Major interaction on record — check this product against your medications before combining. Based on 9 of 12 ingredients. Check your meds →
Dietary supplement

EAA Surge Pineapple Ingredients & Drug Interactions

by Jacked Factory

EAA Surge Pineapple label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking EAA Surge Pineapple against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

EAA Surge Pineapple is a dietary supplement by Jacked Factory with 12 active ingredients. Its ingredients are commonly taken for exercise performance and endurance, heart health, energy support.Based on those ingredients, 670 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Tryptophan, L-Citrulline Malate, Taurine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against EAA Surge Pineapple by Jacked Factory

Ask about any prescription or over-the-counter medication and we check it for interactions with EAA Surge Pineapple by Jacked Factory — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of EAA Surge Pineapple by Jacked Factory

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 12 active ingredients.
  • “Amino Blend” is a proprietary blend — the label gives one combined amount (6.70 Gram(s)) without saying how much of each component you get.

EAA Surge Pineapple is a powder blend of 12 essential amino acids — the building blocks your muscles need for repair and growth. It contains L-leucine, L-isoleucine, L-valine (the branched-chain amino acids, or BCAAs), plus L-methionine, L-lysine hydrochloride, taurine, L-phenylalanine, L-histidine, L-threonine, L-tryptophan, and L-citrulline malate.

The formula also includes a coconut water powder blend for electrolytes and flavor. The inactive ingredients are excipients — malic acid, citric acid, natural flavors, silicon dioxide, calcium silicate, acesulfame potassium, sucralose, and beta-carotene — that provide taste, texture, and stability.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle protein synthesis and athletic performance.
  • We looked for evidence on: Athletic performance, Physical performance, Exercise-induced muscle soreness, Muscle strength, Postoperative recovery, muscle recovery — and 2 related terms.
  • The strongest evidence on file: L-citrulline is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength.
  • Also on file: L-tryptophan is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

The evidence we hold does not establish that this EAA blend works for athletic performance or muscle recovery as a whole product. Individual amino acids show mixed ratings: L-citrulline malate is possibly effective for athletic performance, taurine is possibly effective for heart health and liver function, L-phenylalanine is possibly effective for vitiligo, and L-lysine is possibly effective for cold sores.

However, most of the other amino acids lack established evidence for common fitness goals. If you're considering this for a specific purpose, talk it over with your doctor or trainer.

The evidence, ingredient by ingredient Taurine L-citrulline Methionine Lysine Phenylalanine Histidine Threonine L-tryptophan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 9 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 9 of 9.
  • General safety write-ups exist for 9 of 9.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of the amino acids in this product are generally well tolerated in typical doses — L-methionine, L-lysine, taurine, L-histidine, and L-citrulline are tolerated short-term in healthy people, though long-term safety isn't fully studied for all of them. Common mild side effects reported with individual ingredients include constipation, diarrhea, headache, nausea, and heartburn.

L-tryptophan has a concerning history: in 1989, a contaminated batch from a Japanese manufacturer caused over 1,500 cases of a serious neurological condition called eosinophilia-myalgia syndrome, though current products are considered safer. L-phenylalanine should be avoided if you have phenylketonuria (PKU).

Coconut powder may trigger allergic reactions in those sensitive to coconut or tree nuts, ranging from hives to anaphylaxis in severe cases.

Side effects, ingredient by ingredient Taurine L-citrulline Methionine Lysine Phenylalanine Histidine Threonine L-tryptophan

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 9 matched ingredients can interact with medications — Lysine, L-tryptophan, Phenylalanine, Taurine, Threonine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; lithium; Parkinson's medications.
  • For scale: 670 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check before starting if you take levodopa (Parkinson disease), CNS depressants (sedatives, opioids, alcohol in quantity), serotonergic drugs (SSRIs, SNRIs, some migraine treatments), MAOIs, antihypertensives, lithium, baclofen, diabetes medications, or PDE-5 inhibitors. These are the medication types with documented interactions in this product's ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

EAA Surge is designed for people looking to support muscle recovery with essential amino acids, but the product's effectiveness for that goal isn't established in the data we hold. If you take levodopa for Parkinson disease, sedating medications, serotonin-boosting antidepressants, MAOIs, blood pressure medications, lithium, baclofen, diabetes drugs, or PDE-5 inhibitors, check with your own doctor or pharmacist before using this product.

Anyone with PKU or a coconut allergy should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about EAA Surge Pineapple, straight from the product label.

Brand Jacked Factory
Barcode (UPC) 628250670820
Net contents 10.23 Ounce(s); 290 Gram(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 257588
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for EAA Surge Pineapple by Jacked Factory, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
14.5 Gram(s)
Maximum serving Sizes:
14.5 Gram(s)
Servings per container
20
UPC/BARCODE
628250670820
IngredientAmount% DV
L-Leucine0 NP--
L-Isoleucine0 NP--
L-Methionine0 NP--
L-Lysine Hydrochloride0 NP--
Taurine2 Gram(s)--
L-Phenylalanine0 NP--
L-Valine0 NP--
L-Histidine0 NP--
L-Threonine0 NP--
L-Tryptophan0 NP--
L-Citrulline Malate2 Gram(s)--
Amino Blend6.7 Gram(s)--
Coconut Water powder blend500 mg--

Other ingredients: Malic Acid, Citric Acid, Natural Flavors, Silicon Dioxide, Calcium Silicate, Acesulfame Potassium, Sucralose, Beta-Carotene

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

EAA Surge is setting the gold standard for intra-workout performance enhancement with a revolutionary EAA Matrix called Amino9. This precise ratio of all 9 EAAs is backed by science to increase muscle protein synthesis 50% greater than a BCAA supplement, making EAA Surge the superior option for athletes, bodybuilders, and gym-goers who demand the most from their training.

Best of all, EAA Surge contains absolutely no artificial dyes or fillers.

Premium EAA formula

Muscle growth Improved recovery Easy to digest Rapid absorption

Formula

This precise ratio of all 9 EAAs is backed by science to increase muscle protein synthesis 50% greater than a BCAA supplement, making EAA Surge the superior option for athletes, bodybuilders, and gym-goers who demand the most from their training.

But EAAs are only part of the equation, so we incorporated a synergistic blend of L-Citrulline Malate, Taurine, and coconut water powder to take your muscle pumps, blood flow, recovery, and strength gains to the next level.

This is the best tasting EAA supplement you will ever try, made with high-quality fermented amino acids that are easy on the stomach and rapidly absorbed.

6.7 g Amino9 2 g L-Citrulline malate 2 g Taurine

Suggested/Recommended/Usage/Directions

1 Scoop - 12 oz. water - 1x daily Directions: Mix 1 serving (1 scoop) of EAA Surge with 12 oz. of water and consume during your workout. On non-training days, consume 1 serving (1 scoop) of EAA Surge in the morning.

Precautions

Warning: Check with a qualified healthcare professional before taking this product.

Do not use if you are pregnant or nursing a baby, under 18 years of age, have any known or suspected medical conditions, and/or if you are taking any prescription or OTC medications.

Do not use if you are pregnant or nursing a baby, under 18 years of age, have any known or suspected medical conditions, and/or if you are taking any prescription or OTC medications. Keep out of reach of children.

Do not use if safety seal is broken or missing.

Contains: Tree nuts (Coconut).

Storage

Store in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Amino9 is a registered trademark of Compound Solutions.

General Statements

Contents sold by weight, not volume. Some settling may occur during shipping and handling. The amount of product contained in 1 scoop may be above or below 15.4 grams due to variations in handling and product density. +1 Scoop serving

Please recycle container

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

EAA Surge Pineapple by Jacked Factory label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

EAA Surge Pineapple label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in EAA Surge Pineapple by Jacked Factory

These are the 12 active ingredients this product is made of. Select any to open its full monograph.

Serving size14.5 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Taurine

Interacts with
173 drugs
2 Gram(s) per serving

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements,...

Taurine monograph & interactions

L-Citrulline Malate

Interacts with
178 drugs
2 Gram(s) per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline Malate monograph & interactions

Amino Blend

6.7 Gram(s) per serving

Coconut Water powder blend

Interacts with
86 drugs
500 mg per serving

Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses...

Coconut Water powder blend monograph & interactions

Other (inactive) ingredients: Malic Acid, Citric Acid, Natural Flavors, Silicon Dioxide, Calcium Silicate, Acesulfame Potassium, Sucralose, Beta-Carotene. These complete the product’s ingredient list but are not active constituents.

Interaction report

EAA Surge Pineapple by Jacked Factory Drug Interactions

Want to check YOUR meds against EAA Surge Pineapple?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
670Drugs
256 Major 328 Moderate 86 Minor

Ingredients driving the most interactions

L-Tryptophan 394
L-Citrulline Malate 178
Taurine 173
Coconut Water powder blend 86
L-Phenylalanine 16

Individual Drug Interactions

The ingredients in EAA Surge Pineapple interact with 670 drugs. Click any drug to see the details.

7 of the 12 ingredients in EAA Surge Pineapple interact with drugs. Each result below shows which ingredient is responsible. L-Tryptophan L-Citrulline Malate Taurine Coconut Water powder blend L-Phenylalanine L-Threonine L-Lysine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in EAA Surge Pineapple with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Tryptophan2 drug types · 394 drugs

Cns Depressants

Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Clinical research shows that L-tryptophan can cause fatigue and drowsiness.

Likelihood Probable Evidence B
Serotonergic Drugs

Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.
L-tryptophan is a precursor to serotonin. Theoretically, combining serotonergic drugs with L-tryptophan might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Likelihood Possible Evidence D
L-Tryptophan full monograph & interactions

L-Citrulline Malate2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline Malate full monograph & interactions

Taurine2 drug types · 173 drugs

Antihypertensive Drugs

Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Some clinical evidence suggests that taurine can reduce both systolic and diastolic blood pressure.

Likelihood Probable Evidence D
Lithium

Theoretically, taurine might reduce excretion and increase plasma levels of lithium.
Taurine is thought to have diuretic properties, which might reduce the excretion of lithium.

Likelihood Probable Evidence D
Taurine full monograph & interactions

Coconut Water powder blend1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that coconut milk might increase insulin levels and/or decrease blood glucose levels.

Likelihood Unlikely Evidence D
Coconut Water powder blend full monograph & interactions

L-Phenylalanine3 drug types · 16 drugs

Levodopa

Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Phenylalanine competes with levodopa for carrier-mediated transport into the brain. The resulting reduction in levels of levodopa in the brain can exacerbate tremor, rigidity, and the "on-off" phenomenon in patients with Parkinson disease.

Likelihood Probable Evidence B
Baclofen

Concomitant intake of phenylalanine may reduce the intestinal absorption of baclofen.
Phenylalanine and baclofen share the same intestinal carrier for absorption; phenylalanine competitively inhibits the absorption of baclofen, reducing its plasma levels.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.
L-phenylalanine is metabolized to tyrosine. Some evidence suggests that L-phenylalanine, given with the non-selective MAOI pargyline, might prevent the elimination of tyramine, increasing the risk of hypertensive crisis. However, this was not reported in a small number of patients when using L-phenylalanine with the partially selective MAO-B inhibitor, selegiline.

Likelihood Possible Evidence D
L-Phenylalanine full monograph & interactions

L-Threonine1 drug type · 3 drugs

Nmda Antagonists

Theoretically, threonine might decrease the effects of NMDA antagonists.
Threonine increases central nervous system (CNS) glycine levels. Glycine seems to bind a site on NMDA receptors and enhance the activity of the receptors.

Likelihood Likely Evidence B
L-Threonine full monograph & interactions

L-Lysine Hydrochloride1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
L-Lysine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for EAA Surge Pineapple, from the product label.

Jacked Factory

See all Jacked Factory products
Name
Jacked Factory
City
St. John's
ZipCode
A1A 5A1
Phone Number
1-877-250-5237
Pharmacist Counseling Corner

EAA Surge Pineapple by Jacked Factory: Common Questions

Does EAA Surge Pineapple by Jacked Factory interact with any medications?
Yes. Based on its ingredients, EAA Surge Pineapple has a known interaction with 670 medications, including 256 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
EAA Surge Pineapple contains 12 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data on file is mixed. L-phenylalanine should be avoided in pregnancy. L-tryptophan and L-citrulline are best avoided while pregnant or breastfeeding due to insufficient safety data. L-methionine, L-histidine, and taurine are rated likely safe in pregnancy, but breastfeeding safety isn't well established for most. Talk with your doctor or pharmacist before using this product during pregnancy or while nursing — it's a personal decision that depends on your situation.
What side effects might I experience?
Common mild side effects from the amino acids include constipation, diarrhea, headache, nausea, heartburn, and drowsiness. L-phenylalanine may also cause anxiety or insomnia. If you're allergic to coconut or tree nuts, you could have an allergic reaction ranging from hives to anaphylaxis. Stop and contact your doctor if you experience serious symptoms.
Is this safe for long-term use?
Short-term tolerability in healthy people is generally good, but long-term safety for most of these amino acids hasn't been fully studied. It's worth checking in with your doctor if you plan to use this regularly.
What is taurine in this product for?
Taurine is an amino acid your body uses for heart and nervous system function. It's included here to support muscle performance and recovery, though evidence for that specific role isn't established in the data we hold. Taurine is possibly effective for heart failure and liver health.
Does this product actually work for muscle growth?
The overall product's effectiveness for muscle growth or athletic performance isn't established in our data. L-citrulline malate is possibly effective for athletic performance, but we can't say the blend as a whole is proven to build muscle. Talk with your trainer or doctor about whether it makes sense for your goals.
What's the coconut water powder in here?
It's added for electrolytes and flavor. Coconut is generally well tolerated in food amounts, though people with a coconut allergy can have severe reactions. The effectiveness of coconut powder for any health condition isn't well established.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if EAA Surge Pineapple is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

EAA Surge Pineapple label
Go deeper

The Full Monographs Behind EAA Surge Pineapple’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Taurine

Interacts with 173 drugs

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements, and short-term use appears generally sa...

Read the full Taurine monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Methionine

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...

Read the full Methionine monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph → Herb & supplement monograph

Phenylalanine

Interacts with 16 drugs

Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitiligo, or pain, but the evidence is mostly l...

Read the full Phenylalanine monograph → Herb & supplement monograph

Histidine

Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from a normal diet, and good-quality researc...

Read the full Histidine monograph → Herb & supplement monograph

Threonine

Interacts with 3 drugs

Threonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a normal diet, and high-quality evidence for ta...

Read the full Threonine monograph → Herb & supplement monograph

L-tryptophan

Interacts with 394 drugs

L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood. The evidence for supplement use is limited and mixed, and...

Read the full L-tryptophan monograph → Herb & supplement monograph

Coconut

Interacts with 86 drugs

Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses (like skin moisturizing and hydration) h...

Read the full Coconut monograph →
Sources

Sources & How We Checked

EAA Surge Pineapple's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 106 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Methionine 12 references
  1. La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
  2. Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
  3. Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
  4. Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
  5. Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
  6. McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
  7. Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
  8. Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
  9. Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
  10. Talukdar R, Murthy HV, Reddy DN. Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis. Pancreatology 2015;15(2):136-44. PubMed
  11. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI
  12. Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila) 2022;15(2):101-110. PubMed

See these in context on the Methionine monograph →

Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
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Taurine 21 references
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  15. Franconi, F., Bennardini, F., Mattana, A., Miceli, M., Ciuti, M., Mian, M., Gironi, A., Anichini, R., and Seghieri, G. Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation. Am.J. DOI
  16. Stohs SJ, Miller M. A case study involving allergic reactions to sulfur-containing compounds including, sulfite, taurine, acesulfame potassium and sulfonamides. Food Chem Toxicol. 2014 Jan;63:240-3. PubMed
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Phenylalanine 23 references
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Histidine 3 references
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Threonine 4 references
  1. Tandan R, Bromberg MB, Forshew D, et al. A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology 1996;47:1220-6. PubMed
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  4. Roufs JB. L-threonine as a symptomatic treatment for amyotrophic lateral sclerosis (ALS). Med Hypotheses 1991;34:20-3. PubMed

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L-tryptophan 18 references
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  2. Devoe LD, Castillo RA, Searle NS. Maternal dietary substrates and human fetal biophysical activity. The effects of tryptophan and glucose on fetal breathing movements. Am J Obstet Gynecol 1986;155:135-9. DOI
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  4. U. S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling, and Dietary Supplements. Information Paper on L-Tryptophan and 5-hydroxy-L-tryptophan, February 2001.
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  13. Kilbourne EM, Philen RM, Kamb ML, Falk H. Tryptophan produced by Showa Denko and epidemic eosinophilia-myalgia syndrome. J Rheumatol Suppl 1996;46:81-8.
  14. Horwitz RI, Daniels SR. Bias or biology: evaluating the epidemiologic studies of L-tryptophan and the eosinophilia-myalgia syndrome. J Rheumatol Suppl 1996;46:60-72.
  15. Shapiro S. Epidemiologic studies of the association of L-tryptophan with the eosinophilia-myalgia syndrome: a critique. J Rheumatol Suppl 1996;46:44-58.
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L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
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  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

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Coconut 10 references
  1. Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
  2. Rosado A, Fernandez-Rivas M, Gonzalez-Mancebo E, et al. Anaphylaxis to coconut. Allergy 2002;57(2):182-3. PubMed
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  4. Anagnostou K. Coconut Allergy Revisited. Children (Basel). 2017;4(10). pii: E85. PubMed
  5. Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015;115(6):530-2. PubMed
  6. Michavila Gomez A, Amat Bou M, Gonzalez Cortés MV, Segura Navas L, Moreno Palanques MA, Bartolomé B. Coconut anaphylaxis: Case report and review. Allergol Immunopathol (Madr). 2015;43(2):219-20. PubMed
  7. 21CFR170.3. U.S. Food and Drug Administration Department of Health and Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=170.3
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  9. Kruse L, Lor J, Yousif R, Pongracic JA, Fishbein AB. Coconut allergy: Characteristics of reactions and diagnostic predictors in a pediatric tertiary care center. Ann Allergy Asthma Immunol 2021;126(5):562-568.
  10. Pathmanandavel K, Kaur N, Joshi P, Ford LS. Anaphylaxis and allergy to coconut: An Australian pediatric case series. J Allergy Clin Immunol Pract 2020;8(10):3657-3659. PubMed

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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