Double-Strength SAM-e 400 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Double-Strength SAM-e 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Double-Strength SAM-e 400 mg is a dietary supplement by Doctor's Best with 1 active ingredient. Its ingredients are commonly taken for depression, osteoarthritis joint pain, liver conditions.Based on those ingredients, 189 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are SAM-e. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Double-Strength SAM-e 400 mg by Doctor's Best
Ask about any prescription or over-the-counter medication and we check it for interactions with Double-Strength SAM-e 400 mg by Doctor's Best — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Double-Strength SAM-e 400 mg by Doctor's Best
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: SAM-e at 400 mg per tablet. SAM-e (S-adenosyl methionine) is a naturally occurring compound in your body that plays a role in mood regulation, joint health, and liver function.
The tablet also contains inactive ingredients—microcrystalline cellulose, magnesium silicate, stearic acid, magnesium stearate, flake shellac, magnesium hydroxide, glycerol, silica, arginine, sodium alginate, and calcium oxide—which serve as binders, fillers, and capsule materials.
Does it work?
Strong evidence
SAM-e is likely effective for osteoarthritis, so if you're dealing with joint pain and stiffness, the research supports its use. For depression, the evidence suggests it may help, though the data isn't as robust as it is for osteoarthritis—it's rated possibly effective.
The same applies to cholestasis (a liver condition involving reduced bile flow). For Alzheimer disease and ADHD, we don't yet have enough reliable evidence to know whether SAM-e works.
How safe is it?
Well-documented data
SAM-e is generally well tolerated at typical doses, though some people experience stomach upset, nausea, constipation, diarrhea, dizziness, headache, insomnia, or nervousness. Higher doses tend to cause more side effects.
One important caution: SAM-e may trigger mania in people with bipolar disorder, so if that applies to you, talk with your doctor before taking it. Safety hasn't been fully established, so use it only with guidance from your healthcare provider.
For pregnancy, the data suggests it's possibly safe, though there isn't enough reliable information to be certain—you and your doctor should discuss whether it's right for you. Lactation data isn't on file.
Meds to double-check
Moderate interaction found
Double-check this supplement before taking it if you use any serotonergic drugs—that's antidepressants (SSRIs, SNRIs, tricyclics), certain pain relievers, migraine medications, and some others that affect serotonin. Also confirm with your pharmacist if you take levodopa for Parkinson disease, as SAM-e may reduce how well it works.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This supplement makes sense if you have osteoarthritis or are exploring options for depression under professional guidance. If you take any antidepressant, anti-anxiety medication, or Parkinson treatment, or if you have bipolar disorder, check with your doctor or pharmacist before starting SAM-e.
Have a full conversation with your healthcare provider about whether it's appropriate for your specific situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Double-Strength SAM-e 400 mg, straight from the product label.
| Brand | Doctor's Best |
|---|---|
| Barcode (UPC) | 753950002524 |
| Net contents | 60 Enteric Coated Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 269568 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Double-Strength SAM-e 400 mg by Doctor's Best, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| SAM-e | 400 mg | -- |
Other ingredients: Microcrystalline Cellulose, Magnesium Silicate, Stearic Acid, Magnesium Stearate, Flake Shellac dewaxed, Magnesium Hydroxide, Glycerol, Silica, Arginine, Sodium Alginate, Calcium Oxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Science-Based Nutrition
Soloesse is a registered trademark of Gnosis SpA.
Formulation
Helps support mood and neural function Helps support joint comfort and mobility Helps support liver health and detoxification
Vegetarian
Non-GMO Gluten free Soy free
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Adult Use: Take 1 tablet daily between meals, or as recommended by a nutritionally informed physician. Do not chew or crush tablet.
Precautions
Warning: Individuals using antidepressant medications should consult with their prescribing physician prior to using this product.
Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe.
Do not use if pregnant or nursing.
May cause gastrointestinal discomfort in a small percentage of people.
Storage
Store in a cool dry place.
General Statements
Double Strength SAM-e is sealed in blister packs for freshness and stability.
Formula
Doctor’s Best SAM-e helps replenish your SAM-e levels and promote a healthy mood. SAM-e (S-Adenosyl-L-Methionine) is naturally produced by your body and helps maintain healthy emotions. Various factors such as diet and aging can cause low levels of SAM-e, leaving you feeling unbalanced and moody. Supplementing with SAM-e Soloesse Italian SAM-e is processed to yield the highest available percentage of the active pure S,S form which helps mediate biochemical activity in the human body.
SAM-e and Mood and Cognitive Function SAM-e helps facilitate DNA enzymatic actions. These enzymatic actions are required for the healthy conversion of neurotransmitters responsible for healthy emotions, such as serotonin and dopamine. SAM-e also facilitates glutathione usage which improves the body’s antioxidant defense and helps maintain acetylcholine levels necessary for cognitive function.
SAM-e and Joint Function In clinical trials, SAM-e has been shown to help increase joint comfort and mobility by promoting the synthesis of proteoglycans, essential components of connective tissue.
SAM-e and Liver Function SAM-e helps support healthy levels of glutathione, a critical antioxidant which helps protect against free radicals. SAM-e acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.
Doctor's Best utilizes only the highest quality Italian Soloesse SAM-e providing slow and targeted release for improved GI tolerance and absorption. Our Double-Strength SAM-e 400 contains 400 mg of active Soloesse SAM-e in each tablet. This ensures that you receive the most potent SAM-e product with the highest percentage of the active S,S form per serving.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Double-Strength SAM-e 400 mg by Doctor's Best label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Double-Strength SAM-e 400 mg by Doctor's Best
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.
SAM-e
Interacts with189 drugs
SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis. Some research suggests it ma...
SAM-e monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Magnesium Silicate, Stearic Acid, Magnesium Stearate, Flake Shellac dewaxed, Magnesium Hydroxide, Glycerol, Silica, Arginine, Sodium Alginate, Calcium Oxide. These complete the product’s ingredient list but are not active constituents.
Double-Strength SAM-e 400 mg by Doctor's Best Drug Interactions
HelloPharmacist Interaction Report
Doctor's Best Double-Strength SAM-e 400 mg can interact with medications through its single active ingredient, SAM-e.
The most serious documented interaction is with serotonergic drugs (antidepressants, certain pain relievers, and others that affect serotonin)—combining them with SAM-e carries a moderate risk of serotonin syndrome, a condition where serotonin levels get dangerously high, causing agitation, confusion, rapid heart rate, and in severe cases, muscle rigidity and high fever.
Read the full breakdown — every affected drug type, severity by severity
SAM-e also interacts with levodopa, a medication used for Parkinson disease. Taking them together may reduce how well levodopa works because SAM-e changes how your body processes it.
Altogether, these interactions span 189 individual medications. Before you start this supplement, run your complete medication list through the checker below—especially if you take any antidepressant, anti-anxiety medication, or Parkinson treatment.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Double-Strength SAM-e 400 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Double-Strength SAM-e 400 mg interact with 189 drugs. Click any drug to see the details.
1 of the 1 ingredient in Double-Strength SAM-e 400 mg interact with drugs. Each result below shows which ingredient is responsible. SAM-e
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Meperidine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAlmotriptanAlmogran, Axert
How Almotriptan interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Almotriptan interactionAlosetronLotronex
How Alosetron interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Alosetron interactionAmitriptylineElavil
How Amitriptyline interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Amitriptyline, Perphenazine interactionAmoxapineAsendin
How Amoxapine interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Amoxapine interactionAmphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine SulfateAdderall, Adderall XR
How Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Double-Strength SAM-e 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Sam-eSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full Sam-e + Aripiprazole interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Double-Strength SAM-e 400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
SAM-e
Levodopa
SAMe might reduce the effectiveness of levodopa.
SAMe methylates levodopa, which might reduce its effectiveness for treating Parkinson disease.
Serotonergic Drugs
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
SAMe has serotonergic effects. Theoretically, combining serotonergic drugs with SAMe might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. In one case report, SAMe 100 mg intramuscularly was given daily with clomipramine (Anafranil) 25 mg per day. When the clomipramine dose was increased to 75 mg per day the patient experienced serotonin syndrome about 48-72 hours later, requiring hospitalization.
Brand information
Manufacturer and brand details for Double-Strength SAM-e 400 mg, from the product label.
Doctor's Best
See all Doctor's Best products- Name
- Doctor's Best, Inc.
- State
- California
- ZipCode
- 92612
- Phone Number
- (800) 777-2474
- Web Address
- www.drbvitamins.com
Double-Strength SAM-e 400 mg by Doctor's Best: Common Questions
Does Double-Strength SAM-e 400 mg by Doctor's Best interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take SAM-e if I'm on an antidepressant?
Will SAM-e help my joint pain?
What are the most common side effects?
Is SAM-e safe to take if I have bipolar disorder?
Can I take SAM-e while pregnant?
Is there anything else in this tablet besides SAM-e?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Double-Strength SAM-e 400 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Double-Strength SAM-e 400 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Double-Strength SAM-e 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 31 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Same 31 references
- Perna AF, Castaldo P, Ingrosso D, et al. Homocysteine, a new cardiovascular risk factor, is also a powerful uremic toxin. J Nephrol 1999;12:230-40.
- Mato JM, Camara J, Fernandez de Paz J, et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999;30:1081-9. PubMed
- Iruela LM, Minguez L, Merino J, Monedero G. Toxic interaction of S-adenosylmethionine and clomipramine. Am J Psychiatry 1993;150:522. PubMed
- Bradley JD, Flusser D, Katz BP, et al. A randomized, double blind, placebo controlled trial of intravenous loading with S-adenosylmethionine (SAM) followed by oral SAM therapy in patients with knee osteoarthritis. J Rheumatol 1994;21:905-11.
- Berlanga C, Ortega-Soto HA, Ontiveros M, Senties H. Efficacy of S-adenosyl-L-methionine in speeding the onset of action of imipramine. Psychiatry Res 1992;44:257-62. PubMed
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