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Dietary supplement

Equolibrium Ingredients & Drug Interactions

by Nature's Sunshine

Equolibrium label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Equolibrium against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Equolibrium is a dietary supplement by Nature's Sunshine with 1 active ingredient. Its ingredients are commonly taken for menopause symptoms (hot flashes), bone health support, skin aging.Based on those ingredients, 133 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Equol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Equolibrium by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Equolibrium by Nature's Sunshine — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Equolibrium by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Equolibrium contains one active ingredient: equol, a compound that your body can produce from soy isoflavones when you consume soy foods. This supplement delivers equol directly as a capsule.

The inactive ingredients are cellulose, vegetable capsule, and magnesium stearate, which are fillers and binders that hold the capsule together.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: prostate function and urinary flow support.
  • We looked for evidence on: Prostate cancer, benign prostatic hyperplasia, lower urinary tract symptoms, DHT-related prostate health.
  • The closest evidence on file: Equol is rated "Insufficient Reliable Evidence To Rate" for Prostate cancer (Natural Medicines).

Equol is possibly effective for menopausal symptoms based on the data we hold. For aging skin, osteoporosis, breast cancer, nonalcoholic fatty liver disease, and cardiovascular disease, the evidence isn't established—there's insufficient reliable data to rate whether it works for those purposes.

The evidence, ingredient by ingredient Equol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Equol is generally well tolerated in studies, but long-term safety and its effects on hormone-sensitive conditions aren't well established. The most common side effects reported are abdominal distension and constipation.

Depression has been rarely reported. Because equol has hormone-like effects and safety data are limited, it's best avoided during pregnancy.

There isn't enough reliable safety information to use it while breastfeeding—talk with your doctor or pharmacist about whether this product is right for you in either situation.

Side effects, ingredient by ingredient Equol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Equol.
  • The most serious interaction on file is rated Moderate.
  • For scale: 133 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Equolibrium, check with your doctor or pharmacist if you're on contraceptive drugs, estrogen therapy (including hormone replacement therapy), testosterone replacement, or diuretic medications (water pills). Equol may change how these work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Equolibrium may help with menopausal symptoms, but it carries Moderate interaction risks with hormonal medications—contraceptives, estrogen therapy, and testosterone replacement. If you take any of those, or if you're on a diuretic for blood pressure or fluid management, check your exact medications with your doctor or pharmacist before starting.

Long-term safety data are limited, so this isn't a casual add-on.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Equolibrium, straight from the product label.

Brand Nature's Sunshine
Barcode (UPC) 099904035423
Net contents 60 VegCap(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 221207
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Equolibrium by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
099904035423
IngredientAmount% DV
Equol6 mg--

Other ingredients: Cellulose, Vegetable Capsule, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Bottle made from 100% post consumer recycled material. We are committed to you and our planet. Scan to learn more.

New look! Same great product

Herbal experts since 1972

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

The powerful, unique antioxidant Equol binds directly to dihydrotestosterone (DHT) to help protect the prostate gland.

Formulation

Equolibrium supports urinary flow without side effects and improves sleep duration.

Promotes healthy urinary flow Supports & protects prostate function Promotes better sleep

Precautions

Do not use if inner seal is missing or damaged.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended use: Take 1 VegCap twice daily. Best results seen after 3-6 months of use.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Equolibrium by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Equolibrium label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Equolibrium by Nature's Sunshine

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Equol

Interacts with
133 drugs
6 mg per serving

Equol is a compound made in the gut when some people break down soy isoflavones, and it is also sold as a supplement. Early research links it to possi...

Equol monograph & interactions

Other (inactive) ingredients: Cellulose, Vegetable Capsule, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Equolibrium by Nature's Sunshine Drug Interactions

Want to check YOUR meds against Equolibrium?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
133Drugs
58 Moderate 75 Minor

Ingredients driving the most interactions

Equol 133

Individual Drug Interactions

The ingredients in Equolibrium interact with 133 drugs. Click any drug to see the details.

1 of the 1 ingredient in Equolibrium interact with drugs. Each result below shows which ingredient is responsible. Equol

Each ingredient & the kinds of drugs it affects

For each ingredient in Equolibrium with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Equol4 drug types · 133 drugs

Contraceptive Drugs

Theoretically, equol might increase the levels and clinical effects of ethinyl estradiol found in contraceptive drugs.
In vitro research shows that equol inhibits the binding of estradiol to serum proteins. Theoretically, this might increase the concentration of free, bioactive estradiol, thereby increasing the risk of adverse effects from ethinyl estradiol, including headaches, breast tenderness, dysmenorrhea, and weight gain.

Likelihood Possible Evidence D
Estrogens

Theoretically, equol might increase the levels and clinical effects of estrogens.
In vitro research shows that equol inhibits the binding of estradiol to serum proteins. Theoretically, this might increase the concentration of free, bioactive estradiol, thereby increasing the risk of adverse effects from estrogen replacement therapy, including headaches, breast tenderness, and weight gain.

Likelihood Possible Evidence D
Testosterone

Theoretically, equol might increase the levels and clinical effects of testosterone.
In vitro research shows that equol inhibits the binding of testosterone to serum proteins. Theoretically, equol supplementation might increase the concentration of free, bioactive testosterone, thereby increasing the risk of adverse effects from testosterone replacement therapy, including fluid retention, headache, acne, and gynecomastia.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, equol might cause additive diuretic effects when used with diuretic drugs.
In vitro and animal studies suggest that equol has diuretic effects, likely via inhibition of the Na-K-Cl cotransporter.

Likelihood Unlikely Evidence D
Equol full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Equolibrium, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc.
City
Spanish Fork
State
UT
ZipCode
84660
Phone Number
1-800-223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

Equolibrium by Nature's Sunshine: Common Questions

Does Equolibrium by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, Equolibrium has a known interaction with 133 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Equolibrium contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does equol actually work for hot flashes and night sweats?
Equol is possibly effective for menopausal symptoms based on available data. Whether it'll work for you is individual—talk with your doctor about whether to try it alongside or instead of other approaches.
What's the most common side effect I might notice?
Abdominal distension and constipation are the most common side effects people report. If your stomach feels bloated or you have trouble with bowel movements after starting, let your doctor or pharmacist know.
Can I take this if I'm on birth control?
No—equol has a Moderate interaction with contraceptive drugs and may raise how much active hormone your body absorbs. Talk with your doctor before adding this supplement if you're on any hormonal birth control.
Is equol the same as soy isoflavones?
No, but related. Your body can make equol from soy isoflavones when you eat soy foods, but most people don't produce enough on their own. This supplement gives you equol directly without having to eat soy.
Can I take this while breastfeeding?
There isn't enough reliable safety information about equol in breast milk. Talk with your doctor or pharmacist for personalized advice on whether it's right for you during this time.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Equolibrium is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Equolibrium label
Go deeper

The Full Monographs Behind Equolibrium’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Equol

Interacts with 133 drugs

Equol is a compound made in the gut when some people break down soy isoflavones, and it is also sold as a supplement. Early research links it to possible benefits for menopause symptoms and...

Read the full Equol monograph →
Sources

Sources & How We Checked

Equolibrium's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Equol 7 references
  1. Aso T. Equol improves menopausal symptoms in Japanese women. J Nutr 2010;140:1386S-9S. PubMed
  2. Jenks BH, Iwashita S, Nakagawa Y, et al. A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency. J Womens Health (Larchmt) 2012;21:674-82.
  3. Oyama A, Ueno T, Uchiyama S, et al. The effects of natural S-equol supplementation on skin aging in postmenopausal women: a pilot randomized placebo-controlled trial. Menopause 2012;19:202-10. PubMed
  4. Gimenez I, Lou M, Vargas F, et al. Renal and vascular actions of equol in the rat. J Hypertens 1997;15:1303-8. PubMed
  5. Martin ME, Haouriqui M, Pelissero C, et al. Interactions between phytoestrogens and human sex steroid binding protein. Life Sci 1996;58:429-36. PubMed
  6. Martinez RM, Gimenez I, Lou JM, et al. Soy isoflavonoids exhibit in vitro biological activities of loop diuretics. Am J Clin Nutr 1998;68:1354S-57S. PubMed
  7. Alda JO, Mayoral JA, Lou M, et al. Purification and chemical characterization of a potent inhibitor of the Na-K-Cl cotransport system in rat urine. Biochem Biophys Res Commun 1996;221:279-85. PubMed

See these in context on the Equol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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