Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Enzymes + Ingredients & Drug Interactions

by New Earth

Enzymes + label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Enzymes + against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Enzymes + is a dietary supplement by New Earth with 5 active ingredients. Its ingredients are commonly taken for nausea and vomiting, motion sickness, morning sickness in pregnancy.Based on those ingredients, 1,124 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ginger, Fennel, Aphanizomenon flos-aquae. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Enzymes + by New Earth

Ask about any prescription or over-the-counter medication and we check it for interactions with Enzymes + by New Earth — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Enzymes + by New Earth

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 16 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (164 mg) without saying how much of each component you get.
  • “Plant-Based Enzymes” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Enzymes + contains 16 active and inactive ingredients designed to support digestive function. The active ingredients are multiple digestive enzymes — amylase, papain, bromelain, lipase, lactase, cellulase, invertase, glucoamylase, pectinase, Acid Protease, Protease I, and Protease II — grouped with plant-based botanicals including ginger, fennel, cayenne pepper, and blue-green algae (Aphanizomenon flos-aquae).

The inactive ingredients are rice bran, plant fiber, and beet root fiber. These enzymes work in different parts of digestion: amylase breaks down starches, lipase handles fats, lactase helps with dairy digestion, and the proteases break down proteins.

Papain and bromelain are proteolytic enzymes sourced from plant matter. The botanicals contribute additional phytonutrients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: enhanced digestion with botanicals.
  • We looked for evidence on: Dyspepsia, Flatulence, Colic, Diarrhea, Cough, bloating — and 3 related terms.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Fennel is rated "Insufficient Reliable Evidence To Rate" for Cough, Dyspepsia, Flatulence, Colic.
  • Also on file: Lactase is rated "Insufficient Reliable Evidence To Rate" for Colic.

The evidence for effectiveness varies by ingredient. Ginger is rated Possibly Effective for pregnancy-induced nausea and vomiting and dysmenorrhea, and Possibly Ineffective for exercise-induced muscle soreness.

Cayenne pepper is rated Likely Effective for postherpetic neuralgia and diabetic neuropathy. Lactase is rated Effective for lactose intolerance.

Fennel is rated Possibly Effective for dysmenorrhea, and blue-green algae is rated Possibly Effective for hypertension. For papain, bromelain, lipase, Acid Protease, Protease I, and Protease II, the evidence we hold is insufficient to rate them — we cannot confirm these ingredients work for their intended purposes based on reliable data.

The same applies to most other conditions listed for the other ingredients in this product.

The evidence, ingredient by ingredient Ginger Fennel Capsicum Blue-green Algae

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 9 of the 9 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 9 of 9.
  • General safety write-ups exist for 9 of 9.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated at typical doses. Ginger is safe in food and supplement amounts for most healthy adults, though doses above 5 grams daily increase side effects.

Papain may irritate the digestive tract and cause allergic reactions; concentrated forms and unripe papaya are best avoided in pregnancy. Bromelain is generally well tolerated short-term, but long-term safety data is limited; it should be avoided during pregnancy and breastfeeding.

Lipase has no reported adverse effects in adults and is likely low-risk in pregnancy, though medical guidance is advised. Lactase is generally well tolerated and likely safe in pregnancy.

Protease enzymes are well tolerated for most adults but may cause digestive upset or allergic reactions; safety in pregnancy is not established. Fennel is safe as food but concentrated supplements should be avoided in pregnancy due to hormone-like effects.

Cayenne pepper is generally safe in food amounts, though concentrated supplements are not well studied. Blue-green algae quality varies and contamination risk exists; it should be avoided in pregnancy and breastfeeding.

Common side effects across the product may include mild digestive upset, diarrhea, heartburn, and allergic reactions in sensitive individuals.

Side effects, ingredient by ingredient Ginger Fennel Capsicum Blue-green Algae

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 9 matched ingredients can interact with medications — Papain, Fennel, Bromelain, Blue-green Algae, Capsicum, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,125 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Enzymes +, double-check with your pharmacist if you take blood thinners or antiplatelet drugs (warfarin, phenprocoumon, aspirin, clopidogrel), antidiabetes medications, ciprofloxacin or tetracycline antibiotics, birth control pills, estrogen replacement therapy, theophylline, nifedipine, losartan, ACE inhibitors, tamoxifen, or any drugs processed by CYP3A4 or P-glycoprotein enzymes, or immunosuppressants. For the enzymes amylase, cellulase, invertase, glucoamylase, and pectinase, no interactions are documented in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is an enzyme blend aimed at digestive support, with added botanicals. If you take blood thinners, antidiabetes drugs, birth control, immunosuppressants, or antibiotics like ciprofloxacin or tetracyclines, you need to check your medications with the tool below before using it.

If you're pregnant or breastfeeding, talk to your doctor or pharmacist first — some ingredients aren't well studied in these situations. A pharmacist can help you sort out whether this product works for your specific needs and your current medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 11 of 16 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Enzymes +, straight from the product label.

Brand New Earth
Barcode (UPC) 850057861198
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 335746
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Halal
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Enzymes + by New Earth, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
850057861198
IngredientAmount% DV
Proprietary Blend164 mg--
Amylase0 NP--
Papain0 NP--
Bromelain0 NP--
Plant-Based Enzymes0 NP--
Lipase0 NP--
Lactase0 NP--
Cellulase0 NP--
Invertase0 NP--
Ginger0 NP--
Glucoamylase0 NP--
Pectinase0 NP--
Acid Protease0 NP--
Fennel0 NP--
Protease I0 NP--
Protease II0 NP--
Cayenne Pepper0 NP--
Aphanizomenon flos-aquae0 NP--

Other ingredients: Rice Bran, Plant Fiber, Beet root Fiber

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Enhanced digestion with botanicals Many of the foods we consume are cooked, processed, and often reheated which diminishes the digestion and absorption of needed micronutrients. Processing and cooking destroy nearly all of the enzymes that are naturally present in food. To get the most out of what we eat, Enzymes + unlocks the nutrition potential in all foods and releases micronutrients from a wide range of foods. 12 natural plant-based enzymes Lipase breaks down fat, protease breaks down protein, cellulase helps break down fiber, and amylase breaks down starch

Enhanced digestion with botanicals

Star-K (Kosher)

Crescent M (Halal)

Formulation

Helps prevent energy lulls after big meals

Product of USA

Suggested/Recommended/Usage/Directions

Suggested use: 1 capsule just before eating.

Storage

Keep in a cool, dry place.

General Statements

Please recycle

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Star-K (Kosher) Crescent M (Halal)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Enzymes + by New Earth label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Enzymes + label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Enzymes + by New Earth

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

164 mg per serving

Other (inactive) ingredients: Rice Bran, Plant Fiber, Beet root Fiber. These complete the product’s ingredient list but are not active constituents.

Interaction report

Enzymes + by New Earth Drug Interactions

Want to check YOUR meds against Enzymes +?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,124Drugs
973 Moderate 151 Minor

Ingredients driving the most interactions

Ginger 1,007
Fennel 740
Aphanizomenon flos-aquae 327
Cayenne Pepper 239

Individual Drug Interactions

The ingredients in Enzymes + interact with 1,124 drugs. Click any drug to see the details.

4 of the 5 ingredients in Enzymes + interact with drugs. Each result below shows which ingredient is responsible. Ginger Fennel Aphanizomenon flos-aquae Cayenne Pepper

Each ingredient & the kinds of drugs it affects

For each ingredient in Enzymes + with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ginger14 drug types · 1,007 drugs

Anticoagulant/Antiplatelet Drugs

Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.

Likelihood Possible Evidence D
Phenprocoumon (Marcoumar, Others)

Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.

Likelihood Possible Evidence B
Calcium Channel Blockers

Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.

Likelihood Unlikely Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Metronidazole (Flagyl)

Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.

Likelihood Possible Evidence D
Ginger full monograph & interactions

Fennel6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
Fennel full monograph & interactions

Aphanizomenon flos-aquae3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs. However, this is unlikely.
Spirulina blue-green algae have shown antiplatelet and anticoagulant effects in vitro. However, one preliminary study in 24 patients receiving spirulina blue-green algae 2.3 grams daily for 2 weeks showed no effect on platelet activation or measures of clotting time.

Likelihood Unlikely Evidence D
Antidiabetes Drugs

Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Human research shows that spirulina blue-green algae can have hypoglycemic effects in patients with diabetes, at least some of whom were using antidiabetes drugs. However, blue-green algae does not seem to improve glycated hemoglobin (HbA1c) levels in patients with diabetes. A meta-analysis of animal studies also suggests that spirulina blue-green algae have hypoglycemic effects.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Blue-green algae have been shown to stimulate the immune system.

Likelihood Possible Evidence D
Aphanizomenon flos-aquae full monograph & interactions

Cayenne Pepper6 drug types · 239 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro research shows that capsicum might increase the effects of antiplatelet drugs. Also, population research shows that capsicum is associated with an increased risk of self-reported bleeding in patients taking warfarin. However, clinical research shows that taking a single dose of capsaicin (Asian Herbex Ltd.), the active ingredient in capsicum, 400-800 mcg orally in combination with aspirin 500 mg does not decrease platelet aggregation when compared with taking aspirin 500 mg alone. Also, there was no notable effect on measures of platelet aggregation with capsaicin. It is unclear whether capsaicin must be used in more than a single dose to affect platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical research shows that consuming capsicum 5 grams along with a glucose drink attenuates the rise in plasma glucose after 30 minutes by 21%, decreases the 2-hour postprandial area under the curve of plasma glucose by 11%, and increases the 2-hour postprandial area under the curve of plasma insulin by 58% in healthy individuals when compared with placebo. Other clinical research shows that taking capsicum 5 mg daily for 28 days significantly reduces postprandial blood glucose and insulin levels, but not fasting blood glucose and insulin levels, in patients with gestational diabetes.

Likelihood Possible Evidence B
Aspirin

Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Animal research shows that acute or chronic intake of capsicum pepper reduces oral aspirin bioavailability. This has not been shown in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, taking capsicum with theophylline might increase the levels and adverse effects of theophylline.
In animal research, oral administration of capsicum reduced excretion of theophylline. However, capsicum does not seem to affect the pharmacokinetics of theophylline when administered intravenously.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.
There is one case report of a topically applied capsaicin cream contributing to the cough reflex in a patient using an ACEI. However, it is unclear if this interaction is clinically significant.

Likelihood Unlikely Evidence D
Ciprofloxacin (Cipro)

Theoretically, taking capsicum with ciprofloxacin might increase levels and adverse effects of ciprofloxacin.
Animal research shows that concomitant use of capsaicin, the active constituent of capsicum, and ciprofloxacin increases the bioavailability of ciprofloxacin by up to 70%.

Likelihood Possible Evidence D
Cayenne Pepper full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Enzymes +, from the product label.

New Earth

See all New Earth products
Name
New Earth Life Sciences, Inc.
Street Address
1360 South Sixth Street
City
Klamath Falls
State
OR
ZipCode
97601
Phone Number
800.800.1300
Web Address
www.NewEarth.com
Pharmacist Counseling Corner

Enzymes + by New Earth: Common Questions

Does Enzymes + by New Earth interact with any medications?
Yes. Based on its ingredients, Enzymes + has a known interaction with 1,124 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Enzymes + contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
It depends on the ingredient. Papain and concentrated papaya forms should be avoided — safety data advises against them. Bromelain, fennel in medicinal amounts, and blue-green algae should also be avoided due to insufficient safety data. Ginger in moderate food amounts is often used for morning sickness, but check with your doctor. Lipase and lactase are likely low-risk, but talk to your doctor before regular use. Overall, it's best to discuss this product with your doctor or pharmacist before taking it during pregnancy.
Is this safe while breastfeeding?
Most ingredients lack reliable safety data during breastfeeding. Bromelain, blue-green algae, and concentrated fennel should be avoided. Papain, Acid Protease, Protease I, and Protease II are not recommended without medical advice. Ginger in food amounts is likely okay, and lactase is probably safe since it works only in the gut, but check with your doctor or pharmacist first. Food amounts of cayenne pepper are likely fine, but medicinal doses are not well studied.
Does ginger in this product really affect blood thinners?
Yes, potentially. Ginger has antiplatelet effects and may increase bleeding risk if you take warfarin or other blood thinners. One case report documented a patient on warfarin who developed dangerously elevated blood thinning (INR of 7.4) after taking a papaya supplement with papain. While not everyone will have this problem, it's serious enough that you must check with your pharmacist before combining this product with any blood thinner.
What are these digestive enzymes supposed to do?
The enzymes in this blend each target different parts of digestion: amylase breaks down carbohydrates, lipase breaks down fats, lactase helps digest milk sugar, and the proteases (including papain and bromelain) break down proteins. Taken together, they're meant to support overall digestive function, though the evidence that supplemental enzymes improve digestion in otherwise healthy people is not well established in the data we hold.
Is lactase effective for lactose intolerance?
Yes, lactase is rated Effective for lactose intolerance. It's also generally well tolerated and likely safe in pregnancy with doctor approval. If you're lactose intolerant, this ingredient may help you digest dairy products.
What side effects should I watch for?
The most common side effects are mild digestive symptoms — diarrhea, gas, bloating, heartburn, nausea, and abdominal discomfort. Allergic reactions are possible in sensitive individuals, especially to papain, bromelain, fennel, and blue-green algae. Stop use and call your doctor if you develop signs of an allergic reaction, severe stomach pain, or unusual bruising or bleeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Enzymes + label
Go deeper

The Full Monographs Behind Enzymes +’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ginger

Interacts with 1,007 drugs

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...

Read the full Ginger monograph → Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Capsicum

Interacts with 239 drugs

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin products are supported by reasonable evid...

Read the full Capsicum monograph → Herb & supplement monograph

Blue-green Algae

Interacts with 327 drugs

Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and general wellness. Evidence for most heal...

Read the full Blue-green Algae monograph →
Sources

Sources & How We Checked

Enzymes +'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 227 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
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Lipase 1 reference
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Lactase 1 reference
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Ginger 64 references
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