Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Drain Dampness Ingredients & Drug Interactions

by Health Concerns

Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Drain Dampness is a dietary supplement by Health Concerns with 5 active ingredients. Its ingredients are commonly taken for digestive upset and poor appetite, bloating and fluid retention, general fatigue or 'weakness'.Based on those ingredients, 1,267 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are White Atractylodes, Cinnamon, Poria sclerotium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Drain Dampness by Health Concerns

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (750 mg) without saying how much of each component you get.

Drain Dampness contains five active ingredients in a proprietary blend: white atractylodes, alisma, poria sclerotium (a medicinal mushroom), cinnamon, and polyporus sclerotium (another poria mushroom form). The product also includes inactive ingredients—vegetable gum, silicon dioxide, stearic acid, and cellulose—which serve as binders and fillers in the tablet.

This is a traditional Chinese herbal formula designed to support the body's water-balance processes. Each ingredient plays a role in that traditional framework, though the clinical evidence for their effectiveness in humans is not established in our data.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for atractylodes, poria mushroom, and cinnamon in Drain Dampness is not established. Our data shows insufficient reliable evidence to rate any of these ingredients for their intended uses—including common cold, diarrhea, cachexia, diabetes, dementia, chronic fatigue, and cancer.

This does not mean the formula is ineffective; it means the clinical trial evidence in humans is too limited for us to make a confident claim.

The evidence, ingredient by ingredient Atractylodes Poria Mushroom Cassia Cinnamon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

White atractylodes, poria mushroom, and cinnamon are generally well tolerated in traditional use, but human safety data are limited for all three. The most commonly reported adverse effects from atractylodes are allergic reaction, dry mouth, and nausea.

Poria mushroom rarely causes allergic reactions such as allergic rhinitis or asthma. Cinnamon at high doses over long periods carries a theoretical concern for liver damage due to its coumarin content, though clinical trials at typical supplement doses have not shown significant liver enzyme changes; one case of contact dermatitis and one report of low blood sugar (hypoglycemia) seizure have been documented.

Atractylodes is rated possibly unsafe in pregnancy and should be avoided; safety while breastfeeding is unknown, so avoidance is recommended. Poria mushroom is not recommended during pregnancy or breastfeeding due to insufficient safety data.

Cinnamon at food amounts is likely safe in pregnancy and breastfeeding, but high-dose supplement amounts should be avoided during pregnancy and breastfeeding. If you are pregnant, planning pregnancy, or breastfeeding, discuss this product with your doctor or pharmacist before starting.

Side effects, ingredient by ingredient Atractylodes Poria Mushroom Cassia Cinnamon

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Poria Mushroom, Cassia Cinnamon, Atractylodes.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,268 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Drain Dampness, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (moderate risk of increased bleeding), diabetes medications (moderate risk of additive blood-sugar-lowering effects), sedatives or central nervous system depressants (moderate risk of enhanced drowsiness), cancer medications like aromatase inhibitors (moderate risk of additive effects), anticholinergic drugs for overactive bladder (moderate risk of reduced effectiveness), or cholinergic drugs for Alzheimer's disease (moderate risk of additive effects). Atractylodes may also alter how your liver processes certain medications.

We could not check alisma for interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Drain Dampness is a traditional herbal formula with limited human safety and effectiveness data. If you take blood thinners, diabetes medications, sedatives, cancer drugs, or medications for bladder or neurological conditions, check your specific prescriptions with your doctor or pharmacist before adding this product.

Pregnant and breastfeeding individuals should avoid it or discuss it with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Drain Dampness, straight from the product label.

Brand Health Concerns
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Apr 25, 2017
DSLD ID 72834
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Drain Dampness by Health Concerns, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Tablet(s)
Maximum serving Sizes:
3 Tablet(s)
Servings per container
30
IngredientAmount% DV
Proprietary Blend750 mg--
White Atractylodes0 NP--
Alisma0 NP--
Poria sclerotium0 NP--
Cinnamon0 NP--
Polyporus sclerotium0 NP--

Other ingredients: Vegetable Gum, Silicon Dioxide, Stearic Acid, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Notice: This product is not intended for use by pregnant women.

Brand IP Statement(s)

Chinese traditional formulas

Combining modern research and ancient wisdom

FDA Statement of Identity

Wu Ling San Herbal Supplement

Formula

Pin Yin: Ze Xie, Fu Ling, Zhu Ling, Gui Zhi, Bai Zhu.

Suggested/Recommended/Usage/Directions

Suggested Use: Three tablets 3 times per day between meals.

See for yourself

Drain Dampness by Health Concerns label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Drain Dampness by Health Concerns

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

750 mg per serving

Other (inactive) ingredients: Vegetable Gum, Silicon Dioxide, Stearic Acid, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Drain Dampness by Health Concerns Drug Interactions

Want to check YOUR meds against Drain Dampness?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1,267Drugs
897 Moderate 370 Minor

Ingredients driving the most interactions

Cinnamon 442

Each ingredient & the kinds of drugs it affects

For each ingredient in Drain Dampness with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

White Atractylodes5 drug types · 801 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Laboratory research suggests that atractylenolides II and III, constituents of atractylodes, reduce platelet activation. So far, this has not been shown in humans.

Likelihood Possible Evidence D
Aromatase Inhibitors

Theoretically, atractylodes may have an additive effect when used with other aromatase inhibitors.
Laboratory research suggests that atractylodes and its constituents exhibit aromatase inhibitor effects.

Likelihood Possible Evidence D
Hexobarbital

Theoretically, taking atractylodes may prolong the therapeutic and adverse effects of hexobarbital.
In animals, atractylodes has been shown to prolong the effects of hexobarbital. These effects have not been shown in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
In animals, atractylodes administered at high doses has been shown to induce CYP1A2 activity. This effect has not been shown in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
In animals, atractylodes administered at high doses has been shown to inhibit CYP3A1 activity, which is a homolog to the human CYP3A4 enzyme. This effect has not been shown in humans.

Likelihood Possible Evidence D

Cinnamon2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D

Poria sclerotium3 drug types · 417 drugs

Anticholinergic Drugs

Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Drain Dampness, from the product label.

Health Concerns

See all Health Concerns products
Name
Health Concerns
Street Address
8001 Capwell Drive
City
Oakland
State
CA
ZipCode
94621
Phone Number
(800) 233-9355
Web Address
www.healthconcerns.com/pro
Pharmacist Counseling Corner

Drain Dampness by Health Concerns: Common Questions

Does Drain Dampness by Health Concerns interact with any medications?
Yes. Based on its ingredients, Drain Dampness has a known interaction with 1,267 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Drain Dampness contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Atractylodes is rated possibly unsafe in pregnancy and should be avoided; safety while breastfeeding is unknown, so avoidance is recommended. Poria mushroom is not recommended during pregnancy or breastfeeding due to insufficient safety data. Cinnamon at food amounts is likely safe, but high-dose supplement forms should be avoided during pregnancy and breastfeeding. Talk with your doctor or pharmacist before taking this product if you are pregnant, planning pregnancy, or breastfeeding.
What are the most common side effects?
The most commonly reported side effects from atractylodes are allergic reaction, dry mouth, and nausea. Poria mushroom rarely causes allergic reactions such as allergic rhinitis or asthma. At high doses over long periods, cinnamon carries a theoretical concern for liver damage due to its coumarin content.
Does this product have any fillers?
Yes, Drain Dampness includes inactive ingredients: vegetable gum, silicon dioxide, stearic acid, and cellulose, which are used as binders and fillers in the tablet.
Is there clinical evidence this formula works?
The clinical evidence for atractylodes, poria mushroom, and cinnamon in humans is not established in our data. We have insufficient reliable evidence to rate any of these ingredients for their intended uses. This does not mean the formula is ineffective—it means the human trial evidence is too limited for us to make a confident claim.
What is cinnamon doing in this formula if it can harm the liver?
Cinnamon has liver-damaging potential mainly at very high doses over extended periods. The clinical trials testing typical supplement doses (360 mg to 12 grams daily for 3 months) did not show significant liver enzyme changes. Food amounts are considered likely safe.
One of my medications is metabolized by my liver enzymes—is that a problem?
Atractylodes may theoretically alter how your liver processes certain medications via CYP1A2 and CYP3A4 pathways, though this has not been shown in humans. Check your specific medications with your doctor or pharmacist before starting this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Drain Dampness is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Drain Dampness label
Sources

Sources & How We Checked

Drain Dampness's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 29 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Atractylodes 6 references
  1. Liu Y, Jia Z, Dong L, et al. A randomized pilot study of atractylenolide I on gastric cancer cachexia patients. Evid Based Complement Alternat Med 2008;5:337-44. PubMed
  2. Chen Y, Yang W, Guo L, Wu X, Zhang T, Liu J, Zhang J. Atractylodes lactone compounds inhibit platelet activation. Platelets. 2017 Mar;28(2):194-202. PubMed
  3. Jiang H, Shi J, Li Y. Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz. Molecules. 2011 Apr 14;16(4):3146-51. PubMed
  4. Koonrungsesomboon N, Na-Bangchang K, Karbwang J. Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC. Asian Pac J Trop Med. 2014 Jun;7(6):421-8. PubMed
  5. Li L, Tang LY, Man GC, Yeung BH, Lau CB, Leung PC, Wang CC. Potential reproductive toxicity of Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage. Hum Reprod. 2011 Dec;26(12):3280-8. PubMed
  6. Muhamad N, Plengsuriyakarn T, Na-Bangchang K. Atractylodes lancea for cholangiocarcinoma: Modulatory effects on CYP1A2 and CYP3A1 and pharmacokinetics in rats and biodistribution in mice. PLoS One 2022;17(11):e0277614. PubMed

See these in context on the Atractylodes monograph →

Poria Mushroom 3 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Kim H, Park I, Park K, Park S, Kim YI, Park BG. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. Int J Environ Res Public Health 2022;19(11):6629. PubMed
  3. Lv Q, Di X, Bian B, Li K, Guo J. Neuroprotective effects of Poria cocos (Agaricomycetes) essential oil on Aß1-40-induced learning and memory deficit in rats. Int J Med Mushrooms 2022;24(10):73-82.

See these in context on the Poria Mushroom monograph →

Cassia Cinnamon 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
  3. De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
  4. Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
  5. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
  6. Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
  7. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
  8. Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
  9. Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
  10. Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
  11. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
  12. Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
  13. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
  14. Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
  15. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
  16. Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
  17. Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
  18. Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
  19. Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
  20. Patel K, Howard M, Tate B. Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: A case report. Contact Dermatitis 2023;88(3):239-240. PubMed

See these in context on the Cassia Cinnamon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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