Drug & supplement interaction

Blue-green Algae + Abrocitinib

Abrocitinib brand name: Cibinqo.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Abrocitinib falls into 2 drug categories that Blue-green Algae can interact with; the most serious is rated moderate. Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodUnlikely
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Blue-green Algae and Abrocitinib

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Blue-green Algae interacts with whole categories of medication. Abrocitinib falls into 2 of those categories, so it can interact with Blue-green Algae in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

1 of 2

Why this applies to Abrocitinib

Abrocitinib falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Blue-green Algae interacts with.

Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs. However, this is unlikely.
Spirulina blue-green algae have shown antiplatelet and anticoagulant effects in vitro. However, one preliminary study in 24 patients receiving spirulina blue-green algae 2.3 grams daily for 2 weeks showed no effect on platelet activation or measures of clotting time.
Severity Moderate Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the honest picture for Cibinqo (abrocitinib). This medicine quiets an overactive immune system to calm eczema, and one thing to know about it is that it can slightly lower your platelet count in some people, which plays a role in clotting. Spirulina blue-green algae, on paper, has shown mild blood-thinning and antiplatelet activity in lab studies, so the theoretical worry is that stacking the two could nudge your bleeding risk up a bit.

I want to keep this in perspective, though. This is a theoretical concern only, based on test-tube data, and a small human study using about 2.3 grams of spirulina daily showed no real change in clotting. So the actual risk looks low. Still, watch for easy bruising, nosebleeds, or cuts that bleed longer than usual, and check with your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Chiu HF, Yang SP, Kuo YL, et al. Mechanisms involved in the antiplatelet effect of C-phycocyanin. Br J Nutr 2006;95:435-40. PubMed
  2. Hsiao G, Chou PH, Shen MY, et al. C-phycocyanin, a very potent and novel platelet aggregation inhibitor from Spirulina platensis. J Agric Food Chem 2005;53:7734-40.
  3. Madhyastha, H. K., Radha, K. S., Sugiki, M., Omura, S., and Maruyama, M. Purification of c-phycocyanin from Spirulina fusiformis and its effect on the induction of urokinase-type plasminogen activator from calf pulmonary endothelial cells. Phytomedicine PubMed
  4. Majdoub H, Ben Mansour M, Chaubet F, et al. Anticoagulant activity of a sulfated polysaccharide from the green alga Arthrospira platensis. Biochim Biophys Acta 2009;1790(10):1377-81. PubMed
  5. Cha BG, Kwak HW, Park AR, et al. Structural characteristics and biological performance of silk fibroin nanofiber containing microalgae spirulina extract. Biopolymers 2014;101(4):307-18. PubMed
  6. Jensen GS, Drapeau C, Lenninger M, Benson KF. Clinical safety of a high dose of phycocyanin-enriched aqueous extract from Arthrospira (Spirulina) platensis: results from a randomized, double-Blind, placebo-controlled study with a focus on anticoagulant ac
Moderate

IMMUNOSUPPRESSANTS

2 of 2

Abrocitinib also falls under IMMUNOSUPPRESSANTS.

Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Blue-green algae have been shown to stimulate the immune system.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to keep in mind with Cibinqo (abrocitinib): it works by calming down an overactive immune system to help your eczema settle. Blue-green algae, like spirulina, may do the opposite and gently nudge the immune system to be more active. In theory, that could work against abrocitinib and make it less effective, meaning your itching, dryness, and rashes might not stay as well controlled.

I want to be honest with you though, this concern comes from lab and animal research, not from real-world cases in people, so it's more of a theoretical caution than a proven problem. Still, since you're relying on this medication to manage your skin, it's worth a quick chat with your doctor or pharmacist before adding the supplement.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Jensen GS, Ginsberg DJ, Huerta P, et al. Consumption of Aphanizomenon flos-aquae has rapid effects on the circulation and function of immune cells in humans. A novel approach to nutritional mobilization of the immune system. JANA 2000;2:50-6.
  2. Hayashi O, Katoh T, Okuwaki Y. Enhancement of antibody production in mice by dietary Spirulina platensis. J Nutr Sci Vitaminol (Tokyo) 1994;40:431-41.. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Blue-green Algae Also Interacts With Other Medications

Blue-green Algae has 326 moderate known drug interactions in our database — the Abrocitinib one above is among them. If you take anything else, check it against the full list below.

Moderate 326 No known interaction 2,504 (incl. Abrocitinib)
Taking anything else?

Check Another of Your Medications Against Blue-green Algae

Covers the 2,830 medications we’ve checked against Blue-green Algae. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Abrocitinib

This page covers Blue-green Algae only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Abrocitinib page lists 290 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Piracetam (major), Aconite (moderate) and Active Hexose Correlated Compound (ahcc) (moderate).

By severity: 3 major · 252 moderate · 35 minor.

From our pharmacist’s overview on the Abrocitinib page

“Bleeding is where I'd focus first with abrocitinib (Cibinqo), an eczema pill that can itself lower platelet counts. Of the 290 supplements and herbs with an interaction on file, 202 have blood-thinning or antiplatelet activity, and two of the three major-rated entries, danshen and piracetam, sit in that group.”

Reviewed by 2 · Jul 18, 2026

Open the Abrocitinib interaction page

One more smart check

Taking Blue-green Algae as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3,180 real supplement products containing Blue-green Algae, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Blue-green Algae. Your product may carry other ingredients that interact with Abrocitinib too, on top of Blue-green Algae — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Blue-green Algae and Abrocitinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Blue-green Algae
Top 10%

#80 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Abrocitinib
Top 25%

#430 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Blue-green Algae

What is Blue-green Algae?

Blue-green Algae
  • General nutrition and energy
  • Antioxidant support
  • Cholesterol and metabolic health
  • Immune support
  • Weight management

Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and general wellness. Evidence for most health claims is limited, and some products can be contaminated with toxins or heavy metals, so quality testing matters. Talk to your pharmacist or doctor before using, especially during pregnancy or breastfeeding.

Read the full Blue-green Algae monograph & all interactions
Medication

About Abrocitinib

What Is Abrocitinib Used For?

Brand name: Cibinqo

Abrocitinib (sold as Cibinqo tablets) treats refractory, moderate-to-severe atopic dermatitis, a long-lasting itchy skin condition also called eczema. It is for adults and children 12 years and older.

It is meant for people whose disease is not well controlled with other systemic (whole-body) medicines, including biologics, or when those medicines are not a good option. It is not recommended together with other JAK inhibitors, biologic immunomodulators, or other immunosuppressants.

See full Abrocitinib drug information
Keep checking

Other Drugs & Blue-green Algae

Browse every other medication we’ve checked against Blue-green Algae — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
326Moderate
0Minor
2,503No known interaction
326 Moderate 2,503 No interaction
Moderate

326 interactions

Showing 60 of 326 moderate interactions — see all 326 on the Blue-green Algae page.

No interaction 2,503 drugs checked — show the list

We also checked Blue-green Algae against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,503 medications checked with no known interaction — see the full Blue-green Algae list.

See the full Blue-green Algae interactions page
See every supplement checked against Abrocitinib, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Blue-green Algae monograph › Uses, safety, and every drug interaction in one place Abrocitinib supplement interactions › Every supplement checked against Abrocitinib, ranked by severity Abrocitinib drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Blue-green Algae and Abrocitinib Together: Common Questions

Can you take Blue-green Algae with Abrocitinib?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Blue-green Algae and Abrocitinib?
Abrocitinib belongs to more than one drug category, and Blue-green Algae interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Blue-green Algae and Abrocitinib interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Abrocitinib and Blue-green Algae?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.