting.

A rare serious side effect called DRESS (drug rash with eosinophilia and systemic symptoms) has been reported. One case of ischemic stroke was reported in someone taking 200 mg daily, though that person had multiple other stroke risk factors and was taking several other supplements, so it's unclear if diindolylmethane played a role.

There isn't enough safety data during pregnancy, so it's best avoided if you're pregnant. No reliable safety information is available for breastfeeding, so you should avoid it while nursing.

Side effects, ingredient by ingredient Diindolylmethane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Diindolylmethane.
  • The most serious interaction on file is rated Moderate.
  • For scale: 269 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take DIM – Avail, check with your doctor or pharmacist if you're on estrogens (including birth control and hormone replacement therapy), diuretics (water pills), or any medications metabolized by the liver enzyme CYP1A2. The estrogen and diuretic interactions are Moderate-severity, and the CYP1A2 group is Minor — but the CYP1A2 category includes a very large number of medications, so it's worth confirming your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

DIM – Avail is a single-ingredient supplement with potential interactions involving estrogens, water pills, and numerous medications your liver processes. If you take any hormonal medications, diuretics, or other regular prescriptions, check them with your own pharmacist or doctor before starting this product.

The safety profile in pregnancy and breastfeeding favors avoiding it during those times.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DIM - Avail, straight from the product label.

Brand Designs for Health
Barcode (UPC) 879452002968
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Jul 25, 2013
DSLD ID 22392
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DIM - Avail by Designs for Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
879452002968
IngredientAmount% DV
Diindolymethane100 mg--

Other ingredients: Medium chain triglycerides, Mixed Tocopherols, yellow Beeswax, canola lecithin oil, Gelatin, Glycerine, purified Water, annatto

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Notice: Color, size or shape may appear different between lots.

For Professional Use Only

Formulation

Does not contain gluten.

General

DIM120-1

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take one softgel per day with a meal, or as directed by your health care practitioner.

Seals/Symbols

Guaranteed GMP COMPLIANT Products

MADE WITH NON-GMO INGREDIENTS

Storage

STORE IN A COOL, DRY PLACE.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DIM - Avail by Designs for Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DIM - Avail label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DIM - Avail by Designs for Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Diindolymethane

Interacts with
269 drugs
100 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

Diindolymethane monograph & interactions

Other (inactive) ingredients: Medium chain triglycerides, Mixed Tocopherols, Yellow Beeswax, Canola lecithin oil, Gelatin, Glycerine, Purified Water, Annatto. These complete the product’s ingredient list but are not active constituents.

Interaction report

DIM - Avail by Designs for Health Drug Interactions

Want to check YOUR meds against DIM - Avail?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
269Drugs
116 Moderate 153 Minor

Ingredients driving the most interactions

Diindolymethane 269

Individual Drug Interactions

The ingredients in DIM - Avail interact with 269 drugs. Click any drug to see the details.

1 of the 1 ingredient in DIM - Avail interact with drugs. Each result below shows which ingredient is responsible. Diindolymethane

Each ingredient & the kinds of drugs it affects

For each ingredient in DIM - Avail with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Diindolymethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Diindolymethane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DIM - Avail, from the product label.

Designs for Health

See all Designs for Health products
Name
Designs for Health, Inc.
Street Address
980 South Street
City
Suffield
State
CT
ZipCode
06078
Web Address
www.designsforhealth.com
Pharmacist Counseling Corner

DIM - Avail by Designs for Health: Common Questions

Does DIM - Avail by Designs for Health interact with any medications?
Yes. Based on its ingredients, DIM - Avail has a known interaction with 269 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DIM - Avail contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on birth control or hormone replacement therapy?
Not without checking first with your doctor or pharmacist. Diindolylmethane might increase or decrease how well estrogens work, and at high doses it could potentially interfere with hormone therapy. Your provider needs to know you're considering this product.
What are the most common side effects?
Diarrhea, gas, headache, nausea, rash, and vomiting are the most common. They're usually mild, but if they persist or worsen, let your pharmacist or doctor know.
Is it safe to take while pregnant or breastfeeding?
There isn't enough safety data to know for sure. The facts available advise against it during pregnancy and breastfeeding, so talk with your doctor or pharmacist if you're pregnant or nursing and considering this product.
Does this actually work for prostate health or cancer prevention?
The evidence we hold doesn't establish that it works for those purposes. The research so far hasn't been strong enough to draw firm conclusions, so we can't say whether it's effective.
I take a water pill for my blood pressure — is that a problem?
Possibly, depending on which water pill you take. At high doses, diindolylmethane has been associated with low blood sodium, and some diuretics already lower sodium, so the combination could raise that risk. Check with your doctor or pharmacist before starting.
What exactly is diindolylmethane?
It's a compound found naturally in cruciferous vegetables like broccoli and cabbage. This softgel delivers a concentrated dose of it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DIM - Avail label
Go deeper

The Full Monographs Behind DIM - Avail’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph →
Sources

Sources & How We Checked

DIM - Avail's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
  11. Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
  12. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
  13. Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
  14. Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed

See these in context on the Diindolylmethane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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