Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

DIM-plus Ingredients & Drug Interactions

by Nature's Way

DIM-plus label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DIM-plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

DIM-plus is a dietary supplement by Nature's Way with 4 active ingredients. Its ingredients are commonly taken for general nutrition and antioxidant support, heart and digestive health, detoxification support.Based on those ingredients, 401 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cabbage, Indolplex Diindolylmethane (BR-DIM) Complex, Broccoli. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against DIM-plus by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with DIM-plus by Nature's Way — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of DIM-plus by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 4 active ingredients.
  • “Protectamins Vegetable Blend” is a proprietary blend — the label gives one combined amount (100 mg) without saying how much of each component you get.

DIM-plus contains four active ingredients: broccoli, spinach, a proprietary blend of vegetables (Protectamins), and diindolylmethane, also called DIM or indole-3-carbinol — a compound naturally found in cruciferous vegetables. The product also includes several inactive ingredients (cellulose, hypromellose, modified food starch, and others) that serve as fillers and capsule material.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Balance estrogen metabolism and support prostate function.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Premenstrual syndrome (PMS), Mastalgia, Breast cancer, Prostate cancer, Uterine cancer — and 4 related terms.
  • The closest evidence on file: Cabbage is rated "Insufficient Reliable Evidence To Rate" for Prostate cancer (Natural Medicines).
  • Also on file: Spinach is rated "Insufficient Reliable Evidence To Rate" for Polycystic ovary syndrome (PCOS).
  • Also on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH), Breast cancer, Uterine cancer, Cervical dysplasia, and more.

The effectiveness evidence for these ingredients is mixed and mostly limited. Broccoli is possibly effective for colorectal cancer prevention, but evidence is insufficient for other conditions like breast cancer and bladder cancer.

For spinach and cabbage, the evidence we hold doesn't establish effectiveness for any of the conditions studied — cognitive function, muscle strength, cancer prevention, and others all lack reliable data. Diindolylmethane's effectiveness hasn't been established for benign prostatic hyperplasia, breast cancer, cervical dysplasia, or other conditions we reviewed.

If you're considering this product for a specific health goal, it's worth talking through the evidence with us.

The evidence, ingredient by ingredient Broccoli Spinach Cabbage Diindolylmethane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Broccoli as a food is safe for most people, but concentrated broccoli supplements are less studied — the data advises caution unless your doctor approves. Reported side effects from broccoli extracts include loose stools, diarrhea, abdominal pain, and cramping, especially at higher doses.

Spinach as a food is considered safe, even in pregnancy and while breastfeeding. Cabbage as food is safe, though concentrated supplements lack study.

Diindolylmethane is generally well tolerated in short-term studies, but long-term safety isn't well established. Common side effects include diarrhea, gas, headache, nausea, and rash.

For breastfeeding, diindolylmethane safety data is insufficient, so it's best avoided unless your doctor says otherwise.

Side effects, ingredient by ingredient Broccoli Spinach Cabbage Diindolylmethane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Cabbage, Spinach, Diindolylmethane, Broccoli.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 401 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking DIM-plus, double-check with your pharmacist if you take blood thinners like warfarin (spinach and cabbage may interfere), medications metabolized by CYP1A2 (broccoli and cabbage may reduce their levels), diabetes drugs (spinach and cabbage may increase low blood sugar risk), acetaminophen or oxazepam (cabbage may reduce their effectiveness), estrogen-based medications (diindolylmethane may interfere), or diuretics that lower sodium (diindolylmethane may increase risk of low sodium). No interactions are documented for the Protectamins Vegetable Blend component.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

DIM-plus may be worth considering if you're interested in vegetable-based support and have no medication concerns, but the effectiveness evidence is limited. If you take warfarin, any CYP1A2 substrate, diabetes medications, acetaminophen, oxazepam, or hormone-based medications, check your exact prescriptions with our tool before starting.

Talk to your pharmacist to make sure this product fits your health plan.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DIM-plus, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674148501
Net contents 120 Vegan Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 333911
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DIM-plus by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
60
UPC/BARCODE
033674148501
IngredientAmount% DV
Broccoli0 NP--
Spinach0 NP--
Protectamins Vegetable Blend100 mg--
Indolplex Diindolylmethane (BR-DIM) Complex100 mg--
Cabbage0 NP--

Other ingredients: Cellulose, Hypromellose, Food Starch, Modified, Tocophersolan, Phosphatidylcholine, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Balances Estrogen Metabolism in Women and Men Promotes a beneficial ratio of estrogens Helps support premenstrual breast comfort Supports prostate function

No artificial colors

Bottled and tested in the USA

Vegan Gelatin free

Vegan Gelatin free

The DIM-plus Difference Superior bioavailability With clinically studied Indolplex BR-DIM Complex, a delivery system for diindolylmethane Enhanced absorption delivers a consistent dose of DIM Compared to regular DIM

Supports Balanced Estrogen Metabolism Enhanced absorption

Gluten free. No salt, wheat, dairy, gelatin, or artificial colors or flavors.

General Statements

New Capsule Look Explore more products at NATURESWAY.COM

Questions? 1-800-962-8873 / naturesway.com

Brand IP Statement(s)

Copyright 2024 Nature's Way Brands, LLC

Indolplex and BR-DIM is a proprietary, enhanced bioavailability complex containing Diindolylmethane licensed from BioResponse, LLC., Boulder, CO.

Seals/Symbols

Vegan Gelatin free

FDA Disclaimer Statement

This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

With Protectamins, a plant-based blend of spinach, cabbage, and broccoli DIM-plus Diindolylmethane

Clinically studied BR-DIM

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Women take 2 capsules daily with food. Men take 2 capsules twice daily with food. For intensive use: Women take 2 capsules twice daily with food. Men take 2 capsules four times daily with food.

Precautions

Not formulated for children under 18 years of age. Keep out of reach of children.

Take only as directed. Do not exceed recommended dose. A harmless but noticeable change in urine color may occur during use of this product. Safety sealed with inner seal. Do not use if seal is broken or missing.

Warning: Do not use if you are pregnant, nursing, or attempting to become pregnant. If you have a hormone-sensitive condition, medical condition, or if you are taking any medications, consult a healthcare professional before use.

Storage

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DIM-plus by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DIM-plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DIM-plus by Nature's Way

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protectamins Vegetable Blend

100 mg per serving

Indolplex Diindolylmethane (BR-DIM) Complex

Interacts with
269 drugs
100 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

Indolplex Diindolylmethane (BR-DIM) Complex monograph & interactions

Other (inactive) ingredients: Cellulose, Hypromellose, Food Starch, Modified, Tocophersolan, Phosphatidylcholine, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

DIM-plus by Nature's Way Drug Interactions

Want to check YOUR meds against DIM-plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
401Drugs
401 Moderate

Ingredients driving the most interactions

Cabbage 325
Indolplex Diindolylmethane (BR-DIM) Complex 269
Broccoli 187
Spinach 88

Individual Drug Interactions

The ingredients in DIM-plus interact with 401 drugs. Click any drug to see the details.

4 of the 4 ingredients in DIM-plus interact with drugs. Each result below shows which ingredient is responsible. Cabbage Indolplex Diindolylmethane (BR-DIM) Complex Broccoli Spinach

Each ingredient & the kinds of drugs it affects

For each ingredient in DIM-plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Cabbage6 drug types · 325 drugs

Acetaminophen (Tylenol, Others)

Cabbage might increase clearance and reduce the effects of acetaminophen.
A small clinical study shows that daily consumption of cabbage and Brussels sprout decreases acetaminophen levels by as much as 16%, with some evidence suggesting that this effect is due to increased elimination through glucuronide conjugation.

Likelihood Probable Evidence B
Antidiabetes Drugs

Theoretically, cabbage might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vivo research suggests that cabbage might have hypoglycemic effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, cabbage might decrease levels of drugs metabolized by CYP1A2.
Some animal research suggests that cabbage or its constituent indole-3-carbinol might increase drug metabolism and elimination by stimulating CYP1A2 activity.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, cabbage might increase clearance and decrease the effects of drugs metabolized through glucuronide conjugation.
A small clinical study shows that daily consumption of cabbage and Brussels sprout decreases levels of some drugs metabolized through glucuronide conjugation.

Likelihood Probable Evidence B
Oxazepam (Serax)

Cabbage might increase clearance and reduce the effects of oxazepam.
A small clinical study shows that daily consumption of cabbage and brussels sprout decreases oxazepam levels by as much as 17%, with some evidence suggesting that this effect is due to increased elimination through glucuronide conjugation.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, cabbage might decrease the anticoagulant effects of warfarin.
Cabbage contains vitamin K. If consumed in large quantities, cabbage might decrease the anticoagulant effects of warfarin.

Likelihood Possible Evidence D
Cabbage full monograph & interactions

Indolplex Diindolylmethane (BR-DIM) Complex3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Indolplex Diindolylmethane (BR-DIM) Complex full monograph & interactions

Broccoli2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Broccoli full monograph & interactions

Spinach2 drug types · 88 drugs

Antidiabetes Drugs

There are claims that spinach leaves have hypoglycemic effects. Evidence from clinical research suggests that consumption of a spinach-rich meal reduces post-meal blood glucose levels. Theoretically, spinach might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia. Monitor blood glucose levels closely. Dose adjustments might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Spinach contains vitamin K, which can interfere with the activity of warfarin.
In human research, although eating spinach with one meal does not result in coagulation test results outside the therapeutic range, daily consumption for one week necessitates dose adjustment of warfarin. Individuals using anticoagulants should consume a consistent daily amount of spinach to maintain the effect of anticoagulant therapy.

Likelihood Possible Evidence D
Spinach full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DIM-plus, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

DIM-plus by Nature's Way: Common Questions

Does DIM-plus by Nature's Way interact with any medications?
Yes. Based on its ingredients, DIM-plus has a known interaction with 401 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DIM-plus contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is DIM-plus safe to take while breastfeeding?
Spinach and broccoli are considered safe foods while breastfeeding, but safety data for concentrated supplements isn't well established. Diindolylmethane safety during breastfeeding is insufficient, so it's best avoided unless your doctor approves. Talk with your pharmacist or doctor about whether this product is right for you.
Is DIM-plus safe during pregnancy?
Broccoli, spinach, and diindolylmethane are rated likely safe in pregnancy based on available data. Cabbage has no pregnancy safety rating on file. Because pregnancy is a special situation, check with your doctor or pharmacist before starting any supplement.
What are the side effects of diindolylmethane?
The most common side effects are diarrhea, gas, headache, nausea, rash, and vomiting. A rare serious side effect called DRESS (drug rash with eosinophilia and systemic symptoms) has been reported. Headache can occur with this ingredient. If you notice any of these, stop and talk to your pharmacist.
Can I expect to see results from DIM-plus?
The evidence for these ingredients is limited. Broccoli is possibly effective for colorectal cancer prevention, but for most other conditions, evidence is insufficient — that includes breast cancer, bladder cancer, and other health claims. If you're taking this for a specific reason, it's worth discussing what the research actually shows with your pharmacist.
What does DIM stand for and why is it in this product?
DIM stands for diindolylmethane, a compound naturally found in cruciferous vegetables like broccoli and cabbage. This product combines DIM with whole vegetable sources of broccoli, spinach, and cabbage, though we hold no effectiveness data that establishes what DIM or this combination is meant to do.
Are there fillers in DIM-plus?
Yes. The product contains inactive ingredients including cellulose, hypromellose, modified food starch, tocophersolan, phosphatidylcholine, and silica — these are fillers and binders that help form the capsule and keep it stable.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DIM-plus label
Go deeper

The Full Monographs Behind DIM-plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph → Herb & supplement monograph

Spinach

Interacts with 88 drugs

Spinach is a nutrient-dense leafy green that is a healthy part of a balanced diet, providing vitamins, minerals, fiber, and antioxidants. While it is very safe as a food, concentrated supple...

Read the full Spinach monograph → Herb & supplement monograph

Cabbage

Interacts with 325 drugs

Cabbage is a nutritious, low-calorie vegetable that is safe to eat as food and is sometimes applied to the skin as a leaf wrap for breast engorgement or sore joints. Most medicinal claims ar...

Read the full Cabbage monograph → Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph →
Sources

Sources & How We Checked

DIM-plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 40 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Spinach 6 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Karlson, B., Leijd, B., and Hellstrom, K. On the influence of vitamin K-rich vegetables and wine on the effectiveness of warfarin treatment. Acta Med Scand. 1986;220(4):347-350. PubMed
  3. Roller, E., Meller, S., Homey, B., Ruzicka, T., and Neumann, N. J. [Contact dermatitis caused by spinach, hedge mustard and chives]. Hautarzt 2003;54(4):374-375.
  4. Schuller, A., Morisset, M., Maadi, F., Kolopp Sarda, M. N., Fremont, S., Parisot, L., Kanny, G., and Moneret-Vautrin, D. A. Occupational asthma due to allergy to spinach powder in a pasta factory. Allergy 2005;60(3):408-409. PubMed
  5. Gustafsson, K., Asp, N. G., Hagander, B., and Nyman, M. Satiety effects of spinach in mixed meals: comparison with other vegetables. Int.J.Food Sci.Nutr. 1995;46(4):327-334. PubMed
  6. Schreiber, J., Muller, E., Becker, W. M., Zabel, P., Schlaak, M., and Amthor, M. [Spinach powder-induced exogenous allergic alveolitis]. Pneumologie 1998;52(1):61-65.

See these in context on the Spinach monograph →

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
  11. Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
  12. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
  13. Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
  14. Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed

See these in context on the Diindolylmethane monograph →

Cabbage 15 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9. PubMed
  3. Roberts KL. A comparison of chilled cabbage leaves and chilled gelpaks in reducing breast engorgement. J Hum Lact 1995;11:17-20. PubMed
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See these in context on the Cabbage monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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