Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Essiac Tonic Ingredients & Drug Interactions

by Herbs Etc.

Essiac Tonic label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Essiac Tonic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Essiac Tonic is a dietary supplement by Herbs Etc. with 4 active ingredients. Its ingredients are commonly taken for skin conditions like acne and eczema, digestive support, diuretic ('detox') and blood purifier.Based on those ingredients, 2,130 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Slippery Elm Inner Bark Extract, Chinese Rhubarb Root Extract, Sheep Sorrel herb extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Essiac Tonic by Herbs Etc.

Ask about any prescription or over-the-counter medication and we check it for interactions with Essiac Tonic by Herbs Etc. — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Essiac Tonic by Herbs Etc.

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (1 mL) without saying how much of each component you get.

Essiac Tonic contains 4 active ingredients: burdock root extract, sheep sorrel herb extract, slippery elm inner bark extract, and Chinese rhubarb root extract. These are traditional botanical ingredients historically blended together as a tonic.

The product also contains inactive ingredients—alcohol, purified water, and glycerin—which serve as the liquid base and preservative.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Traditional herbal cleanse supplement.
  • We looked for evidence on: detoxification, immune support, general wellness.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence data we hold doesn't establish effectiveness for any condition this product might be used for. Burdock shows insufficient evidence for acne, aging skin, breast cancer, common cold, and eczema.

Sheep sorrel is similarly unproven for bronchitis, breast cancer, and sinus inflammation. Slippery elm has insufficient evidence for cancer, constipation, cough, inflammatory bowel disease, and diarrhea.

Rhubarb is rated possibly effective for pancreatitis and menopausal symptoms, but insufficient evidence supports its use for appendicitis, nasopharyngeal cancer, fatty liver disease, or constipation.

The evidence, ingredient by ingredient Burdock Sorrel Slippery Elm Rhubarb

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Burdock is likely safe as a food and for short-term use in healthy adults, though human safety data are limited. It's well tolerated when eaten, but rare allergic reactions including anaphylaxis have been reported, and a single case of drug-induced liver injury was noted (though it's unclear if burdock alone was responsible).

Avoid medicinal amounts during pregnancy due to possible effects on the uterus, and avoid medicinal use while breastfeeding. Sheep sorrel is possibly safe in pregnancy but carries caution during breastfeeding.

Its high oxalate content poses a kidney-stone risk with large or concentrated doses; a case of kidney inflammation was reported in a young person after consuming wild sorrel. Slippery elm is generally well tolerated but can cause contact dermatitis topically, and not enough data exists for safety in pregnancy or breastfeeding.

Chinese rhubarb root should not be used long-term; medicinal amounts may stimulate the uterus and are avoided in pregnancy and breastfeeding. Common side effects include cramps, diarrhea, nausea, and vomiting; chronic overuse risks potassium depletion, kidney damage, and other electrolyte problems.

Side effects, ingredient by ingredient Burdock Sorrel Slippery Elm Rhubarb

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Burdock, Rhubarb, Sorrel, Slippery Elm.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; heart-rhythm medications.
  • For scale: 2,131 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Essiac Tonic, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin)—burdock, sorrel, and rhubarb may increase bleeding risk. Also check if you take heart medications (digoxin), diuretics, corticosteroids, or allergy drugs like fexofenadine, since rhubarb may worsen potassium loss with the first three, and sorrel may reduce fexofenadine absorption.

If you take any oral medication regularly, note that slippery elm may slow its absorption. Lastly, avoid high doses of rhubarb if you take hepatotoxic or nephrotoxic drugs or other laxatives.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Essiac Tonic is a traditional herbal blend with little established effectiveness for any specific condition—most ingredients lack sufficient research. If you take blood thinners, heart drugs, diuretics, or corticosteroids, or if you have kidney or liver concerns, run this product through a medication check with your own doctor or pharmacist before starting.

Pregnant or breastfeeding people should talk with their healthcare provider first, since several ingredients carry safety cautions during these times.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Essiac Tonic, straight from the product label.

Brand Herbs Etc.
Barcode (UPC) 765704112014
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 299993
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Essiac Tonic by Herbs Etc., sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
40 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
30
UPC/BARCODE
765704112014
IngredientAmount% DV
Burdock root extract0 NP--
Proprietary Extract Blend1 mL--
Sheep Sorrel herb extract0 NP--
Slippery Elm Inner Bark Extract0 NP--
Chinese Rhubarb Root Extract0 NP--

Other ingredients: Alcohol, Water, Purified, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Herbal medicine

Gluten free No artificial preservatives.

Vegan

Made in Santa Fe, NM.

Formula

Traditional four herb Ojibwa cleanse

Essiac Tonic stays true to the traditional four herb Ojibwa cleanse formula.

FDA Statement of Identity

Herbal Supplement

General Statements

We apply our company philosophy to Essiac Tonic, as we do to all of our herbal medicines. That philosophy is to do what's right, which extends to choosing the right herbs, using the right processes and making the right formulations that support your health needs. We do all of this to bring you herbal medicines made right.

Quality Control #: 1234567

Servings per container about 30

Brand IP Statement(s)

We do all of this to bring you herbal medicines made right.

Suggested/Recommended/Usage/Directions

Suggested use: Take 40 drops in water twice a day on an empty stomach.

Precautions

Caution: Do not use during pregnancy.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Essiac Tonic by Herbs Etc. label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Essiac Tonic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Essiac Tonic by Herbs Etc.

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size40 Drop(s) Dosage formLiquid Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Alcohol, Water, Purified, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Essiac Tonic by Herbs Etc. Drug Interactions

Want to check YOUR meds against Essiac Tonic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,130Drugs
2,130 Moderate

Ingredients driving the most interactions

Slippery Elm Inner Bark Extract 2,022
Chinese Rhubarb Root Extract 658
Sheep Sorrel herb extract 169
Burdock root extract 122

Individual Drug Interactions

The ingredients in Essiac Tonic interact with 2,130 drugs. Click any drug to see the details.

4 of the 4 ingredients in Essiac Tonic interact with drugs. Each result below shows which ingredient is responsible. Slippery Elm Inner Bark Extract Chinese Rhubarb Root Extract Sheep Sorrel herb extract Burdock root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Essiac Tonic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Slippery Elm Inner Bark Extract1 drug type · 2,022 drugs

Oral Drugs

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.

Likelihood Possible Evidence D
Slippery Elm Inner Bark Extract full monograph & interactions

Chinese Rhubarb Root Extract8 drug types · 658 drugs

Corticosteroids

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia when taken with corticosteroids.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might compound corticosteroid-induced potassium loss.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, taking rhubarb with cyclosporine might reduce cyclosporine levels.
Animal research shows that co-administration of rhubarb decoction 0.25 or 1 gram/kg with cyclosporine 2.5 mg/kg, decreases cyclosporine maximum plasma concentration and overall exposure levels when compared with taking cyclosporine alone. The authors theorize that rhubarb might reduce cyclosporine bioavailability by inducing of P-glycoprotein and/or cytochrome P450 3A4. However, since rhubarb was administered as a single oral dose and enzyme induction usually occurs after multiple doses, it is possible that cyclosporine absorption was actually reduced via rhubarb's stimulant laxative effects. Also, the composition of the rhubarb decoction was not described.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, overuse of rhubarb might increase the risk of adverse effects when taken with digoxin.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion, increasing the risk of digoxin toxicity.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion and compound diuretic-induced potassium loss.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Some animal research suggests that anthraquinones in rhubarb might have hepatotoxic effects. Also, rhubarb use has been linked to at least 24 cases of liver injury, although details on the dose of rhubarb and duration of use in these cases is unclear.

Likelihood Possible Evidence D
Nephrotoxic Drugs

Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
The anthraquinone constituents of rhubarb have been shown to induce nephrotoxicity in animal research. Additionally, in a case report, a 23-year old female presented with kidney failure after taking 6 tablets of a proprietary slimming agent (found to contain the anthraquinones emodin and aloe-emodin from rhubarb) daily for 6 weeks and then adding diclofenac 25 mg 4 times daily for 2 days. The authors postulate that the anthraquinone constituents of rhubarb contributed to the renal dysfunction, and the addition of diclofenac, a nephrotoxic drug, led to renal failure. Until more is known, advise patients to avoid taking rhubarb if they are taking other potentially nephrotoxic drugs.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, rhubarb might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Rhubarb has stimulant laxative effects. Concomitant use with stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, excessive use of rhubarb might increase the risk of bleeding when taken with warfarin.
Rhubarb has stimulant laxative effects and can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of rhubarb.

Likelihood Possible Evidence D
Chinese Rhubarb Root Extract full monograph & interactions

Sheep Sorrel herb extract3 drug types · 169 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
In vitro, sorrel has been shown to inhibit platelet aggregation. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Fexofenadine (Allegra)

Sorrel might reduce the effectiveness of fexofenadine by reducing its absorption from the gut.
In vitro research shows that an ethanol extract of sorrel inhibits organic anion-transporting polypeptide 1A2 (OATP1A2), which transports fexofenadine from the intestine into cells. In rats, concomitant administration of sorrel extract with fexofenadine reduces oral absorption of fexofenadine and the area under the plasma concentration-time curve (AUC).

Likelihood Likely Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Sorrel might reduce the effectiveness of OATP substrates by reducing their absorption from the gut.
In vitro research shows that sorrel inhibits OATP1A2. Theoretically it may inhibit other OATPs. The OATPs are expressed in the small intestine and liver and transport drugs into cells. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
Sheep Sorrel herb extract full monograph & interactions

Burdock root extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

In vitro research shows that lignans from burdock reduce rabbit platelet aggregation by inhibiting platelet activating factor. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Burdock root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Essiac Tonic, from the product label.

Herbs Etc.

Name
Herbs, Etc., Inc.
Street Address
1340 Rufina Circle
City
Sante Fe
State
NM
ZipCode
87507
Web Address
www.herbsetc.com
Pharmacist Counseling Corner

Essiac Tonic by Herbs Etc.: Common Questions

Does Essiac Tonic by Herbs Etc. interact with any medications?
Yes. Based on its ingredients, Essiac Tonic has a known interaction with 2,130 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Essiac Tonic contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Essiac Tonic safe during pregnancy or breastfeeding?
No—medicinal amounts of burdock and rhubarb should be avoided in pregnancy due to possible effects on the uterus. Sheep sorrel is rated possibly safe in pregnancy, but the data on rhubarb advise against it. For breastfeeding, burdock and rhubarb aren't recommended because laxative compounds may pass into milk. Talk with your doctor or pharmacist about whether this product is right for you during these times.
What are the most common side effects?
Rhubarb, the main laxative ingredient, commonly causes cramps, diarrhea, nausea, and vomiting. Sorrel may cause nausea and an unpleasant aftertaste when combined with other herbs. Rare allergic reactions to burdock (including anaphylaxis) and contact dermatitis from slippery elm have been reported, but serious effects are uncommon.
Can I take this if I have kidney or liver problems?
You should check with your doctor first. Sorrel's high oxalate content poses kidney-stone risk; rhubarb carries theoretical risk to kidneys and liver with long-term use, and a case of drug-induced liver injury has been reported with burdock in a detox blend. Your doctor can advise whether this product is appropriate for you.
Does Essiac Tonic actually work for cancer or other serious conditions?
We don't have evidence in our data that it's effective for any condition. Burdock and sorrel lack sufficient research for breast cancer, and slippery elm and rhubarb similarly lack proof for cancer or other serious diseases. If you're considering it for a medical condition, talk with your doctor about evidence-based treatments.
Why does this liquid contain alcohol?
Alcohol is listed as an inactive ingredient and serves as a preservative and extraction medium in liquid herbal formulas. The amount per dose may vary; if you need to avoid alcohol, check the label or ask your pharmacist for the concentration.
Is this safe to take long-term?
Burdock and slippery elm data note limited safety for long-term use. Rhubarb root specifically should not be used long-term—chronic overuse risks potassium loss, kidney damage, and other problems. If you're considering ongoing use, talk with your doctor or pharmacist about whether it's appropriate and for how long.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Essiac Tonic label
Go deeper

The Full Monographs Behind Essiac Tonic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Burdock

Interacts with 122 drugs

Burdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and most claims are not well proven. It is wid...

Read the full Burdock monograph → Herb & supplement monograph

Sorrel

Interacts with 169 drugs

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for any health benefit is limited, and its hig...

Read the full Sorrel monograph → Herb & supplement monograph

Slippery Elm

Interacts with 2,022 drugs

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...

Read the full Slippery Elm monograph → Herb & supplement monograph

Rhubarb

Interacts with 658 drugs

Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food. Most medicinal claims are backed by limited or low-quality...

Read the full Rhubarb monograph →
Sources

Sources & How We Checked

Essiac Tonic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 42 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Burdock 11 references
  1. Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8. PubMed
  2. Sasaki Y, Kimura Y, Tsunoda T, Tagami H. Anaphylaxis due to burdock. Int J Dermatol 2003;42:472-3. PubMed
  3. Rhoads PM, Tong TG, Banner W Jr, Anderson R. Anticholinergic poisonings associated with commercial burdock root tea. J Toxicol Clin Toxicol 1984-85;22:581-4. PubMed
  4. Rodriguez P, Blanco J, Juste S, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis 1995;33:134-5.
  5. Kassler, W. J., Blanc, P., and Greenblatt, R. The use of medicinal herbs by human immunodeficiency virus-infected patients. Arch Intern Med 1991;151(11):2281-2288. DOI
  6. Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M., Leung, G. P., Yu, P. H., and Chan, S. W. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19(5):245-254. PubMed
  7. Breed, F. B. and Kuwabara, T. Burdock ophthalmia. Arch Ophthalmol 1966;75(1):16-20.
  8. Bryson, P. D., Watanabe, A. S., Rumack, B. H., and Murphy, R. C. Burdock root tea poisoning. Case report involving a commercial preparation. JAMA 5-19-1978;239(20):2157. DOI
  9. <p>Fletcher GF<span>, </span>Cantwell JD. Burdock root tea poisoning. JAMA <span>1978 Oct 6;240(15):1586.</span></p> DOI
  10. Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. PubMed
  11. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed

See these in context on the Burdock monograph →

Sorrel 8 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Zick, S. M., Sen, A., Feng, Y., Green, J., Olatunde, S., and Boon, H. Trial of Essiac to ascertain its effect in women with breast cancer (TEA-BC). J Altern Complement Med 2006;12(10):971-980. PubMed
  4. Sanz, P. and Reig, R. Clinical and pathological findings in fatal plant oxalosis. A review. Am J Forensic Med Pathol. 1992;13(4):342-345. PubMed
  5. Gniazdowska, B., Doroszewska, G., and Doroszewski, W. [Hypersensitivity to weed pollen allergens in the region of Bygdoszcz]. Pneumonol.Alergol.Pol. 1993;61(7-8):367-372.
  6. Selçuk SN, Gülhan B, Düzova A, Teksam Ö. Acute tubulointerstitial nephritis due to large amount of sorrel (Rumex acetosa) intake. Clin Toxicol (Phila) 2015;53(5):497. PubMed
  7. Ahn JH, Kim J, Rehman NU, Kim HJ, Ahn MJ, Chung HJ. Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine. Pharmaceutics. 2020;12(6):E547. PubMed
  8. Jeong D, Irfan M, Lee DH, Hong SB, Oh JW, Rhee MH. Rumex acetosa modulates platelet function and inhibits thrombus formation in rats. BMC Complement Med Ther. 2020;20(1):98. PubMed

See these in context on the Sorrel monograph →

Slippery Elm 3 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Czarnecki D, Nixon R, Bekhor P, and et al. Delayed prolonged contact urticaria from the elm tree. Contact Dermatitis 1993;28:196-197. PubMed

See these in context on the Slippery Elm monograph →

Rhubarb 20 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
  6. Kwan TH, Tong MK, Leung KT, et al. Acute renal failure associated with prolonged intake of slimming pills containing anthraquinones. Hong Kong Med J 2006;12:394-7.
  7. Fairbairn JW. The anthraquinone laxatives. Biological assay and its relation to chemical structure. Pharmacology 1976;14:48-61. PubMed
  8. Siegers, C. P., Hertzberg-Lottin, E., Otte, M., and Schneider, B. Anthranoid laxative abuse--a risk for colorectal cancer? Gut 1993;34(8):1099-1101. PubMed
  9. Fan, J. G. Evaluating the efficacy and safety of Danning Pian in the short-term treatment of patients with non-alcoholic fatty liver disease: a multicenter clinical trial. Hepatobiliary.Pancreat.Dis.Int 2004;3(3):375-380.
  10. Yan, M., Zhang, L. Y., Sun, L. X., Jiang, Z. Z., and Xiao, X. H. Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays. J Ethnopharmacol. 4-15-2006; PubMed
  11. Zhang, J. H., Li, L. S., and Zhang, M. Clinical effects of rheum and captopril on preventing progression of chronic renal failure. Chin Med J (Engl.) 1990;103(10):788-793.
  12. Mitsuma, T., Yokozawa, T., Oura, H., and Terasawa, K. [Rhubarb therapy in patients with chronic renal failure (Part 2)]. Nippon Jinzo Gakkai Shi 1987;29(2):195-207.
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See these in context on the Rhubarb monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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