Essential Aminos Complex Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Essential Aminos Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Essential Aminos Complex is a dietary supplement by Puritan's Pride with 8 active ingredients. Its ingredients are commonly taken for acetaminophen (tylenol) overdose support, liver health, urinary tract acidification.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Phenylalanine, L-Threonine, L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Essential Aminos Complex by Puritan's Pride
Ask about any prescription or over-the-counter medication and we check it for interactions with Essential Aminos Complex by Puritan's Pride — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Essential Aminos Complex by Puritan's Pride
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Essential Aminos Complex is a capsule containing eight amino acids: L-Leucine, L-Isoleucine, L-Methionine, L-Phenylalanine, L-Valine, L-Histidine, L-Threonine, and L-Lysine. These are the building blocks your body uses to make and repair muscle, enzymes, hormones, and other proteins.
The product also contains cellulose and magnesium stearate as inactive ingredients (fillers and binders that help hold the capsule together).
Does it work?
Moderate evidence
The evidence for these amino acids varies widely depending on what you're taking them for. L-Lysine shows possibly effective evidence for cold sores (herpes labialis).
L-Methionine is possibly effective for neural tube birth defects in pregnancy. L-Phenylalanine is possibly effective for vitiligo but appears possibly ineffective for ADHD.
L-Histidine is possibly effective for cholera. For most other uses listed — including multiple sclerosis, asthma, kidney failure, and rheumatoid arthritis — the evidence is insufficient to say whether these ingredients work.
This product isn't marketed for a specific condition, so whether it helps you will depend on your own situation.
How safe is it?
Well-documented data
L-Methionine, L-Histidine, and L-Lysine are generally well tolerated at typical doses. L-Phenylalanine is also generally well tolerated in food amounts and typical supplement doses but can cause anxiety, insomnia, constipation, heartburn, nausea, and headache in some people.
L-Threonine has been associated with headache, diarrhea, and gastrointestinal upset including gas and constipation. L-Methionine at high supplement doses may raise dizziness, drowsiness, and vomiting.
People with phenylketonuria (PKU) should not take L-phenylalanine supplements. For pregnancy: L-Methionine and L-Histidine are rated Likely Safe.
L-Phenylalanine's safety in pregnancy has not been established and should be avoided during pregnancy; the same goes for L-Phenylalanine while breastfeeding. For L-Lysine and L-Threonine, supplement safety during pregnancy and breastfeeding has not been well studied — talk with your doctor before use.
We have no pregnancy or breastfeeding data on file for L-Methionine's effectiveness claims regarding birth defects, so discuss this with your clinician.
Meds to double-check
Major interaction found
If you take levodopa (for Parkinson's disease), baclofen (a muscle relaxant), MAOIs (older antidepressants), NMDA antagonists (like memantine for memory loss or ketamine for depression), or 5-HT4 agonists (gut-motility drugs), check your specific medications before starting. The first four carry the most serious concerns.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.
This blend of amino acids is generally well tolerated, but before you start it — especially if you take a Parkinson's medication, a muscle relaxant, an older antidepressant (MAOI), or any neurological medication — check your exact drugs with our tool or ask your pharmacist. If you're pregnant or breastfeeding, talk with your doctor first; some ingredients lack safety data in these situations.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Essential Aminos Complex, straight from the product label.
| Brand | Puritan's Pride |
|---|---|
| Barcode (UPC) | 025077002467 |
| Net contents | 60 Rapid Release Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2024 |
| DSLD ID | 318139 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Essential Aminos Complex by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Leucine | 75 mg | -- |
| L-Isoleucine | 75 mg | -- |
| L-Methionine | 75 mg | -- |
| L-Phenylalanine | 75 mg | -- |
| L-Valine | 75 mg | -- |
| L-Histidine | 75 mg | -- |
| L-Threonine | 75 mg | -- |
| L-Lysine | 75 mg | -- |
Other ingredients: Cellulose, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Puritan's Pride supplements are produced from the finest raw materials under stringent quality control standards. State-of-the-art manufacturing and packaging facilities ensure you the highest quality nutritional supplements money can buy. When it comes to your health...choose the best.
To reorder item # 26226 www.puritan.com 1-800-645-1030
Precautions
Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of reach of children.
Do not use if seal under cap is broken or missing.
Storage
Store at room temperature.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
Puritan's Pride is a registered trademark
Seals/Symbols
QA Quality Assured
Formulation
Protein Building Blocks
Cellular Health & Function
No artificial color, flavor or sweetener, no sugar, no starch, no milk, no lactose, no soy, no gluten, no wheat, no yeast, no fish. Sodium free.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: For adults, take one (1) vegetable capsule, twice daily, between meals.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Essential Aminos Complex by Puritan's Pride label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Essential Aminos Complex by Puritan's Pride
These are the 8 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Vegetable Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Leucine
L-Isoleucine
L-Methionine
No knowninteractions
Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a norma...
L-Methionine monograph & interactionsL-Phenylalanine
Interacts with16 drugs
Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitilig...
L-Phenylalanine monograph & interactionsL-Valine
L-Histidine
No knowninteractions
Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from...
L-Histidine monograph & interactionsL-Threonine
Interacts with3 drugs
Threonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a norma...
L-Threonine monograph & interactionsL-Lysine
Interacts with1 drug
Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...
L-Lysine monograph & interactionsOther (inactive) ingredients: Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Essential Aminos Complex by Puritan's Pride Drug Interactions
HelloPharmacist Interaction Report
Puritan's Pride Essential Aminos Complex contains eight amino acids, and we've found documented interactions with 20 individual medications across the ingredients we were able to check.
Read the full breakdown — every affected drug type, severity by severity
L-Phenylalanine carries the most serious concern: it can reduce how well levodopa (a Parkinson's medication) works in your brain by competing with it for entry into the nervous system. This is a Major interaction.
If you take levodopa, you'll want to check before starting this product.
L-Phenylalanine also has Moderate interactions with baclofen (a muscle relaxant) — it can lower how much baclofen your body absorbs — and with monoamine oxidase inhibitors (MAOIs), older antidepressants that carry a theoretical risk of dangerously high blood pressure if combined with high-dose phenylalanine. L-Threonine has a Major interaction with NMDA antagonists (medications like ketamine and memantine), which it may make less effective by raising nervous system glycine levels.
L-Lysine carries a Minor interaction with 5-HT4 agonists (gut-motility drugs like cisapride), which it may reduce in effect.
We could not check L-Leucine, L-Isoleucine, or L-Valine — we hold no interaction data for these three. Run your exact medications through the search tool on this page to be sure.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Essential Aminos Complex?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Essential Aminos Complex interact with 20 drugs. Click any drug to see the details.
3 of the 8 ingredients in Essential Aminos Complex interact with drugs. Each result below shows which ingredient is responsible. L-Phenylalanine L-Threonine L-Lysine
Benserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with Essential Aminos Complex — through 1 ingredient. Tap an ingredient for the detail:
L-phenylalanineLevodopa Major
Interaction Summary
Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Read the full L-phenylalanine + Benserazide, Levodopa interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with Essential Aminos Complex — through 1 ingredient. Tap an ingredient for the detail:
L-phenylalanineLevodopa Major
Interaction Summary
Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Read the full L-phenylalanine + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with Essential Aminos Complex — through 1 ingredient. Tap an ingredient for the detail:
L-phenylalanineLevodopa Major
Interaction Summary
Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Read the full L-phenylalanine + Carbidopa, Levodopa, Entacapone interactionLevodopaInbrija, Larodopa
How Levodopa interacts with Essential Aminos Complex — through 1 ingredient. Tap an ingredient for the detail:
L-phenylalanineLevodopa Major
Interaction Summary
Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Read the full L-phenylalanine + Levodopa interactionLevodopa, CarbidopaDuodopa
How Levodopa, Carbidopa interacts with Essential Aminos Complex — through 1 ingredient. Tap an ingredient for the detail:
L-phenylalanineLevodopa Major
Interaction Summary
Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Read the full L-phenylalanine + Levodopa, Carbidopa interactionMemantineEbixa
How Memantine interacts with Essential Aminos Complex — through 1 ingredient. Tap an ingredient for the detail:
L-threonineNmda Antagonists Major
Interaction Summary
Theoretically, threonine might decrease the effects of NMDA antagonists.
Read the full L-threonine + Memantine interactionMemantine HydrochlorideNamenda
How Memantine Hydrochloride interacts with Essential Aminos Complex — through 1 ingredient. Tap an ingredient for the detail:
L-threonineNmda Antagonists Major
Interaction Summary
Theoretically, threonine might decrease the effects of NMDA antagonists.
Read the full L-threonine + Memantine Hydrochloride interactionMemantine, DonepezilNamzaric
How Memantine, Donepezil interacts with Essential Aminos Complex — through 1 ingredient. Tap an ingredient for the detail:
L-threonineNmda Antagonists Major
Interaction Summary
Theoretically, threonine might decrease the effects of NMDA antagonists.
Read the full L-threonine + Memantine, Donepezil interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Essential Aminos Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Phenylalanine
Levodopa
Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Phenylalanine competes with levodopa for carrier-mediated transport into the brain. The resulting reduction in levels of levodopa in the brain can exacerbate tremor, rigidity, and the "on-off" phenomenon in patients with Parkinson disease.
Baclofen
Concomitant intake of phenylalanine may reduce the intestinal absorption of baclofen.
Phenylalanine and baclofen share the same intestinal carrier for absorption; phenylalanine competitively inhibits the absorption of baclofen, reducing its plasma levels.
Monoamine Oxidase Inhibitors (Maois)
Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.
L-phenylalanine is metabolized to tyrosine. Some evidence suggests that L-phenylalanine, given with the non-selective MAOI pargyline, might prevent the elimination of tyramine, increasing the risk of hypertensive crisis. However, this was not reported in a small number of patients when using L-phenylalanine with the partially selective MAO-B inhibitor, selegiline.
L-Threonine
Nmda Antagonists
Theoretically, threonine might decrease the effects of NMDA antagonists.
Threonine increases central nervous system (CNS) glycine levels. Glycine seems to bind a site on NMDA receptors and enhance the activity of the receptors.
L-Lysine
5-Ht4 Agonists
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.
Brand information
Manufacturer and brand details for Essential Aminos Complex, from the product label.
Puritan's Pride
See all Puritan's Pride products- Name
- Puritan's Pride, Inc.
- City
- Ronkonkoma
- State
- NY
- ZipCode
- 11779
- Phone Number
- 1-800-645-1030
- Web Address
- www.puritan.com
Essential Aminos Complex by Puritan's Pride: Common Questions
Does Essential Aminos Complex by Puritan's Pride interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this product actually help build muscle?
Is it safe to take if I have phenylketonuria (PKU)?
Can I take this while I'm pregnant?
What are the most common side effects?
Do I need to worry about interactions with my medications?
What is histidine and what's it for?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Essential Aminos Complex is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Essential Aminos Complex’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Methionine
Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...
Read the full Methionine monograph → Herb & supplement monographPhenylalanine
Interacts with 16 drugsPhenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitiligo, or pain, but the evidence is mostly l...
Read the full Phenylalanine monograph → Herb & supplement monographHistidine
Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from a normal diet, and good-quality researc...
Read the full Histidine monograph → Herb & supplement monographThreonine
Interacts with 3 drugsThreonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a normal diet, and high-quality evidence for ta...
Read the full Threonine monograph → Herb & supplement monographLysine
Interacts with 1 drugLysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...
Read the full Lysine monograph →Sources & How We Checked
Essential Aminos Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 49 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Methionine 12 references
- La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
- Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
- Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
- Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
- Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
- McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
- Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
- Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
- Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
- Talukdar R, Murthy HV, Reddy DN. Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis. Pancreatology 2015;15(2):136-44. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI
- Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila) 2022;15(2):101-110. PubMed
Phenylalanine 23 references
- Rouse B, Azen C, Koch R, et al. Maternal phenylketonuria collaborative Study (MPKUCS) offspring: facial anomalies, malformations, and early neurological sequelae. Am J Med Genet 1997;69:89-95. DOI
- Sturtevant FM. Use of aspartame in pregnancy. Int J Fertil 1985;30:85-7.
- Silkaitis RP, Mosnaim AD. Pathways linking L-phenylalanine and 2-phenylethylamine with p-tyramine in rabbit brain. Brain Res 1976;114:105-15.
- Lehmann WD, Theobald N, Fischer R, Heinrich HC. Stereospecificity of phenylalanine plasma kinetics and hydroxylation in man following oral application of a stable isotope-labelled pseudo-racemic mixture of L- and D-phenylalanine. Clin Chim Acta 1983;128 PubMed
- Mosnik DM, Spring B, Rogers K, Baruah S. Tardive dyskinesia exacerbated after ingestion of phenylalanine by schizophrenic patients. Neuropsychopharmacology 1997;16:136-46. PubMed
- Siddiqui AH, Stolk LM, Bhaggoe R, et al. L-phenylalanine and UVA irradiation in the treatment of vitiligo. Dermatology 1994;88:215-8. PubMed
- Birkmayer W, Riederer P, Linauer W, Knoll J. L-deprenyl plus L-phenylalanine in the treatment of depression. J Neural Transm 1984;59:81-7. PubMed
- Nutt JG, Woodward WR, Hammerstad JP, et al. The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. N Engl J Med 1984;310:483-8. PubMed
- Baruzzi A, Contin M, Riva R, et al. Influence of meal ingestion time on pharmacokinetics of orally administered levodopa in parkinsonian patients. Clin Neuropharmacol 1987;10:527-37. PubMed
- Juncos JL, Fabbrini G, Mouradian MM, et al. Dietary influences on the antiparkinsonian response to levodopa. Arch Neurol 1987;44:1003-5. PubMed
- Eriksson T, Granerus AK, Linde A, et al. "On-off" phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology 1988;38:1245-8. PubMed
- Baker GB, Bornstein RA, Rouget AC, et al. Phenylethylaminergic mechanisms in attention-deficit disorder. Biol Psychiatry 1991;29:15-22.. PubMed
- Wood DR, Reimherr FW, Wender PH. Treatment of attention deficit disorder with DL-phenylalanine. Psychiatry Res 1985;16:21-6.. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: National Academy Press, 2002. Available at: http://www.n
- Cederbaum S. Phenylketonuria: an update. Curr Opin Pediatr 2002;14:702-6. PubMed
- Cejudo-Ferragud, E., Nacher, A., Polache, A., Cercos-Fortea, T., Merino, M., and Casabo, V. G. Evidence of competitive inhibition for the intestinal absorption of baclofen by phenylalanine. Int J of Pharm (Amsterdam) 1996;132:63-69. DOI
- Fischer, E., Heller, B., Nachon, M., and Spatz, H. Therapy of depression by phenylalanine. Preliminary note. Arzneimittelforschung. 1975;25(1):132.
- Beckmann, H., Strauss, M. A., and Ludolph, E. Dl-phenylalanine in depressed patients: an open study. J.Neural Transm. 1977;41(2-3):123-134. PubMed
- Sabelli, H. C., Fawcett, J., Gusovsky, F., Javaid, J. I., Wynn, P., Edwards, J., Jeffriess, H., and Kravitz, H. Clinical studies on the phenylethylamine hypothesis of affective disorder: urine and blood phenylacetic acid and phenylalanine dietary supplem
- Cotzias, G. C., Van Woert, M. H., and Schiffer, L. M. Aromatic amino acids and modification of parkinsonism. N Engl.J Med 2-16-1967;276(7):374-379. PubMed
- Kravitz, H. M., Sabelli, H. C., and Fawcett, J. Dietary supplements of phenylalanine and other amino acid precursors of brain neuroamines in the treatment of depressive disorders. J Am Osteopath.Assoc 1984;84(1 Suppl):119-123. DOI
- Mann, J., Peselow, E. D., Snyderman, S., and Gershon, S. D-phenylalanine in endogenous depression. Am.J.Psychiatry 1980;137(12):1611-1612. PubMed
- Katoulis AC, Alevizou A, Bozi E, et al. A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines. Clin Exp Dermatol 2010;35(5):473-6. PubMed
Histidine 3 references
Threonine 4 references
- Tandan R, Bromberg MB, Forshew D, et al. A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology 1996;47:1220-6. PubMed
- Lee A, Patterson V. A double blind study of L-threonine in patients with spinal spasticity. Acta Neurol Scand 1993;88:334-8. PubMed
- Blin O, Pouget J, Aubrespy G, et al. A double-blind placebo controlled trial of L-threonine in amyotrophic lateral sclerosis. J Neurol 1992;239:79-81.
- Roufs JB. L-threonine as a symptomatic treatment for amyotrophic lateral sclerosis (ALS). Med Hypotheses 1991;34:20-3. PubMed
Lysine 7 references
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
- DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
- Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC