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Dietary supplement

Elderflower Sambucus 400 mg Ingredients & Drug Interactions

by Puritan's Pride

Elderflower Sambucus 400 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Elderflower Sambucus 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Elderflower Sambucus 400 mg is a dietary supplement by Puritan's Pride with 1 active ingredient. Its ingredients are commonly taken for cold and flu symptoms, immune support, fever and congestion (traditional).Based on those ingredients, 644 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Elder flower. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Elderflower Sambucus 400 mg by Puritan's Pride

Ask about any prescription or over-the-counter medication and we check it for interactions with Elderflower Sambucus 400 mg by Puritan's Pride — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Elderflower Sambucus 400 mg by Puritan's Pride

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: elder flower at 400 mg per capsule. The capsule shell is gelatin, and magnesium stearate is added as an inactive ingredient to help with manufacturing.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient American Elder product and its label doesn't state a use — see American Elder's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that elder flower works for asthma, cancer, headache, common cold, cough, or flatulence — the data shows insufficient reliable evidence for all of these uses. If you're considering this for one of those reasons, talk with your pharmacist about what the current research actually supports.

The evidence, ingredient by ingredient American Elder

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cooked ripe elder berries and flowers are generally well tolerated, but raw or unripe berries and other parts of the plant can be toxic, so stick to properly prepared products. When taken in medicinal amounts, there's limited safety data available.

The most common side effects reported are dizziness, nausea, numbness, vomiting, and weakness — especially when people drink several glasses of elderberry juice. Because there isn't enough reliable safety information, this supplement should be avoided during pregnancy and while breastfeeding.

Side effects, ingredient by ingredient American Elder

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — American Elder.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 645 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this if you're on any heart, blood pressure, or psychiatric medications — especially those metabolized by your liver. Lithium is a particular concern because elder flower may raise its levels dangerously.

Immunosuppressants and many other drugs are also affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take heart or blood pressure medications, immunosuppressants, or lithium, this isn't the right choice without talking to your pharmacist first. The safety profile during pregnancy and breastfeeding also advises against use.

Check your medications before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Elderflower Sambucus 400 mg, straight from the product label.

Brand Puritan's Pride
Barcode (UPC) 074312127311
Net contents 100 Rapid Release Capsule(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 286296
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Elderflower Sambucus 400 mg by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
074312127311
IngredientAmount% DV
Elder flower400 mg--

Other ingredients: Gelatin, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Puritan's Pride supplements are produced from the finest raw materials under stringent quality control standards. State-of-the-art manufacturing and packaging facilities ensure you the highest quality nutritional supplements money can buy. When it comes to your health...choose the best.

To reorder item # 2731 www.puritan.com 1-800-645-1030

Precautions

WARNING: If you are the pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Contains soy ingredients.

Storage

Store at room temperature.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Copyright 2019 Puritan's Pride, Inc.

Seals/Symbols

QA Quality Assured

Formulation

General Wellness

Puritan's Pride's Natural Whole Herb products utilize ground plant parts.

No Artificial Color, Flavor or Sweetener, No Sugar, No Starch, No Milk, No Lactose, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

Formula

Natural Whole Herb

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) capsule three times daily, preferably with meals. Capsules may be opened and prepared as a tea.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Elderflower Sambucus 400 mg by Puritan's Pride label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Elderflower Sambucus 400 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Elderflower Sambucus 400 mg by Puritan's Pride

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Elder flower

Interacts with
644 drugs
400 mg per serving

American elder is a North American plant whose cooked, ripe berries and flowers are used mainly for colds, flu, and general immune support. The scienc...

Elder flower monograph & interactions

Other (inactive) ingredients: Gelatin, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Elderflower Sambucus 400 mg by Puritan's Pride Drug Interactions

Want to check YOUR meds against Elderflower Sambucus 400 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
644Drugs
644 Moderate

Ingredients driving the most interactions

Elder flower 644

Individual Drug Interactions

The ingredients in Elderflower Sambucus 400 mg interact with 644 drugs. Click any drug to see the details.

1 of the 1 ingredient in Elderflower Sambucus 400 mg interact with drugs. Each result below shows which ingredient is responsible. Elder flower

Each ingredient & the kinds of drugs it affects

For each ingredient in Elderflower Sambucus 400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Elder flower2 drug types · 644 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, taking American elder might increase levels of CYP3A4 substrates.
In vitro research shows that American elder inhibits CYP3A4 enzymes.

Likelihood Possible Evidence D
Lithium

Theoretically, American elder might reduce excretion and increase levels of lithium.
American elder is thought to have diuretic properties. Theoretically, American elder might reduce the excretion of lithium, increasing serum levels.

Likelihood Probable Evidence D
Elder flower full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Elderflower Sambucus 400 mg, from the product label.

Puritan's Pride

See all Puritan's Pride products
Name
Puritan's Pride, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-800-645-1030
Web Address
www.puritan.com
Pharmacist Counseling Corner

Elderflower Sambucus 400 mg by Puritan's Pride: Common Questions

Does Elderflower Sambucus 400 mg by Puritan's Pride interact with any medications?
Yes. Based on its ingredients, Elderflower Sambucus 400 mg has a known interaction with 644 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Elderflower Sambucus 400 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No — the safety data advises against it. There isn't enough reliable information to know it's safe during pregnancy or while breastfeeding, so it's best to avoid it during those times. Talk with your doctor or pharmacist about what's right for your situation.
What are the most common side effects?
Dizziness, nausea, numbness, vomiting, and weakness have been reported. These tend to show up more when people drink several glasses of elderberry juice. Since there's limited safety data on medicinal amounts in general, we don't have a complete picture of how often side effects occur.
Is raw elderberry safe?
No — raw or unripe berries and other parts of the elder plant can be toxic. This product uses cooked ripe flowers and berries, which are generally well tolerated, but don't prepare or eat raw elder parts on your own.
What does elder flower actually help with?
The evidence we hold doesn't establish that it works reliably for asthma, cancer, headaches, common cold, cough, or flatulence. If you're thinking about it for one of those reasons, ask your pharmacist what the current research actually shows.
Why does this interact with so many medications?
Elder flower inhibits an enzyme in your liver called CYP3A4 that breaks down a huge number of different drugs — from heart medications to psychiatric drugs to immunosuppressants. When the enzyme is slowed down, those drugs can accumulate in your blood. That's why checking your specific medications is so important.
Is it safe to take with my blood pressure medication?
It depends on which one. Many blood pressure drugs are processed by the same liver enzyme that elder flower affects. Use the search tool on this page to check your exact medication, or call your pharmacist — don't guess.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Elderflower Sambucus 400 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Elderflower Sambucus 400 mg label
Go deeper

The Full Monographs Behind Elderflower Sambucus 400 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

American Elder

Interacts with 644 drugs

American elder is a North American plant whose cooked, ripe berries and flowers are used mainly for colds, flu, and general immune support. The science behind these uses is limited and most...

Read the full American Elder monograph →
Sources

Sources & How We Checked

Elderflower Sambucus 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

American Elder 2 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed

See these in context on the American Elder monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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