ElderClenz Ingredients & Drug Interactions
by North American Herb & Spice
What is this page for?
First and foremost: checking ElderClenz against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
ElderClenz is a dietary supplement by North American Herb & Spice with 5 active ingredients. Its ingredients are commonly taken for antioxidant support, immune support, vitamin c source.Based on those ingredients, 712 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are wild High Bush Cranberry extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against ElderClenz by North American Herb & Spice
Ask about any prescription or over-the-counter medication and we check it for interactions with ElderClenz by North American Herb & Spice — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of ElderClenz by North American Herb & Spice
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
ElderClenz is a 5-ingredient liquid blend centered on fruit extracts. The active ingredients are cold-pressed Elderberry juice extract, wild Amazon Camu Camu extract, wild High Bush Cranberry extract, Peruvian Maracuya (Passion fruit) extract, and Peruvian Aguaymanto (a relative of ground cherry).
The product also contains inactive ingredients — spring water, cinnamon oil, oregano oil, and clove bud oil — which serve as the liquid base and flavoring.
Does it work?
Not established
The data we have covers cranberry and Aguaymanto (listed here under Maca). Cranberry is possibly effective for urinary tract infections (UTIs), though it's not a substitute for medical treatment when you have one.
For everything else listed — age-related cognitive decline, prostate health, cancer prevention, liver disease, and chronic fatigue — the evidence isn't established. Aguaymanto's effectiveness for its listed uses, from amenorrhea to bone health, also lacks reliable evidence in our data.
Elderberry, Camu Camu, and Passion fruit effectiveness ratings aren't on file for us.
How safe is it?
Well-documented data
Cranberry is generally well tolerated as a food or supplement, though concentrated supplement doses haven't been studied much — ask your provider before using them. The most common side effects are diarrhea and stomach discomfort; in very large doses (3-4 liters of juice daily) it can cause nausea and vomiting, especially in young children.
Camu Camu lacks strong long-term safety data in supplement form. Aguaymanto is generally well tolerated as a food but has no long-term supplement safety studies.
For pregnancy: cranberry is likely safe, but Camu Camu and Aguaymanto should be avoided in pregnancy and breastfeeding because there isn't enough safety information. We don't have pregnancy or breastfeeding data on file for Elderberry or Passion fruit.
Meds to double-check
Moderate interaction found
Double-check these medication types before taking ElderClenz: blood thinners like warfarin (Coumadin) — Moderate severity — and cholesterol-lowering statins such as atorvastatin (Lipitor) — Moderate severity. Blood pressure medicines like nifedipine (Procardia) are also a Moderate concern.
Pain relievers like diclofenac (Voltaren) and any drug processed through liver enzyme CYP2C9 are Minor concerns, though evidence is mixed. Use the medication checker on this page to search your exact drugs.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
ElderClenz is built mostly on cranberry, which has the strongest evidence for urinary tract infection support. It's not a substitute for treating an active infection.
If you take a statin, blood thinner, or blood pressure medication, you need to check your specific drugs against the interaction tool below before starting — the cranberry here could affect how your body processes them. Talk to your pharmacist or doctor first, especially if you're pregnant, breastfeeding, or taking multiple medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about ElderClenz, straight from the product label.
| Brand | North American Herb & Spice |
|---|---|
| Barcode (UPC) | 635824007005 |
| Net contents | 8 Fluid Ounce(s); 240 Milliliter(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 269324 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for ElderClenz by North American Herb & Spice, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 5 Gram(s) | -- |
| cold-pressed Elderberry juice extract | 0 NP | -- |
| wild Amazon Camu Camu extract | 0 NP | -- |
| wild High Bush Cranberry extract | 0 NP | -- |
| Peruvian Maracuya (Passion fruit) extract | 0 NP | -- |
| Peruvian Aguaymanto | 0 NP | -- |
Other ingredients: spring Water, Cinnamon Oil, Oregano Oil, Clove bud Oil
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: Take one teaspoon daily. Makes a tasty addition to any food such as salad, soup, or vegetables. Also add to smoothies.
Formula
ElderClenz is the power of wild and organic, fresh, cold-pressed elderberry extract plus raw, wild camu camu. For added cleansing power it also contains wild, high-bush cranberry extract, Peruvian maracuya (passion fruit) extract, and Peruvian aguaymanto (goldenberry) extract. This potent combination of raw, wild berries supports the body’s natural detoxification response.
Formulation
ElderClenz strengthens the body’s cells and provides vital nutrients which help to support a healthy immune system response.
Freshly cold-pressed
Wild & organic 5-fruit extract
Ideal source of raw enzymes & nutrients Supports natural detoxification response Supports healthy cell strength
Non-GMO Gluten-free No additives No added sugar Nothing artificial
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
ElderClenz by North American Herb & Spice label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in ElderClenz by North American Herb & Spice
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size5 Gram(s) Dosage formLiquid Servings per container48 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Cold-pressed Elderberry juice extract
- › Wild Amazon Camu Camu extract
- › Wild High Bush Cranberry extract
- › Peruvian Maracuya (Passion fruit) extract
- › Peruvian Aguaymanto
Other (inactive) ingredients: Spring Water, Cinnamon Oil, Oregano Oil, Clove bud Oil. These complete the product’s ingredient list but are not active constituents.
ElderClenz by North American Herb & Spice Drug Interactions
HelloPharmacist Interaction Report
ElderClenz by North American Herb & Spice contains wild High Bush Cranberry extract, which interacts with several medications.
The most serious concerns are with cholesterol-lowering statins (especially atorvastatin) and blood thinners like warfarin — cranberry can increase their levels in your bloodstream and raise the risk of side effects. One patient taking atorvastatin with high-dose cranberry juice developed muscle breakdown and liver problems, though the case was resolved after stopping the juice.
Read the full breakdown — every affected drug type, severity by severity
Cranberry also affects a group of medications processed through a liver enzyme called CYP3A4, which includes many common drugs — nifedipine (a blood pressure medicine) is a documented concern at Moderate severity. Minor interactions are possible with pain relievers like diclofenac and another liver enzyme group (CYP2C9 substrates), though the evidence for those is mixed.
We could not check two other ingredients — cold-pressed Elderberry juice extract and Peruvian Maracuya (Passion fruit) extract — because we hold no interaction data for them. Altogether, these interactions span 702 individual medications.
If you take any prescription medication, run it through the checker below before adding this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against ElderClenz?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in ElderClenz interact with 712 drugs. Click any drug to see the details.
1 of the 5 ingredients in ElderClenz interact with drugs. Each result below shows which ingredient is responsible. wild High Bush Cranberry extract
Chlorpheniramine Tannate, Phenylephrine TannateRicobid
How Chlorpheniramine Tannate, Phenylephrine Tannate interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine Tannate, Phenylephrine Tannate interactionChlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine TannateHistatan, R Tannamine, R-Tannate, Rhinatate, Tri Tannate, Triotann +1 more
How Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate interactionChlorpheniramine, Hydrocodone, PseudoephedrineTussend
How Chlorpheniramine, Hydrocodone, Pseudoephedrine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine, Hydrocodone, Pseudoephedrine interactionChlorpheniramine, MethscopolamineAllerx
How Chlorpheniramine, Methscopolamine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine, Methscopolamine interactionChlorpheniramine, Methscopolamine, PhenylephrineAH Chew, DA, DA II, Dallergy, Dallergy ER, Dura Vent DA +9 more
How Chlorpheniramine, Methscopolamine, Phenylephrine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine, Methscopolamine, Phenylephrine interactionChlorpheniramine, Methscopolamine, PhenylpropanolaminePannaz
How Chlorpheniramine, Methscopolamine, Phenylpropanolamine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine, Methscopolamine, Phenylpropanolamine interactionChlorpheniramine, Methscopolamine, PseudoephedrineMescolor, Rescon-Mx, Xiral
How Chlorpheniramine, Methscopolamine, Pseudoephedrine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine, Methscopolamine, Pseudoephedrine interactionChlorpheniramine, Phenindamine, PhenylpropanolamineNolamine
How Chlorpheniramine, Phenindamine, Phenylpropanolamine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine, Phenindamine, Phenylpropanolamine interactionChlorpheniramine, PhenylephrineDallergy JR, Ed A Hist, Histatab Plus, Rynatan
How Chlorpheniramine, Phenylephrine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine, Phenylephrine interactionChlorpheniramine, Phenylephrine, PhenylpropanolamineRutuss
How Chlorpheniramine, Phenylephrine, Phenylpropanolamine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine, Phenylephrine, Phenylpropanolamine interactionChlorpheniramine, Phenylephrine, Phenylpropanolamine, PhenyltoloxamineDe Con, Decongest, Naldecon, Nalspan SR, Tri Phen Mine Sr, Uni Decon +1 more
How Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine interactionChlorpheniramine, Phenylephrine, Phenylpropanolamine, PyrilamineHistalet Forte, Poly Hist Forte, Vanex Forte
How Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Pyrilamine interactionChlorpheniramine, Phenylephrine, PhenyltoloxamineCom Time, Comhist, Comhist LA, Linhist LA, Q Hist LA
How Chlorpheniramine, Phenylephrine, Phenyltoloxamine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine, Phenylephrine, Phenyltoloxamine interactionChlorpheniramine, Phenylephrine, PyrilamineTanamine
How Chlorpheniramine, Phenylephrine, Pyrilamine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine, Phenylephrine, Pyrilamine interactionChlorpheniramine, PhenylpropanolamineAler-Releaf, Conex DA, Contac, Dehist, Histabid Duracaps, Ornade +1 more
How Chlorpheniramine, Phenylpropanolamine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine, Phenylpropanolamine interactionChlorpheniramine, Pheylephrine, PyrilaminePhena-Plus
How Chlorpheniramine, Pheylephrine, Pyrilamine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine, Pheylephrine, Pyrilamine interactionChlorpheniramine, PseudoephedrineA.R.M., Anamine TD, Atrohist, Atrohist Ped, Brexin LA, Children's Deconamine +26 more
How Chlorpheniramine, Pseudoephedrine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine, Pseudoephedrine interactionChlorpheniramine, Pyrilamine, PhenylephrineDuphrene
How Chlorpheniramine, Pyrilamine, Phenylephrine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Chlorpheniramine, Pyrilamine, Phenylephrine interactionCiclesonideAlvesco, Omnaris, Zetonna
How Ciclesonide interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Ciclesonide interactionCilostazolPletal
How Cilostazol interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Cilostazol interactionCisapridePropulsid
How Cisapride interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Cisapride interactionCitalopramCelexa
How Citalopram interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Citalopram interactionClarithromycinBiaxin, Biaxin XL
How Clarithromycin interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Clarithromycin interactionClindamycinCleocin, Cleocin T Gel, ClindaMax, Clindesse, Dalacin C
How Clindamycin interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Clindamycin interactionClomipramineAnafranil, Anafranil SR
How Clomipramine interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Wild High Bush Cranberry Extract + Clomipramine interactionClonazepamCeberclon, Klonopin, Rivotril
How Clonazepam interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Clonazepam interactionClopidogrelPlavix
How Clopidogrel interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Wild High Bush Cranberry Extract + Clopidogrel interactionCobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide FumarateGenvoya
How Cobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide Fumarate interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Cobicistat, Elvitegravir, Emtricitabine, Tenofovir Alafenamide Fumarate interactionCobimetinib FumarateCotellic
How Cobimetinib Fumarate interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Cobimetinib Fumarate interactionCocaine Hydrochloride (prescription Drug)Goprelto, Numbrin
How Cocaine Hydrochloride (prescription Drug) interacts with ElderClenz — through 1 ingredient. Tap an ingredient for the detail:
Wild High Bush Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Wild High Bush Cranberry Extract + Cocaine Hydrochloride (prescription Drug) interactionEach ingredient & the kinds of drugs it affects
For each ingredient in ElderClenz with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
wild High Bush Cranberry extract
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Brand information
Manufacturer and brand details for ElderClenz, from the product label.
North American Herb & Spice
See all North American Herb & Spice products- Name
- North American Herb & Spice
- Street Address
- 13900 W. Polo Trail Drive
- City
- Lake Forest
- State
- IL
- ZipCode
- 60045
- Phone Number
- 1-847-473-4700
- Web Address
- www.oreganol.com
ElderClenz by North American Herb & Spice: Common Questions
Does ElderClenz by North American Herb & Spice interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take ElderClenz if I'm pregnant or breastfeeding?
Is ElderClenz proven to work for UTIs?
What are the side effects I should watch for?
Does ElderClenz have any fillers or inactive ingredients?
Can I take this if I'm on a blood thinner like warfarin?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind ElderClenz’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Camu Camu
Camu camu is an Amazonian berry that is very high in vitamin C and plant antioxidants, which is why it is popular as an immune and antioxidant supplement. Human research is still limited, so...
Read the full Camu Camu monograph → Herb & supplement monographCranberry
Interacts with 712 drugsCranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. It is not a reliable treatment for an act...
Read the full Cranberry monograph → Herb & supplement monographMaca
Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evide...
Read the full Maca monograph →Sources & How We Checked
ElderClenz's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 36 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Camu Camu 2 references
Cranberry 33 references
- Anon. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance 2003;29:8. PubMed
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
- Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.. PubMed
- Grant P. Warfarin and cranberry juice: An interaction? J Heart Valve Dis 2004;13:25-6.
- Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ 2003;327:1454. PubMed
- Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. PubMed
- Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam - probes of CYP2C9, CYP1A2 and CYP3A4. Clin Pharmacol The 2007:81:833-9. PubMed
- Wing DA, Rumney PJ, Preslicka CW, Chung JH. Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study. J Urol 2008;180:1367-72. PubMed
- Mohammed Abdul MI, Jiang X, Williams KM, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 2008;154:1691-700. PubMed
- McMurdo MET, Argo I, Phillips G, et al. Cranberry or trimethoprim for the prevention of recurrently urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother 2009;63:389-95.
- Mergenhagen KA, Sherman O. Elevated International Normalized Ratio after concurrent ingestion of cranberry sauce and warfarin. Am J Health-Syst Pharm 2008;65:2113-6. PubMed
- Ansell J, McDonough M, Zhao Y, et al. The absence of an interaction between warfarin and cranberry juice: a randomized, double-blind trial. J Clin Pharmacol 2009;49:824-30. PubMed
- Haber SL, Cauthon KA, Raney EC. Cranberry and warfarin interaction: a case report and review of the literature. Consult Pharm 2012;27:58-65. PubMed
- Hamann GL, Campbell JD, George CM. Warfarin-cranberry juice interaction. Ann Pharmacother 2011;45:e17. PubMed
- Roberts D, Flanagan P. Case report: Cranberry juice and warfarin. Home Healthc Nurse 2011;29:92-7.
- Garcia-Calatayud, S., Larreina Cordoba, J. J., and Lozano De La Torre MJ. [Severe cranberry juice poisoning]. An.Esp.Pediatr. 2002;56(1):72-73.
- Patel, D. A., Gillespie, B., Sobel, J. D., Leaman, D., Nyirjesy, P., Weitz, M. V., and Foxman, B. Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study. Am J Obstet.Gy PubMed
- Isele, H. [Fatal bleeding under warfarin plus cranberry juice. Is it due to salicylic acid?]. MMW.Fortschr.Med 3-11-2004;146(11):13.
- Linsenmeyer, T. A., Harrison, B., Oakley, A., Kirshblum, S., Stock, J. A., and Millis, S. R. Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury. A prospecti
- McMurdo, M. E., Bissett, L. Y., Price, R. J., Phillips, G., and Crombie, I. K. Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial. Age Ageing 2005;34(3):256- PubMed
- Sylvan, L. and Justice, N. P. Possible interaction between warfarin and cranberry juice. Am Fam.Physician 9-15-2005;72(6):1000.
- Niklasson, A. and Andren, L. [Interaction between Waran and cranberry juice]. Lakartidningen 3-15-2006;103(11):853-854.
- Rindone, J. P. and Murphy, T. W. Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding. Am J Ther 2006;13(3):283-284. PubMed
- Uesawa, Y. and Mohri, K. Effects of cranberry juice on nifedipine pharmacokinetics in rats. J Pharm Pharmacol 2006;58(8):1067-1072. PubMed
- Valentova, K., Stejskal, D., Bednar, P., Vostalova, J., Cihalik, C., Vecerova, R., Koukalova, D., Kolar, M., Reichenbach, R., Sknouril, L., Ulrichova, J., and Simanek, V. Biosafety, antioxidant status, and metabolites in urine after consumption of dried
- Royer, D. J., George, J. N., and Terrell, D. R. Thrombocytopenia as an adverse effect of complementary and alternative medicines, herbal remedies, nutritional supplements, foods, and beverages. Eur J Haematol 2010;84(5):421-429. PubMed
- Stapleton, A. E., Dziura, J., Hooton, T. M., Cox, M. E., Yarova-Yarovaya, Y., Chen, S., and Gupta, K. Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial. Mayo.Clin.Proc. PubMed
- Doad GJ, Kabange W. Cranberry juice, atorvastatin and back pain. J Med Assoc Ga 2014;103(1):14.
- Griffiths AP, Beddall A, Pegler S. Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin. J R Soc Promot Health 2008;128(6):324-6. PubMed
- Mellen CK, Ford M, Rindone JP. Effect of high-dose cranberry juice on the pharmacodynamics of warfarin in patients. Br J Clin Pharmacol 2010;70(1):139-42. PubMed
- Ushijima K, Tsuruoka S, Tsuda H, Hasegawa G, Obi Y, Kaneda T, Takahashi M, Maekawa T, Sasaki T, Koshimizu TA, Fujimura A. Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects. Br J Clin Pharmaco PubMed
- Ngo N, Brantley SJ, Carrizosa DR, et al. The warfarin-cranberry juice interaction revisited: A systematic in vitro-in vivo evaluation. J Exp Pharmacol. 2010;2010(2):83-91.
- Williams G, Stothart CI, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 2023;11(11):CD001321. PubMed
Maca 1 reference
- Valerio, L. G., Jr. and Gonzales, G. F. Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis. Toxicol.Rev 2005;24(1):11-35. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC